070302-分析化学

核磁共振，结构生物学，生物大分子动态学

2010-09--2015-12   中国科学院武汉物理与数学研究所   博士学位

   

2018-10~现在, 中国科学院武汉物理与数学研究所, 副研究员
2016-02~2018-10,中国科学院武汉物理与数学研究所, 助理研究员

   

[1] Ji, Shixia, Luo, Liang, Li, Conggang, Liu, Maili, Liu, Yixiang, Jiang, Ling. Rational modulation of the enzymatic intermediates for tuning the phosphatase activity of histidine kinase HK853. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2020, 523(3): 733-738, http://dx.doi.org/10.1016/j.bbrc.2020.01.036.
[2] Huang, Liqun, Kou, Xinhui, Zheng, Wenwen, Xiao, Xiong, Li, Conggang, Liu, Maili, Liu, Yixiang, Jiang, Ling. 05SAR-PAGE: Separation of protein dimerization and modification using a gel with 0.05% sarkosyl. ANALYTICA CHIMICA ACTA[J]. 2020, 1101: 193-198, http://dx.doi.org/10.1016/j.aca.2019.12.013.
[3] Zhou, Yuan, Liu, Xinghong, Li, Conggang, Liu, Maili, Jiang, Ling, Liu, Yixiang. Chemical shift assignments of the catalytic and ATP-binding domain of HK853 from Thermotoga maritime. BIOMOLECULAR NMR ASSIGNMENTS[J]. 2019, 13(1): 173-176, https://www.webofscience.com/wos/woscc/full-record/WOS:000463649500033.
[4] Zhou, Yuan, Huang, Liqun, Ji, Shixia, Hou, Shi, Luo, Liang, Li, Conggang, Liu, Maili, Liu, Yixiang, Jiang, Ling. Structural Basis for the Inhibition of the Autophosphorylation Activity of HK853 by Luteolin. MOLECULES[J]. 2019, 24(5): [5] Kou, Xinhui, Liu, Xinghong, Liu, Yixiang, Li, Conggang, Liu, Maili, Jiang, Ling. Backbone resonance assignment of the response regulator protein PhoB(N) (F20D) from Escherichia coli. BIOMOLECULAR NMR ASSIGNMENTS[J]. 2018, 12(1): 133-137, [6] Kou, Xinhui, Liu, Yixiang, Li, Conggang, Liu, Maili, Jiang, Ling. Dimerization and Conformational Exchanges of the Receiver Domain of Response Regulator PhoB from Escherichia coli. JOURNAL OF PHYSICAL CHEMISTRY B[J]. 2018, 122(22): 5749-5757, [7] Gao, Jia, Liang, E, Ma, Rongsheng, Li, Fudong, Liu, Yixiang, Liu, Jiuyang, Jiang, Ling, Li, Conggang, Dai, Haiming, Wu, Jihui, Su, Xuncheng, He, Wei, Ruan, Ke. Fluorine Pseudocontact Shifts Used for Characterizing the Protein-Ligand Interaction Mode in the Limit of NMR Intermediate Exchange. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 56(42): 12982-12986, http://dx.doi.org/10.1002/anie.201707114.
[8] Yixiang Liu, Joshua Rose, Shaojia Huang, Yangbo Hu, Qiong Wu, Dan Wang, Conggang Li, Maili Liu, Pei Zhou, Ling Jiang. A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases. NATURE COMMUNICATIONS[J]. 2017, 8(1): http://dx.doi.org/10.1038/s41467-017-02310-9.
[9] Liu Yixiang, Mao Xian, Liu Maili, Jiang Ling. Beryllium fluoride exchange rate accelerated by Mg²⁺ as discovered by ¹⁹F NMR.. THE JOURNAL OF PHYSICAL CHEMISTRY. A. 2015, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPD0DEB9DE54EF745CA9EFDE0B46A395D9C&DbName=SJPD_01&DbCode=SJPD&yx=&pr=&URLID=&bsm=.

   

（ 1 ） 组氨酸激酶HK853的动态ATP lid对反应调节蛋白RR468磷酸活化的影响, 主持, 国家级, 2017-01--2019-12
（ 2 ） 细胞内蛋白质结构和互作的原位NMR分析新技术与新方法, 参与, 国家级, 2017-07--2022-07
（ 3 ） 应答调节蛋白RR468磷酸活化动态机理研究, 主持, 研究所（学校）, 2016-01--2018-12
（ 4 ） 细胞中原子分辨的功能分子构象变化、相互作用和微环境效应的测定方法, 参与, 国家级, 2020-01--2024-12

（1）Detecting a pH-gated conformational switch of bifunctional histidine kinases by 19F NMR   2017-07-23