Xinyu Liu, Associate Professor

Dalian Institute of Chemical Physics, Chinese Academy of Sciences


Research Areas

Analytical methods for extremely complex samples and their applications



1. 2012/09-2017/01, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, PhD, tutor: Guowang Xu

2. 2009/09-2012/07, Shenyang Pharmaceutical University, Master's degree, tutor: Zhili Xiong

3. 2005/09-2009/07, Shenyang Pharmaceutical University, Bachelor


Work Experience

1. 2019/7 to present, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Associate professor

2. 2017/2 - 2019/7, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Assistant researcher



1.      Liu X#, Zhou L#, Shi X, Xu G* (2019) New advances in analytical methods for mass spectrometry-based large-scale metabolomics study. Trac-Trends in Analytical Chemistry 121.115665.

2.      Liu X#, Hoene M, Yin P, Fritsche L, Plomgaard P, Hansen JS, Nakas CT, Niess AM, Hudemann J, Haap M, Mendy M, Weigert C, Wang X, Fritsche A, Peter A, Haring H-U, Xu G*, Lehmann R* (2018) Quality Control of Serum and Plasma by Quantification of (4E,14Z)-Sphingadienine-C18-1-Phosphate Uncovers Common Preanalytical Errors During Handling of Whole Blood. Clinical chemistry 64 (5):810-819.

3.      Liu X#, Hoene M, Wang X, Yin P, Haering H-U, Xu G*, Lehmann R* (2018) Serum or plasma, what is the difference? Investigations to facilitate the sample material selection decision making process for metabolomics studies and beyond. Analytica chimica acta 1037:293-300.

4.      Liu X#, Xu G* (2018) Recent advances in using mass spectrometry for mitochondrial metabolomics and lipidomics - A review. Analytica chimica acta 1037:3-12.

5.      Liu X#, Yin P, Shao Y, Wang Z, Wang B, Lehmann R*, Xu G* (2020) Which is the urine sample material of choice for metabolomics-driven biomarker studies? Analytica chimica acta 1105:120-127.

6.      Liu X#, Zheng P#, Zhao X, Zhang Y, Hu C, Li J, Zhao J, Zhou J, Xie P*, Xu G* (2015) Discovery and Validation of Plasma Biomarkers for Major Depressive Disorder Classification Based on Liquid Chromatography-Mass Spectrometry. Journal of proteome research 14 (5):2322-2330.

7.      Liu X#, Li J#, Zheng P#, Zhao X, Zhou C, Hu C, Hou X, Wang H, Xie P*, Xu G* (2016) Plasma lipidomics reveals potential lipid markers of major depressive disorder. Analytical and Bioanalytical Chemistry 408 (23):6497-6507.

8.      Liu X#, Zhang S, Lu X, Zheng S, Li F, Xiong Z* (2012) Metabonomic study on the anti-osteoporosis effect of Rhizoma Drynariae and its action mechanism using ultra-performance liquid chromatography-tandem mass spectrometry. Journal of Ethnopharmacology 139 (1):311-317.

9.      Chen Q#, Liu X#, Zhao P, Sun Y, Zhao X, Xiong Y, Xu G*, Xia Q* (2015) GC/MS-based metabolomic studies reveal key roles of glycine in regulating silk synthesis in silkworm, Bombyx mori. Insect biochemistry and molecular biology 57:41-50.

10.   Pu J#, Liu X#, Liu Y#, Gui S, Zhong X, Tian L, Yang L, Xu S, Song X, Chen X, Chen Y, Wang H, Xu G*, Xie P* (2019) Sex-specific plasma metabolome signatures in major depressive disorder. Psychiatry and Clinical Neurosciences 73 (11):713-714.

11.   Gui S#, Liu Y#, Zhong X#, Liu X#, Zheng P, Pu J, Zhou J, Chen J, Zhao L, Liu L, Xu G*, Xie P* (2018) Plasma disturbance of phospholipid metabolism in major depressive disorder by integration of proteomics and metabolomics. Neuropsychiatric Disease and Treatment 14:1451-1461.

12.   Fang C#, Wang Q#, Liu X*, Xu G* (2017) Metabolic profiling analysis of Siraitia grosvenorii revealed different characteristics of green fruit and saccharified yellow fruit. Journal of Pharmaceutical and Biomedical Analysis 145:158-168.

13.   Noreldeen HAA#, Du L#, Li W, Liu X*, Wang Y*, Xu G (2020) Serum lipidomic biomarkers for non-small cell lung cancer in nonsmoking female patients. Journal of pharmaceutical and biomedical analysis 185:113220-113220.

14.   Noreldeen HAA, Liu X* Xu G (2019) Metabolomics of lung cancer: Analytical platforms and their applications. Journal of Separation Science.

15. 徐天润,刘心昱*,许国旺(2020)基于液相色谱-质谱联用技术的代谢组学分析方法研究进展,分析测试学报,39 (1):10-18


1.     夏庆友, 许国旺, 陈全梅, 刘心昱, 赵萍, 孙艳慧. 甘氨酸或其代谢调节剂在提高家蚕丝产量中的应用及其方法. 专利号: ZL201410233620.X. 已授权.

2.     许国旺,Hamada刘心昱. 血清脂质代谢物组合及试剂盒和应用.专利号202010066810.申请日:2020.1.20.

3.     许国旺,由蕾,刘心昱,路鑫.一种组合物和应用及肺癌患者诊断试剂盒.专利号:202010064504.5.申请:2020.1.20.

4.     许国旺,王利超,赵欣捷,刘心昱,路鑫. 一种筛查糖尿病的联合型代谢标志物的应用及其试剂盒. 专利号:201911218594.2.申请日:2019.12.03.

5.     许国旺,王晴晴,刘心昱.一种用于肝癌预后风险评估的试剂盒及应用.专利号: 201911199103.4. 申请日:2019.11.29.

6.     许国旺,由蕾,刘心昱.一种组合物及应用和诊断试剂盒. 专利号:201911074550.7. 申请日:2019.11.6.


1.      67th ASMS Conference on Mass Spectrometry. Atlanta GA, United States, 2019. Poster.

2.      第三届中国生物物理学会代谢生物学分会学术研讨会. 上海, 中国. 2019. 邀请报告.

3.      19届全国色谱学术报告会及仪器展览会。 福州,中国,2013年。口头报告。

4.      9th Annual Conference of the Metabolomics Society. Glasgow, Scotland, 2013. Poster.

5.      31st International symposium on Microscale Bioseparation, Shanghai, China. 2015. Poster.

6.      中国化学会第二届全国质谱分析学术报告会。杭州,中国,201510月。口头报告。