LI Yan, Professor of molecular pharmacology. The major research of my group is screening, pharmacology and chemical biology research of new anti-cancer natural compounds, and evaluating the in vivo activity with animal model. We are focused our research and drug discovery on certain signaling pathways which are closely related with tumorigenesis, such as WNT pathway in colon tumor and mTOR pathway in breast tumor. We are aiming to find anti-tumor lead compounds and novel potential drug targets for cancer therapy.

        1. Zhou HY#, Yu CL#, Kong LM#, Xu XL, Yan JM,  Li YC, An T, Gong L, Gong YX, Zhu HF, Zhang HB*Yang XD*, Li Y*. B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells. Oncogene, 2019, DOI: 10.1038/s41388-018-0674-5        

        2. Tang JW#, Kong LM#, Zu WY, Hu K, Su XZ, Li XN, Yan BC, Wang WG, Sun HD, Li Y*, Puno PT*. Isopenicins A–C: Two Types of Novel Antitumor Meroterpenoids from the Plant Endophytic Fungus Penicillium sp. sh18. Organic Letters, 2019, DOI: 10.1021/acs.orglett.8b04020

        3. Gao ZH#, Chen KQ#, Zhang Y, Kong LM, Li Y*, Ye S*. Enantioselective N.Heterocyclic Carbene-Catalyzed Synthesis of Spirocyclic Oxindole-benzofuroazepinones. The Journal of Organic Chemistry, 2018, 83, 15225-15235

        4. An T, Gong YX, Li X, Kong LM, Ma PC, Gong L, Zhu HF, Yu CL, Liu JM, Zhou HY, Mao BY, Li Y*. USP7 inhibitor P5091 inhibits Wnt signaling and coloreal tumor growth. Biochemical Pharmacology, 2017.02.11. 131(1):29-39

　　5. Yu CL, Gong YX, Zhou HY, Wang M, Kong LM, Liu JM, An T, Zhu HF, Li Y*. Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthpic humanbreast cancer model. Cell Death & Disease, 2017, 8 (2): e2582.

　　6. Shao LD#, Su J#, Ye BX#, Liu JX#, Zuo ZL, Li Y, Wang YY*, Xia CF*, Zhao QS*. Design, Synthesis, and Biological Activities of Vibsanin B Derivatives: A New Class of HSP90 C-Terminal Inhibitors. Journal of Medicinal Chemistry, 2017, 60 (21): 9053–9066 60(21).

　　7. Zhou HY#, Shang CW#, Wang M, Shen T, Kong LM, Yu CL, Ye ZN, Luo Y, Liu L, Li Y*, Huang SL*. Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK. Biochemical Pharmacology, 2016, 16:39-50

　　8. Wang M, Zhou AK, An T, Kong LM, Yu CL, Liu JM, Xia CF*, Zhou HY*, Li Y*. N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells. Journal of Experimental & Clinical Cancer Research, 2016, 35:41

　　9. Li XY , Bai B, Liu L, Ma PC, Kong LM, Yan JM, Zhang J, Ye ZN, Zhou HY, Mao BY , Zhu HJ* and Li Y*. Novel β-Carbolines Against Colorectal Cancer Cell Growth Via  Inhibition of Wnt/β-catenin signaling. Cell Death & Discovery 2015,1, 15033

　　10. Kong LM, Mao BY, Zhu HJ* and Li Y*. Novel β-carbolines inhibit Wnt/β-catenin signaling. Cell Death & Disease, 2015, 6, e1983

　　11. Ye ZN, Yu MY, Kong LM, Wang WH, Yang YF, Liu JQ, Qiu MH*, Li Y*. Biflavone Ginkgetin, a Novel Wnt Inhibitor, Suppresses the Growth of Medulloblma. Natural Products and Bioprospecting, 2015, 5(2): 91–97

　　12. Ma PC, Yang XC, Kong QH, Li CC, Yang SJ, Li Y, Mao B*. The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of β-Catenin. Mol Cell Biol, 2014, 34(23):4355-66

　　13. Zhou HY, Shen T, Shang C, Lou Y, Liu L, Yan J, Li Y*, Huang S*. Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK  signaling pathway. Oncotarget, 2014, 5(20):10140-50.

　　14. Kong LM#, DengX#, Zuo ZL, Sun HD, Zhao QS*, Li Y*. Identification and validation of p50 as the cellular target of eriocalyxin B. Oncotarget, 2014, 5(22):11354-64

　　15. Liu WP, Su J, Jiang J, Li XY, Ye QS, Zhou HY, Chen JL, Li Y*. Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group. Scientific Reports, 2013, 3 : 2464.

　　16. Li XY, Pu JX, Jiang SY, Su J, Kong LM, Mao BY, Sun HD*, Li Y*. Henryin, an ent-kaurane Diterpenoid, Inhibits Wnt Signaling through Interference with β-Catenin/TCF4 Interaction in Colorectal Cancer Cells. PLoS One, 2013, 8(7):e68525.

　　17. Zhao Y#, Su J#, Goto M, Morris-Natschke SL, Li Y, Zhao QS*, Yao ZJ*, Lee KH*, Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation. J Med Chem, 2013, 56(11):4749-57.

　　18. Liu LX, Wang XQ, Yan JM, Li Y*, Sun CJ, Chen W, Zhou B, Zhang HB, Yang XD*, Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds. Eur J Med Chem, 2013, 66:423-37.

　　19. Li XY, Wang YY, Yuan CM, Hao XJ*, Li Y*. A reporter gene system for screening inhibitors of Wnt signaling pathway. Natural Products and Bioprospecting, 2013, 3, 24-28.

　　20. Li Y#, Rankin SA#, Sinner D, Kenny AP, Krieg PA, Zorn AM*, Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. Genes Dev, 2008, 22(21), 3050-63.

　　21. Pollet N*, Muncke N, Verbeek B, Li Y, Fenger U, Delius H, Niehrs C*, An atlas of differential gene expression during early Xenopus embryogenesis. Mech Dev, 2005,122(3), 365-439.

　　22. Li Y, Fenger U, Niehrs C, Pollet N*, an Cyclic expression of esr9 gene in Xenopus presomitic mesoderm. Differentiation, 2003,71(1), 83-9.

　　23. Mao B#, Wu W#, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C*, LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature, 2001, 411(6835), 321-5