（1）利用生物信息学手段并结合实验室多年积累的RNA组学技术，深入开展在肿瘤发生、发展以及干细胞重编程过程中长非编码RNA的系统发现与功能机制研究；

（2）非编码RNA 翻译复杂性的理论与功能机制研究；

（3）RNA研究新技术、新方法；

（4）着丝粒及组成型异染色质建成过程中非编码RNA的功能与调控机制研究；

（5）小鼠早期胚胎发育过程中非编码RNA的功能与调控机制研究。

欢迎有志于非编码RNA研究的学生来信联系推免或报考陈润生院士团队！

整个团队，既有生物信息学（组学大数据）“干”实验，更有围绕非编码RNA 调控功能与机制研究的基于人源肿瘤细胞、肿瘤干细胞、小鼠胚胎干细胞、小鼠动物模型以及多种新兴组学技术等“湿”实验的前沿课题。

071010-生物化学与分子生物学
0710J3-生物信息学

非编码RNA组学数据分析、非编码RNA功能调控与非经典翻译

2004-08--2010-07   美国密歇根州立大学   博士
2001-09--2004-07   中国科学院植物研究所   硕士研究生
1997-09--2001-07   中国农业大学   学士

​2020-01~至今，中国科学院生物物理研究所，研究员；

2013-09~2019-12，中国科学院生物物理研究所，副研究员；

2010-08~2013-08，美国约翰霍普金斯大学医学院Sidney Kimmel 癌症综合研究中心，博士后。

   

（1） Genetic alterations in juvenile cervical clear cell adenocarcinoma unrelated to human papillomavirus, FRONTIERS IN MEDICINE, 2023, 通讯作者
（2） LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2’-O-methylation, NATURE COMMUNICATIONS, 2023, 第 17 作者
（3） TGF-βchanges cyto/mito-ribosome balance to target respiratory chain complex V biogenesis in pulmonary fibrosis therapy, TGF-βchanges cyto/mito-ribosome balance to target respiratory chain complex V biogenesis in pulmonary fibrosis therapy, 信号转导与靶向治疗(英文), 2023, 第 7 作者
（4） Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene, COMMUNICATIONS BIOLOGY, 2023, 第 7 作者
（5） LncRNA CCTT-mediated RNA-DNA and RNA-protein interactions facilitate the recruitment of CENP-C to centromeric DNA during kinetochore assembly, MOLECULAR CELL, 2022, 第 5 作者
（6） Identification and characterization of long non-coding RNA Carip in modulating spatial learning and memory, CELL REPORTS, 2022, 通讯作者
（7） Modulated Ultrasmall γ-Fe2O3 Nanocrystal Assemblies for Switchable Magnetic Resonance Imaging and Photothermal-Ferroptotic-Chemical Synergistic Cancer Therapy, Advanced Functional Materials, 2022, 通讯作者
（8） Chromatin lncRNA Platr10 controls stem cell pluripotency by coordinating an intrachromosomal regulatory network, GENOME BIOLOGY, 2021, 第 25 作者
（9） Deeply Mining a Universe of Peptides Encoded by Long Noncoding RNAs, MOLECULAR & CELLULAR PROTEOMICS, 2021, 通讯作者
（10） LncRNA-encoded microproteins: A new form of cargo in cell culture-derived and circulating extracellular vesicles, JOURNAL OF EXTRACELLULAR VESICLES, 2021, 第 8 作者
（11） Discovery of Plasma Membrane-Associated RNAs through APEX-seq, CELL BIOCHEMISTRY AND BIOPHYSICS, 2021, 通讯作者
（12） Long noncoding RNA AVAN promotes antiviral innate immunity by interacting with TRIM25 and enhancing the transcription of FOXO3a, CELL DEATH AND DIFFERENTIATION, 2021, 其他（合作组作者）
（13） Episo: quantitative estimation of RNA 5-methylcytosine at isoform level by high-throughput sequencing of RNA treated with bisulfite, BIOINFORMATICS, 2020, 第 3 作者
（14） LncRNA HRCEG, regulated by HDAC1, inhibits cells proliferation and epithelial-mesenchymal-transition in gastric cancer, CANCER GENETICS, 2020, 通讯作者
（15） Genetic variations associated with long noncoding RNAs, SPOTLIGHT ON CHINA: RNA, 2020, 第 1 作者
（16） LRIKinteracts with the Ku70-Ku80 heterodimer enhancing the efficiency of NHEJ repair, CELL DEATH AND DIFFERENTIATION, 2020, 通讯作者
（17） Aberrant Expression of CHL1 Gene and Long Non-coding RNA CHL1-AS1, CHL1-AS2 in Ovarian Endometriosis, EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2019, 第 5 作者
（18） Profiling the long noncoding RNA interaction network in the regulatory elements of target genes by chromatin in situ reverse transcription sequencing, GENOME RESEARCH, 2019, 第 16 作者
（19） LincK contributes to breast tumorigenesis by promoting proliferation and epithelial-to-mesenchymal transition, JOURNAL OF HEMATOLOGY & ONCOLOGY, 2019, 通讯作者
（20） ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy, NATURE COMMUNICATIONS, 2019, 第 16 作者
（21） LncRNA HAND2‐AS1 promotes liver cancer stem cell self‐renewal via BMP signaling, EMBO JOURNAL, 2019, 第 3 作者
（22） Knockdown of long noncoding RNA CCDC144NL-AS1 attenuates migration and invasion phenotypes in endometrial stromal cells from endometriosis, BIOLOGY OF REPRODUCTION, 2019, 通讯作者
（23） SmProt: a database of small proteins encoded by annotated coding and non-coding RNA loci, BRIEFINGS IN BIOINFORMATICS, 2018, 第 5 作者
（24） Long noncoding RNA lncHand2 promotes liver repopulation via c-Met signaling, JOURNAL OF HEPATOLOGY, 2018, 第 5 作者
（25） A Failsafe for Sensing Chromatid Tension in Mitosis with the Histone H3 Tail in Saccharomyces cerevisiae, GENETICS, 2018, 第 3 作者
（26） Dynamic-BM: multispecies Dynamic BodyMap database from temporal RNA-seq data, BRIEFINGS IN BIOINFORMATICS, 2018, 第11作者
（27） LncVar: A Database of Genetic Variation Associated with Long Non-Coding Genes, BIOINFORMATICS, 2017, 第 6 作者
（28） RNA翻译的复杂性：不翻译、部分翻译、从头翻译及过度翻译, The Complexity of RNA Translation: Non-translation, Part-translation, De Novo-translation and Over-translation, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2017, 第 2 作者
（29） Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 通讯作者
（30） The long noncoding RNA SNHG1 promotes tumor growth through regulating transcription of both local and distal genes, ONCOGENE, 2017, 
（31） Mesenchymal Stem Cells Promote Hepatocarcinogenesis via lncRNA-MUF Interaction with ANXA2 and miR-34a, CANCER RESEARCH, 2017, 其他（合作组作者）
（32） Identification and analysis of intermediate-size noncoding RNAs in the rhesus macaque fetal brain, JOURNAL OF GENETICS AND GENOMICS, 2017, 第11作者
（33） Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress, MOLECULAR CELL, 2017, 第 7 作者
（34） Long noncoding RNA LINC01186, regulated by TGF-beta/SMAD3, inhibits migration and invasion through Epithelial-Mesenchymal-Transition in lung cancer, GENE, 2017, 通讯作者
（35） LncRNA16 is a potential biomarker for diagnosis of early-stage lung cancer that promotes cell proliferation by regulating the cell cycle, ONCOTARGET, 2017, 第11作者
（36） Transcriptional profiling analysis and functional prediction of long noncoding RNAs in cancer, ONCOTARGET, 2016, 第 4 作者
（37） 长链非编码RNA CHL1-AS2在卵巢子宫内膜异位症中的表达及意义初探, The expression of long non-coding RNA CHL1-AS2 in ovarian endometriosis, 中国妇产科临床杂志, 2016, 第 3 作者
（38） Expression profiling and functional prediction of long noncoding rnas in nasopharyngeal nonkeratinizing carcinoma, DISCOVERY MEDICINE, 2016, 通讯作者
（39） Identification of Tension Sensing Motif of Histone H3 in Saccharomyces cerevisiae and Its Regulation by Histone Modifying Enzymes, GENETICS, 2016, 第 1 作者
（40） NPInter v3.0: an upgraded database of noncoding RNA-associated interactions, DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, 2016, 第 5 作者
（41） LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway, ONCOTARGET, 2016, 通讯作者
（42） 自然科学与人文科学大数据——第六届中德前沿探索圆桌会议综述, Big Data in Natural Sciences, Humanities and Social Sciences ——Review of the 6th Exploratory Round Table Conference, 中国科学院院刊, 2016, 第 7 作者
（43） Generating a long DNA fragment of the target ncRNA for quantitative polymerase chain reaction by combining ncRNA-oligos hybridization and oligos ligation, JOURNAL OF BIOTECHNOLOGY, 2016, 第 6 作者
（44） BioCircos.js: An Interactive Circos JavaScript Library for Biological Data Visualization on Web Applications, BIOINFORMATICS, 2016, 第 5 作者
（45） The long noncoding RNA ASNR regulates degradation of Bcl-2 mRNA through its interaction with AUF1, SCIENTIFIC REPORTS, 2016, 第 7 作者
（46） Transcriptome profiling of esophageal squamous cell carcinoma reveals a long noncoding RNA acting as a tumor suppressor, ONCOTARGET, 2015, 第 8 作者
（47） Functional characterization of long noncoding rna lnc_bc060912 in human lung carcinoma cells, BIOCHEMISTRY, 2015, 第 4 作者
（48） The Long Noncoding RNA IncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling, CELL STEM CELL, 2015, 第 6 作者
（49） Analysis of the p53/CEP-1 regulated non-coding transcriptome in C. elegans by an NSR-seq strategy, Analysis of the p53/CEP-1 regulated non-coding transcriptome in C. elegans by an NSR-seq strategy, 蛋白质与细胞：英文版, 2014, 第 4 作者
（50） Histone H3 Exerts a Key Function in Mitotic Checkpoint Control, MOLECULAR AND CELLULAR BIOLOGY, 2010, 第 1 作者

（1） 《解码生命：从多视角看生命》（第二版）, 科学出版社, 2020-12, 第 其他 作者

       主要致力于肿瘤的表观遗传学与生物信息学研究，特别是长非编码RNA在肿瘤发生、发展、早期胚胎发育过程中的系统发现以及功能机制研究。曾负责、参与了人结直肠癌、乳腺癌以及肺癌细胞系中长非编码RNA与Polycomb蛋白复合体、DNA甲基化酶介导的基因表达沉默间的相互调控关系，具有多年的基础科研工作经验。参与了非编码RNA研究技术平台的建设，也深入开展了长非编码RNA翻译编码小肽的调控机理研究、利用CRISPR/Cas9小鼠模型研究长非编码RNA在小鼠早期胚胎发育中的调控功能研究、特定种类长非编码RNA的系统发现与特性分析、长非编码RNA在转化医学中的应用研究等等。已发表SCI学术论文四十多篇，包括核心期刊 Embo J, Proc Natl Acad Sci U S A, Cell Death Differ, Cell Reports, Mol Cell Biol, Journal of Hematology & Oncology, Gene, Discov Med, Genetics, J Hepatol, Mol Cell, Nat Commun, Genome Res, Brief Bioinform, Cancer Res, Bioinformatics, Clin Cancer Res, Cell Stem Cell 等。