基本信息
栾国栋  男  硕导  中国科学院青岛生物能源与过程研究所
电子邮件: luangd@qibebt.ac.cn
通信地址: 青岛市崂山区松岭路189号
邮政编码:

招生信息

   
招生专业
071005-微生物学
招生方向
微生物生理和代谢工程

教育背景

2008-09--2014-01   中国科学院微生物研究所   理学博士学位
2004-09--2008-06   山东大学生命科学学院   理学学士学位

工作经历

   
工作简历
2014-06~现在, 中国科学院青岛生物能源与过程研究所, 博士后,助理研究员,副研究员

专利与奖励

   
专利成果
[1] 吕雪峰, 齐凤霞, 栾国栋, 朱涛, 郭勍. 耐热型环丙烷脂肪酸合成酶NK1-22 ORF3135 及其应用. 202310243123.7, 2023-03-14.

[2] 吕雪峰, 齐凤霞, 栾国栋, 朱涛, 郭勍. 耐热型环丙烷脂肪酸合成酶NK1-22 ORF1256 及其应用. 202310243099.7, 2023-03-14.

[3] 吕雪峰, 孙绘梨, 栾国栋, 马依凡. 一种在高温高光下快速生长的工程蓝细菌及其制备方法. 202310163037.5, 2023-02-24.

[4] 吕雪峰, 孙绘梨, 栾国栋, 马依凡. 一种获得遗传稳定的具有目标性状的微藻的方法及超突变株. 202310163031.8, 2023-02-24.

[5] 吕雪峰, 孙绘梨, 栾国栋, 马依凡. 一种基于莽草酸激酶的耐受高温高光的工程蓝细菌及其制备方法. 202310163034.1, 2023-02-24.

[6] 吕雪峰, 齐凤霞, 朱涛, 栾国栋. 一种念珠藻及其培养方法和应用. 202211053967.7, 2022-08-30.

[7] 吕雪峰, 齐凤霞, 朱涛, 栾国栋, 韩晓娟. 一种波斯枝藻及其培养方法和应用. 202211045959.8, 2022-08-30.

[8] 吕雪峰, 孙佳慧, 栾国栋. 一种可合成倍半萜的工程藻株及其制备方法. 202210878235.5, 2022-07-25.

[9] 吕雪峰, 孙佳慧, 栾国栋. 一种可合成瓦伦烯的工程藻株及其制备方法. 202210878230.2, 2022-07-25.

[10] 吕雪峰, 吴彦楠, 孙佳慧, 栾国栋. 一种高产并分泌异麦芽酮糖和海藻酮糖的工程藻及其制备方法. 202210878243.X, 2022-07-25.

[11] 吕雪峰, 孙佳慧, 栾国栋. 可分泌和高产果糖的聚球藻YD03及其制备方法. 202210460183.X, 2022-04-28.

[12] 吕雪峰, 孙佳慧, 栾国栋, 但玉. 可分泌和高产果糖的聚球藻JS50及其制备方法. 202210460804.4, 2022-04-28.

[13] 吕雪峰, 孙佳慧, 栾国栋. 果糖激酶失能的蓝细菌及其在分泌和生产果糖中的应用. 202210460174.0, 2022-04-28.

[14] 吕雪峰, 朱至, 谈晓明, 栾国栋. 一种产乙醇基因工程蓝藻培养方法. CN: CN105950668B, 2019-08-16.

[15] 吕雪峰, 朱至, 谈晓明, 栾国栋. 一种产乙醇基因工程蓝藻培养体系乙醇消耗菌的污染防治方法. CN: CN105950668A, 2016-09-21.

[16] 蔡真, 栾国栋, 李寅. 改造微生物获得改进表型的方法. CN: CN102911962A, 2013-02-06.

出版信息

   
发表论文
[1] Sun, Huili, Luan, Guodong, Ma, Yifan, Lou, Wenjing, Chen, Rongze, Feng, Dandan, Zhang, Shanshan, Sun, Jiahui, Lu, Xuefeng. Engineered hypermutation adapts cyanobacterial photosynthesis to combined high light and high temperature stress. NATURE COMMUNICATIONS[J]. 2023, 14(1): http://dx.doi.org/10.1038/s41467-023-36964-5.
[2] Wu, Yannan, Sun, Jiahui, Xu, Xuejing, Mao, Shaoming, Luan, Guodong, Lu, Xuefeng. Engineering cyanobacteria for converting carbon dioxide into isomaltulose. JOURNAL OF BIOTECHNOLOGY[J]. 2023, 364: 1-4, http://dx.doi.org/10.1016/j.jbiotec.2023.01.007.
[3] Shanshan Zhang, Jiahui Sun, Dandan Feng, Huili Sun, Jinyu Cui, Xuexia Zeng, Yannan Wu, Guodong Luan, Xuefeng Lu. Unlocking the potentials of cyanobacterial photosynthesis for directly converting carbon dioxide into glucose. Nature Communications[J]. 2023, [4] 郑思妮, 孙绘梨, 毛绍名, 栾国栋, 吕雪峰. 基于糖原代谢调控的蓝细菌光合细胞工厂优化研究进展. 生物工程学报[J]. 2022, 38(2): 592-604, http://lib.cqvip.com/Qikan/Article/Detail?id=7106678251.
[5] Zhang, Shanshan, Zheng, Sini, Sun, Jiahui, Zeng, Xuexia, Duan, Yangkai, Luan, Guodong, Lu, Xuefeng. Rapidly Improving High Light and High Temperature Tolerances of Cyanobacterial Cell Factories Through the Convenient Introduction of an AtpA-C252F Mutation. FRONTIERS IN MICROBIOLOGY[J]. 2021, 12: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060558/.
[6] 栾国栋, 张杉杉, 吕雪峰. 微藻合成生物技术发展总结与展望:从底盘细胞到光合生物制造. 生物学杂志[J]. 2021, 38(2): 22-25, http://lib.cqvip.com/Qikan/Article/Detail?id=7104431904.
[7] Wang, Min, Luan, Guodong, Lu, Xuefeng. Engineering ethanol production in a marine cyanobacterium Synechococcus sp. PCC7002 through simultaneously removing glycogen synthesis genes and introducing ethanolgenic cassettes. JOURNAL OF BIOTECHNOLOGY[J]. 2020, 317: 1-4, http://dx.doi.org/10.1016/j.jbiotec.2020.04.002.
[8] Luan, Guodong, Zhang, Shanshan, Lu, Xuefeng. Engineering cyanobacteria chassis cells toward more efficient photosynthesis. CURRENT OPINION IN BIOTECHNOLOGYnull. 2020, 62: 1-6, http://dx.doi.org/10.1016/j.copbio.2019.07.004.
[9] Zhang, Mingyi, Qiao, Cuncun, Luan, Guodong, Luo, Quan, Lu, Xuefeng. Systematic Identification of Target Genes for Cellular Morphology Engineering inSynechococcus elongatusPCC7942. FRONTIERS IN MICROBIOLOGY[J]. 2020, 11: https://doaj.org/article/90d293740acd4f13ace35e9ac981d0b5.
[10] Luan, Guodong, Zhang, Shanshan, Wang, Min, Lu, Xuefeng. Progress and perspective on cyanobacterial glycogen metabolism engineering. BIOTECHNOLOGY ADVANCESnull. 2019, 37(5): 771-786, http://dx.doi.org/10.1016/j.biotechadv.2019.04.005.
[11] Wang, Min, Luan, Guodong, Lu, Xuefeng. Systematic identification of a neutral site on chromosome of Synechococcus sp. PCC7002, a promising photosynthetic chassis strain. JOURNAL OF BIOTECHNOLOGY[J]. 2019, 295: 37-40, http://dx.doi.org/10.1016/j.jbiotec.2019.02.007.
[12] 栾国栋. Engineering cyanobacteria chassis cells toward more efficient photosynthesis.. Current Opinion in Biotechnology. 2019, [13] 郗欣彤, 张杉杉, 毛绍名, 栾国栋, 罗泉, 吕雪峰. 蓝细菌光驱固碳合成蔗糖技术的发展与展望. 生物工程学报[J]. 2019, 35(8): 1411-1423, http://lib.cqvip.com/Qikan/Article/Detail?id=7002704206.
[14] 张杉杉, 栾国栋, 吕雪峰. 蓝细菌光驱固碳细胞工厂的合成生物学开发策略. 生命科学[J]. 2019, 31(4): 372-384, http://lib.cqvip.com/Qikan/Article/Detail?id=7002279533.
[15] Chi, Xintong, Zhang, Shanahan, Sun, Huili, Duan, Yangkai, Qiao, Cuncun, Luan, Guodong, Lu, Xuefeng. Adopting a Theophylline-Responsive Riboswitch for Flexible Regulation and Understanding of Glycogen Metabolism in Synechococcus elongatus PCC7942. FRONTIERS IN MICROBIOLOGY[J]. 2019, 10: https://doaj.org/article/0f3fc127afa94e19a8fafd0a00cbace5.
[16] Luan, Guodong, Lu, Xuefeng. Tailoring cyanobacterial cell factory for improved industrial properties. BIOTECHNOLOGY ADVANCES[J]. 2018, 36(2): 430-442, http://dx.doi.org/10.1016/j.biotechadv.2018.01.005.
[17] Lou, Wenjing, Tan, Xiaoming, Song, Kuo, Zhang, Shanshan, Luan, Guodong, Li, Cheng, Lu, Xuefeng. A Specific Single Nucleotide Polymorphism in the ATP Synthase Gene Significantly Improves Environmental Stress Tolerance of Synechococcus elongatus PCC 7942. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2018, 84(18): http://dx.doi.org/10.1128/AEM.01222-18.
[18] 栾国栋, 吕雪峰. 蓝藻光驱固碳合成乙醇技术的发展回顾和未来展望. 生物产业技术[J]. 2018, 68-73, http://lib.cqvip.com/Qikan/Article/Detail?id=7000734596.
[19] Zhu, Zhi, Luan, Guodong, Tan, Xiaoming, Zhang, Haocui, Lu, Xuefeng. Rescuing ethanol photosynthetic production of cyanobacteria in non-sterilized outdoor cultivations with a bicarbonate-based pH-rising strategy. BIOTECHNOLOGY FOR BIOFUELS[J]. 2017, 10(1): http://dx.doi.org/10.1186/s13068-017-0765-5.
[20] 齐允晶王家林栾国栋谈晓明吕雪峰, 栾国栋. 蓝细菌乙醇光合细胞工厂的发展与展望. 生物工程学报[J]. 2017, 33(6): 891-909, [21] Luan, Guodong, Qi, Yunjing, Wang, Min, Li, Zhimin, Duan, Yangkai, Tan, Xiaoming, Lu, Xuefeng. Combinatory strategy for characterizing and understanding the ethanol synthesis pathway in cyanobacteria cell factories. BIOTECHNOLOGY FOR BIOFUELS[J]. 2015, 8(1): http://ir.qibebt.ac.cn/handle/337004/6800.
[22] Luan, Guodong, Bao, Guanhui, Lin, Zhao, Li, Yang, Chen, Zugen, Li, Yin, Cai, Zhen. Comparative genome analysis of a thermotolerant Escherichia coli obtained by Genome Replication Engineering Assisted Continuous Evolution (GREACE) and its parent strain provides new understanding of microbial heat tolerance. NEW BIOTECHNOLOGY[J]. 2015, 32(6): 732-738, http://dx.doi.org/10.1016/j.nbt.2015.01.013.
[23] Cai, Zhen, Luan, Guodong, Zhu, Linjiang, Li, Yin. Development of two continuous genome engineering strategies for efficient microbial evolution. NEW BIOTECHNOLOGYnull. 2014, 31: S24-S24, http://dx.doi.org/10.1016/j.nbt.2014.05.1667.
[24] 栾国栋, 蔡真, 李寅. 超突变细胞在进化工程中的开发与应用. 生物技术进展[J]. 2014, 4(4): 229-235, http://lib.cqvip.com/Qikan/Article/Detail?id=663952725.
[25] Luan, Guodong, Dong, Hongjun, Zhang, Tianrui, Lin, Zhao, Zhang, Yanping, Li, Yin, Cai, Zhen. Engineering cellular robustness of microbes by introducing the GroESL chaperonins from extremophilic bacteria. JOURNAL OF BIOTECHNOLOGY[J]. 2014, 178: 38-40, http://dx.doi.org/10.1016/j.jbiotec.2014.03.010.
[26] Luan, Guodong, Cai, Zhen, Li, Yin, Ma, Yanhe. Genome replication engineering assisted continuous evolution (GREACE) to improve microbial tolerance for biofuels production. BIOTECHNOLOGY FOR BIOFUELS[J]. 2013, 6(1): 137-137, http://dx.doi.org/10.1186/1754-6834-6-137.
[27] Luan, Guodong, Cai, Zhen, Gong, Fuyu, Dong, Hongjun, Lin, Zhao, Zhang, Yanping, Li, Yin. Developing controllable hypermutable Clostridium cells through manipulating its methyl-directed mismatch repair system. PROTEIN & CELL[J]. 2013, 4(11): 854-862, https://www.webofscience.com/wos/woscc/full-record/WOS:000326939900007.
[28] Wang, Shaohua, Zhang, Yanping, Dong, Hongjun, Mao, Shaoming, Zhu, Yan, Wang, Runjiang, Luan, Guodong, Li, Yin. Formic Acid Triggers the "Acid Crash" of Acetone-Butanol-Ethanol Fermentation by Clostridium acetobutylicum. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2011, 77(5): 1674-1680, http://124.16.144.217/handle/311023/1514.

科研活动

   
科研项目
( 1 ) 基因组复制工 程辅助的连续 进化技术提高 蓝细菌高pH耐 受性的研究, 主持, 国家级, 2018-01--2021-12
( 2 ) Engineering of photosynthetic microorganisms for improved cell growth, carbon fixation and medium-chain olefin production, 主持, 院级, 2020-01--2021-12
( 3 ) 基于ATP合成酶扰动的蓝细菌高温高光耐受性改造和机制研究, 主持, 市地级, 2019-01--2021-12
参与会议
(1)蓝细菌光驱固碳合成乙醇技术系统研究   中国藻类协会微藻分会第五届学术年会   2019-09-02