色谱-质谱分析

代谢组学

暴露组学

070302-分析化学

色谱质谱分析
代谢组学
暴露组学

2014-09--2014-11   德国Tuebingen大学医学院   交流与访问
2012-09--2017-01   中国科学院大学，大连化学物理研究所   理学博士
2009-09--2012-07   沈阳药科大学   理学硕士
2005-09--2009-07   沈阳药科大学   学士

2005年9月-2009年7月，沈阳药科大学，药学专业，本科。

2009年9月-2012年7月，沈阳药科大学，药物分析学专业，硕士。

2012年9月-2017年1月，中国科学院大学，中国科学院大连化学物理研究所高分辨分离分析及代谢组学研究组，分析化学专业，博士。

2014年9月-11月, 德国Tuebingen大学医学院，交流与访问。

最高学历：理学博士

2019-07~现在, 中国科学院大连化学物理研究所, 副研究员
2017-02~2019-07,中国科学院大连化学物理研究所, 助理研究员

2023-04-06-今,辽宁省免疫学会生物质谱分会, 副主任委员

   

（1） 基于液相色谱-质谱联用的高覆盖代谢组学方法开发及应用, 特等奖, 其他, 2020
（2） 辽宁省自然科学学术成果奖, 三等奖, 其他, 2019

[1] 许国旺, 欧阳润泽, 刘心昱, 路鑫. 一种新型肠道菌群体外培养的装置和方法. CN: CN114181806A, 2022-03-15.

[2] 许国旺, 方成男, 刘心昱. 联合型代谢标志物及应用和试剂盒与评分方法. CN: CN113970599A, 2022-01-25.

[3] 许国旺, 方成男, 刘心昱. 一种联合型代谢标志物及应用和试剂盒与评分方法. CN: CN113970598A, 2022-01-25.

[4] 许国旺, 哈马达努尔, 刘心昱. 血清脂质代谢物组合物及试剂盒和应用. CN: CN113138275A, 2021-07-20.

[5] 许国旺, 由蕾, 刘心昱, 路鑫. 一种组合物和应用及肺癌患者诊断试剂盒. CN: CN113138274A, 2021-07-20.

[6] 许国旺, 王利超, 赵欣捷, 刘心昱, 路鑫. 一种筛查糖尿病的联合型代谢标志物的应用及其试剂盒. CN: CN112903885A, 2021-06-04.

[7] 许国旺, 王晴晴, 刘心昱. 一种用于肝癌预后风险评估的试剂盒及应用. CN: CN112881578A, 2021-06-01.

[8] 许国旺, 由蕾, 刘心昱. 一种组合物及应用和诊断试剂盒. CN: CN112782403A, 2021-05-11.

[9] 夏庆友, 许国旺, 陈全梅, 刘心昱, 赵萍, 孙艳慧, 赵欣捷. 甘氨酸或其代谢调节剂在提高家蚕丝产量中的应用及其方法. CN: CN103983726A, 2014-08-13.

   

[1] Wang, Lichao, Lv, Wangjie, Sun, Xiaoshan, Zheng, Fujian, Xu, Tianrun, Liu, Xinyu, Li, Hang, Lu, Xin, Peng, Xiaojun, Hu, Chunxiu, Xu, Guowang. Strategy for Nontargeted Metabolomic Annotation and Quantitation Using a High-Resolution Spectral-Stitching Nanoelectrospray Direct-Infusion Mass Spectrometry with Data-Independent Acquisition. ANALYTICAL CHEMISTRY[J]. 2021, 93(30): 10528-10537, http://dx.doi.org/10.1021/acs.analchem.1c01480.
[2] Wang, Yuting, Wang, Yisheng, Chen, Chen, Ren, Fang, Cao, Rui, Wang, Yuefei, Han, Pin, Zhang, Xiaoyan, Xu, Congjian, Liu, Xinyu, Xu, Guowang. Serum lipid profiling analysis and potential marker discovery for ovarian cancer based on liquid chromatography-Mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS[J]. 2021, 199: http://dx.doi.org/10.1016/j.jpba.2021.114048.
[3] Fang, Chengnan, Su, Benzhe, Jiang, Tianyi, Li, Chao, Tan, Yexiong, Wang, Qingqing, Dong, Liwei, Liu, Xinyu, Lin, Xiaohui, Xu, Guowang. Prognosis prediction of hepatocellular carcinoma after surgical resection based on serum metabolic profiling from gas chromatography-mass spectrometry. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2021, 413(12): 3153-3165, http://dx.doi.org/10.1007/s00216-021-03281-z.
[4] Ye, Guozhu, Zhang, Xu, Liu, Xinyu, Liao, Xu, Zhang, Han, Yan, Changzhou, Lin, Yi, Huang, Qiansheng. Polystyrene microplastics induce metabolic disturbances in marine medaka (Oryzias melastigmas) liver. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2021, 782: http://dx.doi.org/10.1016/j.scitotenv.2021.146885.
[5] Wang, Lichao, Zhang, Yinan, Liu, Xinyu, Zhao, Xinjie, Ouyang, Yang, Qiu, Gaokun, Lv, Wangjie, Zheng, Fujian, Wang, QingQing, Lu, Xin, Peng, Xiaojun, Wu, Tangchun, Lehmann, Rainer, Wang, Congrong, Jia, Weiping, Xu, Guowang. Metabolite Triplet in Serum Improves the Diagnostic Accuracy of Prediabetes and Diabetes Screening. JOURNAL OF PROTEOME RESEARCH[J]. 2021, 20(1): 1005-1014, https://www.webofscience.com/wos/woscc/full-record/WOS:000605145400087.
[6] Zhang, Yuqing, Xie, Yunpeng, Lv, Wangjie, Hu, Chunxiu, Xu, Tianrun, Liu, Xinyu, Zhang, Rongfeng, Xu, Guowang, Xia, Yunlong, Zhao, Xinjie. A high throughput lipidomics method and its application in atrial fibrillation based on 96-well plate pretreatment and liquid chromatography-mass spectrometry. JOURNAL OF CHROMATOGRAPHY A[J]. 2021, 1651: http://dx.doi.org/10.1016/j.chroma.2021.462271.
[7] Lin, Xiangping, Lecuyer, Lucie, Liu, Xinyu, Triba, Mohamed N, DeschasauxTanguy, Melanie, Demidem, Aicha, Liu, Zhicheng, Palama, Tony, Rossary, Adrien, Vasson, MariePaule, Hercberg, Serge, Galan, Pilar, Savarin, Philippe, Xu, Guowang, Touvier, Mathilde. Plasma Metabolomics for Discovery of Early Metabolic Markers of Prostate Cancer Based on Ultra-High-Performance Liquid Chromatography-High Resolution Mass Spectrometry. CANCERS[J]. 2021, 13(13): http://dx.doi.org/10.3390/cancers13133140.
[8] Ye, Guozhu, Gao, Han, Zhang, Xu, Liu, Xinyu, Chen, Jinsheng, Liao, Xu, Zhang, Han, Huang, Qiansheng. Aryl hydrocarbon receptor mediates benzo[a]pyrene-induced metabolic reprogramming in human lung epithelial BEAS-2B cells. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2021, 756: http://dx.doi.org/10.1016/j.scitotenv.2020.144130.
[9] Liu, Yiyun, Song, Xuemian, Liu, Xinyu, Pu, Juncai, Gui, Siwen, Xu, Shaohua, Tian, Lu, Zhong, Xiaogang, Zhao, Libo, Wang, Haiyang, Liu, Lanxiang, Xu, Guowang, Xie, Peng. Alteration of lipids and amino acids in plasma distinguish schizophrenia patients from controls: A targeted metabolomics study. PSYCHIATRY AND CLINICAL NEUROSCIENCES[J]. 2021, 75(4): 138-144, http://dx.doi.org/10.1111/pcn.13194.
[10] 徐天润, 刘心昱, 许国旺. 基于液相色谱-质谱联用技术的代谢组学分析方法研究进展. 分析测试学报[J]. 2020, 39(1): 10-18, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2020&filename=TEST202001003&v=MDk3NTkxRnJDVVI3cWVaK2R2RmlqZ1VicklNU2pZZXJHNEhOSE1ybzlGWjRSOGVYMUx1eFlTN0RoMVQzcVRyV00=.
[11] Liu, Xinyu, Yin, Peiyuan, Shao, Yaping, Wang, Zhichao, Wang, Bohong, Lehmann, Rainer, Xu, Guowang. Which is the urine sample material of choice for metabolomics-driven biomarker studies?. ANALYTICA CHIMICA ACTA[J]. 2020, 1105: 120-127, http://dx.doi.org/10.1016/j.aca.2020.01.028.
[12] Wang, Qingqing, Su, Benzhe, Dong, Liwei, Jiang, Tianyi, Tan, Yexiong, Lu, Xin, Liu, Xinyu, Lin, Xiaohui, Xu, Guowang. Liquid Chromatography-Mass Spectrometry-Based Nontargeted Metabolomics Predicts Prognosis of Hepatocellular Carcinoma after Curative Resection. JOURNAL OF PROTEOME RESEARCH[J]. 2020, 19(8): 3533-3541, https://www.webofscience.com/wos/woscc/full-record/WOS:000562081000057.
[13] Noreldeen, Hamada A A, Liu, Xinyu, Xu, Guowang. Metabolomics of lung cancer: Analytical platforms and their applications. JOURNAL OF SEPARATION SCIENCEnull. 2020, 43(1): 120-133, http://dx.doi.org/10.1002/jssc.201900736.
[14] Fan, Yingying, Noreldeen, Hamada A A, You, Lei, Liu, Xinyu, Pan, Xue, Hou, Zhichao, Li, Qiangming, Li, Xiangnan, Xu, Guowang. Lipid alterations and subtyping maker discovery of lung cancer based on nontargeted tissue lipidomics using liquid chromatography-mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS[J]. 2020, 190: http://dx.doi.org/10.1016/j.jpba.2020.113520.
[15] Lv, Wangjie, Guo, Lei, Zheng, Fujian, Wang, Qingqing, Wang, Wen, Cui, Lin, Ouyang, Yang, Liu, Xinyu, Li, Enyou, Shi, Xianzhe, Xu, Guowang. Alternate reversed-phase and hydrophilic interaction liquid chromatography coupled with mass spectrometry for broad coverage in metabolomics analysis. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES[J]. 2020, 1152: http://dx.doi.org/10.1016/j.jchromb.2020.122266.
[16] Hu, Chunxiu, Zhou, Yang, Feng, Jie, Zhou, Shiyu, Li, Chuzhong, Zhao, Sida, Shen, Yutao, Hong, Lichuan, Xuan, Quhui, Liu, Xinyu, Li, Qi, Wang, Xiaolin, Zhang, Yazhuo, Xu, Guowang. Untargeted Lipidomics Reveals Specific Lipid Abnormalities in Nonfunctioning Human Pituitary Adenomas. JOURNAL OF PROTEOME RESEARCH[J]. 2020, 19(1): 455-463, https://www.webofscience.com/wos/woscc/full-record/WOS:000506722100043.
[17] Ju, Ran, Liu, Xinyu, Zheng, Fujian, Zhao, Xinjie, Lu, Xin, Lin, Xiaohui, Zeng, Zhongda, Xu, Guowang. A graph density-based strategy for features fusion from different peak extract software to achieve more metabolites in metabolic profiling from high-resolution mass spectrometry. ANALYTICA CHIMICA ACTA[J]. 2020, 1139: 8-14, http://dx.doi.org/10.1016/j.aca.2020.09.029.
[18] Franko, Andras, Shao, Yaping, Heni, Martin, Hennenlotter, Joerg, Hoene, Miriam, Hu, Chunxiu, Liu, Xinyu, Zhao, Xinjie, Wang, Qingqing, Birkenfeld, Andreas L, Todenhoefer, Tilman, Stenzl, Arnulf, Peter, Andreas, Haering, HansUlrich, Lehmann, Rainer, Xu, Guowang, Lutz, Stefan Z. Human Prostate Cancer Is Characterized by an Increase in Urea Cycle Metabolites. CANCERS[J]. 2020, 12(7): https://doaj.org/article/2d93dba4fbff48f88360a756cf2b7726.
[19] Noreldeen, Hamada A A, Du, Lijie, Li, Wei, Liu, Xinyu, Wang, Yanfu, Xu, Guowang. Serum lipidomic biomarkers for non-small cell lung cancer in nonsmoking female patients. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS[J]. 2020, 185: http://dx.doi.org/10.1016/j.jpba.2020.113220.
[20] Lv, Wangjie, Wang, Lichao, Xuan, Qiuhui, Zhao, Xinjie, Liu, Xinyu, Shi, Xianzhe, Xu, Guowang. Pseudotargeted Method Based on Parallel Column Two- Dimensional Liquid Chromatography-Mass Spectrometry for Broad Coverage of Metabolome and Lipidome. ANALYTICAL CHEMISTRY[J]. 2020, 92(8): 6043-6050, https://www.webofscience.com/wos/woscc/full-record/WOS:000527779200054.
[21] You, Lei, Fan, Yingying, Liu, Xinyu, Shao, Shujuan, Guo, Lei, Noreldeen, Hamada A A, Li, Zaifang, Ouyang, Yang, Li, Enyou, Pan, Xue, Liu, Tianyang, Tian, Xin, Ye, Fei, Li, Xiangnan, Xu, Guowang. Liquid Chromatography-Mass Spectrometry-Based Tissue Metabolic Profiling Reveals Major Metabolic Pathway Alterations and Potential Biomarkers of Lung Cancer. JOURNAL OF PROTEOME RESEARCH[J]. 2020, 19(9): 3750-3760, http://dx.doi.org/10.1021/acs.jproteome.0c00285.
[22] Qin, Qian, Feng, Disheng, Hu, Chunxiu, Wang, Bohong, Chang, Mengmeng, Liu, Xinyu, Yin, Peiyuan, Shi, Xianzhe, Xu, Guowang. Parallel derivatization strategy coupled with liquid chromatography-mass spectrometry for broad coverage of steroid hormones. JOURNAL OF CHROMATOGRAPHY A[J]. 2020, 1614: http://dx.doi.org/10.1016/j.chroma.2019.460709.
[23] Xuan, Qiuhui, Ouyang, Yang, Wang, Yanfeng, Wu, Liang, Li, Huating, Luo, Yuanyuan, Zhao, Xinjie, Feng, Disheng, Qin, Wangshu, Hu, Chunxiu, Zhou, Lina, Liu, Xinyu, Zou, Haidong, Cai, Chun, Wu, Jiarui, Jia, Weiping, Xu, Guowang. Multiplatform Metabolomics Reveals Novel Serum Metabolite Biomarkers in Diabetic Retinopathy Subjects. ADVANCED SCIENCE[J]. 2020, 7(22): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675050/.
[24] Ju, Ran, Liu, Xinyu, Zheng, Fujian, Zhao, Xinjie, Lu, Xin, Zeng, Zhongda, Lin, Xiaohui, Xu, Guowang. Removal of false positive features to generate authentic peak table for high-resolution mass spectrometry-based metabolomics study. ANALYTICA CHIMICA ACTA[J]. 2019, 1067: 79-87, http://cas-ir.dicp.ac.cn/handle/321008/165512.
[25] Ye, Guozhu, Chen, Guoyou, Gao, Han, Lin, Yi, Liao, Xu, Zhang, Han, Liu, Xinyu, Chi, Yulang, Huang, Qiansheng, Zhu, Huimin, Fan, Yuhua, Dong, Sijun. Resveratrol inhibits lipid accumulation in the intestine of atherosclerotic mice and macrophages. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE[J]. 2019, 23(6): 4313-4325, https://www.webofscience.com/wos/woscc/full-record/WOS:000470659500047.
[26] Pu, Juncai, Liu, Xinyu, Liu, Yiyun, Gui, Siwen, Zhong, Xiaogang, Tian, Lu, Yang, Lining, Xu, Shaohua, Song, Xuemian, Chen, Xiang, Chen, Yue, Wang, Haiyang, Xu, Guowang, Xie, Peng. Sex-specific plasma metabolome signatures in major depressive disorder. PSYCHIATRY AND CLINICAL NEUROSCIENCESnull. 2019, 73(11): 713-714, https://www.webofscience.com/wos/woscc/full-record/WOS:000486277900001.
[27] Niu, Huan, Li, Xin, Peng, Jiaxi, Zhang, Hongyan, Zhao, Xingyun, Zhou, Xiaoyu, Yu, Dongping, Liu, Xinyu, Wu, Renan. The efficient profiling of serum N-linked glycans by a highly porous 3D graphene composite. ANALYST[J]. 2019, 144(17): 5261-5270, [28] Cui, Bai, Luo, Yuanyuan, Tian, Pengfei, Peng, Fei, Lu, Jinxin, Yang, Yongliang, Su, Qitong, Liu, Bing, Yu, Jiachuan, Luo, Xi, Yin, Liu, Cheng, Wei, An, Fan, He, Bin, Liang, Dapeng, Wu, Sijin, Chu, Peng, Song, Luyao, Liu, Xinyu, Luo, Huandong, Xu, Jie, Pan, Yujia, Wang, Yang, Li, Dangsheng, Huang, Peng, Yang, Qingkai, Zhang, Lingqiang, Zhou, Binhua P, Liu, Suling, Xu, Guowang, Lam, Eric WF, Kelley, Keith W, Liu, Quentin. Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells. JOURNAL OF CLINICAL INVESTIGATION[J]. 2019, 129(3): 1030-1046, http://cas-ir.dicp.ac.cn/handle/321008/165838.
[29] Liu, Xinyu, Zhou, Lina, Shi, Xianzhe, Xu, Guowang. New advances in analytical methods for mass spectrometry-based large-scale metabolomics study. TRAC-TRENDS IN ANALYTICAL CHEMISTRYnull. 2019, 121: http://dx.doi.org/10.1016/j.trac.2019.115665.
[30] Liu, Xinyu, Hoene, Miriam, Yin, Peiyuan, Fritsche, Louise, Plomgaard, Peter, Hansen, Jakob S, Nakas, Christos T, Niess, Andreas M, Hudemann, Jens, Haap, Michael, Mendy, Maimuna, Weigert, Cora, Wang, Xiaolin, Fritsche, Andreas, Peter, Andreas, Haering, HansUlrich, Xu, Guowang, Lehmann, Rainer. Quality Control of Serum and Plasma by Quantification of (4E, 14Z)-Sphingadienine-C18-1-Phosphate Uncovers Common Preanalytical Errors During Handling of Whole Blood. CLINICAL CHEMISTRY[J]. 2018, 64(5): 810-819, http://www.corc.org.cn/handle/1471x/2373149.
[31] Liu, Xinyu, Xu, Guowang. Recent advances in using mass spectrometry for mitochondrial metabolomics and lipidomics - A review. ANALYTICA CHIMICA ACTA[J]. 2018, 1037: 3-12, http://cas-ir.dicp.ac.cn/handle/321008/166876.
[32] Liu, Xinyu, Hoene, Miriam, Wang, Xiaolin, Yin, Peiyuan, Haering, HansUlrich, Xu, Guowang, Lehmann, Rainer. Serum or plasma, what is the difference? Investigations to facilitate the sample material selection decision making process for metabolomics studies and beyond. ANALYTICA CHIMICA ACTA[J]. 2018, 1037: 293-300, http://cas-ir.dicp.ac.cn/handle/321008/166914.
[33] Gui, SiWen, Liu, YiYun, Zhong, XiaoGang, Liu, Xinyu, Zheng, Peng, Pu, JunCai, Zhou, Jian, Chen, JianJun, Zhao, LiBo, Liu, LanXiang, Xu, Guowang, Xie, Peng. Plasma disturbance of phospholipid metabolism in major depressive disorder by integration of proteomics and metabolomics. NEUROPSYCHIATRIC DISEASE AND TREATMENT[J]. 2018, 14: 1451-1461, https://doaj.org/article/ab1b9860c43441569dd362b7acc188c9.
[34] Zhao, Xinjie, Zeng, Zhongda, Chen, Aiming, Lu, Xin, Zhao, Chunxia, Hu, Chunxiu, Zhou, Lina, Liu, Xinyu, Wang, Xiaolin, Hou, Xiaoli, Ye, Yaorui, Xu, Guowang. Comprehensive Strategy to Construct In-House Database for Accurate and Batch Identification of Small Molecular Metabolites. ANALYTICAL CHEMISTRY[J]. 2018, 90(12): 7635-7643, https://www.webofscience.com/wos/woscc/full-record/WOS:000436028800074.
[35] Fang, Chengnan, Wang, Qingqing, Liu, Xinyu, Xu, Guowang. Metabolic profiling analysis of Siraitia grosvenorii revealed different characteristics of green fruit and saccharified yellow fruit. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS[J]. 2017, 145: 158-168, http://dx.doi.org/10.1016/j.jpba.2017.06.046.
[36] Fang Chengnan, Wang Qingqing, Liu Xinyu, Xu Guowang. Metabolic profiling analysis of Siraitia grosvenorii revealed different characteristics of green fruit and saccharified yellow fruit. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS[J]. 2017, [37] Zhou, Yang, Song, Ruixiang, Ma, Chong, Zhou, Lina, Liu, Xinyu, Yin, Peiyuan, Zhang, Zhensheng, Sun, Yinghao, Xu, Chuanliang, Lu, Xin, Xu, Guowang. Discovery and validation of potential urinary biomarkers for bladder cancer diagnosis using a pseudotargeted GC-MS metabolomics method. ONCOTARGET[J]. 2017, 8(13): 20719-20728, http://cas-ir.dicp.ac.cn/handle/321008/169394.
[38] Zhou, Yang, Song, Ruixiang, Zhang, Zhensheng, Lu, Xin, Zeng, Zhongda, Hu, Chunxiu, Liu, Xinyu, Li, Yanli, Hou, Jianguo, Sun, Yinghao, Xu, Chuanliang, Xu, Guowang. The development of plasma pseudotargeted GC-MS metabolic profiling and its application in bladder cancer. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2016, 408(24): 6741-6749, http://cas-ir.dicp.ac.cn/handle/321008/170256.
[39] Zhang, Yuansheng, Liu, Yongtao, Cao, Xupeng, Gao, Peng, Liu, Xinyu, Wang, Xiyue, Zhang, Junjie, Zhou, Jiannan, Xue, Song, Xu, Guowang, Tian, Jing. Free amino acids and small molecular acids profiling of marine microalga Isochrysis zhangjiangensis under nitrogen deficiency. ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS[J]. 2016, 13: 207-217, http://cas-ir.dicp.ac.cn/handle/321008/171262.
[40] Yuansheng Zhang, Yongtao Liu, Xupeng Cao, Peng Gao, Xinyu Liu, Xiyue Wang, Junjie Zhang, Jiannan Zhou, Song Xue, Guowang Xu, Jing Tian. Free amino acids and small molecular acids profiling of marine microalga Isochrysis zhangjiangensis under nitrogen deficiency. ALGAL RESEARCH. 2016, 13: 207-217, http://cas-ir.dicp.ac.cn/handle/321008/171262.
[41] Liu, Xinyu, Li, Jia, Zheng, Peng, Zhao, Xinjie, Zhou, Chanjuan, Hu, Chunxiu, Hou, Xiaoli, Wang, Haiyang, Xie, Peng, Xu, Guowang. Plasma lipidomics reveals potential lipid markers of major depressive disorder. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2016, 408(23): 6497-6507, http://www.corc.org.cn/handle/1471x/2375650.
[42] 张元圣, 刘永涛, 曹旭鹏, 高鹏, 刘心昱, 王希越, 张俊杰, 周建南, 薛松, 许国旺, 田晶. Free amino acids and small molecular acids profiling of marine microalga Isochrysis zhangjiangensis under nitrogen deficiency. ALGALRESEARCHBIOMASSBIOFUELSANDBIOPRODUCTS[J]. 2016, 13: 207-, http://cas-ir.dicp.ac.cn/handle/321008/148466.
[43] Chen, Quanmei, Liu, Xinyu, Zhao, Ping, Sun, Yanhui, Zhao, Xinjie, Xiong, Ying, Xu, Guowang, Xia, Qingyou. GC/MS-based metabolomic studies reveal key roles of glycine in regulating silk synthesis in silkworm, Bombyx mori. INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY[J]. 2015, 57: 41-50, http://dx.doi.org/10.1016/j.ibmb.2014.12.007.
[44] Liu, Xinyu, Zheng, Peng, Zhao, Xinjie, Zhang, Yuqing, Hu, Chunxiu, Li, Jia, Zhao, Jieyu, Zhou, Jingjing, Xie, Peng, Xu, Guowang. Discovery and Validation of Plasma Biomarkers for Major Depressive Disorder Classification Based on Liquid Chromatography-Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH[J]. 2015, 14(5): 2322-2330, http://cas-ir.dicp.ac.cn/handle/321008/146252.
[45] Hansen, Jakob S, Zhao, Xinjie, Irmler, Martin, Liu, Xinyu, Hoene, Miriam, Scheler, Mika, Li, Yanjie, Beckers, Johannes, de Angelis, Martin Hrabe, Haering, HansUlrich, Pedersen, Bente K, Lehmann, Rainer, Xu, Guowang, Plomgaard, Peter, Weigert, Cora. Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery. DIABETOLOGIA[J]. 2015, 58(8): 1845-1854, http://cas-ir.dicp.ac.cn/handle/321008/146436.
[46] Zeng, Zhongda, Liu, Xinyu, Dai, Weidong, Yin, Peiyuan, Zhou, Lina, Huang, Qiang, Lin, Xiaohui, Xu, Guowang. Ion Fusion of High-Resolution LC MS-Based Metabolomics Data to Discover More Reliable Biomarkers. ANALYTICAL CHEMISTRY[J]. 2014, 86(8): 3793-3800, http://cas-ir.dicp.ac.cn/handle/321008/144481.
[47] Huang, Yan, Chen, Guoyou, Liu, Xinyu, Shao, Yaping, Gao, Peng, Xin, Chenchen, Cui, Zhenze, Zhao, Xinjie, Xu, Guowang. Serum Metabolomics Study and Eicosanoid Analysis of Childhood Atopic Dermatitis Based on Liquid Chromatography-Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH[J]. 2014, 13(12): 5715-5723, http://cas-ir.dicp.ac.cn/handle/321008/144196.
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（ 1 ） 线粒体代谢组分析新方法的建立及在肝癌细胞研究中的应用, 负责人, 国家任务, 2018-01--2020-12
（ 2 ） 大规模临床样本高通量代谢组学分析新方法研究, 参与, 国家任务, 2017-01--2020-12
（ 3 ） 代谢组学中时间序列算法及应用研究, 参与, 国家任务, 2014-01--2017-12
（ 4 ） 母乳唾液酸预防儿童肥胖及代谢性疾病的机制研究, 负责人, 研究所自选, 2019-08--2021-07
（ 5 ） 食用农产品残留农药兽药在人体残留形态与健康风险相关性关键技术研究, 参与, 国家任务, 2019-12--2022-12
（ 6 ） 应用于临床样本检测的超灵敏、高覆盖代谢组定量分析技术研发, 参与, 国家任务, 2017-07--2019-12
（ 7 ） 中国科学院青年创新促进会, 负责人, 中国科学院计划, 2020-01--2024-12
（ 8 ） 母乳对婴儿肠道菌群发育的影响及对儿童青少年肥胖的预防作用研究, 负责人, 地方任务, 2020-01--2022-12
（ 9 ） 暴露组全景分析新方法及在环境污染物与慢病关系研究中的应用, 负责人, 研究所自选, 2023-01--2024-12

（1）恶性肿瘤的暴露组学和代谢组学研究   “代谢组学与生命健康：机遇和挑战”研讨会   2023-05-19
（2）组学关联研究揭示化学污染物暴露与慢病风险的关联   第十一届全国环境化学大会   2022-07-25
（3）代谢组学中生物样本的“分析前”因素和质量控制研究   中国化学会第23届全国色谱学术报告会及仪器展览会   2021-10-22
（4）外源性化学残留对慢病影响的代谢组关联研究   第二届中国生物物理学会代谢组学分会年会暨2021年代谢组学国际研讨会   2021-09-24
（5）外源性化学残留对慢病影响的代谢组关联研究   第二届中国生物物理学会代谢组学分会年会暨2021年代谢组学国际研讨会   2021-09-24
（6）Pre-analytical variation and sample quality control of human blood for metabolomics   2019-06-01
（7）Liquid Chromatography-Mass Spectrometry Based Metabolomics Technology and Its Applications   第三届中国生物物理学会代谢生物学分会学术研讨会   2019-05-11
（8）基于色谱质谱联用的代谢组学研究揭示甘氨酸在家蚕丝合成中的重要作用   中国化学会第二届全国质谱分析学术报告会   2015-10-17
（9）Untargeted and targeted approaches for metabolomics based on ultra high performance liquid chromatography–mass spectrometry   2013-07-01
（10）基于UPLC-Q-TOF-MS技术的家蚕血淋巴代谢组学研究   第19届全国色谱学术报告会及仪器展览会   2013-03-31

现指导学生

杨军  硕士研究生  070302-分析化学