071011-生物物理学
071023-计算生物学
083100-生物医学工程

肿瘤免疫识别与调控,T细胞功能化改造,力免疫学
跨细胞膜信号传导
单分子生物物理学,分子动力学模拟

1997-09--2000-08   中国科学院理论物理研究所   博士
1994-09--1997-07   北京大学   硕士
1990-10--1994-07   吉林大学   学士

   

2009-10~现在, 中国科学院生物物理研究所, 研究员，课题组长
2005-08~2009-09,佐治亚理工学院, 研究助理教授
2001-10~2005-07,佐治亚理工学院, 博士后
2000-10~2001-09,美国拉斯韦加斯 内华达大学, 博士后

2016-01-01-2017-12-31,杂志编委, 《医用生物力学》杂志编委

单分子技术专业研讨课
文献阅读-5
文献阅读-12
结构生物学技术
细胞的物理生物学
生物物理学概论
高等生物物理学
计算生物学专业研讨
计算生物学专业研讨课
生物信息学应用
结构生物学导论
现代生物物理前沿系列讲座

   

[1] Dong Li, Yihong Yang, Chenglin Lv, Yingjie Wang, Xiaoting Chao, Jiafeng Huang, Shashi P. Singh, Ye Yuan, Chengyu Zhang, Jizhong Lou, Pu Gao, Shanjin Huang, Bo Li, Huaqing Cai. GxcM-Fbp17/RacC-WASP signaling regulates polarized cortex assembly in migrating cells via Arp2/3. JOURNAL OF CELL BIOLOGY[J]. 2023, [2] Chen, Hui, Xu, Xinyi, Hu, Wei, Wu, Songfang, Xiao, Jianhui, Wu, Peng, Wang, Xiaowen, Han, Xuling, Zhang, Yanruo, Zhang, Yong, Jiang, Ning, Liu, Wanli, Lou, Changjie, Chen, Wei, Xu, Chenqi, Lou, Jizhong. Self- programmed dynamics of T cell receptor condensation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2023, 120(28): http://dx.doi.org/10.1073/pnas.2217301120.
[3] Choi, HyunKyu, Cong, Peiwen, Ge, Chenghao, Natarajan, Aswin, Liu, Baoyu, Zhang, Yong, Li, Kaitao, Rushdi, Muaz Nik, Chen, Wei, Lou, Jizhong, Krogsgaard, Michelle, Zhu, Cheng. Catch bond models may explain how force amplifies TCR signaling and antigen discrimination. NATURE COMMUNICATIONS[J]. 2023, 14(1): http://dx.doi.org/10.1038/s41467-023-38267-1.
[4] Yu, Guimei, Hao, Jingfang, Pan, Xiaowei, Shi, Lifang, Zhang, Yong, Wang, Jifeng, Fan, Hongcheng, Xiao, Yang, Yang, Fuquan, Lou, Jizhong, Chang, Wenrui, Malnoe, Alizee, Li, Mei. Structure of Arabidopsis SOQ1 lumenal region unveils C-terminal domain essential for negative regulation of photoprotective qH. NATURE PLANTS[J]. 2022, 8(7): 840-+, http://dx.doi.org/10.1038/s41477-022-01177-z.
[5] Wang, Z., Lou, J., Zhang, H.. Essence determines phenomenon: Assaying the material properties of biological condensates. J. Biol Chem[J]. 2022, [6] Chen, Yiran, Li, Li, Lan, Jie, Cui, Yang, Rao, Xiaosong, Zhao, Jing, Xing, Tao, Ju, Gaoda, Song, Guangtao, jlou@ibp.ac.cn, Liang, Jun. CRISPR screens uncover protective effect of PSTK as a regulator of chemotherapy-induced ferroptosis in hepatocellular carcinoma. Molecular Cancer[J]. 2022, [7] Fan, Juan, Shi, Jiawei, Zhang, Yong, Liu, Junwei, An, Chenyi, Zhu, Huaying, Wu, Peng, Hu, Wei, Qin, Rui, Yao, Danmei, Shou, Xin, Xu, Yibing, Tong, Zhou, Wen, Xue, Xu, Jianpo, Zhang, Jin, Fang, Weijia, Lou, Jizhong, Yin, Weiwei, Chen, Wei. NKG2D discriminates diverse ligands through selectively mechano-regulated ligand conformational changes. EMBO JOURNAL[J]. 2022, 41(2): http://dx.doi.org/10.15252/embj.2021107739.
[8] Hu, Wei, Zhang, Yong, Fei, Panyu, Zhang, Tongtong, Yao, Danmei, Gao, Yufei, Liu, Jia, Chen, Hui, Lu, Qiao, Mudianto, Tenny, Zhang, Xinrui, Xiao, Chuxuan, Ye, Yang, Sun, Qiming, Zhang, Jing, Xie, Qi, Wang, PeiHui, Wang, Jun, Li, Zhenhai, Lou, Jizhong, Chen, Wei. Mechanical activation of spike fosters SARS-CoV-2 infection (Aug, 10.1038/s41422-021-00576-9, 2021). CELL RESEARCH. 2021, 31(11): 1223-1223, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000701385200001.
[9] 胡炜, 秦瑞, 张勇, 武鹏, 费攀宇, 张同同, 安宸毅, 尹巍巍, 李振海, 娄继忠, 陈伟. 新冠病毒入侵与免疫防御的分子力学生物学研究进展. 医用生物力学[J]. 2021, 36(S01): 13-13, http://lib.cqvip.com/Qikan/Article/Detail?id=00002EKL4J3O7JP0MN508JP16JR.
[10] 陈辉, 崔蕾, 宋广涛, 娄继忠. 机械力调控的PD-1信号通路. 医用生物力学[J]. 2021, 36(S01): 293-293, http://lib.cqvip.com/Qikan/Article/Detail?id=00002EKL4J3O7JP0MN508J5WMHR.
[11] 胡炜, 安辰毅, 张同同, 廖泰霖, 刘俊伟, 张勇, 欧阳波, 娄继忠, 许均瑜, 陈伟. 神经突触后膜蛋白Neuroligin-1的力-电感知及其耦合调控分子机制的研究. 医用生物力学[J]. 2021, 36(S01): 89-89, http://lib.cqvip.com/Qikan/Article/Detail?id=00002EKL4J3O7JP0MN508JLWMJR.
[12] 秦瑞, 武鹏, 施佳未, 张勇, 娄继忠, 尹巍巍, 陈伟. CD8选择性利用生物力增强TCR抗原识别的灵敏度和鲁棒性. 医用生物力学[J]. 2021, 36(S01): 295-295, http://lib.cqvip.com/Qikan/Article/Detail?id=00002EKL4J3O7JP0MN508J5WM7R.
[13] Chen, Hui, Song, Guangtao, Zhang, Yong, Ni, Dongchun, Zhang, Xinwei, Huang, Yihua, Lou, Jizhong. Mechanical unfolding of a beta-barrel membrane protein by single-molecule force spectroscopy. SCIENCE CHINA-LIFE SCIENCES. 2021, 64(2): 334-336, https://www.webofscience.com/wos/woscc/full-record/WOS:000554343200003.
[14] Hu, Wei, Zhang, Yong, Fei, Panyu, Zhang, Tongtong, Yao, Danmei, Gao, Yufei, Liu, Jia, Chen, Hui, Lu, Qiao, Mudianto, Tenny, Zhang, Xinrui, Xiao, Chuxuan, Ye, Yang, Sun, Qiming, Zhang, Jing, Xie, Qi, Wang, PeiHui, Wang, Jun, Li, Zhenhai, Lou, Jizhong, Chen, Wei. Mechanical activation of spike fosters SARS-CoV-2 viral infection. CELL RESEARCH[J]. 2021, 31(10): 1047-1060, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7070199&detailType=1.
[15] Zhang, Hong, Ji, Xiong, Li, Pilong, Liu, Cong, Lou, Jizhong, Wang, Zheng, Wen, Wenyu, Xiao, Yue, Zhang, Mingjie, Zhu, Xueliang. Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases. SCIENCE CHINA-LIFE SCIENCES[J]. 2020, 63(7): 953-985, http://lib.cqvip.com/Qikan/Article/Detail?id=7102303892.
[16] Li, Qian, Wang, Xi, Dou, Zhihui, Yang, Weishan, Huang, Beifang, Lou, Jizhong, Zhang, Zhuqing. Protein Databases Related to Liquid-Liquid Phase Separation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESnull. 2020, 21(18): https://doaj.org/article/9344764dfc024a8b87a73828fccf7a7a.
[17] Chen, Hui, Cui, Yang, Han, Xuling, Hu, Wei, Sun, Min, Zhang, Yong, Wang, PeiHui, Song, Guangtao, Chen, Wei, Lou, Jizhong. Liquid-liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA. CELL RESEARCHnull. 2020, 30(12): 1143-1145, http://lib.cqvip.com/Qikan/Article/Detail?id=7104154148.
[18] Wei YiCheng, Yu Pei, Chen Ming, Sun ZiTing, Zeng Yan, Lou JiZhong, Chen SanYou, Shi FaZhan, Du JiangFeng. Preparation of DNA Origami for Ordered Immobilization of Single Molecules on Diamond Surface. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2020, 47(1): 53-60, https://www.webofscience.com/wos/woscc/full-record/WOS:000508748200006.
[19] Song, Guangtao, Xu, Benjin, Shi, Huigang, Zhang, Yong, Zhang, Dejiu, Cao, Xintao, Liu, Zengrui, Guo, Ran, Guan, YanZhong, Chu, Yanhui, Zhang, Xinzheng, Lou, Jizhong, Qin, Yan. Conformational activation of ribosome recycling by intra- and inter-molecular dynamics of RRF. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2020, 160: 1212-1219, http://dx.doi.org/10.1016/j.ijbiomac.2020.05.254.
[20] 魏一成, 余佩, 陈明, 孙梓庭, 曾俨, 娄继忠, 陈三友, 石发展, 杜江峰. 用于金刚石表面单分子有序固定的DNA折纸制备. 生物化学与生物物理进展[J]. 2020, 47(1): 53-60, http://lib.cqvip.com/Qikan/Article/Detail?id=7101073705.
[21] Cui, Yang, Tang, Yangchao, Liang, Meng, Ji, Qinghua, Zeng, Yan, Chen, Hui, Lan, Jie, Jin, Peng, Wang, Lei, Song, Guangtao, Lou, Jizhong. Direct observation of the formation of a CRISPR-Cas12a R-loop complex at the single-molecule level. CHEMICAL COMMUNICATIONS[J]. 2020, 56(14): 2123-2126, https://www.webofscience.com/wos/woscc/full-record/WOS:000516611700007.
[22] Yu, Jiaojiao, Li, Tao, Liu, Yu, Wang, Xi, Zhang, Jianchao, Wang, Xie, Shi, Guizhi, Lou, Jizhong, Wang, Likun, Wang, Chihchen, VVang, Lei. Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress. EMBO JOURNAL[J]. 2020, 39(10): e103841-, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232009/.
[23] Wu, Peng, Zhang, Tongtong, Liu, Baoyu, Fei, Panyu, Cui, Lei, Qin, Rui, Zhu, Huaying, Yao, Danmei, Martinez, Ryan J, Hu, Wei, An, Chenyi, Zhang, Yong, Liu, Junwei, Shi, Jiawei, Fan, Juan, Yin, Weiwei, Sun, Jie, Zhou, Chun, Zeng, Xun, Xu, Chenqi, Wang, Jianan, Evavold, Brian D, Zhu, Cheng, Chen, Wei, Lou, Jizhong. Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition. MOLECULAR CELL[J]. 2019, 73(5): 1015-+, http://dx.doi.org/10.1016/j.molcel.2018.12.018.
[24] Huang, Yuwei, Zucker, Ben, Zhang, Shaojin, Elias, Sharon, Zhu, Yun, Chen, Hui, Ding, Tianlun, Li, Ying, Sun, Yujie, Lou, Jizhong, Kozlov, Michael M, Yu, Li. Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains. NATURE CELL BIOLOGY[J]. 2019, 21(8): 991-+, http://dx.doi.org/10.1038/s41556-019-0367-5.
[25] Liu, Yanqing, Sun, Chuanqi, Han, Long, Yu, Yuqi, Zhou, Haizhen, Shao, Qiang, Lou, Jizhong, Zhao, Yongfang, Huang, Yihua. Conformational Dynamics, Intramolecular Domain Conformation Signaling, and Activation of Apo-FimD Revealed by Single-Molecule Fluorescence Resonance Energy Transfer Studies. BIOCHEMISTRY[J]. 2019, 58(14): 1931-1941, http://dx.doi.org/10.1021/acs.biochem.9b00080.
[26] Sun, Wei, Yang, Jing, Cheng, Zhi, Amrani, Nadia, Liu, Chao, Wang, Kangkang, Ibraheim, Raed, Edraki, Alireza, Huang, Xue, Wang, Min, Wang, Jiuyu, Liu, Liang, Sheng, Gang, Yang, Yanhua, Lou, Jizhong, Sontheimer, Erik J, Wang, Yanli. Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States. MOLECULAR CELL[J]. 2019, 76(6): 938-+, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934045/.
[27] Zhu, Cheng, Chen, Wei, Lou, Jizhong, Rittase, William, Li, Kaitao. Mechanosensing through immunoreceptors. NATURE IMMUNOLOGY[J]. 2019, 20(10): 1269-1278, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592628/.
[28] Shen, Xiaofei, Zhao, Lin, Chen, Peihao, Gong, Yanqiu, Liu, Dingdong, Zhang, Xia, Dai, Lunzhi, Sun, Qingxiang, Lou, Jizhong, Jin, Zhong, Zhang, Baohua, Niu, Dawen, Chen, Ceshi, Qi, Xiangbing, Jia, Da. A thiazole-derived oridonin analogue exhibits antitumor activity by directly and allosterically inhibiting STAT3. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2019, 294(46): 17471-17486, http://dx.doi.org/10.1074/jbc.RA119.009801.
[29] Hu, Wei, Zhang, Yong, Sun, Xiaolin, Zhang, Tongtong, Xu, Liling, Xie, Hengyi, Li, Zhanguo, Liu, Wanli, Lou, Jizhong, Chen, Wei. Fc gamma RIIB-I232T polymorphic change allosterically suppresses ligand binding. ELIFE[J]. 2019, 8: http://dx.doi.org/10.7554/eLife.46689.
[30] Meng Liang, Yang Cui, Jie Lan, Guangtao Song, Jizhong Lou. Two chemical-controlled switchable Cas9s for tunable gene editing. 生物物理学报:英文版[J]. 2019, 5(3): 161-165, http://dx.doi.org/10.1007/s41048-019-0093-3.
[31] Ren, Jinqi, Zhang, Yong, Wang, Shuang, Huo, Lin, Lou, Jizhong, Feng, Wei. Structural Delineation of the Neck Linker of Kinesin-3 for Processive Movement. JOURNAL OF MOLECULAR BIOLOGY[J]. 2018, 430(14): 2030-2041, http://dx.doi.org/10.1016/j.jmb.2018.05.010.
[32] Wan, Zhengpeng, Xu, Chenguang, Chen, Xiangjun, Xie, Hengyi, Li, Zongyu, Wang, Jing, Ji, Xingyu, Chen, Haodong, Ji, Qinghua, Shaheen, Samina, Xu, Yang, Wang, Fei, Tang, Zhuo, Zheng, JiShen, Chen, Wei, Lou, Jizhong, Liu, Wanli. PI(4,5)P2 determines the threshold of mechanical force-induced B cell activation. JOURNAL OF CELL BIOLOGY[J]. 2018, 217(7): 2565-2582, http://dx.doi.org/10.1083/jcb.201711055.
[33] Chen, Xiangjun, Sun, Xiaolin, Yang, Wei, Yang, Bing, Zhao, Xiaozhen, Chen, Shuting, He, Lili, Chen, Hui, Yang, Changmei, Xiao, Le, Chang, Zai, Guo, Jianping, He, Jing, Zhang, Fuping, Zheng, Fang, Hu, Zhibin, Yang, Zhiyong, Lou, Jizhong, Zheng, Wenjie, Qi, Hai, Xu, Chenqi, Zhang, Hong, Shan, Hongying, Zhou, Xujie, Wang, Qingwen, Shi, Yi, Lai, Luhua, Li, Zhanguo, Liu, Wanli. An autoimmune disease variant of IgG1 modulates B cell activation and differentiation. SCIENCE[J]. 2018, 362(6415): 700-+, http://202.127.25.143/handle/331003/3378.
[34] Zeng, Yan, Cui, Yang, Zhang, Yong, Zhang, Yanruo, Liang, Meng, Chen, Hui, Lan, Jie, Song, Guangtao, Lou, Jizhong. The initiation, propagation and dynamics of CRISPR-SpyCas9 R-loop complex. NUCLEIC ACIDS RESEARCH[J]. 2018, 46(1): 350-361, https://www.webofscience.com/wos/woscc/full-record/WOS:000423811200033.
[35] Song, Guangtao, Chen, Hui, Sheng, Gang, Wang, Yanli, Lou, Jizhong. Argonaute Facilitates the Lateral Diffusion of the Guide along Its Target and Prevents the Guide from Being Pushed Away by the Ribosome. BIOCHEMISTRY[J]. 2018, 57(15): 2179-2183, https://www.webofscience.com/wos/woscc/full-record/WOS:000430514800002.
[36] Chen, Ridao, Gao, Bingquan, Liu, Xiao, Ruan, Feiying, Zhang, Yong, Lou, Jizhong, Feng, Keping, Wunsch, Carsten, Li, ShuMing, Dai, Jungui, Sun, Fei. Molecular insights into the enzyme promiscuity of an aromatic prenyltransferase. NATURE CHEMICAL BIOLOGY[J]. 2017, 13(2): 226-234, https://www.webofscience.com/wos/woscc/full-record/WOS:000393533000019.
[37] Zhu, Kang, Shan, Zelin, Chen, Xing, Cai, Yuqun, Cui, Lei, Yao, Weiyi, Wang, Zhen, Shi, Pan, Tian, Changlin, Lou, Jizhong, Xie, Yunli, Wen, Wenyu. Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch. EMBO REPORTS[J]. 2017, 18(9): 1618-1630, http://dx.doi.org/10.15252/embr.201744454.
[38] Shi, Yi, Zhang, Yong, Lou, Jizhong. The influence of cell membrane and SNAP25 linker loop on the dynamics and unzipping of SNARE complex. PLOS ONE[J]. 2017, 12(4): https://doaj.org/article/e0e4305741ca4cbea874e3ad7310f774.
[39] Guangyuan Lu, Yingzhi Xu, Kai Zhang, Yong Xiong, He Li, Lei Cui, Xianping Wang, Jizhong Lou, Yujia Zhai, Fei Sun, Xuejun C Zhang. Crystal structure of E. coli apolipoprotein N-acyl transferase. NATURE COMMUNICATIONS[J]. 2017, 8(1): https://doaj.org/article/67a94a7b84f249a9bdda4b3c76aeaf39.
[40] Swarts, Daan C, Szczepaniak, Malwina, Sheng, Gang, Chandradoss, Stanley D, Zhu, Yifan, Timmers, Elizabeth M, Zhang, Yong, Zhao, Hongtu, Lou, Jizhong, Wang, Yanli, Joo, Chirlmin, van der Oost, John. Autonomous Generation and Loading of DNA Guides by Bacterial Argonaute. MOLECULAR CELL[J]. 2017, 65(6): 985-+, http://dx.doi.org/10.1016/j.molcel.2017.01.033.
[41] Ren, Jinqi, Huo, Lin, Wang, Wenjuan, Zhang, Yong, Li, Wei, Lou, Jizhong, Xu, Tao, Feng, Wei. Structural Correlation of the Neck Coil with the Coiled-coil (CC1)-Forkhead-associated (FHA) Tandem for Active Kinesin-3 KIF13A. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2016, 291(7): 3581-3594, http://dx.doi.org/10.1074/jbc.M115.689091.
[42] Liang, Xiaoping, Shan, Shan, Pan, Lu, Zhao, Jicheng, Ranjan, Anand, Wang, Feng, Zhang, Zhuqiang, Huang, Yingzi, Feng, Hanqiao, Wei, Debbie, Huang, Li, Liu, Xuehui, Zhong, Qiang, Lou, Jizhong, Li, Guohong, Wu, Carl, Zhou, Zheng. Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2016, 23(4): 317-323, http://dx.doi.org/10.1038/nsmb.3190.
[43] Jizhong Lou. Structural basis of H2A.Z recognition by SRCAP chromatin remodelling subunit YL1. Nat. Struct. Mol. Biol. 2016, [44] Han, Long, Zheng, Jiangge, Wang, Yan, Yang, Xu, Liu, Yanqing, Sun, Chuanqi, Cao, Baohua, Zhou, Haizhen, Ni, Dongchun, Lou, Jizhong, Zhao, Yongfang, Huang, Yihua. Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2016, 23(3): 192-196, http://dx.doi.org/10.1038/nsmb.3181.
[45] Gao, Kai, Zhang, Yong, Lou, Jizhong. Exploring the membrane fusion mechanism through force-induced disassembly of HIV-1 six-helix bundle. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2016, 473(4): 1185-1190, https://www.webofscience.com/wos/woscc/full-record/WOS:000375823700064.
[46] Lee, Choyin, Lou, Jizhong, Wen, KuoKuang, McKane, Melissa, Eskin, Suzanne G, Rubenstein, Peter A, Chien, Shu, Ono, Shoichiro, Zhu, Cheng, McIntire, Larry V. Regulation of actin catch-slip bonds with a RhoA-formin module. SCIENTIFIC REPORTS[J]. 2016, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000384991900001.
[47] Su, Qian Peter, Du, Wanqing, Ji, Qinghua, Xue, Boxin, Jiang, Dong, Zhu, Yueyao, Lou, Jizhong, Yu, Li, Sun, Yujie. Vesicle Size Regulates Nanotube Formation in the Cell. SCIENTIFIC REPORTS[J]. 2016, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000373575200001.
[48] Yi, Fengshuang, Kong, Ruirui, Ren, Jinqi, Zhu, Li, Lou, Jizhong, Wu, Jane Y, Feng, Wei. Noncanonical Myo9b-RhoGAP Accelerates RhoA GTP Hydrolysis by a Dual-Arginine-Finger Mechanism. JOURNAL OF MOLECULAR BIOLOGY[J]. 2016, 428(15): 3043-3057, http://www.corc.org.cn/handle/1471x/2374370.
[49] Zhang, Dejiu, Yan, Kaige, Liu, Guangqiao, Song, Guangtao, Luo, Jiejian, Shi, Yi, Cheng, Erchao, Wu, Shan, Jiang, Taijiao, Lou, Jizhong, Gao, Ning, Qin, Yan. EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2016, 23(2): 125-+, http://dx.doi.org/10.1038/nsmb.3160.
[50] Yu, Zhouliang, Zhou, Xiang, Wang, Wenjing, Deng, Wenqiang, Fang, Junnan, Hu, Hao, Wang, Zichen, Li, Shangze, Cui, Lei, Shen, Jing, Zhai, Linhui, Peng, Shengyi, Wong, Jiemin, Dong, Shuo, Yuan, Zengqiang, Ou, Guangshuo, Zhang, Xiaodong, Xu, Ping, Lou, Jizhong, Yang, Na, Chen, Ping, Xu, RuiMing, Li, Guohong. Dynamic Phosphorylation of CENP-A at Ser68 Orchestrates Its Cell-Cycle-Dependent Deposition at Centromeres. DEVELOPMENTAL CELL[J]. 2015, 32(1): 68-81, http://dx.doi.org/10.1016/j.devcel.2014.11.030.
[51] Zeng Yan, Zhang Yong, Song XianQiang, Ji QingHua, Ye Sheng, Zhang RongGuang, Lou JiZhong. The conformational states of talin autoinhibition complex and its activation under forces. SCIENCE CHINA-LIFE SCIENCES[J]. 2015, 58(7): 694-703, https://www.webofscience.com/wos/woscc/full-record/WOS:000359146700009.
[52] Lining Ju, Jizhong Lou, Yunfeng Chen, Zhenhai Li, Cheng Zhu. Force-Induced Unfolding of Leucine-Rich Repeats of Glycoprotein Ib α Strengthens Ligand Interaction. BIOPHYSICAL JOURNAL. 2015, 109(9): 1781-1784, [53] Ju, Lining, Lou, Jizhong, Chen, Yunfeng, Li, Zhenhai, Zhu, Cheng. Force-Induced Unfolding of Leucine-Rich Repeats of Glycoprotein Ib alpha Strengthens Ligand Interaction. BIOPHYSICAL JOURNAL[J]. 2015, 109(9): 1781-1784, https://www.webofscience.com/wos/woscc/full-record/WOS:000364009200004.
[54] Wan, Zhengpeng, Chen, Xiangjun, Chen, Haodong, Ji, Qinghua, Chen, Yingjia, Wang, Jing, Cao, Yiyun, Wang, Fei, Lou, Jizhong, Tang, Zhuo, Liu, Wanli. The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold. ELIFE[J]. 2015, 4: https://doaj.org/article/4dd3978ba64a4f358e4353f822caa50b.
[55] 曾俨, 张勇, 宋先强, 季庆华, 叶盛, 张荣光, 娄继忠. Talin自抑制复合物的构象状态及力介导的激活. 中国科学（生命科学）[J]. 2015, 45(6): 604-613, https://d.wanfangdata.com.cn/periodical/zgkx-cc201506009.
[56] Liu, Weixiao, Shang, Yongliang, Zeng, Yan, Liu, Chao, Li, Yanchang, Zhai, Linhui, Wang, Pan, Lou, Jizhong, Xu, Ping, Ye, Yihong, Li, Wei. Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chains. EMBO JOURNAL[J]. 2014, 33(1): 46-61, https://www.webofscience.com/wos/woscc/full-record/WOS:000329346500007.
[57] Ma, Jun, Wu, Rong, Zhang, Qiang, Wu, Junbing, Lou, Jizhong, Zheng, Zheng, Ding, Jianqing, Yuan, Zengqiang. DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis. BIOCHEMICAL JOURNAL[J]. 2014, 462: 489-497, http://dx.doi.org/10.1042/BJ20140235.
[58] Liu, Baoyu, Chen, Wei, Martinez, Ryan, Lou, Jizhong, Zhu, Cheng, Evavold, Brian. Structural mechanism of TCR-pMHC catch bond revealed by molecular dynamics, mutagenesis, and single-molecule kinetics analyses. JOURNAL OF IMMUNOLOGYnull. 2014, 192: https://www.webofscience.com/wos/woscc/full-record/WOS:000209765005093.
[59] Yang, Shang, Wang, Xi, Cui, Lei, Ding, Xiang, Niu, Lili, Yang, Fuquan, Wang, Chao, Wang, Chihchen, Lou, Jizhong. Compact Conformations of Human Protein Disulfide Isomerase. PLOS ONE[J]. 2014, 9(8): https://doaj.org/article/018e58240135461486e86ccd2bc92afc.
[60] 章燕, 娄继忠, 许向红, 詹世革. 第一届全国生物力学青年学者学术研讨会报告综述. 力学学报[J]. 2014, 994-998, http://lib.cqvip.com/Qikan/Article/Detail?id=76888866504849524854485049.
[61] Lee, Choyin, Lou, Jizhong, Wen, Kuokuang, McKane, Melissa, Eskin, Suzanne G, Ono, Shoichiro, Chien, Shu, Rubenstein, Peter A, Zhu, Cheng, McIntire, Larry V. Actin depolymerization under force is governed by lysine 113:glutamic acid 195-mediated catch-slip bonds. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2013, 110(13): 5022-5027, http://www.irgrid.ac.cn/handle/1471x/756533.
[62] Wang, Jing, Xing, Xueqing, Fang, Xiaocui, Zhou, Chang, Huang, Feng, Wu, Zhonghua, Lou, Jizhong, Liang, Wei. Cationic amphiphilic drugs self-assemble to the core-shell interface of PEGylated phospholipid micelles and stabilize micellar structure. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES[J]. 2013, 371(2000): http://ir.ihep.ac.cn/handle/311005/224718.
[63] Wang, Li, Li, Qian, Wu, Lianfeng, Liu, Shengwu, Zhang, Yong, Yang, Xuan, Zhu, Pingping, Zhang, Honglian, Zhang, Kai, Lou, Jizhong, Liu, Pingsheng, Tong, Liang, Sun, Fei, Fan, Zusen. Identification of SERPINB1 As a Physiological Inhibitor of Human Granzyme H. JOURNAL OF IMMUNOLOGY[J]. 2013, 190(3): 1319-1330, http://www.irgrid.ac.cn/handle/1471x/756559.
[64] Sun, Wei, Zhu, Ye Julia, Wang, Zhizhi, Zhong, Qiang, Gao, Feng, Lou, Jizhong, Gong, Weimin, Xu, Wenqing. Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations. NATURE COMMUNICATIONS[J]. 2013, 4: https://www.webofscience.com/wos/woscc/full-record/WOS:000323716300005.
[65] Zhang, Dandan, Liu, Guangqiao, Xue, Jiaying, Lou, Jizhong, Nierhaus, Knud H, Gong, Weimin, Qin, Yan. Common chaperone activity in the G-domain of trGTPase protects L11-L12 interaction on the ribosome. NUCLEICACIDSRESEARCH[J]. 2012, 40(21): 10851-10865, http://www.irgrid.ac.cn/handle/1471x/756741.
[66] Chen, Wei, Lou, Jizhong, Evans, Evan A, Zhu, Cheng. Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells. JOURNAL OF CELL BIOLOGY[J]. 2012, 199(3): 497-512, http://www.irgrid.ac.cn/handle/1471x/756878.
[67] Chen, Wei, Lou, Jizhong, Evans, Evan A, Zhu, Cheng. Observing Real-Time Force-Dependent Conformational Changes of Single Integrin on Living Cells and Their Regulation of Ligand Dissociation. BIOPHYSICAL JOURNAL[J]. 2012, 102(3): 26A-26A, http://www.irgrid.ac.cn/handle/1471x/757986.
[68] Zhang, Yong, Lou, Jizhong. The Ca2+ Influence on Calmodulin Unfolding Pathway: A Steered Molecular Dynamics Simulation Study. PLOS ONE[J]. 2012, 7(11): http://www.irgrid.ac.cn/handle/1471x/756957.
[69] Bai, Ming, Pang, Xiaoyun, Lou, Jizhong, Zhou, Qiangjun, Zhang, Kai, Ma, Jun, Li, Jian, Sun, Fei, Hsu, Victor W. Mechanistic Insights into Regulated Cargo Binding by ACAP1 Protein. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2012, 287(34): 28675-28685, http://dx.doi.org/10.1074/jbc.M112.378810.
[70] Xiang, Xue, Lee, Choyin, Li, Tian, Chen, Wei, Lou, Jizhong, Zhu, Cheng. Structural Basis and Kinetics of Force-Induced Conformational Changes of an alpha A Domain-Containing Integrin. PLOS ONE[J]. 2011, 6(11): http://www.irgrid.ac.cn/handle/1471x/757302.
[71] Huang, Qingsheng, Lou, Jizhong, Wu, Jianhua, Zhu, Cheng. Conformational Transition of Glycoprotein Ib alpha Mutants in Flow Molecular Dynamics Simulation. CELLULAR AND MOLECULAR BIOENGINEERING[J]. 2011, 4(3): 495-504, http://www.irgrid.ac.cn/handle/1471x/757375.
[72] Jizhong Lou. Conformational transitions of glycoprotein Ibalpha mutants in flow molecular dynamics simulation. Cellular and Molecular Bioengineering. 2011, [73] Chen, Wei, Lou, Jizhong, Hsin, Jen, Schulten, Klaus, Harvey, Stephen C, Zhu, Cheng. Molecular Dynamics Simulations of Forced Unbending of Integrin alpha(V)beta(3). PLOS COMPUTATIONAL BIOLOGY[J]. 2011, 7(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000287698700021.
[74] Zhou, Qiangjun, Zhai, Yujia, Lou, Jizhong, Liu, Man, Pang, Xiaoyun, Sun, Fei. Thiabendazole inhibits ubiquinone reduction activity of mitochondrial respiratory complex II via a water molecule mediated binding feature. PROTEIN & CELL[J]. 2011, 2(7): 531-542, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=4323660&detailType=1.
[75] Chen, Wei, Lou, Jizhong, Zhu, Cheng. Forcing Switch from Short- to Intermediate- and Long-lived States of the alpha A Domain Generates LFA-1/ICAM-1 Catch Bonds. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2010, 285(46): 35967-35978, http://dx.doi.org/10.1074/jbc.M110.155770.
[76] Chen, Wei, Lou, Jizhong, Zhu, Cheng. Simulated Thermal Unfolding of the von Willebrand Factor A Domains. CELLULAR AND MOLECULAR BIOENGINEERING[J]. 2010, 3(2): 117-127, https://www.webofscience.com/wos/woscc/full-record/WOS:000277368900003.
[77] Jizhong Lou. Forcing switch from short- to intermediate- and long-lived states of the αA domain generates LFA-1/ICAM-1 catch bond. J. Biol Chem. 2010, [78] Chen, Wei, Lou, Jizhong, Zhu, Cheng. Molecular Dynamics Simulated Unfolding of von Willebrand Factor A Domains by Force. CELLULAR AND MOLECULAR BIOENGINEERING[J]. 2009, 2(1): 75-86, [79] Wu, T, Yago, T, Lou, J, Yang, J, Miner, J, Coburn, L, Lopez, J A, Cruz, M A, McIntire, L V, McEver, R P, Zhu, C. Platelet glycoprotein Ib alpha forms catch bonds with WT VWF but not with type 2B von Willebrand disease VWF. BIORHEOLOGYnull. 2008, 45(1-2): 72-73, https://www.webofscience.com/wos/woscc/full-record/WOS:000258929100089.
[80] Jizhong Lou, Cheng Zhu. Flow induces loop-to-β-hairpin transition on the β-switch of platelet glycoprotein Ibα. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008, 105(37): 13847-13852, [81] Wei Hu, Yong Zhang, Xiaolin Sun, Tongtong Zhang, Liling Xu, Hengyi Xie, Zhanguo Li, Wanli Liu, Jizhong Lou, Wei Chen. FcγRIIB-I232T polymorphic change allosterically suppresses ligand binding. ELIFE[J]. "null", 8: https://doaj.org/article/b9f1505abb5b472cbe4efad510407d5e.
[82] Yu Cong, Lou Jizhong, Wu Jingjing, Pan Lifeng, Feng Wei, Zhang Mingjie. Membrane-induced Lever Arm Expansion Allows Myosin VI to Walk with Large and Variable Step Sizes *. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 287(42): 35021-35035, http://dx.doi.org/10.1074/jbc.M111.328781.
[83] Chen Wei, Lou Jizhong, Evans Evan A., Zhu Cheng. Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells. THE JOURNAL OF CELL BIOLOGY. 199(3): 497-512, http://www.irgrid.ac.cn/handle/1471x/756878.

   

（ 1 ） Talin激活aIIbb3整合素的分子机理及外力的调制作用, 主持, 国家级, 2011-01--2013-12
（ 2 ） 中科院****, 主持, 部委级, 2011-01--2013-12
（ 3 ） 非编码RNA和系统生物学网络分析算法研究, 参与, 部委级, 2011-01--2013-12
（ 4 ） 小核酸创新药物孵化基地（百奥-吉康工程中心）, 参与, 国家级, 2011-01--2013-12
（ 5 ） 选择素与配体相互作用中的力学激励效应, 主持, 国家级, 2012-01--2012-12
（ 6 ） 生物力学, 主持, 国家级, 2013-01--2015-12
（ 7 ） 细胞重编程中非编码RNA 与蛋白质相互作用的动态性质研究, 主持, 国家级, 2013-01--2015-12
（ 8 ） 神经元物质转运的结构基础与调控机制, 主持, 国家级, 2014-01--2018-08
（ 9 ） 机械力对PD-1与配体相互作用调控的分子机制研究, 主持, 国家级, 2017-01--2020-12
（ 10 ） 新型生物纳米孔测序技术的研发及测序仪的研制, 主持, 国家级, 2019-12--2023-11
（ 11 ） 相分离与相变介导染色体蛋白质机器动态组装研究的新技术方法, 主持, 国家级, 2021-01--2025-12

已指导学生

曾俨  博士研究生  071011-生物物理学  

季庆华  博士研究生  071010-生物化学与分子生物学  

王薇  硕士研究生  0710J3-生物信息学  

孙敏  硕士研究生  085238-生物工程  

李阗  博士研究生  071010-生物化学与分子生物学  

高铠  博士研究生  071011-生物物理学  

陈辉  博士研究生  071010-生物化学与分子生物学  

梁蒙  博士研究生  071011-生物物理学  

孙敏  博士研究生  071011-生物物理学  

崔洋  博士研究生  071010-生物化学与分子生物学  

兰洁  博士研究生  071011-生物物理学  

梁晓博  硕士研究生  071011-生物物理学  

现指导学生

张彦若  博士研究生  071011-生物物理学  

柳超  硕士研究生  071010-生物化学与分子生物学  

肖建辉  博士研究生  071011-生物物理学  

韩旭凌  博士研究生  071011-生物物理学  

吴迪  博士研究生  071011-生物物理学