基本信息
李志远  男  博导  中国科学院广州生物医药与健康研究院
电子邮件: li_zhiyuan@gibh.ac.cn
通信地址: 广州市萝岗区开源大道190号
邮政编码: 510530

研究领域

神经生物学
离子通道结构与功能

招生信息

   
招生专业
071009-细胞生物学
0710J6-再生医学
071006-神经生物学
招生方向
细胞膜生物学
干细胞
离子通道

教育背景

2000-09--2001-12   美国范德堡大学   医学院临床药理系博士后
1997-09--2000-07   日本德岛大学   内科营养系博士
1994-09--1997-07   中南大学湘雅医学院   药理系博士
1991-09--1994-07   湖南医科大学   解剖和神经生物学系硕士
1983-09--1988-07   湖南医科大学   医学学士
学历
-- 研究生
学位
-- 博士
出国学习工作

2000年07月-2001年12月 美国范德堡大学医学院临床药理系 博士后
1997年09月-2000年06月 日本德岛大学医学院内科营养系 博士
2002年01月-2008年07月 助理教授 美国圣路易大学医学院生理药理
2000年07月-2001年12月 博士后 美国Vanderbilt 大学医学院生理药理系
1997年09月-2000年06月 博士 日本德岛大学医学院内科营养系

工作经历

2008年9月-至今 研究员 中国科学院广州生物医药与健康研究院
2002年01月-2008年07月 助理教授 美国圣路易大学医学院生理药理系
2000年07月-2001年12月 博士后 美国Vanderbilt 大学医学院生理药理系
1994年07月-2000年06月 讲师 湖南医科大学
1988年07月-1994年07月 助教 湖南医科大学解剖和神经生物学系

工作简历
2008-08~现在, 中国科学院广州生物医药与健康研究院, 研究员
2002-01~2008-07,美国圣路易大学, 医学院生理药理系助理教授
1997-09~1999-11,日本德岛大学, 访问学者
1994-07~1997-07,湖南医科大学, 讲师
1988-07~1991-07,湖南医科大学, 解剖和神经生物学系助教
社会兼职
北美神经科学学会会员
北美生物物理学会会员
中国解剖学会会员
中国神经生物学会会员

专利与奖励

   
奖励信息
(1) 湖南省自然科学奖, 三等奖, 省级, 2018
(2) 湖南省科学技术进步二等奖, 二等奖, 省级, 2004
(3) 湖南医学科学科技奖一等奖, 一等奖, 省级, 2004
(4) 湖南省解剖学会优秀论文奖, 一等奖, 省级, 1998
(5) 湖南省自然科学二等优秀论文, 二等奖, 省级, 1998
专利成果
( 1 ) 一种整合性肿瘤细胞行为实验用芯片, 发明专利, 2021, 第 1 作者, 专利号: CN112646713A

( 2 ) 一种血小板衍生生长因子PDGF-BB的胶体金核酸适配体试纸条及其制备方法, 发明专利, 2019, 第 1 作者, 专利号: CN109738624A

( 3 ) 一种间充质干细胞无血清培养基, 专利授权, 2018, 第 1 作者, 专利号: CN108118028A

( 4 ) 一种含有干细胞成分的组合物及其应用, 发明专利, 2018, 第 1 作者, 专利号: CN108096175A

( 5 ) 一种含有干细胞成分的组合物及其应用, 发明专利, 2018, 第 1 作者, 专利号: CN108070553A

( 6 ) 一种新型抗体分装保存盒, 发明专利, 2018, 第 1 作者, 专利号: CN107814060A

( 7 ) 一种热激活离子通道钙成像实验方法, 发明专利, 2017, 第 1 作者, 专利号: CN106568512A

( 8 ) 一种质粒提取吸附柱, 实用新型, 2017, 第 1 作者, 专利号: CN205933799U

( 9 ) 一种间充质干细胞无血清培养基, 专利授权, 2016, 第 1 作者, 专利号: CN106190964A

( 10 ) 丹皮酚在制备激活hERG离子通道药物中的应用, 发明专利, 2016, 第 1 作者, 专利号: CN105456237A

( 11 ) 一种半自动吸头分装仪, 发明专利, 2015, 第 3 作者, 专利号: CN105173200A

( 12 ) 一种避光的载玻片保存盒子, 发明专利, 2015, 第 1 作者, 专利号: CN104960739A

( 13 ) 一种小鼠皮肤组织TRPV3蛋白的提取方法, 发明专利, 2015, 第 1 作者, 专利号: CN104910267A

( 14 ) 一种高效转染HaCaT细胞的方法, 发明专利, 2015, 第 1 作者, 专利号: CN104911212A

( 15 ) 一种快速增加细胞膜通透性的细胞内液及其方法, 发明专利, 2015, 第 1 作者, 专利号: CN104911241A

( 16 ) 有效抑制小鼠KCNA3基因表达的DNA、shRNA及其应用, 发明专利, 2015, 第 1 作者, 专利号: CN104878007A

( 17 ) 神经干细胞分化培养基及应用, 发明专利, 2015, 第 1 作者, 专利号: CN104762263A

( 18 ) 一种改进的细胞冻存盒, 实用新型, 2014, 第 1 作者, 专利号: CN203575473U

( 19 ) 胺类化合物及其制备方法和在制备抗流感病毒药物中的应用, 发明专利, 2014, 第 1 作者, 专利号: CN103664639A

( 20 ) 一种改进的防震台, 实用新型, 2014, 第 1 作者, 专利号: CN203500797U

( 21 ) 一种新型导流柱式抗体结合收集管, 实用新型, 2014, 第 1 作者, 专利号: CN203494219U

( 22 ) 一种能快速增加细胞膜通透性从而快速破膜形成高阻封接的方法, 发明专利, 2014, 第 1 作者, 专利号: CN103571819A

( 23 ) 一种质粒提取吸附柱, 实用新型, 2013, 第 1 作者, 专利号: CN203269924U

( 24 ) 一种微量磁珠分离器, 实用新型, 2013, 第 1 作者, 专利号: CN203164185U

( 25 ) 一种微孔板式磁珠分离器, 实用新型, 2013, 第 1 作者, 专利号: CN203155368U

( 26 ) 分离器(磁圈板), 外观设计, 2013, 第 1 作者, 专利号: CN302528021S

( 27 ) 分离器(磁棒板), 外观设计, 2013, 第 1 作者, 专利号: CN302528020S

( 28 ) 记录槽, 实用新型, 2013, 第 2 作者, 专利号: CN202912958U

( 29 ) 一种高效评估药物对hERG通道安全性的评价方法, 发明专利, 2012, 第 2 作者, 专利号: CN102747129A

( 30 ) 具有抑制和阻断M2离子通道活性的化合物及其应用, 发明专利, 2011, 第 3 作者, 专利号: CN101531637B

( 31 ) 具有抑制和阻断M2离子通道活性的新化合物及其应用, 发明专利, 2009, 第 3 作者, 专利号: CN101531637A

出版信息

   
发表论文
(1) Harnessing enhanced CRISPR/Cas12a trans-cleavage activity with extended reporters and reductants for early diagnosis of Helicobacter pylori, the causative agent of peptic ulcers and stomach cancer, BIOSENSORS AND BIOELECTRONICS, 2023, 第 17 作者
(2) Large-scale expansion of human umbilical cord-derived mesenchymal stem cells using PLGA@PLL scaffold, BIORESOURCES AND BIOPROCESSING, 2023, 第 13 作者
(3) Ameliorating Effect of Umbilical Cord Mesenchymal Stem Cells in a Human Induced Pluripotent Stem Cell Model of Dravet Syndrome, MOLECULAR NEUROBIOLOGY, 2022, 通讯作者
(4) Thermal stress involved in TRPV2 promotes tumorigenesis through the pathways of HSP70/27 and PI3K/Akt/mTOR in esophageal squamous cell carcinoma, BRITISH JOURNAL OF CANCER, 2022, 通讯作者
(5) MicroRNA-206 down-regulated human umbilical cord mesenchymal stem cells alleviate cognitive decline in D-galactose-induced aging mice, CELL DEATH DISCOVERY, 2022, 通讯作者
(6) Rational Programming of Cas12a for Early-Stage Detection of COVID-19 by Lateral Flow Assay and Portable Real-Time Fluorescence Readout Facilities, BIOSENSORS, 2022, 第 4 作者
(7) Mycotoxins detection: view in the lens of molecularly imprinted polymer and nanoparticles, CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2022, 通讯作者
(8) Transcription factor EB-mediated mesenchymal stem cell therapy induces autophagy and alleviates spinocerebellar ataxia type 3 defects in neuronal cells model, CELL DEATH & DISEASE, 2022, 通讯作者
(9) Mechanistic insights of CRISPR/Cas nucleases for programmable targeting and early-stage diagnosis: A review, BIOSENSORS & BIOELECTRONICS, 2022, 通讯作者
(10) CRISPR/Cas9 mediated gene correction ameliorates abnormal phenotypes in spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cells, TRANSLATIONAL PSYCHIATRY, 2021, 第 20 作者
(11) Proarrhythmic effects induced by benzethonium chloride and domiphen bromide in vitro and in vivo, TOXICOLOGY AND APPLIED PHARMACOLOGY, 2021, 通讯作者
(12) Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle, STEM CELL RESEARCH & THERAPY, 2021, 通讯作者
(13) Generation of UCiPSC-derived neurospheres for cell therapy and its application, STEM CELL RESEARCH & THERAPY, 2021, 通讯作者
(14) Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line (CSUXHi005-A) from human urine epithelial cells, STEM CELL RESEARCH, 2021, 第 10 作者
(15) Generation of UCiPSCs-derived neurospheres for cell therapy and its application, Stem Cell Research & Therapy, 2021, 通讯作者
(16) S100A4 plays a key role in TRPV3 ion channel expression and its electrophysiological function, NEUROSCIENCE LETTERS, 2021, 通讯作者
(17) hucMSCs transplantation promotes locomotor function recovery, reduces apoptosis and inhibits demyelination after SCI in rats, NEUROPEPTIDES, 2021, 通讯作者
(18) Human Umbilical Cord Mesenchymal Stem Cells-Secreted TSG-6 Is Anti-Inflammatory and Promote Tissue Repair After Spinal Cord Injury, ASN NEURO, 2021, 第 9 作者
(19) circRNA_100859 functions as an oncogene in colon cancer by sponging the miR-217-HIF-1α pathway, AGING (ALBANY NY), 2020, 第 8 作者
(20) 马王堆古尸蛋白质及蛋白质组学的分析与鉴定, Analysis and Identification of Protein and Proteomics of Mawangdui Ancient Corpse, 医学临床研究, 2020, 第 3 作者
(21) An ultrasensitive and specific point-of-care CRISPR/Cas12 based lateral flow biosensor for the rapid detection of nucleic acids, BIOSENSORS & BIOELECTRONICS, 2020, 第 3 作者
(22) Transient Receptor Potential Ankyrin 1 Contributes to Lysophosphatidylcholine-Induced Intracellular Calcium Regulation and THP-1-Derived Macrophage Activation, JOURNAL OF MEMBRANE BIOLOGY, 2020, 通讯作者
(23) Sorting nexin 11 knockout mice exhibit enhanced thermosensing behaviour, GENES BRAIN AND BEHAVIOR, 2020, 通讯作者
(24) circRNA_100859 functions as an oncogene in colon cancer by sponging the miR-217-HIF-1 alpha pathway, AGING-US, 2020, 通讯作者
(25) A high fidelity CRISPR/Cas12a based lateral flow biosensor for the detection of HPV16 and HPV18, SENSORS AND ACTUATORS B-CHEMICAL, 2020, 第 4 作者
(26) A rapid and sensitive CRISPR/Cas12a based lateral flow biosensor for the detection of Epstein-Barr virus, ANALYST, 2020, 第 3 作者
(27) Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage, MOLECULAR AND CELLULAR BIOCHEMISTRY, 2020, 通讯作者
(28) Generation of corrected-hiPSC (USTCi001-A-1) from epilepsy patient iPSCs using TALEN-mediated editing of the SCN1A gene, STEM CELL RESEARCH, 2020, 通讯作者
(29) Generation of an induced pluripotent stem cell line (XHCSUi001-A) from urine cells of a patient with spinocerebellar ataxia type 3 (vol 40, 101555, 2019), STEM CELL RESEARCH, 2020, 第 10 作者
(30) A heterozygous SCN1A (c.A5768G/+) mutant human induced pluripotent stem cell line (USTCi002-A) generated using TALEN-mediated precise gene editing, STEM CELL RESEARCH, 2020, 通讯作者
(31) A CRISPR/Cas12a Based Universal Lateral Flow Biosensor for the Sensitive and Specific Detection of African Swine-Fever Viruses in Whole Blood, BIOSENSORSBASEL, 2020, 第 4 作者
(32) Corrigendum to "Generation of an induced pluripotent stem cell line (XHCSUi001-A) from urine cells of a patient with spinocerebellar ataxia type 3" Stem Cell Research Vol 40 (2019) 101555, STEM CELL RESEARCH, 2020, 第 10 作者
(33) Generation of a tdTomato-GAD67 reporter human epilepsia mutation induced pluripotent stem cell line, USTCi001-A-2, using CRISPR/Cas9 editing, STEM CELL RESEARCH, 2020, 通讯作者
(34) Transient receptor potential ankyrin 1 contributes to the lysophosphatidylcholine-induced oxidative stress and cytotoxicity in OLN-93 oligodendrocyte, CELL STRESS & CHAPERONES, 2020, 通讯作者
(35) Generation of iPSC line (USTCi001-A) from human skin fibroblasts of a patient with epilepsy, STEM CELL RESEARCH, 2020, 通讯作者
(36) A signal-enhanced and sensitive lateral flow aptasensor for the rapid detection of PDGF-BB, RSC ADVANCES, 2020, 通讯作者
(37) Generation of an induced pluripotent stem cell line (XHCSUi001-A) from urine cells of a patient with spinocerebellar ataxia type 3, STEM CELL RESEARCH, 2019, 第 10 作者
(38) Sorting Nexin 11 (SNX11) Knockout Mice Exhibit Enhanced Thermosensing Behaviour, Genes Brain and Behavior, 2019, 通讯作者
(39) Recurrent activations of transient receptor potential vanilloid‐1 and vanilloid‐4 promote cellular proliferation and migration in esophageal squamous cell carcinoma cells, FEBS OPEN BIO, 2019, 通讯作者
(40) Promoting Osteogenesis of Human Umbilical Cord Mesenchymal Stem Cells Using 1α, 25-(OH)2D3 to Change Intracellular Calcium Concentration, J Nanosci. Nanotechnol, 2019, 通讯作者
(41) Generation of iPSC line (GIBHi001-A) from a patient with autism spectrum disorder, STEM CELL RESEARCH, 2019, 通讯作者
(42) Promoting Osteogenesis of Human Umbilical Cord Mesenchymal Stem Cells Using 1 alpha, 25-(OH)(2)D-3 to Change Intracellular Calcium Concentration, JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2019, 通讯作者
(43) Neuroprotection of Transplanting Human Umbilical Cord Mesenchymal Stem Cells in a Microbead Induced Ocular Hypertension Rat Model, CURRENT EYE RESEARCH, 2018, 通讯作者
(44) Second-Law Analysis of Irreversible Losses in Gas Turbines, ENTROPY, 2017, 第 3 作者
(45) Anterior cingulate cortex involved in social food‐foraging decision‐making strategies of rats, BRAIN AND BEHAVIOR, 2017, 通讯作者
(46) CRISPR/Cas9 facilitates investigation of neural circuit disease using human iPSCs: mechanism of epilepsy caused by an SCN1A loss-of-function mutation, TRANSLATIONAL PSYCHIATRY, 2016, 
(47) Sorting Nexin 11 Regulates Lysosomal Degradation of Plasma Membrane TRPV3, TRAFFIC, 2016, 通讯作者
(48) Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A, STEM CELLS TRANSLATIONAL MEDICINE, 2016, 其他(合作组作者)
(49) Psora‐4, a Kv1.3 Blocker, Enhances Differentiation and Maturation in Neural Progenitor Cells, CNS NEUROSCIENCE & THERAPEUTICS, 2015, 通讯作者
(50) Novel role of TRPV2 in promoting the cytotoxicity of H2O2-mediated oxidative stress in Human hepatoma cells, FREE RADICAL BIOLOGY AND MEDICINE, 2015, 通讯作者
(51) Differential roles of hippocampal glutamatergic receptors in neuropathic anxiety-like behavior after partial sciatic nerve ligation in rats, BMC NEUROSCIENCE, 2015, 通讯作者
(52) Vitamin E isomer δ-tocopherol enhances the efficiency of neural stem cell differentiation via L-type calcium channel, NEUROSCIENCE LETTERS, 2015, 第 8 作者
(53) Vitamin E isomer delta-tocopherol enhances the efficiency of neural stem cell differentiation via L-type calcium channel, NEUROSCIENCE LETTERS, 2015, 通讯作者
(54) Effects of total saponins of Panax notoginseng on immature neuroblasts in the adult olfactory bulb following global cerebral ischemia, NEURAL REGENERATION RESEARCH, 2015, 第 6 作者
(55) Roles of the lateral fenestration residues of the P2X(4) receptor that contribute to the channel function and the deactivation effect of ivermectin, PURINERGIC SIGNALLING, 2015, 通讯作者
(56) Principles and properties of ion flow in P2X receptors, FRONTIERS IN CELLULAR NEUROSCIENCE, 2014, 第 2 作者
(57) Involvement of the left-flipper-to-dorsal-fin interface of the zebrafish P2X4 receptor in ATP binding and structural rearrangement, NEUROSCIENCE LETTERS, 2014, 通讯作者
(58) Inhibition of HERG potassium channels by domiphen bromide and didecyl dimethylammonium bromide, EUROPEAN JOURNAL OF PHARMACOLOGY, 2014, 通讯作者
(59) Involvement of Ectodomain Leu 214 in ATP Binding and Channel Desensitization of the P2X4 Receptor, BIOCHEMISTRY, 2014, 通讯作者
(60) Generation of the SCN1A epilepsy mutation in hiPS cells using the TALEN technique, SCIENTIFIC REPORTS, 2014, 通讯作者
(61) Neurod1 Modulates Opioid Antinociceptive Tolerance via Two Distinct Mechanisms, BIOLOGICAL PSYCHIATRY, 2014, 第 10 作者
(62) Targeting microRNA-23a to inhibit glioma cell invasion via HOXD10, SCIENTIFIC REPORTS, 2013, 第 4 作者
(63) Immediate expression of Cdh2 is essential for efficient neural differentiation of mouse induced pluripotent stem cells, STEM CELL RESEARCH, 2013, 第 8 作者
(64) Transplanted motoneurons derived from human induced pluripotent stem cells form functional connections with target muscle, STEM CELL RESEARCH, 2013, 第 9 作者
(65) New Strategy for High Throughput Screening of Anti-Influenza Virus M2 Ion Channel Inhibitors, CURRENT PHARMACEUTICAL DESIGN, 2013, 第 10 作者
(66) Mechanism of HERG potassium channel inhibition by tetra-n-octylammonium bromide and benzethonium chloride, TOXICOLOGY AND APPLIED PHARMACOLOGY, 2013, 通讯作者
(67) Molecular mechanism of ATP binding and ion channel activation in P2X receptors, NATURE, 2012, 
(68) Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 第 9 作者
(69) Design and synthesis of pinanamine derivatives as anti-influenza A M2 ion channel inhibitors, ANTIVIRAL RESEARCH, 2012, 第 8 作者
(70) Modeling abnormal early development with induced pluripotent stem cells from aneuploid syndromes, HUMAN MOLECULAR GENETICS, 2012, 第 24 作者
(71) A Comparison of the Performance and Application Differences Between Manual and Automated Patch-Clamp Techniques, CURRENT CHEMICAL GENOMICS, 2012, 第 3 作者
(72) P2X7 receptor positively regulates MyD88-dependent NF-kappa B activation, CYTOKINE, 2011, 通讯作者
(73) P2X7 receptor positively regulates MyD88-dependent NF-κB activation, LI ZHIYUAN, 2011, 第 1 作者
(74) Ion Channels as Antivirus Targets, Ion Channels as Antivirus Targets, VIROLOGICA SINICA, 2010, 第 2 作者
(75) Heterodimers of Histidine and Amantadine as Inhibitors for Wild Type and Mutant M2 Channels of Influenza A, CHINESE JOURNAL OF CHEMISTRY, 2010, 第 7 作者
(76) Generation of Human Induced Pluripotent Stem Cells from Umbilical Cord Matrix and Amniotic Membrane Mesenchymal Cells, JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 第 14 作者
(77) Identification of Hits as Matrix-2 Protein Inhibitors through the Focused Screening of a Small Primary Amine Library, JOURNAL OF MEDICINAL CHEMISTRY, 2010, 第 5 作者
(78) On the Role of the First Transmembrane Domain in Cation Permeability and Flux of the ATP-gated P2X2 Receptor, JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 第 3 作者
(79) Potential therapeutic targets for ATP-Gated P2X receptor ion channels, ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2008, 通讯作者
(80) A型流感病毒H5N1的M2离子通道稳定细胞株的建立, Establish Stable Cell Line to Express M2 Ion Channel of Influenza a Virus H5N1, 生物工程学报, 2008, 第 4 作者
(81) Biophysics of P2X receptors. Pflugers Arch, PFLUG ARCH EUR J PHY, 2006, 
(82) Gain and loss of channel function by alanine-substitutions in the transmembrane segments of the ATP-gated P2X2 receptor, J NEUROSCI, 2004, 
(83) Molecular characterization of the zebrafish P2X receptor subunit gene family, NEUROSCIENCE, 2003, 
(84) K-Ca channel-opening activity of Ginkgo biloba extracts and ginsenosides in cultured endothelial cells, CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2001, 
(85) Involvement of Ca2+-activated K+ channels in ginsenosides-induced aortic relaxation in rats, JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2001, 
(86) Induction of inducible nitric oxide synthase by ginsenosides in cultured porcine endothelial cells, LIFE SCIENCES, 2000, 
(87) Estrogen modulates a large conductance chloride channel in cultured porcine aortic endothelial cells, JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2000, 
(88) Expression of endothelial-1 in macrophages and mast cells in hyperplastic human tonsils, FEBS LETT, 1999, 
(89) Generation of Human Induced Pluripotent Stem Cells from Umbilical Cord Matrix and Amniotic Membrane Mesenchymal Cells *, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 第 14 作者
(90) Roles of the lateral fenestration residues of the P2X4 receptor that contribute to the channel function and the deactivation effect of ivermectin, SPRINGER NETHERLANDS, 第 3 作者
发表著作
(1) Research Signpost(NY)专著中的Binding, gating and conduction of ATP-gated P2X receptor channels章节, Binding, gating and conduction of ATP-gated P2X receptor channels, 81-7736-254-2, 2006-07, 第 2 作者
(2) Encyclopedia of Neuroscience专著中的P2X Receptors章节, Encyclopedia of Neuroscience, Elsevier, Boston. 3rd Edit, 2007-07, 第 2 作者
(3) Encyclopedia of Neuroscience专著中的P2X Receptors章节, P2X Receptors, Elsevier, Boston. 4th Edit, 2009-12, 第 1 作者
(4) P2X receptors as new drug therapeutic targets, Intech, 2011-08, 第 2 作者
(5) Drug screening and drug safety evaluation by patch clamp technique., Intech, 2012-08, 第 2 作者
(6) The antibacterial drug discovery, Intech, 2013-04, 第 2 作者
(7) Current status and potential challenges of cell-based therapy for treating status epilepticus and chronic epilepsy, IntechOpen, 2021-07, 第 2 作者

科研活动

   
科研项目
( 1 ) 中国科学院“****”择优基金, 负责人, 国家任务, 2009-12--2012-12
( 2 ) 中国科学院科研启动资金, 负责人, 国家任务, 2008-07--2013-06
( 3 ) 广东省中国科学院全面战略合作项目, 负责人, 中国科学院计划, 2010-01--2012-12
( 4 ) 中国科学院院地合作专项储备项目, 负责人, 国家任务, 2011-01--2013-12
( 5 ) 中国科学院佛山产业技术创新与育成中心生物医药科技产业中心储备项目, 负责人, 地方任务, 2011-01--2012-01
( 6 ) 人多能干细胞向神经细胞分化的功能性研究, 负责人, 国家任务, 2012-01--2016-12
( 7 ) 与疼痛相关的P2X离子通道的分子结构和功能的研究, 负责人, 国家任务, 2012-01--2015-12
( 8 ) 药物开发的临床试验和GCP平台, 负责人, 中国科学院计划, 2012-01--2014-12
( 9 ) 自动化磁珠分离设备的应用开发, 负责人, 地方任务, 2012-01--2015-12
( 10 ) 自动化干细胞分选设备的研究开发, 负责人, 地方任务, 2015-01--2017-12
( 11 ) 脐带间充质干细胞治疗股骨头缺血性坏死干细胞制剂的临床前研究, 负责人, 地方任务, 2015-01--2017-12
( 12 ) Kv1.3调节神经干细胞, 负责人, 地方任务, 2016-01--2018-12
( 13 ) Kv1.3离子通道功能变化调节神经干细胞成熟与分化的机制研究, 负责人, 国家任务, 2017-01--2020-12
( 14 ) TALEN/CRISPR定点突变修复癫痫病人钠通道(龙雁博士启动), 负责人, 地方任务, 2016-01--2018-12
( 15 ) 药用季铵盐类化合物心肌毒性研究(龙雁主持人), 负责人, 国家任务, 2016-01--2018-12
( 16 ) 广州开发区博士后启动(王飞), 负责人, 地方任务, 2017-01--2019-12
( 17 ) 离子通道相关小分子化合物提高神经干细胞功能性分化的机制研究, 负责人, 地方任务, 2018-12--2021-12
参与会议
Aurora Biomed Ion Channel Retreat, Vancouver, Canada (2010 July)
Chinese Academy of Sciences Graduate College, Beijing (2010 July)
Central South University, Xian-Ya Medical College, Changsha, China (2010 April)
Hainan University, Medical School, Hainan (2009 November)
Central South University, Xian-Ya Medical College, Changsha, China (2009 October)
Guangzhou Institute of Biomedicine and Health, Chinese Academy Sciences,
Guangzhou, China (2009 August)
Aurora Biomed Ion Channel Retreat, Vancouver, Canada (2009 July)
Hundred Talent Forum of Chinese Academy of Sciences, Beijing (2009 May)
Hundred Talent Forum of Chinese Academy of Sciences, Chengdu (2008 August)
Aurora Biomed Ion Channel Retreat, Vancouver, Canada (2008 June)
Central South University, Xian-Ya Medical College, Changsha, China (2007 November)
Guangzhou Institute of Biomedicine and Health, Chinese Academy Sciences,
Guangzhou, China (2007 June)
AT Still University, Kirksville College of Osteopathic Medicine, Kirksville, MO (2006
November).
Southern Illinois University, School of Medicine, Carbondale, IL (2006 March)
Indiana State University, School of Medicine, Terre Haute, IN 47809 (2005 November)
Hunan Medical University, Changsha, China (1999 November)
4th Military Medical University, Xian, China (1994 October)
应邀作报告
2nd International Stem Cell Conference, Guangzhou, China (December 2009)
14th SBS Annual Conference, St. Louis, MO (April 2008)
The Society for Neuroscience 34th Annual Meeting, San Diego, CA (Oct. 22 – 27, 2004)
The Society for Neuroscience 33rd Annual Meeting, New Orleans, LA (Nov. 8 – 12, 2003)
The 14th World Congress of Pharmacology, San Francisco, CA (Jul. 7 – 12, 2002)
The 7th International Conference on Eicosanoids and other Bioactive Lipids in
Cancer, Inflammation and Related Diseases, Nashville, TN (Oct. 14 – 17, 2001)
The 16th Shiguguo Conference on Biochemistry, Naruto, Japan (May 1999)
The 14th International Conference on Morphology, Beijing, China (Oct. 1997) 
The 10th National Conference on Anatomy, Xian, China (Oct. 1994)

指导学生

已指导学生

肖雅娟  硕士研究生  071009-细胞生物学  

梁欣  博士研究生  071010-生物化学与分子生物学  

范文霞  博士研究生  071010-生物化学与分子生物学  

李彩月  博士研究生  071010-生物化学与分子生物学  

周雨叶  博士研究生  071010-生物化学与分子生物学  

马文波  博士研究生  071010-生物化学与分子生物学  

黄荣奇  博士研究生  071009-细胞生物学  

黄华林  博士研究生  071009-细胞生物学  

李帅  博士研究生  071009-细胞生物学  

汤凤  硕士研究生  085238-生物工程  

韩晓博  博士研究生  100101-人体解剖与组织胚胎学  

现指导学生

丁暄妍  硕士研究生  086000-生物与医药