General
Xin Lu, Professor, Dalian Institute of Chemical Physics, CAS
Email:luxin001@dicp.ac.cn
Telephone: 0411-84379532
Mobile phone:
Address: Zhongshan Road 457, Dalian, China
Postcode:116023
Research Areas
- Methodology of extremely complex systems analysis and its application.
- Metabolomics / metabonomics analytical platform and its application in disease biomarker discovery, plant functional genome etc.
Education
2000-2004, PhD, Analytical Chemistry, Dalian Institute of Chemical Physics , CAS
1993-1996, M.E, Fine Chemical, Dalian University of Technology
1989-1993, B.E, Fine Chemical, Dalian University of Technology
Publications
1. Liang, W. Y.; Zheng, F. J.; Chen, T. T.; Zhang, X. Q.; Xia, Y. Y.; Li, Z. F.; Lu, X.; Zhao, C. X.; Xu, G. W., Nontargeted screening method for veterinary drugs and their metabolites based on fragmentation characteristics from ultrahigh-performance liquid chromatography-high-resolution mass spectrometry. Food Chemistry 2022, 369.
2. Yu, D.; Zheng, F. J.; Wang, L. C.; Li, C.; Lu, X.; Lin, X. H.; Zhou, L. N.; Xu, G. W., Novel Stable Isotope-Resolved Metabolomics Method for a Small Number of Cells Using Chip-Based Nanoelectrospray Mass Spectrometry. Analytical Chemistry 2021, 93, 13765-13773.
3. Xia, Y. Y.; Ma, C. F.; Ju, R.; Zhao, C. X.; Zheng, F. J.; Sun, X. S.; Li, Z. F.; Wang, C. Y.; Shi, D. J.; Lin, X. H.; Lu, X.; Xu, G. W., Characterization of nitrogen-containing compounds in petroleum fractions by online reversed-phase liquid chromatography-electrospray ionization Orbitrap mass spectrometry. Fuel 2021, 284.
4. Wang, L. C.; Zhang, Y. N.; Liu, X. Y.; Zhao, X. J.; Ouyang, Y.; Qiu, G. K.; Lv, W. J.; Zheng, F. J.; Wang, Q. Q.; Lu, X.; Peng, X. J.; Wu, T. C.; Lehmann, R.; Wang, C. R.; Jia, W. P.; Xu, G. W., Metabolite Triplet in Serum Improves the Diagnostic Accuracy of Prediabetes and Diabetes Screening. Journal of Proteome Research 2021, 20, 1005-1014.
5. Wang, L. C.; Lv, W. J.; Sun, X. S.; Zheng, F. J.; Xu, T. R.; Liu, X. Y.; Li, H.; Lu, X.; Peng, X. J.; Hu, C. X.; Xu, G. W., Strategy for Nontargeted Metabolomic Annotation and Quantitation Using a High-Resolution Spectral-Stitching Nanoelectrospray Direct-Infusion Mass Spectrometry with Data-Independent Acquisition. Analytical Chemistry 2021, 93, 10528-10537.
6. Lu, X.; Dou, P.; Xie, X. Y.; Wang, X. L.; Liu, X. Y.; Hua, R.; Xu, G. W., Development of a novel analytical method for inflammation and immunity-related metabolites in serum based on liquid chromatography tandem mass spectrometry. Talanta 2021, 234.
7. Ju, R.; Liu, X. Y.; Zheng, F. J.; Lu, X.; Xu, G. W.; Lin, X. H., Deep Neural Network Pretrained by Weighted Autoencoders and Transfer Learning for Retention Time Prediction of Small Molecules. Analytical Chemistry 2021, 93, 15651-15658.
8. Zhou, Z. H.; Feng, D. S.; Liang, W. Y.; Lu, X.; Shi, X. Z.; Zhao, C. X.; Xu, G. W., Synthesis of metal-organic framework-5@chitosan material for the analysis of microcystins and nodularin based on ultra-performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography A 2020, 1623.
9. Zhang, S.; Lu, X.; Hu, C. X.; Li, Y. L.; Yang, H.; Yan, H. J.; Fan, J. H.; Xu, G. W.; Abnet, C. C.; Qiao, Y. L., Serum Metabolomics for Biomarker Screening of Esophageal Squamous Cell Carcinoma and Esophageal Squamous Dysplasia Using Gas Chromatography-Mass Spectrometry. Acs Omega 2020, 5, 26402-26412.
10. Wang, Y. F.; Zhou, L. N.; Zhou, Y.; Zhao, C. X.; Lu, X.; Xu, G. W., A rapid GC method coupled with quadrupole or time of flight mass spectrometry for metabolomics analysis. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2020, 1160.
11. Wang, Q. Q.; Su, B. Z.; Dong, L. W.; Jiang, T. Y.; Tan, Y. X.; Lu, X.; Liu, X. Y.; Lin, X. H.; Xu, G. W., Liquid Chromatography-Mass Spectrometry-Based Nontargeted Metabolomics Predicts Prognosis of Hepatocellular Carcinoma after Curative Resection. Journal of Proteome Research 2020, 19, 3533-3541.
12. Sun, X. S.; Wu, P. C.; Zhao, C. X.; Zheng, F. J.; Hu, C. X.; Lu, X.; Xu, G. W., Protein profiling analysis based on matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometry and its application in typing Streptomyces isolates. Talanta 2020, 208.
13. Liu, P. P.; Luo, J.; Zheng, Q. X.; Chen, Q. S.; Zhai, N.; Xu, S. C.; Xu, Y. L.; Jin, L. F.; Xu, G. Y.; Lu, X.; Xu, G. W.; Wang, G. J.; Shao, J. F.; Xu, H. M.; Cao, P. J.; Zhou, H. N.; Wang, X. S., Integrating transcriptome and metabolome reveals molecular networks involved in genetic and environmental variation in tobacco. DNA Research 2020, 27.
14. Ju, R.; Liu, X. Y.; Zheng, F. J.; Zhao, X. J.; Lu, X.; Lin, X. H.; Zeng, Z. D.; Xu, G. W., A graph density-based strategy for features fusion from different peak extract software to achieve more metabolites in metabolic profiling from high-resolution mass spectrometry. Analytica Chimica Acta 2020, 1139, 8-14.
15. Zhou, L. N.; Wang, Z. C.; Hu, C. X.; Zhang, C. Q.; Kovatcheva-Datchary, P.; Yu, D.; Liu, S. S.; Ren, F. F.; Wang, X. L.; Li, Y. L.; Hou, X. L.; Piao, H. L.; Lu, X.; Zhang, Y.; Xu, G. W., Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation. Journal of Proteome Research 2019, 18, 960-969.
16. Mu, Y.; Zhou, Y.; Wang, Y. F.; Li, W.; Zhou, L. N.; Lu, X.; Gao, P.; Gao, M. Y.; Zhao, Y. H.; Wang, Q.; Wang, Y. F.; Xu, G. W., Serum Metabolomics Study of Nonsmoking Female Patients with Non-Small Cell Lung Cancer Using Gas Chromatography-Mass Spectrometry. Journal of Proteome Research 2019, 18, 2175-2184.
17. Ju, R.; Liu, X. Y.; Zheng, F. J.; Zhao, X. J.; Lu, X.; Zeng, Z. D.; Lin, X. H.; Xu, G. W., Removal of false positive features to generate authentic peak table for high-resolution mass spectrometry-based metabolomics study. Analytica Chimica Acta 2019, 1067, 79-87.
18. Fu, Y.; Zhang, Y.; Zhou, Z.; Lu, X.; Liu, X.; Zhao, C.*; Xu, G*. Screening and Determination of Potential Risk Substances Based on Liquid Chromatography-High-Resolution Mass Spectrometry. Analytical Chemistry 2018, 90, 8454-8461.
19. Li, Z.; Zhao, C.; Zhao, X.; Xia, Y.; Sun, X.; Xie, W.; Ye, Y.; Lu, X.*; Xu, G*. Deep Annotation of Hydroxycinnamic Acid Amides in Plants Based on Ultra-High-Performance Liquid Chromatography-High-Resolution Mass Spectrometry and Its In Silico Database. Analytical Chemistry 2018, 90, 14321-14330.
20. Zhao, X.; Zeng, Z.; Chen, A.; Lu, X.; Zhao, C.; Hu, C.; Zhou, L.; Liu, X.; Wang, X.; Hou, X.; Ye, Y.; Xu, G.* Comprehensive Strategy to Construct In-House Database for Accurate and Batch Identification of Small Molecular Metabolites. Analytical Chemistry 2018, 90, 7635-7643.
21. Zhao, J.Y.; Li, L.L.; Zhao Y.N.; Zhao, C.X.; Chen, X.; Liu, P.P.; Zhou, H.N.; Zhang, J.J.; Hu, C.X.; Chen, A.G.; Liu, G.S.; Peng, X.J.; Lu, X. *; Xu, G.W.* Metabolic Changes in Primary, Secondary and Lipid Metabolism in Tobacco Leaf in Response to Topping, Anal. Bioanal. Chem., 2018, 410(3):839-851.
22. Zhou, Y.; Hu, C.; Zhao, X.J.; Luo, P.; Lu, J.Y.; Li, Q.; Chen, M.; Lu, X.*; Kong, H.W.; Jia, W.P.*; Xu, G.W.* Serum Metabolomics Study of Gliclazide Modified-release Treated Type 2 Diabetes Mellitus Patients Using a Gas Chromatography-Mass Spectrometry Method，J. Proteome Res., 2018, 17(4): 1575-1585.
23. Li, L.L.; Ren, W.J.; Kong, H.W.; Zhao, C.X.; Zhao, X.J.; Lin X.H.*; Lu, X.*; Xu, G.W. An alignment algorithm for LC-MS-based metabolomics dataset assisted by MS/MS information. Analytica Chimica Acta, 2017, 990, 96-102.
24. Zhou, Y.; Song, R.X. ; Ma, C.; Zhou, L.N.; Liu, X.Y.; Yin, P.Y.; Zhang, Z.S.; Sun, Y.H.; Xu, C.L.*; Lu, X.*; Xu, G.W. Discovery and validation of potential urinary biomarkers for bladder cancer diagnosis using a pseudotargeted GC-MS metabolomics method. Oncotarget, 2017, 8(13):20719-20728
25. Zhao, Y. N.; Hao, Z. L.; Zhao, C. X.; Zhao, J. Y.; Zhang, J. J.; Li, Y. L.; Li, L. L.; Huang, X.; Lin, X. H.; Zeng, Z. D.; Lu, X.*; Xu, G. W.*, A Novel Strategy for Large-Scale Metabolomics Study by Calibrating Gross and Systematic Errors in Gas Chromatography-Mass Spectrometry. Analytical Chemistry 2016, 88, 2234-2242.
26. Zhao, J. Y.; Zhao, Y. N.; Hu, C. X.; Zhao, C. X.; Zhang, J. J.; Li, L. L.; Zeng, J.; Peng, X. J.; Lu, X.*; Xu, G. W., Metabolic Profiling with Gas Chromatography-Mass Spectrometry and Capillary Electrophoresis-Mass Spectrometry Reveals the Carbon-Nitrogen Status of Tobacco Leaves Across Different Planting Areas. Journal of Proteome Research 2016, 15, 468-476.
27. Zhou, Y.; Song, R.; Zhang, Z.; Lu, X.*; Zeng, Z.; Hu, C.; Liu, X.; Li, Y.; Hou, J.; Sun, Y.; Xu, C.*; Xu, G., The development of plasma pseudotargeted GC-MS metabolic profiling and its application in bladder cancer. Analytical and Bioanalytical Chemistry 2016, 408, 6741-6749.
Fu, Y.; Zhou, Z.; Li, Y.; Lu, X.; Zhao, C.; Xu, G., High-sensitivity detection of biogenic amines with multiple reaction monitoring in fish based on benzoyl chloride derivatization. Journal of Chromatography A 2016, 1465, 30-37.
28. Fu, Y.; Zhou, Z.; Kong, H.; Lu, X.; Zhao, X.; Chen, Y.; Chen, J.; Wu, Z.; Xu, Z.; Zhao, C.; Xu, G., Nontargeted Screening Method for Illegal Additives Based on Ultrahigh-Performance Liquid Chromatography-High-Resolution Mass Spectrometry. Analytical Chemistry 2016, 88, 8870-8877.
29. Zhao, Y. N.; Zhao, J. Y.; Zhao, C. X.; Zhou, H. N.; Li, Y. L.; Zhang, J. J.; Li, L. L.; Hu, C. X.; Li, W. Z.; Peng, X. J.; Lu, X.*; Lin, F. C.; Xu, G. W., A metabolomics study delineating geographical location-associated primary metabolic changes in the leaves of growing tobacco plants by GC-MS and CE-MS. Scientific Reports 2015, 5.
30. Zhao, Y. N.; Zhang, L.; Zhao, C. X.; Hu, C. X.; Li, Y. L.; Zhao, J. Y.; Zhang, J. J.; Li, L. L.; Chang, Y. W.; Wang, F.; Lu, X.*; Zhu, Z.*; Xu, G. W., Metabolic responses of rice leaves and seeds under transgenic backcross breeding and pesticide stress by pseudotargeted metabolomics. Metabolomics 2015, 11, 1802-1814.
31. Li, L. L.; Lu, X.; Zhao, J. Y.; Zhang, J. J.; Zhao, Y. N.; Zhao, C. X.; Xu, G. W., Lipidome and metabolome analysis of fresh tobacco leaves in different geographical regions using liquid chromatography-mass spectrometry. Analytical and Bioanalytical Chemistry 2015, 407, 5009-5020.
32. Zhao, Y. N.; Zhao, C. X.; Li, Y. L.; Chang, Y. W.; Zhang, J. J.; Zeng, Z. D.; Lu, X.*; Xu, G. W., Study of metabolite differences of flue-cured tobacco from different regions using a pseudotargeted gas chromatography with mass spectrometry selected-ion monitoring method. Journal of Separation Science 2014, 37, 2177-2184.
33. Li, L. L.; Zhao, C. X.; Chang, Y. W.; Lu, X.; Zhang, J. J.; Zhao, Y. N.; Zhao, J. Y.; Xu, G. W., Metabolomics study of cured tobacco using liquid chromatography with mass spectrometry: Method development and its application in investigating the chemical differences of tobacco from three growing regions. Journal of Separation Science 2014, 37, 1067-1074.
34. Chang, Y. W.; Zhang, L.; Lu, X.; Zhao, C. X.; Zhu, Z.; Wang, F.; Zhang, J. J.; Chen, S. L.; Zhao, Y. N.; Xu, G. W., A simultaneous extraction method for metabolome and lipidome and its application in cry1Ac and sck-transgenic rice leaf treated with insecticide based on LC-MS analysis. Metabolomics 2014, 10, 1197-1209.
35. Zhang, J. J.; Zhao, C. X.; Chang, Y. W.; Zhao, Y. N.; Li, Q. H.; Lu, X.*; Xu, G. W., Analysis of free amino acids in flue-cured tobacco leaves using ultra-high performance liquid chromatography with single quadrupole mass spectrometry. Journal of Separation Science 2013, 36, 2868-2877.
36. Zhao, Y. N.; Zhao, C. X.; Lu, X.*; Zhou, H. N.; Li, Y. L.; Zhou, J.; Chang, Y. W.; Zhang, J. J.; Jin, L. F.; Lin, F. C.; Xu, G. W.*, Investigation of the Relationship between the Metabolic Profile of Tobacco Leaves in Different Planting Regions and Climate Factors Using a Pseudotargeted Method Based on Gas Chromatography/Mass Spectrometry. Journal of Proteome Research 2013, 12, 5072-5083.
37. Li, Y.; Pang, T.; Li, Y. L.; Ye, G. Z.; Lu, X.*; Xu, G. W., Chemical properties investigation of commercial cigarettes by a "pseudo" targeted method using GC-MS-selected ions monitoring. Journal of Separation Science 2013, 36, 1545-1552.
38. Li, Y.; Pang, T.; Li, Y. L.; Wang, X. L.; Li, Q. H.; Lu, X.*; Xu, G. W., Gas chromatography-mass spectrometric method for metabolic profiling of tobacco leaves. Journal of Separation Science 2011, 34, 1447-1454.
39. Li, X.; Luo, X. X.; Lu, X.; Duan, J. G.; Xu, G. W., Metabolomics study of diabetic retinopathy using gas chromatography-mass spectrometry: a comparison of stages and subtypes diagnosed by Western and Chinese medicine. Molecular Biosystems 2011, 7, 2228-2237.
40. Chen, S. L.; Kong, H. W.; Lu, X.; Li, Y.; Yin, P. Y.; Zeng, Z. D.; Xu, G. W., Pseudotargeted Metabolomics Method and Its Application in Serum Biomarker Discovery for Hepatocellular Carcinoma Based on Ultra High-Performance Liquid Chromatography/Triple Quadrupole Mass Spectrometry. Analytical Chemistry 2013, 85, 8326-8333.
Research Interests
1. High resolution and sensitivity analytical methods
2. Novel analytical method and techniques for metabolomics/metabonomics
3. Plant metabolomics
Students
已指导学生
杨兆鹏 硕士研究生 070302-分析化学
李丽丽 博士研究生 070302-分析化学
王志超 博士研究生 070302-分析化学
王利超 博士研究生 070302-分析化学
周智慧 博士研究生 070302-分析化学
常蒙蒙 博士研究生 070302-分析化学
现指导学生
李在芳 博士研究生 070302-分析化学
欧阳润泽 博士研究生 070302-分析化学
孙晓珊 博士研究生 070302-分析化学
吕王洁 博士研究生 070302-分析化学
张秀琼 博士研究生 070302-分析化学
夏悦怡 博士研究生 070302-分析化学
徐天润 博士研究生 070302-分析化学
王鑫欣 博士研究生 070302-分析化学
王宇婷 博士研究生 070302-分析化学
赵金慧 博士研究生 070302-分析化学
陈田田 博士研究生 070302-分析化学