100706-药理学

分子系统药理学，生理学，生物化学
肿瘤学
肠道炎症性疾病

2001-09--中科院研究生院／中科院昆明动物研究所   硕博连读／理学博士
1997-09--陕西师范大学   本科学习／理学学士

   

2018-04~现在, 中科院昆明植物研究所, 研究员
2010-10~现在, Brigham & Women's hospital, Harvard Medical School, Research Fellow
2008-09~现在, university of illinois -urbana Champaign, Postdoctoral research fellow
2007-07~现在, 中科院昆明动物研究所, 助理研究员

2011-07-13-今,the Innovation Advisory Board member, AB SCIEX, Inc
2011-06-15-今,scientific editor, American Journal of Cardiovascular Disease Research,
2011-05-10-今,scientific editor, International Journal of Genetics and Molecular Biology

   

[1] 刘树柏, 何英英. 一种抗癌活性蛋白妙沙林及其编码基因和应用. CN: CN111534502A, 2020-08-14.

   

[1] He, YingYing, He, Zhicheng, Lin, Jian, Chen, Cheng, Chen, Yuanzhi, Liu, Shubai. CtBP1/2 differentially regulate genomic stability and DNA repair pathway in high-grade serous ovarian cancer cell. ONCOGENESIS[J]. 2021, 10(7): http://dx.doi.org/10.1038/s41389-021-00344-9.

[2] Cheng Chen, Jiao Tian, Zhicheng He, Wenyong Xiong, Yingying He, Shubai Liu. Identified Three Interferon Induced Proteins as Novel Biomarkers of Human Ischemic Cardiomyopathy. International Journal of Molecular Sciences[J]. 2021, 22(23): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657967/.

[3] YingYing He, Shubai Liu, David S Newburg. Musarin, a novel protein with tyrosine kinase inhibitory activity from Trametes versicolor, inhibits colorectal cancer stem cell growth. Biomedicine & Pharmacotherapy[J]. 2021, 144: 
[4] YingYing He, Zhicheng He, Xiaoyu Zhang, Shubai Liu. Platelet-activating factor acetyl hydrolase IB2 dysregulated cell proliferation in ovarian cancer. Cancer Cell International[J]. 2021, 21(1): 1-17, 
[5] He, Yingying, He, Zhicheng, Leone, Serena, Liu, Shubai. Milk Exosomes Transfer Oligosaccharides into Macrophages to Modulate Immunity and Attenuate Adherent-Invasive E. coli (AIEC) Infection. NUTRIENTS[J]. 2021, 13(9): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000700141000001.

[6] Wu, Dandan, Hu, Shudong, Hou, Yongzhong, He, Yingying, Liu, Shubai. Identification of potential novel biomarkers to differentiate malignant thyroid nodules with cytological indeterminate. BMC CANCER[J]. 2020, 20(1): http://dx.doi.org/10.1186/s12885-020-6676-z.

[7] Choi, PuiWah, So, Wai Wing, Yang, Junzheng, Liu, Shubai, Tong, Ka Kui, Kwan, Kin Ming, Kwok, Jamie S L, Tsui, Stephen K W, Ng, ShuKay, Hales, Karen H, Hales, Dale B, Welch, William R, Crum, Christopher P, Fong, WingPing, Berkowitz, Ross S, Ng, ShuWing. MicroRNA-200 family governs ovarian inclusion cyst formation and mode of ovarian cancer spread. ONCOGENE[J]. 2020, 39(20): 4045-4060, https://www.webofscience.com/wos/woscc/full-record/WOS:000521526300003.

[8] Cai, Ying, Yang, Wenjiao, Li, Xiaomei, Zhou, Lutan, Wang, Zhongjuan, Lin, Lisha, Chen, Dingyuan, Zhao, Longyan, Li, Zhongkun, Liu, Shubai, Yin, Ronghua, Zuo, Zhili, Gao, Na, Zhao, Jinhua. Precise structures and anti-intrinsic tenase complex activity of three fucosylated glycosaminoglycans and their fragments. CARBOHYDRATE POLYMERS[J]. 2019, 224: http://dx.doi.org/10.1016/j.carbpol.2019.115146.

[9] He, YingYing, Liu, ShuBai, Kling, David E, Leone, Serena, Lawlor, Nathan T, Huang, Yi, Feinberg, Samuel B, Hill, David R, Newburg, David S. The human milk oligosaccharide 2 '-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation. GUT[J]. 2016, 65(1): 33-+, http://dx.doi.org/10.1136/gutjnl-2014-307544.

[10] M.J. Worley Jr., S. Liu, Y. Hua, A. Samuel, C.E. Parra-Herran, W.R. Welch, C.P. Crum, R.S. Berkowitz, S.W. Ng. Putative events in the development of clear cell ovarian carcinoma from endometriosis: An evaluation using immunohistochemistry and gene expression profiling. Gynecologic Oncology. 2014, 133: 115-115, http://dx.doi.org/10.1016/j.ygyno.2014.03.303.

[11] 刘树柏. A Long Lasting b1 Adrenergic Receptor Stimulation of cAMP/Protein Kinase A (PKA) Signal in Cardiac Myocytes.. J Bio. Chemistry.. 2014, 
[12] He, Y, Liu, S, Leone, S, Newburg, D S. Human colostrum oligosaccharides modulate major immunologic pathways of immature human intestine. MUCOSAL IMMUNOLOGY[J]. 2014, 7(6): 1326-1339, http://dx.doi.org/10.1038/mi.2014.20.

[13] 刘树柏. Inference on differences between classes using cluster-specific contrasts of mixed effects.. Biostatistics. 2014, 
[14] Lui, Kathy O, Howie, Duncan, Ng, ShuWing, Liu, Shubai, Chien, Kenneth R, Waldmann, Herman. Tolerance induction to human stem cell transplants with extension to their differentiated progeny. NATURE COMMUNICATIONS[J]. 2014, 5: https://www.webofscience.com/wos/woscc/full-record/WOS:000347226600001.

[15] 刘树柏. The Application of a Novel Nanovolume Capillary Electrophoresis- Based Protein Analysis System in Personalized & Translational Medicine Research.. Journal of Bioanalysis and Biomedicine,. 2013, 
[16] Taymaa May, Junzheng Yang, Melina Shoni, Shubai Liu, Housheng He, Reddy Gali, ShuKay Ng, Christopher Crum, Ross S Berkowitz, ShuWing Ng. BRCA1 Expression Is Epigenetically Repressed in Sporadic Ovarian Cancer Cells by Overexpression of C-Terminal Binding Protein 2 1 2. Neoplasia (New York, N.Y.). 2013, 15(6): 600-608, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664992/.

[17] Liu, Shubai, Yang, Junzheng, May, Taymaa, Hua, Yuanyuan, Lu, Shi, Elias, Kevin, Drapkin, Ronny, Welch, William, Crum, Christopher, Berkowitz, Ross S, Ng, ShuWing. The role of C-Terminal Binding Proteins in BRCA1 silencing and genetic instability of ovarian cancer cells. CLINICAL CANCER RESEARCHnull. 2013, 19: https://www.webofscience.com/wos/woscc/full-record/WOS:000209496100095.

[18] Saw, YuTing, Yang, Junzheng, Ng, ShuKay, Liu, Shubai, Singh, Surendra, Singh, Margit, Welch, William R, Tsuda, Hiroshi, Fong, WingPing, Thompson, David, Vasiliou, Vasilis, Berkowitz, Ross S, Ng, ShuWing. Characterization of aldehyde dehydrogenase isozymes in ovarian cancer tissues and sphere cultures. BMC CANCER[J]. 2012, 12(1): 329-329, http://dx.doi.org/10.1186/1471-2407-12-329.

[19] Rodriguez, Noah, Yang, Junzheng, Hasselblatt, Kathleen, Liu, Shubai, Zhou, Yilan, RauhHain, Jose A, Ng, ShuKay, Choi, PuiWah, Fong, WingPing, Agar, Nathalie Y R, Welch, William R, Berkowitz, Ross S, Ng, ShuWing. Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells. EMBO MOLECULAR MEDICINE[J]. 2012, 4(9): 952-963, http://dx.doi.org/10.1002/emmm.201101094.

[20] Liu, Shubai, Li, Ying, Kim, Sungjin, Fu, Qin, Parikh, Dippal, Sridhar, Bharat, Shi, Qian, Zhang, Xiaoying, Guan, Yinzheng, Chen, Xiongwen, Xiang, Yang K. Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2012, 109(17): 6578-6583, https://www.webofscience.com/wos/woscc/full-record/WOS:000303249100051.

[21] He, Yuan, Kapoor, Ashish, Cook, Sara, Liu, Shubai, Xiang, Yang, Rao, Christopher V, Kenis, Paul J A, Wang, Fei. The non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL-C3G complex and activating Rap1 at the leading edge. JOURNAL OF CELL SCIENCE[J]. 2011, 124(13): 2153-2164, https://www.webofscience.com/wos/woscc/full-record/WOS:000291537200006.

[22] Chakir, Khalid, Depry, Charlene, Dimaano, Veronica L, Zhu, WeiZhong, Vanderheyden, Marc, Bartunek, Jozef, Abraham, Theodore P, Tomaselli, Gordon F, Liu, Shubai, Xiang, Yang K, Zhang, Manling, Takimoto, Eiki, Dulin, Nickolai, Xiao, Rui Ping, Zhang, Jin, Kass, David A. G alpha(s)-Biased beta(2)-Adrenergic Receptor Signaling from Restoring Synchronous Contraction in the Failing Heart. SCIENCE TRANSLATIONAL MEDICINE[J]. 2011, 3(100): http://dx.doi.org/10.1126/scitranslmed.3001909.

[23] Liu, Shubai, Zhang, Jin, Xiang, Yang K. FRET-based direct detection of dynamic protein kinase A activity on the sarcoplasmic reticulum in cardiomyocytes. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2011, 404(2): 581-586, https://www.webofscience.com/wos/woscc/full-record/WOS:000286543800001.

[24] De Arcangelis, Vania, Liu, Shubai, Zhang, Dawen, Soto, Dagoberto, Xiang, Yang K. Equilibrium between Adenylyl Cyclase and Phosphodiesterase Patterns Adrenergic Agonist Dose-Dependent Spatiotemporal cAMP/Protein Kinase A Activities in Cardiomyocytes. MOLECULAR PHARMACOLOGY[J]. 2010, 78(3): 340-349, https://www.webofscience.com/wos/woscc/full-record/WOS:000281104700003.

[25] ShuBai Liu, YingYing He, Yun Zhang, WenHui Lee, JinQiao Qian, Ren Lai, Yang Jin, Mark R Cookson. A Novel Non-Lens βγ−Crystallin and Trefoil Factor Complex from Amphibian Skin and Its Functional Implications. PLOS ONE. 2008, 3(3): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2262142/.

[26] He, Ying Ying, Liu, Shu Bai, Lee, Wen Hui, Zhang, Yun. Melanoma cell growth inhibition by beta gamma-CAT, which is a novel non-lens betagamma-crystallin and trefoil factor complex from frog Bombina maxima skin. TOXICON[J]. 2008, 52(2): 341-347, http://159.226.149.42:8080/handle/152453/2713.

[27] 刘树柏. bg-CAT, a non-lens bg-crystallin and trefoil factor complex from amphibian skin secretions, caused endothelium-dependent myocardial depression in isolated rabbit hearts,. Toxicon.. 2008, 
[28] Qian, JinQian, Liu, ShuBai, He, YingYing, Lee, WenHui, Zhang, Yun. beta gamma-CAT, a non-lens beta gamma-crystallin and trefoil factor complex from amphibian skin secretions, caused endothelium-dependent myocardial depression in isolated rabbit hearts. TOXICON[J]. 2008, 52(2): 285-292, http://159.226.149.42:8080/handle/152453/2711.

[29] 刘树柏. Acute toxicity of bg-CAT, a naturally existing non-lens -crystallin and trefoil factor complex from frog Bombina maxima skin secretions.. Toxicon.. 2008, 
[30] 刘树柏. Isolation, expression and characterization of a novel dual serine protease inhibitor, OH-TCI, from king cobra.. Peptides.. 2008, 
[31] Liu, ShuBai, He, YingYing, Zhang, Yun, Lee, WenHui, Qian, JinQiao, Lai, Ren, Jin, Yang. A Novel Non-Lens beta gamma-Crystallin and Trefoil Factor Complex from Amphibian Skin and Its Functional Implications. PLOS ONE[J]. 2008, 3(3): https://doaj.org/article/044821d83a7a4bc9bb6d2e8cb7d07999.

[32] 刘树柏. Melanoma cell growth inhibition by -CAT, a non-lens bg-crystallin and trefoil factor complex from frog Bombina maxima skin.. Toxicon. 2008, 
[33] He, YingYing, Liu, ShuBai, Lee, WenHui, Qian, JinQiao, Zhang, Yun. Isolation, expression and characterization of a novel dual serine protease inhibitor, OH-TCI, from king cobra venom. PEPTIDES[J]. 2008, 29(10): 1692-1699, http://dx.doi.org/10.1016/j.peptides.2008.05.025.

[34] Qian, JinQiao, Liu, ShuBai, He, YingYing, Lee, WenHui, Zhang, Yun. Acute toxicity of beta gamma-CAT, a naturally existing non-lens beta gamma-crystallin and trefoil factor complex from frog Bombina maxima skin secretions. TOXICON[J]. 2008, 52(1): 22-31, http://159.226.149.42:8080/handle/152453/2715.

[35] Lee, WH, Liu, SB, Shen, JH, Jin, Y, Zhang, Y. Cloning of bradykinin precursor cDNAs from skin of Bombina maxima reveals novel bombinakinin M antagonists and a bradykinin potential peptide. REGULATORY PEPTIDES[J]. 2005, 127(1-3): 207-215, http://dx.doi.org/10.1016/j.regpep.2004.12.002.

[36] Shen, JH, Liu, SB, Zhang, YX, Jin, Y, Lee, WH, Zhang, Y. Cloning of novel bombesin precursor cDNAs from skin of Bombina maxima. REGULATORY PEPTIDES[J]. 2005, 132(1-3): 102-106, http://dx.doi.org/10.1016/j.regpep.2005.09.007.

[37] Lee, WH, Liu, SB, Shen, JH, Jin, Y, Lai, R, Zhang, Y. Identification and molecular cloning of a novel neuromedin U analog from the skin secretions of toad Bombina maxima. REGULATORY PEPTIDES[J]. 2005, 129(1-3): 43-47, http://dx.doi.org/10.1016/j.regpep.2005.01.007.

[38] Worley Michael J. Jr., Liu Shubai, Hua Yuanyuan, Kwok Jamie Sui-Lam, Samuel Anicka, Hou Lei, Shoni Melina, Lu Shi, Sandberg Evelien M., Keryan Anna, Wu Di, Ng Shu-Kay, Kuo Winston P., Parra-Herran Carlos E., Tsui Stephen KW, Welch William, Crum Christopher, Berkowitz Ross S., Ng Shu-Wing. Molecular Changes in Endometriosis-Associated Ovarian Clear Cell Carcinoma. European journal of cancer (Oxford, England : 1990). 51(13): 1831-1842, http://dx.doi.org/10.1016/j.ejca.2015.05.011.

   

（ 1 ） GPCR动态信号转导解析炎症性疾病机制及天然活性产物筛选(Y8677211K1), 主持, 市地级, 2018-04--2021-04
（ 2 ） 动态解析炎症性心衰中GPCR信号转导机制及天然产物活性筛选(Y8690211Z1), 主持, 市地级, 2018-05--2020-05
（ 3 ） 时空动态筛选炎症性疾病的GPCR靶向药物, 主持, 部委级, 2019-05--2022-04

现指导学生

林健  硕士研究生  078006-药理学  

陈成  博士研究生  100706-药理学