基本信息
李芳  女  硕导  中国科学院深圳先进技术研究院
电子邮件: fang.li@siat.ac.cn
通信地址: 深圳市南山区学苑大道1068号
邮政编码:

招生信息

   
招生专业
070302-分析化学
0703Z1-化学生物学
083100-生物医学工程
招生方向
质谱分析
环境毒理组学
质谱成像

教育背景

2011-09--2016-07   中国科学院大学/中国科学院大连化学物理研究所   博士
2007-09--2011-07   中国地质大学(武汉)   学士

工作经历

   
工作简历
2020-01~现在, 中国科学院深圳先进技术研究院, 副研究员
2018-08~2019-12,中国科学院深圳先进技术研究院, 助理研究员
2016-07~2018-07,中国科学院深圳先进技术研究院, 博士后

专利与奖励

   
专利成果
[1] 罗茜, 李芳, 陈志宇, 傅磊, 李文波. 一种同时检测邻苯二甲酸酯类化合物及其代谢产物的方法及其应用. CN: CN112903884A, 2021-06-04.
[2] 罗茜, 吕悦广, 邓卡, 李芳, 陈志宇. 一种用于质谱成像的低温解吸电喷雾电离装置及方法. CN: CN112599404A, 2021-04-02.
[3] 罗茜, 傅磊, 李芳, 陈志宇, 李文波. 用于抑制儿茶酚类神经递质分解的稳定剂组合物及其应用. CN: CN112516322A, 2021-03-19.
[4] 罗茜, 傅磊, 李芳, 陈志宇, 李文波. 一种斑马鱼胚胎全氟化合物内暴露模型的构建方法及应用. CN: CN111040990A, 2020-04-21.
[5] 罗茜, 杨致一, 刘春花, 李芳. 一种双膦酸类药物的检测方法. 中国: CN108241026A, 2018-07-03.

出版信息

   
发表论文
[1] Zhiyu Chen, Fang Li, Lei Fu, Yu Xia, Ying Luo, Ang Guo, Xiaona Zhu, Huifang Zhong, Qian Luo. Role of inflammatory lipid and fatty acid metabolic abnormalities induced by plastic additives exposure in childhood asthma. JOURNAL OF ENVIRONMENTAL SCIENCES. 2024, 137: 172-180, http://dx.doi.org/10.1016/j.jes.2023.02.005.
[2] Yang, Zhiyi, Fu, Lei, Cao, Mengxi, Li, Fang, Li, Jingguang, Chen, Zhiyu, Guo, Ang, Zhong, Huifang, Li, Wenbo, Liang, Yong, Luo, Qian. PFAS-induced lipidomic dysregulations and their associations with developmental toxicity in zebrafish embryos. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2023, 861: http://dx.doi.org/10.1016/j.scitotenv.2022.160691.
[3] 郭昂, 陈志宇, 李芳, 罗茜. Delineating Regions-of-interest for Mass Spectrometry Imaging by Multimodally Corroborated Spatial Segmentation. GigaScience,[J]. 2023, [4] Chen, Zhiyu, Fu, Lei, Liu, XinAn, Yang, Zhiyi, Li, Wenbo, Li, Fang, Luo, Qian. Real-time effects of nicotine exposure and withdrawal on neurotransmitter metabolism of hippocampal neuronal cells by microfluidic chip-coupled LC-MS. CHINESE CHEMICAL LETTERS[J]. 2022, 33(6): 3101-3105, http://dx.doi.org/10.1016/j.cclet.2021.09.060.
[5] Yang, Zhiyi, Li, Wenbo, Huang, Hao, Ren, Songlei, Men, Yongfan, Li, Fang, Yu, Xuefeng, Luo, Qian. Detection of serum phospholipids by microchannel-integrated black phosphorus-assisted laser desorption/ionization mass spectrometry. TALANTA[J]. 2022, 237: http://dx.doi.org/10.1016/j.talanta.2021.122978.
[6] Yuange Chen, Longling Ouyang, Na Liu, Fang Li, Peiyi Li, Mengmeng Sun, Haiyang Qin, Yang Li, Xueping Xiang, Lidong Wu. pH-responsive magnetic artificial melanin with tunable aggregation-induced stronger magnetism for rapid remediation of plastic fragments. JOURNAL OF HAZARDOUS MATERIALS. 2022, 435: http://dx.doi.org/10.1016/j.jhazmat.2022.128962.
[7] Li, Fang, Fu, Lei, Liu, Xiaoxiong, Liu, Xinan, Liang, Yong, Lv, Yueguang, Yang, Zhiyi, Guo, Ang, Chen, Zhiyu, Li, Wenbo, Pan, Fan, Luo, Qian. Serum metabolomic abnormalities in survivors of non-severe COVID-19. HELIYON[J]. 2022, 8(9): e10473-e10473, http://dx.doi.org/10.1016/j.heliyon.2022.e10473.
[8] Ma, Yinzhong, Chen, Zhiyu, He, Qianyan, Guo, ZhenNi, Yang, Yi, Liu, Fulin, Li, Fang, Luo, Qian, Chang, Junlei. Spatiotemporal lipidomics reveals key features of brain lipid dynamic changes after cerebral ischemia and reperfusion therapy. PHARMACOLOGICAL RESEARCH[J]. 2022, 185: http://dx.doi.org/10.1016/j.phrs.2022.106482.
[9] Geng, Ningbo, Luo, Yun, Cao, Rong, Song, Xiaoyao, Li, Fang, Wang, Feidi, Gong, Yufeng, Xing, Liguo, Zhang, Haijun, Chen, Jiping. Effect of short-chain chlorinated paraffins on metabolic profiling of male SD rats. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2021, 750: http://dx.doi.org/10.1016/j.scitotenv.2020.141404.
[10] Li, Fang, Xiang, Binbin, Jin, Yan, Li, Chao, Ren, Songlei, Wu, Yongning, Li, Jingguang, Luo, Qian. Hepatotoxic effects of inhalation exposure to polycyclic aromatic hydrocarbons on lipid metabolism of C57BL/6 mice. ENVIRONMENT INTERNATIONAL[J]. 2020, 134: http://dx.doi.org/10.1016/j.envint.2019.105000.
[11] Dawei Lu, Qian Luo, Rui Chen, Yongxun Zhuansun, Jie Jiang, Weichao Wang, Xuezhi Yang, Luyao Zhang, Xiaolei Liu, Fang Li, Qian Liu, Guibin Jiang. Chemical multi-fingerprinting of exogenous ultrafine particles in human serum and pleural effusion. NATURE COMMUNICATIONS[J]. 2020, 11(1): http://dx.doi.org/10.1038/s41467-020-16427-x.
[12] Xu, Meijia, Huang, Huiting, Li, Na, Li, Fang, Wang, Donghong, Luo, Qian. Occurrence and ecological risk of pharmaceuticals and personal care products (PPCPs) and pesticides in typical surface watersheds, China. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY[J]. 2019, 175: 289-298, http://dx.doi.org/10.1016/j.ecoenv.2019.01.131.
[13] Li, Fang, Xiang, Binbin, Jin, Yan, Li, Chao, Li, Jingguang, Ren, Songlei, Huang, Huiting, Luo, Qian. Dysregulation of lipid metabolism induced by airway exposure to polycyclic aromatic hydrocarbons in C57BL/6 mice. ENVIRONMENTAL POLLUTION[J]. 2019, 245: 986-993, http://dx.doi.org/10.1016/j.envpol.2018.11.049.
[14] Tan, Dongqin, Jin, Jing, Li, Fang, Sun, Xiaoli, Dhanjai, Ni, Yuwen, Chen, Jiping. Phenyltrichlorosilane-functionalized magnesium oxide microspheres: Preparation, characterization and application for the selective extraction of dioxin-like polycyclic aromatic hydrocarbons in soils with matrix solid-phase dispersion. ANALYTICA CHIMICA ACTA[J]. 2017, 956: 14-23, http://dx.doi.org/10.1016/j.aca.2016.12.040.
[15] Li, Fang, Jin, Jing, Tan, Dongqin, Xu, Jiazhi, Dhanjai, Ni, Yuwen, Zhang, Haijun, Chen, Jiping. High performance solid-phase extraction cleanup method coupled with gas chromatography-triple quadrupole mass spectrometry for analysis of polychlorinated naphthalenes and dioxin-like polychlorinated biphenyls in complex samples. JOURNAL OF CHROMATOGRAPHY A[J]. 2016, 1448: 1-8, http://cas-ir.dicp.ac.cn/handle/321008/170928.
[16] Li, Fang, Jin, Jing, Tan, Dongqin, Wang, Longxing, Geng, Ningbo, Cao, Rong, Gao, Yuan, Chen, Jiping. Hexabromocyclododecane and tetrabromobisphenol A in sediments and paddy soils from Liaohe River Basin, China: Levels, distribution and mass inventory. JOURNAL OF ENVIRONMENTAL SCIENCES[J]. 2016, 48: 209-217, http://cas-ir.dicp.ac.cn/handle/321008/169776.
[17] Li, Fang, Jin, Jing, Gao, Yuan, Geng, Ningbo, Tan, Dongqin, Zhang, Haijun, Ni, Yuwen, Chen, Jiping. Occurrence, distribution and source apportionment of polychlorinated naphthalenes (PCNs) in sediments and soils from the Liaohe River Basin, China. ENVIRONMENTAL POLLUTION[J]. 2016, 211: 226-232, http://cas-ir.dicp.ac.cn/handle/321008/170600.
[18] Li, Fang, Jin, Jing, Sun, Xiaoli, Wang, Xueli, Li, Yun, Shah, Syed Mazhar, Chen, Jiping. Gas chromatography-triple quadrupole mass spectrometry for the determination of atmospheric polychlorinated naphthalenes. JOURNAL OF HAZARDOUS MATERIALS[J]. 2014, 280(1): 111-117, http://dx.doi.org/10.1016/j.jhazmat.2014.07.060.

科研活动

   
科研项目
( 1 ) 基于脂肪酸代谢的动态变化解析邻苯二甲酯对儿童哮喘发生的影响, 主持, 国家级, 2018-01--2020-12
( 2 ) 基于脂质组学的多环芳烃暴露对慢性阻塞性肺病的影响机制及生物标志物研究, 主持, 省级, 2017-07--2020-06
( 3 ) 大气细颗粒物暴露诱发肺部炎症反应的代谢机制研究, 主持, 国家级, 2021-01--2024-12
参与会议
(1)Toxic effects of inhalation exposure to polycyclic aromatic hydrocarbons on lipid metabolism of mice   2019-06-16

指导学生

现指导学生

顾俊杰  硕士研究生  086000-生物与医药