基本信息
李磊  男  博导  中国科学院动物研究所
电子邮件: lil@ioz.ac.cn
通信地址: 北京市朝阳区北辰西路一号院五号中国科学院动物研究所
邮政编码: 100101

研究领域

基础医学

招生信息

博士一名
招生专业
100101-人体解剖与组织胚胎学
招生方向
分子胚胎发育生物学

教育背景

1999-04--2002-03   日本群马大学   博士学位
1990-09--1994-06   中国农业大学   学士学位
学历

-- 研究生

学位
-- 博士
出国学习工作
1998.4-2003.10, 日本群马大学,研修生,博士研究生,博士后
2003.10-2009.5, 美国国立卫生研究院,Visiting Fellow, Research Fellow

工作经历

   
工作简历
2009-05~现在, 中国科学院动物研究所, 研究员
2003-10~2009-05,美国国立卫生研究院, Visiting/Research Fellow
2002-04~2003-10,日本群马大学生体调节研究所, 外国人研究员
1998-05~1999-03,日本群马大学生体调节研究所, 研修生
1994-07~1997-08,江西省明星企业集团, 工程师
社会兼职
   

教授课程

现代组织胚胎学及其技术应用
组织工程学
发育生物学
组织胚胎学
人体组织胚胎学
生殖生物学

专利与奖励

   
奖励信息
(1) NIH Fellow Award for Research Excellent, , 其他, 2008
(2) NIDDK Nancy Nossal Fellowship Award, , 其他, 2007
(3) NIH Fellow Award for Research Excellent, , 其他, 2005
专利成果
   

论文发表


  1.  Wang X, Qin D, Lu X, Li L*. An oocyte-embryo-specific subcortical maternal complex in mammals (in Chinese). Scientia Sinica Vitae. 2018 Jun; 48(6), 609-617.

  2. Zhang Y, Zhang X, Shi J, Tuorto F, Li X, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q. Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs. Nature Cell Biology. 2018 May; 20(5): 535–540. doi: 10.1038/s41556-018-0087-2.

  3. Lu X, Zhao Z, Wang X, Zhang X, Zhai Y, Deng W, Yi Z*, Li L*. Whole-transcriptome splicing profiling of E7.5 mouse primary germ layers reveals frequent usage of alternative promoter during early embryogenesis. Biology Open. 2018, Mar; 7(3). bio032508.

  4. Gao Z, Zhang X, Yu X, Qin D, Yu Y, Liu W, Xiang Y, Xiao Y, Lu X, Yi Z, Li L*. ZBED3 participates in the subcortical maternal complex and regulates the distribution of organelles. Journal of Molecular Cell Biology. 2018 Feb; 10(1): 74-88.

  5. Yu Y, Wang X, Zhang Z, Zhai Y, Lu X, Ma H, Zhu K, Zhao T, Jiao J, Zhao Z*, Li L*. Inhibition of ERK promotes neuroectodermal commitment of EpiSCs by preventing self-renewal and primitive streak formation. Stem Cell Research & Therapy. 2018 Jan; 9(1): 2. doi: 10.1186/s13287-017-0750-8.

  6. Zhang Y, Xiang Y, Yin Q, Du Z, Peng X, Wang Q, Fidalgo M, Xia W, Li Y, Zhao Z, Zhang W, Ma J, Xu F. Wang J, Li L, Xie W. Dynamic epigenomic landscapes during early lineage specification. Nature Genetics. 2018 Jan; 50(1): 96-105.

  7. Lu X, Gao Z, Qin D, Li L*. A Maternal Functional Module in the Mammalian Oocyte-To-Embryo Transition. Trends in Molecular Medicine. 2017 Nov; 23 (11) 1014–1023.

  8. Zhang L, Zhang X, Zhang X, Lu Y, Li L, Cui S*. MiRNA-143 mediates the proliferative signaling pathway of FSH and regulates estradiol production. Journal of Endocrinology. 2017 Jul; 234(1):1-14. doi: 10.1530/JOE-16-0488.

  9. Nie X, Lu X, Li L*. First cell lineage specification in mammalian early development (in Chinese). Chinese Science Bulletin. 2017 May; 62(15), 1569-1577.

  10. Liu W Wang F, Xu Q, Shi J, Zhang X, Lu X, Gao Z, Ma H, Zhao Z, Duan E, Gao F, Gao S*, Yi Z*, Li L*. BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis. Nature Communications. 2017 Jan 27; 8:14182.

  11. Xiao Y, Ma H, Wan P, Qin D, Zhang X, Xiang Y, Wang X, Liu W, Chen J*, Yi Z*, and Li L*. Trp-Asp (WD) repeat domain 1 is Essential for Mouse Peri-implantation Development and Regulates Cofilin Phosphorylation. Journal of Biological Chemistry. 2017 Jan 27; 292(4):1438-1448. 2016 Dec 19. pii: jbc.M116.759886. [Epub ahead of print]

  12. Liu Y, Lu X, Shi J, Yu X, Zhang X, Zhu K, Yi Z, Duan E, Li L*. BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis. Journal of Molecular Cell Biology. 2016 Aug; 8(4):366-8.

  13. Ma H, Lin Y, Zhao Z, Lu X, Yu Y, Zhang X, Wang Q*,Li L*. MicroRNA-127 promotes primitive streak formation by targeting left-right determination factor 2. Journal of Biological Chemistry. 2016 Jun 3; 291(23):12126-35.

  14. Xu Q, Wang F, Xiang Y, Zhang X, Zhao Z, Gao Z, Liu W, Lu X, Liu Y, Yu X, Wang H,  Huang J, Yi Z, Gao S*, Li L*. Maternal BCAS2 protects genomic integrity in mouse early embryonic development.Development. 2015 Nov 15; 142 (22):3943-53.

  15. Zhao Z, Yu Y, Ma H-X, Wang X, Lu X, Zhai Y , Zhang X-X, Wang H, Li L*. The roles of ERAS during cell lineage specification of mouse early embryonic development. Open Biology. 2015 Aug; 5(8).

  16. Zhao B, Zhang W, Duan Y, Lu Y, Cun Y, Li C, Guo K, Nie W,Li L, Zhang R, Zheng P. Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability. Cell Stem Cell. 2015 Apr 29.

  17. Zhu K, Yan L, Zhang X, Lu X, Wang T, Yan J, Liu X, Qiao J*,Li L*. Identification of a human subcortical maternal complex. Molecular Human Reproduction. 2015 Apr; 21(4): 320-9.

  18. Yu X, Yi Z, Gao Z, Qin D, Zhai Y, Chen X, Ou-Yang Y, Wang Z, Zheng P, Zhu M, Wang H, Sun QY, Dean J*, Li L*. The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics. Nature Communications. 2014 Sep 11; 5:4887.

  19. Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang YL, Li B, Chen Q*, Duan E*, Wang H*. Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms.Cell Research. 2014 Aug; 24(8): 925-42.

  20. Fu Z, Wang B, Wang S, Wu W, Wang Q, Chen Y, Kong S, Lu J, Tang Z, Ran H, Tu Z, He B, Zhang S, Chen Q, Jin W, Duan E, Wang H, Wang YL, Li L, Wang F*, Gao S*, Wang H*. Integral proteomic analysis of blastocysts reveals key molecular machinery governing embryonic diapause and reactivation for implantation in mice. Biology of Reproduction. 2014 Mar; 90(3): 52, 1-11.

  21. Li L*, Lu X and Dean J*. The maternal to zygotic transition in mammals. Molecular Aspects of Medicine. 2013 Oct; 34(5): 919-38.

  22. Xia P, Wang S, Du Y, Zhao Z, Shi L, Sun L, Huang G, Ye B, Li C, Dai Z, Hou N, Cheng X, Sun Q, Li L, Yang X*, Fan Z*. WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. The EMBO Journal. 2013 Oct; 32(20): 2685-96.

  23. Wang J, Xu M, Zhu K, Li L*, Liu X*. The N-terminus of FILIA forms an atypical KH domain with a unique extension involved in interaction with RNA. PLoS ONE. 2012; 7(1): e30209.

  24. Chen D, Zhang Y, Yi Q, Huang Y, Hou H, Zhang Y, Hao Q, Cooke HJ, Li L, Sun QY, Shi Q*. Regulation of asymmetrical cytokinesis by cAMP during meiosis I in mouse oocytes. PLoS ONE. 2012; 7(1): e29735.

  25. Li L*, Zheng P and Dean J*. Maternal control of early mouse development. Development. 2010Mar; 137(6): 859-70.

  26. Li L*, Baibakov B and Dean J. A subcortical maternal complex essential for pre-implantation mouse embryogenesis. Developmental Cell. 2008 Sep; 15(3): 416-25.

  27. Ohsugi M, Zheng P, Baibakov B, Li L, Dean J*. Maternally derived FILIA-MATER complex localizes asymmetrically in cleavage-stage mouse embryos. Development. 2008 Jan; 135(2): 259-69.

  28. Ogata T, Li L, Yamada S, Yamamoto Y, Tanaka Y, Takei I, Umezawa K and Kojima I*. Promotion of b-Cell Differentiation by Conophylline in Fetal and Neonatal Rat Pancreas. Diabetes. 2004 Oct; 53(10): 2596-2602.

  29. Li L, Yi Z, Seno M, and Kojima I*. Activin A and Betacellulin: Effect on Regeneration of Pancreatic b-Cells in Neonatal Streptozotocin-treated Rats, Diabetes. 2004 Mar; 53(3): 608-615.

  30. Li L, Seno M, Yamada H, and Kojima I*. Betacellulin Improved Glucose Metabolism by Promoting Conversion of Intra-islet Precursor Cells to-cells in Streptozotocin-treated Diabetic Mice, Am J Physiol Endocrinol Metab. 2003 Sep; 285(3): E577-83. 

  31. Li L, Seno M, Yamada H, and Kojima I*. Promotion of Beta-cell Regeneration by Betacellulin in 90% Pancreatectomized Rats. Endocrinology. 2001 Dec; 142(12): 5379-85.

科研活动

科技部重大科学计划,国家自然基金面上项目,百人计划

科研项目
( 1 ) “雌性生育力维持调节机制研究及生殖资源库建立”二级课题(2011CB944501):雌性生殖细胞发生, 主持, 国家级, 2011-01--2015-12
( 2 ) BCAS2 在小鼠早期胚胎发育过程中的生理功能及分子作用, 主持, 国家级, 2012-01--2015-12
( 3 ) 蛋白复合体新组分SCMC5的鉴定、功能和分子作用机制研究, 主持, 国家级, 2015-01--2018-12
( 4 ) 母源RNA降解和合子基因组激活的分子机制研究, 主持, 国家级, 2016-01--2020-12
( 5 ) 卵泡形成及卵母细胞生长起始的分子机制, 主持, 国家级, 2011-01--2016-12
( 6 ) BCAS2调控小鼠ES细胞增殖和围植入期胚胎发育的作用机制, 主持, 国家级, 2018-01--2021-11
( 7 ) 人类胚胎着床调控及相关重大妊娠疾病发生机制, 主持, 国家级, 2017-07--2020-12
( 8 ) 获得性性状的生殖传递机制, 主持, 国家级, 2018-12--2021-12
参与会议
   

合作情况

   
项目协作单位
   

指导学生

已指导学生

宇兴江  博士研究生  071008-发育生物学  

徐倩华  博士研究生  071008-发育生物学  

朱恺  博士研究生  071008-发育生物学  

马怀孝  硕士研究生  071008-发育生物学  

余洋  博士研究生  071008-发育生物学  

肖翼  博士研究生  071008-发育生物学  

高征  博士研究生  071008-发育生物学  

卢绪坤  博士研究生  100101-人体解剖与组织胚胎学  

马海霞  博士研究生  071008-发育生物学  

林宇轩  硕士研究生  071008-发育生物学  

马怀孝  博士研究生  100101-人体解剖与组织胚胎学  

何波  博士研究生  100101-人体解剖与组织胚胎学  

现指导学生

秦丹丹  博士研究生  100101-人体解剖与组织胚胎学  

王晓晓  博士研究生  100101-人体解剖与组织胚胎学  

全裕军  博士研究生  100101-人体解剖与组织胚胎学  

任伟倩  硕士研究生  100101-人体解剖与组织胚胎学  

张嘉祺  博士研究生  100101-人体解剖与组织胚胎学  

聂晓庆  博士研究生  100101-人体解剖与组织胚胎学  

王琪智  硕士研究生  100101-人体解剖与组织胚胎学