Specialized metabolism in medicinal plants

Molecular reguilation of specialized metabolism

Epigenetic regulation of plant specialized metabolism

September, 1998 ~ July, 2002 B.S., Department of Biochemistry and Molecular Biology, Peking University

September, 2002~ July, 2008 Ph.D., Department of Plant Biology, Cornell University

   

November, 2008 ~November, 2011 Postdoctoral researcher, Department of Plant and Microbial Biology, University of California, Berkeley, USA

December 2011 ~ Now Researcher, South China Botanical Garden, Chinese Acedamy of Sciences

Plant Specilized Metabolites: Metabolism and Regulation  2020-now

   

1.        吴亮其，范占民，郭蕾，李勇青，张文静，瞿礼嘉^*，陈章良. 通过转δ-OAT基因获得抗盐抗旱水稻. 科学通报，2003, 48(19):2050-2056

2.        Liangqi Wu, Zhanmin Fan, Lei Guo, Yongqing Li, Zhang-Liang Chen, Li-Jia Qu^*. Over-expression of the bacterial nhaA gene in rice enhances salt and drought tolerance, Plant Science, 2005, 168(2):297-302.

3.        Huijun Yang, Yongqing Li and Jian Hua^*. The C2 domain protein BAP1 negatively regulates defense responses in Arabidopsis. The Plant Journal, 2006, 48(2):238-248.

4.        Yongqing Li^#, Shuhua Yang^#, Huijun Yang and Jian Hua^*. The TIR-NB-LRR gene SNC1 is regulated at the transcript level by multiple factors. Molecular Plant Microbe Interaction. 2007, 20(11):1449-1456

5.        Huijun Yang, Shuhua Yang, Yongqing Li and Jian Hua^*. The Arabidopsis BAP1 and BAP2 genes are general inhibitors of programmed cell death. Plant Physiology. 2007, 145(1):135-146

6.        Yongqing Li, Britney Pennington, Jian Hua^*. Multiple R-like genes are negatively regulated by BON1 and BON3 in Arabidopsis. Molecular Plant Microbe Interaction. 2009, 22(7):840-848

7.        Yongqing Li^#, Mingyue Gou^#, Qi Sun, Jian Hua^*. Requirement of calcium binding, myristoylation, and protein-protein interaction for the Copine BON1 function in Arabidopsis Journal of Biological Chemistry. 2010, 285(39):29884-91.

8.        Ying Zhou, Ling Zhang, Jiadong Gui, Fang Dong, Sihua Cheng, Xin Mei, Linyun Zhang, Yongqing Li, Xinguo Su, Susanne Baldermann, Naoharu Watanabe, Ziyin Yang^*. Molecular cloning and characterization of a short chain dehydrogenase showing activity with volatile compounds isolated from Camellia sinensis. Plant Molecular Biology Reporter. 2015, 33(2):253-263

9.        Heng Xu, Jian-Dong Bao, Ji-Song Dai, Yongqing Li, Ying Zhu*, Genome-Wide Identification of New Reference Genes for qRT-PCR Normalization under High Temperature Stress in Rice Endosperm. PLoS One. 2015, 10(11):e0142015. doi: 10.1371/journal.pone.0142015.

10.    Lilong He, Xiaoling Ma, Zhenzhen Li, Zhengli Jiao, Yongqing Li^* and David W. Ow^*, Maize OXIDATIVE STRESS 2 homologs enhance cadmium tolerance in Arabidopsis through activation of a putative SAM-dependent methyltransferase gene Plant Physiology. 2016, 171(3):1675-1685.

11.    Johannes Liesche^*, Marcelo R. Pace, Qiyu Xu, Yongqing Li and Shaolin Chen, Height-related scaling of phloem anatomy and the evolution of sieve element end wall types in woody plants. New Phytologist. 2017. 214(1):245-256.

12.    梁海菲^#, 王美丛^#, 陈大清, 李勇青^*. 一个阿罗酸脱水酶调控拟南芥对白粉病的抗性及盐胁迫响应. 农业科学, 2018, 8(9): 1092-1098.

13.    Lilong He, Ying Jing, Jianlin Shen, Xining Li, Huiping Liu, Zilong Geng, Mei Wang, Yongqing Li, Donghua Chen, Jianwei Gao, Wei Zhang*. Mitochondrial Pyruvate Carriers Prevent Cadmium Toxicity by Sustaining the TCA Cycle and Glutathione Synthesis. Plant Physiology. 2019, 180(1):198-211.

14.    黄韵，罗鸣，王瑛，李勇青^*.蛇床子植物学相关研究进展. 热带亚热带植物学报，2020，28(6):644-650

15.    Xiaoling Ma^#, Xing Huang, Zhengli Jiao, Lilong He, Yongqing Li, David W. Ow*, Overproduction of plant nuclear export signals enhances diamide tolerance in Schizosaccharomyces pombe. Biochemical and Biophysical Research Communications. 2020, 531(3):335-340. doi: 10.1016/j.bbrc.2020.07.054.

16.    Yuping Li, Xiaoju Liang, Xuguo Zhou, Zhigeng Wu, Ling Yuan, Ying Wang*, Yongqing Li^*. Selection of reference genes for qRT-PCR analysis in medicinal plant Glycyrrhiza under abiotic stresses and hormonal treatments. Plants (Basel). 2020, 9, 1441; doi:10.3390/plants9111441

17.    陈士林^#*，孙伟^#，吴问广，陈万生，王瑛，董扬，刘义飞，徐志超，孙超，尹青岗，李勇青，罗鸣，肖莹，万会花. 药用植物分子遗传学研究规律的探讨. 中国中药杂志. 2020, 45(23):5577-5588.

18.    Yuping Li^#, Xiaoju Liang^#, Xuguo Zhou, Yu An, Ming Li, Ling Yuan, Yongqing Li^*, Ying Wang^*. Spatio‑temporal selection of reference genes in the two congeneric species of Glycyrrhiza. Scientific Reports. 2021, 11: 1122. https://doi.org/10.1038/s41598-020-79298-8

19.    Jiajia Cai^#, Ting Liu, Yongqing Li, David Ow^*. A C-terminal fragment of Arabidopsis OXIDATIVE STRESS 2 can play a positive role in salt tolerance. Biochemical and Biophysical Research Communications. 2021, 556:23-30. doi: 10.1016/j.bbrc.2021.03.127.

20.    Lilong He^#, Jingjuan Li, Lin Shi, Qianyu Zhao, Zhigeng Wu, Shaohua Zeng, Yongqing Li, Wei Zhang, Feng-De Wang, Shu Zhang and Jianwei Gao^*. Exogenous metabolites spray, which identified from metabolomics analysis and transcriptomic analysis, can improve salt tolerance of Chinese cabbages (Brassica rapa L.ssp pekinensis)* Journal of Plant Interactions. 2021, 16:452-461. doi: 10.1080/17429145.2021.1969457

21.    Yongliang Liu^#, Barunava Patra, Sanjay Kumar Singh, Priyanka Paul, Yan Zhou, Yongqing Li, Ying Wang, Sitakanta Pattanaik, Ling Yuan^* Terpenoid indole alkaloid biosynthesis in Catharanthus roseus: effects and prospects of environmental factors in metabolic engineering. Biotechnology letters. 2021, 43(11):2085-2103.

22.    Huanfang Liu^#*, Honghua Yang, Tong Zhao, Canjia Lin, Yongqing Li, Xinhua Zhang, Yushi Ye, Jingping Liao. Combined metabolome and transcriptome analyses of young, mature, and old rhizome tissues of Zingiber officinale Roscoe Frontiers in Genetics 2021 Dec 8;12:795201. doi: 10.3389/fgene.2021.795201.

23.    Wu Z, Singh SK, Lyu R, Pattanaik S, Wang Y, Li Y, Yuan L, Liu Y. Metabolic engineering to enhance the accumulation of bioactive flavonoids licochalcone A and echinatin in Glycyrrhiza inflata (Licorice) hairy roots. Frontiers in Plant Science 2022 13:932594.

24.    Botir Khaitov, Aziz Karimov, Jamila Khaitbaeva, Obidjon Sindarov, Akmal Karimov, Yongqing Li. Perspectives of licorice production in harsh environments of the Aral Sea regions. International Journal of Environmental Research and Public Health 2022 Sep 18;19(18):11770. doi: 10.3390/ijerph191811770.

25.    Yuping Li, Feng Zhuang, Jiangyi Zeng, Chao Yang, Yongqing Li, Ming Luo Ying Wang Identification of the histone demethylases gene family in Glycyrrhiza inflata reveals genes responding to abiotic stresses Journal of Cellular Biochemistry. 2022 Nov; 123(11):1780-1792. doi: 10.1002/jcb.30315. Epub 2022 Aug 7..

26.    Weijie Zhao, Xiaoyan Wang, Qian Zhang, Qian Zheng, Haitao Yao, Xiangyang Gu, Dongliang Liu, Xuemin Tian, Xiaoji Wang, Yongqing Li, Zhengge Zhu. H3K36 demethylase JMJ710 negatively regulates drought tolerance by suppressing MYB48-1 expression in rice. Plant Physiology 2022 Jun 1;189(2):1050-1064. doi: 10.1093/plphys/kiac095.

27.    Yamei Li, Ruyu Li, Zhiguo Han, Haitang Wang, Sixian Zhou, Yongqing Li, Yumei Wang, Junsheng Qi, David W. Ow. Recombinase-mediated gene stacking in cotton. Plant Physiol. 2022 Mar 28;188(4):1852-1865. doi: 10.1093/plphys/kiac005.

28.    Chao Yang, Guangyu Shi, Yuping Li, Ming Luo, Hongxia Wang, Jihua Wang, Ling Yuan, Ying Wang and Yongqing Li. Genome-Wide Identification of SnRK1 Catalytic Subunit and FLZ Proteins in Glycyrrhiza inflata Bat. Highlights Their Potential Roles in Licorice Growth and Abiotic Stress Responses. International Journal of Molecular Sciences 2023 Jan; 24(1): 121. https://doi.org/10.3390/ijms24010121

29.    Jiangyi Zeng, Yun Huang, Lijun Zhou, Xiaoju Liang, Chao Yang, Hongxia Wang, Ling Yuan, Ying Wang, Yongqing Li Histone Deacetylase GiSRT2 Negatively Regulates Flavonoid Biosynthesis in Glycyrrhiza inflata. Cells. 2023 May 29;12(11):1501. doi: 10.3390/cells12111501.

30.    Chao Yang, Xibao Li, Shunquan Chen, Chuanliang Liu, Lianming Yang, Kailin Li, Jun Liao, Xuanang Zheng, Hongbo Li, Yongqing Li, Shaohua Zeng, Xiaohong Zhuang, Pedro L. Rodriguez, Ming Luo, Ying Wang, Caiji Gao. ABI5-FLZ13 Module Transcriptionally Represses Growth-related Genes to Delay Seed Germination in Response to ABA. Plant Commun. 2023 Jun 9;100636. doi: 10.1016/j.xplc.2023.100636.

31.    谢姿雁，Botir KHAITOV，杨天顺，李重，李勇青，王瑛 胀果甘草花粉生活力测定及甘草的杂交育种 热带亚热带植物学报. 2023,31(05)

32.    Xiaoling Ma, Ningxin Jiang, Jingxian Fu, Yuping Li, Lijun Zhou, Ling Yuan, Ying

33.    Wang, Yongqing Li. A cytosine analogue 5-azacitidine improves the accumulation of licochalcone A in licorice Glycyrrhiza inflata Journal of Plant Physiology

34.    Yuping Li, Ziyan Xie, Yun Huang, Jiangyi Zeng, Chao Yang, Ling Yuan, Ying Wang *, Yongqing Li. Integrated metabolomic and transcriptomic analysis provides insights into the flavonoid formation in different Glycyrrhiza species. Industrial Crops & Products 208 (2024) 117796

Plant specialized metabolism

Molecular regulation

Synthetic biology

已指导学生

李亚平  硕士研究生  085238-生物工程  

焦正利  硕士研究生  071010-生物化学与分子生物学  

李臻臻  硕士研究生  085238-生物工程  

马小玲  硕士研究生  085238-生物工程  

黄杏  硕士研究生  085238-生物工程  

胡瑞彬  硕士研究生  071010-生物化学与分子生物学  

刘亭  博士研究生  071010-生物化学与分子生物学  

梁晓菊  硕士研究生  085238-生物工程  

周思娴  硕士研究生  071010-生物化学与分子生物学  

周丽君  硕士研究生  085238-生物工程  

现指导学生

吴志耿  博士研究生  071010-生物化学与分子生物学  

谢姿雁  硕士研究生  085238-生物工程  

石光禹  硕士研究生  071010-生物化学与分子生物学  

蒋宁馨  硕士研究生  071010-生物化学与分子生物学  

黄琬莹  硕士研究生  071001-植物学