基本信息
李光勋  男  硕导  中国科学院成都生物研究所
电子邮件: ligx@cib.ac.cn
通信地址: 成都市高新区科园南路93号成都生物所
邮政编码:

研究领域

生物启发的有机合成方法学研究,有机小分子不对称催化研究,活性天然产物的结构改造,药物合成工艺研究。


招生信息

   
招生专业
100701-药物化学
070303-有机化学
招生方向
药物化学,有机合成方法学,不对称催化

教育背景

2008-09--中科院成都生物所   博士
2005-09--四川农业大学   学士
2005-09--中科院沈阳应用生态所   硕士

工作经历

   
工作简历
2013-09~现在, 中科院成都生物所, 副研究员
2011-08~现在, 中科院成都有机化学研究所, 博士后

出版信息

   
发表论文
(1) Alloxan-Catalyzed Biomimetic Oxidations with Hydrogen Peroxide or Molecular Oxygen, ACS Catalysis, 2020-01, 第 2 作者
(2) An organocatalytic asymmetric Friedel–Craftsreaction of 2-substituted indoles with aldehydes:enantioselective synthesis ofa-hydroxyl ketonesby low loading of chiral phosphoric acid, chemical communications, 2020-01, 通讯作者
(3) Preparation of Bicyclic Ketal Skeletons with Aldehyde and -Ketone Acid through Cascade Friedel–Crafts Reaction and Stereoselective Acetalization in One Pot, synlett, 2019-07, 通讯作者
(4) Solvent-Free Synthesis of α-Amino Ketones from α-Hydroxyl Ketones via A Novel Tandem Reaction Sequence Based on Heyns Rearrangement, Synlett, 2019, 通讯作者
(5) Chiral Brønsted-Acid-Catalyzed Asymmetric Oxidation of Sulfenamide by Using H2O2: A Versatile Access to Sulfinamide and Sulfoxide with High Enantioselectivity, ACS Catalysis, 2019, 通讯作者
(6) Bioinspired Catalysis: Self-Assembly of a Protein and DNA as a Catalyst for the Aldol Reaction in Aqueous Media, Synlett, 2018, 通讯作者
(7) Using Sulfinamides as High Oxidation State Sulfur Reagent for Preparation of Sulfenamides, Tetrahedron Letters, 2018, 通讯作者
(8) Step-Controlled Povarov-Type Reaction with 1,2-Dihydroquinolines as Precursors of Dienophiles: Direct Synthesis of Spirocyclic Bi-tetrahydroquinolines and Functionalized 1,2-Dihydroquinolines, Organic Letters, 2017, 通讯作者
(9) One Pot Three-Component Reaction for Preparation of Dihydroquinolines with Two Different Ketones and Aromatic Amines, Org. Biomol. Chem., 2017, 通讯作者
(10) Brønsted Acid Catalyzed Substrate-Controlled and Site-selective Friedel-Crafts Alkylation: A New Strategy for Post-modification of 1,2-Dihydroquinolines, Asian Journal of Organic Chemistry, 2017, 通讯作者
(11) Investigation and Application of Amphoteric α-Amino Aldehyde: An in Situ Generated Species Based on Heyns Rearrangement, Organic Letters, 2016, 通讯作者
(12) The catalytic enantioselectivesynthesis of tetrahydroquinolines containing all-carbon quaternary stereocenters via the formation of aza-ortho-xylylene with 1,2-dihydroquinoline as a precursor, Chemical Communications, 2016, 通讯作者
(13) Simple Brønsted acid catalyzed C–H functionalization: efficient access to poly-substituted pyridines, Tetrahedron Letters, 2016, 通讯作者
(14) Enantioselective Organocatalytic Transfer Hydrogenation of 1,2-Dihydroquinoline through Formation of Aza-o-xylylene, Organic Letters, 2015, 通讯作者
(15) Alkyl transfer from C-C cleavage: replacing the nitro group of nitro-olefins, Chemical Communications, 2014, 第 1 作者
(16) Alkyl transfer from C-C cleavage, Angewandte Chemie International Edition, 2013, 第 1 作者
(17) First way of enantioselective synthesis of moxifloxacin intermediate., Science China Chemistry, 2013, 第 1 作者

科研活动

   
科研项目
( 1 ) 生物启发的有机烷基化试剂的开发与应用, 主持, 国家级, 2015-01--2017-12
( 2 ) 若干具有潜在药物活性分子的设计与合成(重点), 主持, 省级, 2017-01--2019-12
( 3 ) 中国科学院青年创新促进会, 主持, 部委级, 2018-01--2021-12
( 4 ) 药物创新研究员西南分部经费, 参与, 部委级, 2017-09--2018-12
( 5 ) 中国科学院“西部青年学者”(A类), 主持, 部委级, 2019-08--2023-07