Guang-Xun Li (李光勋)
Natural Products Research Center, Chengdu Institution of Biology, Chinese
Academy of Science, Chengdu, Sichuan 610041, (PR China).
Tel: +86 15680763328
E-mail: ligx@cib.ac.cn
Research Areas
Education
09/2008-07/2011: Ph.D. in Medicinal Chemistry; Chengdu Institution of Biology, Chinese
Academy of Science.
09/2005-07/2008: M.S. in Forest Cultivation (research in photochemistry); Shenyang Institution of Applied Ecology, Chinese Academy of Science.
09/2005-07/2008: B.S. Forestry; Sichuan Agriculture University
Experience
09/2013–Present: Associate Professor, Chengdu Institution of Biology, Chinese Academy of Science.
07/2011-09/2013: Postdoctoral Research, Chengdu Institution of Organic chemistry, Chinese Academy of Science.
Publications
1. Guangxun Li, Chen Rong, Wu Lei, Fu Qingquan, Zhang Xiaomei, TangZhuo, Alkyl transfer from C-C cleavage, Angewandte Chemie International Edition, 2013, 52(32), 8432-8436. Highlighted by Synfacts 2013, 9(9), 1012.
2. Guangxun Li*, Liu Hongxin, Lv Gang, Wang Yingwei, Fu Qingquan, Tang Zhuo, Enantioselective Organocatalytic Transfer Hydrogenation of 1,2-Dihydroquinoline through Formation of Aza-o-xylylene. Organic Letters, 2015, 17(17), 4125-4127.
3. Guangxun Li,* Ling Tang, Hongxin Liu,Yingwei Wang,Gang Zhao, and Zhuo Tang*, Investigation and Application of Amphoteric α-Amino Aldehyde: An in Situ Generated Species Based on Heyns Rearrangement, Organic Letters, 2016, 18(18), 4526−4529.
4. Xuwen Ren, Guangxun Li*, Jin Huang, Weidong Wang, Yongpo Zhang, Guomin Xing, Chunyan Gao, Gang Zhao, Jinzhong Zhao*, Zhuo Tang*, Step-Controlled Povarov-Type Reaction with 1,2-Dihydroquinolines as Precursors of Dienophiles: Direct Synthesis of Spirocyclic Bi-tetrahydroquinolines and Functionalized 1,2-Dihydroquinolines, Organic Letters, 2017, 19, 58−61
5. Guangxun Li *, Liu Hongxin, Wang Yingwei, Zhang Shiqi, Lai Shujun, Tang Ling, Zhao Jinzhong, Tang Zhuo, The catalytic enantioselectivesynthesis of tetrahydroquinolines containing all-carbon quaternary stereocenters via the formation of aza-ortho-xylylene with 1,2-dihydroquinoline as a precursor. Chemical Communications, 2016, 52(11), 2304-2306.
6. Guangxun Li, Wu Lei, Lv Gang, Liu Hongxin Fu Qingquan, Zhang Xiaomei, Tang Zhuo, Alkyl transfer from C-C cleavage: replacing the nitro group of nitro-olefins, Chemical Communications, 2014, 50(47), 6246-6248.
7. Lai Shujun, Ren Xuwen, Zhao Jinzhong, Tang Zhuo, Guangxun Li *, Simple Brønsted acid catalyzed C–H functionalization: efficient access to poly-substituted pyridines. Tetrahedron Letters, 2016, 57(27–28), 2957-2961.
8. Guangxun Li, Wang Zhizhong, Lu Runhua, Tang Zhuo, Enantiodifferentiating photoisomerization of cyclooctene included and sensitized by benzoate modified β-cyclodextrin derivatives: switching of product chirality by solvent. Tetrahedron Letters, 2011, 52(24), 3097-3101.
9. Guangxun Li, Fu Qingquan, Zhang Xiaomei, Jiang Jun, Tang Zhuo, First asymmetric intermolecular bromoesterification catalyzed by chiral Brønsted acid. Tetrahedron: Asymmetry, 2012, 23(3–4), 245-251.
10. GuangXun Li, Wu Lei, Fu QingQuan, Tang Zhuo, Zhang XiaoMei, First way of enantioselective synthesis of moxifloxacin intermediate. Science China Chemistry, 2013, 56(3), 307-311.
11. Wu Lei, Guangxun Li, Fu Qingquan, Yu Luoting and Tang Zhuo, Organocatalytic asymmetric Michael reaction with acylsilane donors, Organic & Biomolecular Chemistry, 2013, 11(3), 443-447.
12. Wu Lei, Guangxun Li, He Migu, Wang Yingwei, Zhao Gang, Tang Zhuo, First Example of Organocatalytic Asymmetric Mannich Reaction between Aldimines of Glycinates and Sulphonyl Imines, Canadian Journal of Chemistry, 2016, 94, 769-772.
13. Shiqi Zhang, Guangxun Li, Hongxin Liu,Yingwei Wang,Yuan Cao,Gang Zhao,*and Zhuo Tang*, Bio-inspired enantioselective full transamination with readily available cyclodextrin, RSC Adv., 2017,7, 4203-4208.
14. Yingwei Wang, Guangxun Li, Hongxin Liu, Zhuo Tang*, Yuan Cao and Gang Zhao*, Kinetic resolution of indolines through reductive amination of aldehydes by chiral Brønsted acid, Tetrahedron Letters, 2017, 58, 2993-2996.
15. Yingwei Wang, Guangxun Li, Hongxin Liu, Zhuo Tang*, Yuan Cao and Gang Zhao*, A tandem annulation with a [1,3]-hydride transfer as the key step leading to isochromans, Chem. Commun., 2017,53, 10652-10655.
16. Jin Huang, Guangxun Li*, Guobin Yang, Jinzhong Zhao, and Zhuo Tang*, Brønsted Acid Catalyzed Substrate-Controlled and Site-selective Friedel-Crafts Alkylation: A New Strategy for Post-modification of 1,2-Dihydroquinolines, Asian Journal of Organic Chemistry, 2017, 6,1741-1744.
17. Guobing Yang, Guangxun. Li*, Jin.Huang, Zhuo. Tang* and Jingzhong. Zhao*, One Pot Three-Component Reaction for Preparation of Dihydroquinolines with Two Different Ketones and Aromatic Amines, Org. Biomol. Chem., 2017, 15, 10167-10171.
18. Hongxin Liu, Guangxun Li*, Ying-wei Wang, Shiqi Zhang, Zhuo Tang*, Bioinspired Catalysis: Self-Assembly of a Protein and DNA as a Catalyst for the Aldol Reaction in Aqueous Media, Synlett, 2018, 29, 560–565.
19. Long-junMa, Guangxun Li*, JinHuang, JinZhu*, ZhuoTang*, Using Sulfinamides as High Oxidation State Sulfur Reagent for Preparation of Sulfenamides, Tetrahedron Letters, 2018, 59, 1600-1603.
20. Long-junMa, Guangxun Li*, JinHuang, JinZhu*, ZhuoTang*, Synthesis of asymmetrical thioethers with sulfinamides as the sulfenylation agent under metal-free conditions, Tetrahedron Letters, 2018, 59, 4255-4258.
21. Ling-yu Li, Qing-le Zeng*, Guang-xun Li*, Zhuo Tang*, Solvent-Free Synthesis of α-Amino Ketones from α-Hydroxyl Ketones via A Novel Tandem Reaction Sequence Based on Heyns Rearrangement, Synlett, 2019, 30(06): 694-698.
22. Long-jun Ma, Shu-sen Chen, Guang-xun Li*, Jin Zhu, Qi-wei Wang, and Zhuo Tang*，Chiral Brønsted-Acid-Catalyzed Asymmetric Oxidation of Sulfenamide by Using H2O2: A Versatile Access to Sulfinamide and Sulfoxide with High Enantioselectivity，ACS Catal. 2019, 9, 1525−1530. Highlighted by Synfacts, 2019, 15, 0546.
23. Ling Li, Yingwei Wang, Shiqi Zhang, Xiongfei Deng, Guangxun Li*, Gang Zhao*, Zhuo Tang*, Preparation of Bicyclic Ketal Skeletons with Aldehyde and α-Ketone Acid through Cascade Freidel-Crafts Reaction and Stereoselective Acetalization in one pot, Synlett, 2019, 30, 2091-2095.
24. Shiqi Zhang, Guangxun Li, Ling Li, Xiongfei Deng, Gang Zhao*, Xin Cui and Zhuo Tang*, Alloxan-Catalyzed Biomimetic Oxidations with Hydrogen Peroxide or Molecular Oxygen, ACS Catal., 2020, 10, 245−252;
25. Xiong-fei Deng, Ying-wei Wang, Shi-qi Zhang, Ling Li, Guang-xun Li*, Gang Zhao* and Zhuo Tang*, An organocatalytic asymmetric Friedel–Crafts reaction of 2-substituted indoles with aldehydes: enantioselective synthesis of a-hydroxyl ketones by low loading of chiral phosphoric acid, Chem. Commun., 2020, 56, 2499.