有机化学，超分子化学，化学生物学

070303-有机化学
070304-物理化学

有机超分子化学和组装，功能有机分子和材料
软物质组装和传感

2003-08--2008-07   美国圣路易斯华盛顿大学   博士
1999-09--2003-06   复旦大学   理学学士

   

2013-01~现在, 中科院福建物质结构研究所, 研究员
2008-08~2013-01,美国德州大学奥斯汀分校, 博士后

前沿领域系列专题讲座

   

[1] 尤磊, 查代君. 轴手性联苯环-链异构化合物及其制备方法与应用. CN: CN110734387B, 2021-02-12.
[2] 尤磊, 邹汉勋, 叶何波. 一种荧光开关及其制备方法、应用. CN: CN109761930B, 2020-12-29.
[3] 查代君, 尤磊. 一种用于水相中铜离子与氰根离子的可视化检测的聚合物. 中国: CN104927049B, 2018-03-20.

   

[1] She, Zijian, Zou, Hanxun, You, Lei. Tuning the selectivity of amino acid recognition with dynamic covalent bond constrained fluorophores in aqueous media. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2022, 20(34): 6897-6904, http://dx.doi.org/10.1039/d2ob01361d.
[2] Jia, Shuaipeng, Ye, Hebo, You, Lei. Interplay between chalcogen bonds and dynamic covalent bonds. ORGANIC CHEMISTRY FRONTIERS[J]. 2022, 9(15): 3966-3975, http://dx.doi.org/10.1039/d2qo00684g.
[3] Li, Ziyi, Zhang, Ling, Zhou, Yuntao, Zha, Daijun, Hai, Yu, You, Lei. Dynamic Covalent Reactions Controlled by Ring-Chain Tautomerism of 2-Formylbenzoic Acid. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2022, 2022(5): http://dx.doi.org/10.1002/ejoc.202101461.
[4] Jiang, Guoshan, Hai, Yu, Ye, Hebo, You, Lei. Dynamic covalent chemistry constrained diphenylethenes: control over reactivity and luminescence both in solution and in the solid state. ORGANIC CHEMISTRY FRONTIERS[J]. 2022, 9(5): 1343-1353, http://dx.doi.org/10.1039/d2qo00057a.
[5] Qin, Shilong, Zou, Hanxun, Hai, Yu, You, Lei. Aggregation-induced emission luminogens and tunable multicolor polymer networks modulated by dynamic covalent chemistry. CHINESE CHEMICAL LETTERS[J]. 2022, 33(6): 3267-3271, http://dx.doi.org/10.1016/j.cclet.2021.11.001.
[6] Lu, Hanwei, Ye, Hebo, Zhang, Meilan, Wang, Lifeng, You, Lei. Photoswitchable Keto-Enol Tautomerism Driven by Light-Induced Change in Antiaromaticity. ORGANIC LETTERS[J]. 2022, 24(47): 8639-8644, http://dx.doi.org/10.1021/acs.orglett.2c03441.
[7] Hai, Yu, Ye, Hebo, Li, Ziyi, Zou, Hanxun, Lu, Hanwei, You, Lei. Light-Induced Formation/Scission of C-N, C-O, and C-S Bonds Enables Switchable Stability/Degradability in Covalent Systems. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2021, 143(48): 20368-20376, http://dx.doi.org/10.1021/jacs.1c09958.
[8] Zhuo, Youzhen, Wang, Xiuxiu, Chen, Si, Chen, Hang, Ouyang, Jie, Yang, Liulin, Wang, Xinchang, You, Lei, Utz, Marcel, Tian, Zhongqun, Cao, Xiaoyu. Quantification and Prediction of Imine Formation Kinetics in Aqueous Solution by Microfluidic NMR Spectroscopy. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2021, 27(37): 9508-9513, http://dx.doi.org/10.1002/chem.202100874.
[9] Sattar, Fazli, Feng, Zelin, Zou, Hanxun, Ye, Hebo, Zhang, Yi, You, Lei. Dynamic covalent bond constrained ureas for multimode fluorescence switching, thermally induced emission, and chemical signaling cascades. ORGANIC CHEMISTRY FRONTIERS[J]. 2021, 8(14): 3760-3769, http://dx.doi.org/10.1039/d1qo00500f.
[10] Chen, Hang, Tang, Xiao, Ye, Hebo, Wang, Xinchang, Zheng, Hao, Hai, Yu, Cao, Xiaoyu, You, Lei. Effects of n -> pi r* Orbital Interactions on Molecular Rotors: The Control and Switching of Rotational Pathway and Speed. ORGANIC LETTERS[J]. 2021, 23(1): 231-235, http://dx.doi.org/10.1021/acs.orglett.0c03969.
[11] Feng, Zelin, Jia, Shuaipeng, Chen, Hang, You, Lei. Modulation of imine chemistry with intramolecular hydrogen bonding: Effects from ortho-OH to NH. TETRAHEDRON[J]. 2020, 76(17): http://dx.doi.org/10.1016/j.tet.2020.131128.
[12] Mao, Jialin, Hai, Yu, Ye, Hebo, You, Lei. Adaptive Covalent Networks Enabled by Dual Reactivity: The Evolution of Reversible Covalent Bonds, Their Molecular Assemblies, and Guest Recognition. JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 85(8): 5351-5361, https://www.webofscience.com/wos/woscc/full-record/WOS:000607535100019.
[13] Khan, Imran, Wang, Junling, Zou, Hanxun, Ye, Hebo, Zha, Daijun, Zhang, Yi, You, Lei. Noncovalent and Dynamic Covalent Chemistry Strategies for Driving Thermoresponsive Phase Transition with Multistimuli and Controlled Encapsulation/Release. ACS APPLIED MATERIALS & INTERFACES[J]. 2020, 12(2): 2962-2973, https://www.webofscience.com/wos/woscc/full-record/WOS:000508464500109.
[14] Chen, Hang, Ye, Hebo, Hai, Yu, Zhang, Ling, You, Lei. n -> pi* interactions as a versatile tool for controlling dynamic imine chemistry in both organic and aqueous media. CHEMICAL SCIENCE[J]. 2020, 11(10): 2707-2715, https://www.webofscience.com/wos/woscc/full-record/WOS:000519742300009.
[15] Zheng, Hao, Ni, Cailing, Chen, Hang, Zha, Daijun, Hai, Yu, Ye, Hebo, You, Lei. Regulation of Axial Chirality through Dynamic Covalent Bond Constrained Biaryls. ACS OMEGA[J]. 2019, 4(6): 10273-10278, https://doaj.org/article/49cc2887605a4ebf97bed06f5d72d11a.
[16] Zou, Hanxun, Hai, Yu, Ye, Hebo, You, Lei. Dynamic Covalent Switches and Communicating Networks for Tunable Multicolor Luminescent Systems and Vapor-Responsive Materials. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 141(41): 16344-16353, https://www.webofscience.com/wos/woscc/full-record/WOS:000491220300024.
[17] Zheng, Hao, Ye, Hebo, Yu, Xiaoxia, You, Lei. Interplay between n ->pi* Interactions and Dynamic Covalent Bonds: Quantification and Modulation by Solvent Effects. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 141(22): 8825-8833, https://www.webofscience.com/wos/woscc/full-record/WOS:000470939200030.
[18] Hai, Yu, Zou, Hanxun, Ye, Hebo, You, Lei. Three Switchable Orthogonal Dynamic Covalent Reactions and Complex Networks Based on the Control of Dual Reactivity. JOURNAL OF ORGANIC CHEMISTRY[J]. 2018, 83(17): 9858-9869, https://www.webofscience.com/wos/woscc/full-record/WOS:000444364600023.
[19] Ni, Cailing, Wang, Meng, You, Lei. Dynamic Covalent Chemistry within Biphenyl Scaffolds: Effects from Endocyclic to Exocyclic Sulfonamides. SYNLETT[J]. 2018, 29(16): 2131-2136, https://www.webofscience.com/wos/woscc/full-record/WOS:000445494200008.
[20] Ni, Cailing, Zha, Daijun, Ye, Hebo, Hai, Yu, Zhou, Yuntao, Anslyn, Eric V, You, Lei. Dynamic Covalent Chemistry within Biphenyl Scaffolds: Reversible Covalent Bonding, Control of Selectivity, and Chirality Sensing with a Single System. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 57(5): 1300-1305, https://www.webofscience.com/wos/woscc/full-record/WOS:000422940600028.
[21] Gao, Siheng, Li, Lijie, Vohra, Ismail, Zha, Daijun, You, Lei. Differential metal-binding properties of dynamic acylhydrazone polymers and their sensing applications. ROYAL SOCIETY OPEN SCIENCE[J]. 2017, 4(8): https://doaj.org/article/59d0feb5f9444ec391c5640588c42eec.
[22] Ye, Hebo, Hai, Yu, Ren, Yulong, You, Lei. Versatile Dynamic Covalent Assemblies for Probing -Stacking and Chirality Induction from Homotopic Faces. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2017, 23(16): 3804-3809, https://www.webofscience.com/wos/woscc/full-record/WOS:000397505400002.
[23] Wang, Meng, Ye, Hebo, You, Lei, Chen, Xueyuan. A Supramolecular Sensor Array Using Lanthanide-Doped Nanoparticles for Sensitive Detection of Glyphosate and Proteins. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 8(1): 574-581, https://www.webofscience.com/wos/woscc/full-record/WOS:000368563000069.
[24] Zha, Daijun, You, Lei. Multiresponsive Dynamic Covalent Assemblies for the Selective Sensing of Both Cu2+ and CN- in Water. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 8(3): 2399-2405, https://www.webofscience.com/wos/woscc/full-record/WOS:000369044100100.
[25] Zhou, Yuntao, Li, Lijie, Ye, Hebo, Zhang, Ling, You, Lei. Quantitative Reactivity Scales for Dynamic Covalent and Systems Chemistry. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2016, 138(1): 381-389, https://www.webofscience.com/wos/woscc/full-record/WOS:000368323100056.
[26] Ren, Yulong, You, Lei. Dynamic Signaling Cascades: Reversible Covalent Reaction-Coupled Molecular Switches. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2015, 137(44): 14220-14228, https://www.webofscience.com/wos/woscc/full-record/WOS:000364727600034.
[27] Zhou, Yuntao, Ye, Hebo, You, Lei. Reactivity-Based Dynamic Covalent Chemistry: Reversible Binding and Chirality Discrimination of Monoalcohols. JOURNAL OF ORGANIC CHEMISTRY[J]. 2015, 80(5): 2627-2633, https://www.webofscience.com/wos/woscc/full-record/WOS:000350841600017.
[28] You, Lei, Zha, Daijun, Anslyn, Eric V. Recent Advances in Supramolecular Analytical Chemistry Using Optical Sensing. CHEMICAL REVIEWSnull. 2015, 115(15): 7840-7892, http://dx.doi.org/10.1021/cr5005524.
[29] Zhou, Yuntao, Ren, Yulong, Zhang, Ling, You, Lei, Yuan, Yaofeng, Anslyn, Eric V. Dynamic covalent binding and chirality sensing of mono secondary amines with a metal-templated assembly. TETRAHEDRON[J]. 2015, 71(21): 3515-3521, http://dx.doi.org/10.1016/j.tet.2015.03.121.
[30] Jo, Hyun Hwa, Edupuganti, Ramakrishna, You, Lei, Dalby, Kevin N, Anslyn, Eric V. Mechanistic studies on covalent assemblies of metal-mediated hemi-aminal ethers. CHEMICAL SCIENCE[J]. 2015, 6(1): 158-164, https://www.webofscience.com/wos/woscc/full-record/WOS:000345901600012.
[31] Jo, H H, Gao, X, You, L, Anslyn, E V, Krische, M J. Application of a high-throughput enantiomeric excess optical assay involving a dynamic covalent assembly: parallel asymmetric allylation and ee sensing of homoallylic alcohols. CHEMICAL SCIENCE[J]. 2015, 6(12): 6747-6753, https://www.webofscience.com/wos/woscc/full-record/WOS:000365225300006.
[32] Zhou, Yuntao, Yuan, Yaofeng, You, Lei, Anslyn, Eric V. Dynamic Aminal-Based TPA Ligands. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2015, 21(22): 8207-8213, https://www.webofscience.com/wos/woscc/full-record/WOS:000354651300032.
[33] Barman, Sanmitra, You, Lei, Chen, Ran, Codrea, Vlad, Kago, Grace, Edupuganti, Ramakrishna, Robertus, Jon, Krug, Robert M, Anslyn, Eric V. Exploring naphthyl-carbohydrazides as inhibitors of influenza A viruses. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2014, 71: 81-90, http://dx.doi.org/10.1016/j.ejmech.2013.10.063.
[34] Jo, Hyun Hwa, Anslyn, Eric V, You, Lei. Determination of enantiomeric excess of chiral alcohols using a dynamic multi-component assembly. ABSTRACTSOFPAPERSOFTHEAMERICANCHEMICALSOCIETYnull. 2014, 248: https://www.webofscience.com/wos/woscc/full-record/WOS:000349167403459.
[35] Daschbach, Megan M, Negin, Saeedeh, You, Lei, Walsh, Matthew, Gokel, George W. Aggregation and Supramolecular Membrane Interactions that Influence Anion Transport in Tryptophan-Containing Synthetic Peptides. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2012, 18(24): 7608-7623, https://www.webofscience.com/wos/woscc/full-record/WOS:000304755700036.
[36] Lei You. Correlating sterics parameters and diastereomeric ratio values for a multicomponent assembly to predict exciton-coupled circular dichroism intensity and thereby enantiometic excess of chiral secondary alcohols. J. Am. Chem. Soc.. 2012, [37] Zhang, Xiaojun, You, Lei, Anslyn, Eric V, Qian, Xuhong. Discrimination and Classification of Ginsenosides and Ginsengs Using Bis-Boronic Acid Receptors in Dynamic Multicomponent Indicator Displacement Sensor Arrays. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2012, 18(4): 1102-1110, https://www.webofscience.com/wos/woscc/full-record/WOS:000299075600014.
[38] You, Lei, Pescitelli, Gennaro, Anslyn, Eric V, Di Bari, Lorenzo. An Exciton-Coupled Circular Dichroism Protocol for the Determination of Identity, Chirality, and Enantiomeric Excess of Chiral Secondary Alcohols. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2012, 134(16): 7117-7125, https://www.webofscience.com/wos/woscc/full-record/WOS:000303139800041.
[39] You, Lei, Long, S Reid, Lynch, Vincent M, Anslyn, Eric V. Dynamic Multicomponent Hemiaminal Assembly. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2011, 17(39): 11017-11023, https://www.webofscience.com/wos/woscc/full-record/WOS:000296262400030.
[40] You, Lei, Cho, Eun Jeong, Leavitt, John, Ma, LiChung, Montelione, Gaetano T, Anslyn, Eric V, Krug, Robert M, Ellington, Andrew, Robertus, Jon D. Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2011, 21(10): 3007-3011, http://dx.doi.org/10.1016/j.bmcl.2011.03.042.
[41] You, Lei, Berman, Jeffrey S, Anslyn, Eric V. Dynamic multi-component covalent assembly for the reversible binding of secondary alcohols and chirality sensing. NATURE CHEMISTRY[J]. 2011, 3(12): 943-948, https://www.webofscience.com/wos/woscc/full-record/WOS:000297685800012.

   

（ 1 ） 青年****, 主持, 国家级, 2013-01--2017-12
（ 2 ） 酰腙类动态共价双亲分子的组装及其和生物膜的相互作用, 主持, 国家级, 2015-01--2017-12
（ 3 ） 新型动态作用及其对生物分子的修饰、分析和调控, 主持, 市地级, 2015-01--2017-12
（ 4 ） 基于氮杂环鎓盐的新型动态共价键和复杂动态信号级联体系, 主持, 国家级, 2017-01--2020-12
（ 5 ） 动态共价键、组装及其导向的传感和标记功能研究, 主持, 部委级, 2016-07--2021-06
（ 6 ） 基于双重反应性的动态共价化学及其光调控, 主持, 国家级, 2021-01--2024-12
（ 7 ） 动态共价键化学：设计、组装和应用, 主持, 省级, 2020-11--2023-11
（ 8 ） 基于动态共价聚合物的柔性自修复发光材料, 主持, 省级, 2021-03--2023-02

已指导学生

李利杰  硕士研究生  085204-材料工程  

高司恒  硕士研究生  085204-材料工程  

倪彩玲  博士研究生  070304-物理化学  

叶何波  博士研究生  070303-有机化学  

邹汉勋  博士研究生  070303-有机化学  

陈航  博士研究生  070303-有机化学  

毛佳琳  硕士研究生  070304-物理化学  

现指导学生

姜国山  博士研究生  070303-有机化学  

海宇  博士研究生  070303-有机化学  

吕友明  硕士研究生  070303-有机化学  

陆涵葳  博士研究生  070303-有机化学  

尹超伟  硕士研究生  085600-材料与化工