Autophagy-lysosomal system and neurodegenerative diseases

The  mechanisms of Alzheimer's disease and drug intervention

2015-09 - 2019-01 Ph.D., Kunming Institute of Zoology, Chinese Academy of Sciences

2014-08 - 2015-08 Guest Graduate Student., Kunming Institute of Zoology, Chinese Academy of Sciences

2013-02 - 2014-07 Guest Graduate Student., Institute of Zoology, Chinese Academy of Sciences

2012-09 - 2015-06 M.S., Lanzhou University

2008-09 - 2012-07 B.A., Northwest A&F University

2019.6 - Present: Associate Professor, Kunming Institute of Zoology, Chinese Academy of Sciences

2019.2 - 2019.6: Research Assistant, Kunming Institute of Zoology, Chinese Academy of Sciences

（1） A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function and facilitates amyloid-β pathology and cognitive decline, Signal Transduction and Targeted Therapy, 2021, First and co-corresponding author

（2） Perforalactones D and E, two new C-20 Quassinoids with potential activity in inducing lysosomal biogenesis from Twigs of Harrisonia perforata (Blanco) Merr, Organic & Biomolecular Chemistry, 2021, Corresponding author

（3） Harpertrioate A, an A,B,D-seco-Limonoid with Promising Biological Activity against Alzheimer’s Disease from Twigs of Harrisonia perforata (Blanco) Merr, Organic Letters (Cover story), 2021, First author

（4） Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model, Autophagy (Cover story), 2020, First author

（5） The anatomy of the skin of the Chinese tree shrew is very similar to that of human skin, Zool Res, 2020, Second author

（6） Doublecortin-expressing neurons in Chinese tree shrew forebrain exhibit mixed rodent and primate-like topographic characteristics, Frontiers in Neuroanatomy, 2021, Second authors

（7） Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation, Redox Biol, 2020, Sixth author

（8） A positive feedback self-regulatory loop between miR-210 and HIF-1α mediated by CPEB2 is involved in troph. oblast syncytiolization: implication of trophoblast malfunction in preeclampsia, Biol Reprod, 2019, Second author

（9） Complement C7 is a novel risk gene for Alzheimer’s 1 disease in Han Chinese., Natl Sci Rev, 2019, Seventh author

（10） Does the genetic feature of the Chinese tree shrew (Tupaia belangeri chinensis) support its potential as a viable model for Alzheimer's disease Research?, J Alzheimers Dis, 2018,  First author

（11） A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer's disease., Alzheimers Dement, 2018, Second author

（12） Atg5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine, Autophagy (Cover story) , 2017, First author

（13） Female-specific effect of the BDNF gene on Alzheimer's disease, Neurobiol Aging, 2017, 第 5 作者

（14） Hypoxia-inducible miR-210 contributes to preeclampsia via targeting thrombospondin type I domain containing 7A, Sci Rep, 2016, First author

（15） Recovery of fertility in quinestrol- or diethylstilbestrol (DES)-treated mice: implications for rodent management, Integr Zool, 2016, Second author

（16） Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/a-synuclein aggregation, Autophagy, 2015, Fourth author

（17） MicroRNA-210 contributes to preeclampsia by downregulating potassium channel modulatory factor 1, Hypertension, 2014, First author

（18） Study on Spermatogonial Stem Cells in Tree Shrew Models, J Med Mol Biol, 2014, First author

(1) The use of gemfibrozil and its derivatives for the treatment and/or prevention of neurodegenerative diseases, invention, 2020, second author, patent number: PCT/CN2019/106476

(2) The use of gemfibrozil and its derivatives for the treatment and/or prevention of neurodegenerative diseases, invention, 2020, second author, patent number: ZL. 201811241909.0.

(3) The use of pirinic acid and its derivatives for the treatment and/or prevention of neurodegenerative diseases, invention, 2020, second author, patent number: ZL. 201811241897.1.

Autophagy-lysosomal system and neurodegenerative diseases

The  mechanisms of Alzheimer's disease and drug intervention

(1) The molecular mechanism of ACAA1 participating in the occurrence and development of Alzheimer's disease, host, 2020-01 - 2022-12

(2) The molecular mechanism of the antihyperlipidemic drug gemfibrozil in the treatment of Alzheimer's disease, host, 2019-10 - 2024-09

(3) Young Scholar of Western Light, host, 2020-01 - 2022-12

(4) Research on the identification and mechanism of Alzheimer's disease risk gene ACAA1, host, 2020-06 - 2023-05