基本信息
赵岚  女    中国科学院过程工程研究所
电子邮件: lanzhao@ipe.ac.cn
通信地址: 中科院过程工程研究所海淀区中关村北二条1号
邮政编码:

招生信息

   
招生专业
081703-生物化工
招生方向
生物分离材料,层析介质,蛋白分离纯化,生物分离工程

教育背景

2006-09--2012-07   中国科学院过程工程研究所   生物化工博士
2001-09--2004-03   天津大学   材料学硕士
1997-09--2001-06   天津大学   高分子化工学士

工作经历

   
工作简历
2014-08~现在, 中国科学院过程工程研究所, 副研究员
2004-05~2014-08,中国科学院过程工程研究所, 助理研究员

专利与奖励

   
奖励信息
(1) 以保护活性为目标的生物技术药物层析分离纯化技术, 国家级, 2013
专利成果
[1] 马光辉, 郝冬霞, 张荣月, 葛佳, 黄永东, 赵岚, 周炜清. 一种亲和层析介质及其制备方法和应用. CN: CN112206754A, 2021-01-12.
[2] 马光辉, 赵岚, 黄永东, 魏炜, 朱凯, 陶娇丽, 周炜清, 苏志国. 一种磷脂纳米盘层析介质及其制备方法和应用. CN: CN110292916A, 2019-10-01.
[3] 马光辉, 赵岚, 黄永东, 魏炜, 朱凯, 陶娇丽, 周炜清, 苏志国. 一种电荷型纳米盘-膜蛋白复合物及其制备方法和应用. CN: CN110184262A, 2019-08-30.
[4] 马光辉, 赵岚, 黄永东, 巩方玲, 朱凯, 张洪武, 周炜清, 苏志国. 多糖微球及其制备方法. CN: CN110026138A, 2019-07-19.
[5] 马光辉, 郝冬霞, 黄永东, 赵岚, 王伟颖, 葛佳, 苏志国, 周炜清. 一种IgG抗体亲和的小分子肽及其应用. CN: CN109678932A, 2019-04-26.
[6] 马光辉, 李强, 张坤, 赵岚, 黄永东, 周炜清, 吴学星, 朱凯. 聚甲基丙烯酸缩水甘油酯类或其共聚物的亲水改性方法及改性所得材料. CN: CN107365422A, 2017-11-21.
[7] 马光辉, 李强, 巩方玲, 黄永东, 赵岚. 一种聚苯乙烯类材料的亲水改性方法及其产品. CN: CN106589201A, 2017-04-26.
[8] 马光辉, 巩方玲, 李强, 闫晓峰, 赵岚, 周炜清, 苏志国. 一种聚苯乙烯类材料的亲水改性方法及其产品. CN: CN106589201A, 2017-04-26.
[9] 苏志国, 马光辉, 赵岚, 李秀男, 张松平. 一种利用离子液体制备多糖微球的方法. CN: CN106496597A, 2017-03-15.
[10] 赵岚, 苏志国, 闭静秀, 周卫斌, 王阳木, 李岩, 黄永东. 一种琼脂糖疏水层析介质及其在纯化酵母表达HBsAg中的应用. CN: CN101003017A, 2007-07-25.
[11] 闭静秀, 周卫斌, 苏志国, 李岩, 黄永东, 赵岚, 张焱. 一种分离纯化汉逊酵母表达的重组乙肝表面抗原的方法. CN: CN101003564A, 2007-07-25.

出版信息

   
发表论文
[1] Zhao, Lan, Che, Xiangjing, Huang, Yongdong, Zhu, Kai, Du, Yuxiang, Gao, Jingwei, Zhang, Rongyue, Zhang, Yongqiang, Ma, Guanghui. Regulation on both pore structure and pressure-resistant property of uniform agarose microspheres for high-resolution chromatography. JOURNAL OF CHROMATOGRAPHY A[J]. 2022, 1681: http://dx.doi.org/10.1016/j.chroma.2022.463461.
[2] Zhao, Lan, Huang, Lan, Huang, Yongdong, Zhu, Kai, Che, Xiangjing, Du, Yuxiang, Gao, Jingwei, Hao, Dongxia, Zhang, Rongyue, Wang, Qibao, Ma, Guanghui. Preparation and structural regulation of macroporous agarose microspheres for highly efficient adsorption of giant biomolecules. COLLOID AND POLYMER SCIENCE[J]. 2022, 300(6): 691-705, http://dx.doi.org/10.1007/s00396-022-04968-0.
[3] Hao, Dongxia, Zhang, Rongyue, Ge, Jia, Ye, Peili, Song, Cui, Zhu, Kai, Na, Xiangming, Huang, Yongdong, Zhao, Lan, Zhou, Weiqing, Su, Zhiguo, Ma, Guanghui. Rapid and high-capacity loading of IgG monoclonal antibodies by polymer brush and peptides functionalized microspheres. JOURNAL OF CHROMATOGRAPHY A[J]. 2021, 1640: http://dx.doi.org/10.1016/j.chroma.2021.461948.
[4] Zhao, Lan, Tao, Jiaoli, Huang, Yongdong, Zhu, Kai, Du, Yuxiang, Hao, Dongxia, Liu, Hongying, Zhang, Rongyue, Ma, Guanghui. Tailored nanodisc immobilization for one-step purification and reconstitution of cytochrome P450: A tool for membrane proteins' hard cases. JOURNAL OF SEPARATION SCIENCE[J]. 2021, 44(18): 3429-3440, http://dx.doi.org/10.1002/jssc.202100284.
[5] An, Ning, Gong, Pisheng, Hou, Henglei, Chi, Weiya, Jin, Haibo, Zhao, Lan, Tan, Qiqi, Tang, Xu, Wang, Fei, Jin, Hongchao, Zhang, Rongyue. Fabrication of macroporous microspheres with core-shell structure for negative chromatography purification of virus. JOURNAL OF CHROMATOGRAPHY A[J]. 2020, 1610: http://dx.doi.org/10.1016/j.chroma.2019.460578.
[6] 胡胜杰, 黄永东, 赵岚, 朱凯, 苗壮, 王飞, 晋洪超, 李建, 杨珺, 汪和睦, 马光辉, 袁洪水. 基于疫苗颗粒完整性的硅胶吸附/解吸附纯化重组乙肝表面抗原工艺研究. 过程工程学报[J]. 2020, 20(10): 1198-, http://lib.cqvip.com/Qikan/Article/Detail?id=7103330481.
[7] Zhao, Lan, Huang, Yongdong, Zhu, Kai, Miao, Zhuang, Zhao, Jiazhang, Che, Xiang Jing, Hao, Dongxia, Zhang, Rongyue, Ma, Guanghui. Manipulation of pore structure during manufacture of agarose microspheres for bioseparation. ENGINEERING IN LIFE SCIENCES[J]. 2020, 20(11): 504-513, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645642/.
[8] 黄兰, 黄永东, 赵岚, 朱凯, 吴学星, 周丹妮, 苏志国, 马光辉, 王启宝. 复乳法制备大孔琼脂糖分离介质与疫苗结合性能研究. 化学工业与工程[J]. 2019, 36(4): 70-80, http://lib.cqvip.com/Qikan/Article/Detail?id=7002404438.
[9] Wang, Weiying, Hao, Dongxia, Ge, Jia, Zhao, Lan, Huang, Yongdong, Zhu, Kai, Wu, Xvexing, Su, Zhiguo, Yu, Rong, Ma, Guanghui. A minimalist peptide ligand for IgG by minimizing the binding domain of protein A. BIOCHEMICAL ENGINEERING JOURNAL[J]. 2019, 151: http://dx.doi.org/10.1016/j.bej.2019.107327.
[10] Zhao, Xi, Huang, Lan, Wu, Jie, Huang, YongDong, Zhao, Lan, Wu, Nan, Zhou, WeiQing, Hao, DongXia, Ma, GuangHui, Su, ZhiGuo. Fabrication of rigid and macroporous agarose microspheres by pre-cross-linking and surfactant micelles swelling method. COLLOIDS AND SURFACES B-BIOINTERFACES[J]. 2019, 182: http://dx.doi.org/10.1016/j.colsurfb.2019.110377.
[11] Ning Dai, Shaoyun Wang, Heng Li, Lan Zhao, Haibo Jin, Ning An, Pisheng Gong, Qiqi Tan, Xu Tang, Fei Wang, Rongyue Zhang. Fabrication of poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) macroporous microspheres through activators regenerated by electron transfer atom transfer radical polymerization for rapid separation of proteins. JOURNAL OF CHROMATOGRAPHY B. 2019, 1128: http://dx.doi.org/10.1016/j.jchromb.2019.121794.
[12] Dai, Ning, Wang, Shaoyun, Li, Heng, Zhao, Lan, Jin, Haibo, An, Ning, Gong, Pisheng, Tan, Qiqi, Tang, Xu, Wang, Fei, Zhang, Rongyue. Fabrication of poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) macroporous microspheres through activators regenerated by electron transfer atom transfer radical polymerization for rapid separation of proteins. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES[J]. 2019, 1128: http://dx.doi.org/10.1016/j.jchromb.2019.121794.
[13] 韦巍, 黄永东, 赵岚, 吴学星, 朱天孝, 李冬雪, 靳海波, 张荣月, 苏志国, 马光辉. 新型耐碱蛋白A介质的制备与性能. 过程工程学报[J]. 2019, 19(3): 609-616, http://lib.cqvip.com/Qikan/Article/Detail?id=7002388065.
[14] 陶娇丽, 黄永东, 赵岚, 朱凯, 吴学星, 周丹妮, 苏志国, 马光辉, 刘红缨. 新型电荷型纳米盘的可控制备及其与细胞色素P450的结合性能. 过程工程学报[J]. 2019, 19(6): 1197-, http://lib.cqvip.com/Qikan/Article/Detail?id=7100645782.
[15] 张洪武, 赵岚, 黄永东, 朱凯, 朱天孝, 李冬雪, 张荣月, 苏志国, 马光辉, 王启宝. 快速膜乳化技术制备均一小粒径复合多糖微球及其色谱性能评价. 化学世界[J]. 2019, 60(11): 774-, http://lib.cqvip.com/Qikan/Article/Detail?id=7100450938.
[16] Zhang, Hongwu, Zhao, Lan, Huang, Yongdong, Zhu, Kai, Wang, Qibao, Yang, Rui, Su, Zhiguo, Ma, Guanghui. Uniform polysaccharide composite microspheres with controllable network by microporous membrane emulsification technique. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2018, 410(18): 4331-4341, http://ir.ipe.ac.cn/handle/122111/26691.
[17] 余佳, 赵岚, 张瑞华, 王玉兰. 葛仙米藻胆蛋白的提取工艺优化及其纯化研究. 食品研究与开发[J]. 2018, 39(2): 82-89, http://lib.cqvip.com/Qikan/Article/Detail?id=674310073.
[18] Lan MengFei, An Ning, Zhao Ying, Cao Wei, Li Heng, Zhao Lan, Huang YongDong, Zhang RongYue. Effect of Porogen Solubility Parameter on Structure of Chromatographic Supports with Large Pores. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2018, 46(2): 288-292, http://dx.doi.org/10.1016/S1872-2040(17)61069-7.
[19] Li Heng, Wang Shaoyun, Fang Jiaxuan, Zhao Lan, Jin Haibo, He Guangxiang, Guo Xiaoyan, Gu Qingyang, Hao Siwen, Re Ziya, Zhi Weijie, Yu Hongbin, Zhang Rongyue. Effect of Pore Structure on Protein Capacity in Macroporous Polymer Chromatographic Supports. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE[J]. 2018, 39(12): 2673-2678, http://ir.ipe.ac.cn/handle/122111/27755.
[20] 兰梦菲, 安宁, 赵颖, 曹炜, 李恒, 赵岚, 黄永东, 张荣月. 致孔剂溶解度参数对大孔层析介质的结构影响研究. 分析化学[J]. 2018, 46(2): 288-292, http://lib.cqvip.com/Qikan/Article/Detail?id=7000472572.
[21] Zhao, Lan, Wei, Wei, Huang, Yongdong, Zhang, Rongyue, Zhu, Kai, Hao, Dongxia, Su, Zhiguo, Ma, Guanghui. A novel rProtein A chromatographic media for enhancing cleaning-in-place performance. JOURNAL OF IMMUNOLOGICAL METHODS[J]. 2018, 460: 45-50, http://dx.doi.org/10.1016/j.jim.2018.06.008.
[22] Zhang, Kun, Li, Qiang, Fan, Hong, Li, Suning, Su, Yue, Zhao, Lan, Huang, Yongdong, Wang, Dan, Zhang, Zhigang, Su, Zhiguo, Ma, Guanghui. Multi-layer dextran-decorated poly(glycidyl methacrylate)-co-divinyl benzene copolymer matrices enabling efficient protein chromatographic separation. REACTIVE & FUNCTIONAL POLYMERS[J]. 2017, 112: 45-52, http://dx.doi.org/10.1016/j.reactfunctpolym.2017.01.003.
[23] Zhao, Lan, Zhu, Kai, Huang, Yongdong, Li, Qiang, Li, Xiunan, Zhang, Rongyue, Su, Zhiguo, Wang, Qibao, Ma, Guanghui. Enhanced binding by dextran-grafting to Protein A affinity chromatographic media. JOURNAL OF SEPARATION SCIENCE[J]. 2017, 40(7): 1493-1499, https://www.webofscience.com/wos/woscc/full-record/WOS:000399782900007.
[24] Qiang Li, Lan Zhao, Rongyue Zhang, Yongdong Huang, Yan Zhang, Kun Zhang, Xuexing Wu, Zhigang Zhang, Fangling Gong, Zhiguo Su, Guanghui Ma. Functional hydrophilic polystyrene beads with uniformly size and high cross-linking degree facilitated rapid separation of exenatide. JOURNAL OF CHROMATOGRAPHY B. 2016, 1017-1018: 129-135, http://dx.doi.org/10.1016/j.jchromb.2016.02.044.
[25] 朱凯, 赵岚, 黄永东, 李强, 邱晗, 王启宝, 苏志国, 马光辉. 葡聚糖接枝型Protein A介质的层析性能提升. 过程工程学报[J]. 2016, 16(5): "856-861", http://www.irgrid.ac.cn/handle/1471x/1188234.
[26] Hao, Dongxia, Ge, Jia, Huang, Yongdong, Zhao, Lan, Ma, Guanghui, Su, Zhiguo. Microscopic insight into role of protein flexibility during ion exchange chromatography by nuclear magnetic resonance and quartz crystal microbalance approaches. JOURNAL OF CHROMATOGRAPHY A[J]. 2016, 1438(MAR): 65-75, http://dx.doi.org/10.1016/j.chroma.2016.02.010.
[27] Zhao, Lan, Zhang, Jingfei, Huang, Yongdong, Li, Qiang, Zhang, Rongyue, Zhu, Kai, Suo, Jia, Su, Zhiguo, Zhang, Zhigang, Ma, Guanghui. Efficient fabrication of high-capacity immobilized metal ion affinity chromatographic media: The role of the dextran-grafting process and its manipulation. JOURNAL OF SEPARATION SCIENCE[J]. 2016, 39(6): 1130-1136, http://ir.ipe.ac.cn/handle/122111/20991.
[28] Li, Qiang, Zhao, Lan, Zhang, Rongyue, Huang, Yongdong, Zhang, Yan, Zhang, Kun, Wu, Xuexing, Zhang, Zhigang, Gong, Fangling, Su, Zhiguo, Ma, Guanghui. Functional hydrophilic polystyrene beads with uniformly size and high cross-linking degree facilitated rapid separation of exenatide. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES[J]. 2016, 1017(APR): 129-135, http://dx.doi.org/10.1016/j.jchromb.2016.02.044.
[29] 朱凯, 张静飞, 赵岚, 黄永东, 李强, 苏志国, 马光辉. 葡聚糖接枝过程对亲和介质性能提升影响. 2016年全国高分子材料科学与工程研讨会论文摘要集null. 2016, 1-, http://www.irgrid.ac.cn/handle/1471x/6898746.
[30] Li, Qiang, Zhang, Rongyue, Wu, Dexi, Huang, Yongdong, Zhao, Lan, Wang, Dan, Gong, Fangling, Li, Liang, Qiu, Han, Ma, Guanghui. Cell-nanoparticle assembly fabricated for CO2 capture and in situ carbon conversion. JOURNAL OF CO2 UTILIZATION[J]. 2016, 13(MAR): 17-23, http://dx.doi.org/10.1016/j.jcou.2015.11.004.
[31] 苏志国, 马光辉, 李秀男, 李岩, 刘永东, 张贵锋, 周炜清, 孔英俊, 赵岚, 孙李靖, 石红. 以保护活性为目标的生物技术药物层析分离纯化技术. 中国分析测试协会科学技术奖发展回顾null. 2015, http://www.irgrid.ac.cn/handle/1471x/1188363.
[32] Zhang, Rongyue, Li, Qiang, Huang, Yongdong, Zhao, Lan, Ye, Peili, Ma, Guanghui, Su, Zhiguo. Preparation of PEGA grafted poly(chloromethylstyrene-co-ethylene glycol dimethacrylate) monolith for high-efficiency solid phase peptide synthesis under continuous flow techniques. POLYMER[J]. 2015, 61(MAR): 115-122, http://dx.doi.org/10.1016/j.polymer.2015.01.071.
[33] Li, Xiunan, Li, Yaqiong, Chen, Chao, Zhao, Dawei, Wang, Xiaojun, Zhao, Lan, Shi, Hong, Ma, Guanghui, Su, Zhiguo. Pore size analysis from low field NMR spin-spin relaxation measurements of porous microspheres. JOURNAL OF POROUS MATERIALS[J]. 2015, 22(1): 11-20, http://www.irgrid.ac.cn/handle/1471x/944962.
[34] Zhang, Rongyue, Li, Qiang, Ji, Dekun, Pan, Yiting, Xu, Bo, Huang, Yongdong, Zhao, Lan. Preparation of a novel polymer monolith with high loading capacity by grafting block poly(PEGA-mPEGA) for high-efficiency solid phase synthesis. REACTIVE & FUNCTIONAL POLYMERS[J]. 2015, 94(SEP): 63-69, http://dx.doi.org/10.1016/j.reactfunctpolym.2015.08.002.
[35] Zhang, Chenxu, Zhang, Rongyue, Li, Qiang, Huang, Yongdong, Zhao, Lan, Su, Zhiguo, Gong, Fangling, Lv, Zheng, Song, Hongyan, Li, Wei, Yuan, Qipeng, Ma, Guanghui. Rapid octreotide separation from synthetic peptide crude mixtures by chromatography on poly(styrene-co-divinylbenzene)-based reversed phases. SEPARATION AND PURIFICATION TECHNOLOGY[J]. 2015, 154(NOV): 351-358, http://dx.doi.org/10.1016/j.seppur.2015.09.050.
[36] 朱凯, 赵岚, 黄永东, 李强, 苏志国, 马光辉, 王启宝. 葡聚糖接枝型高载量抗体介质的载量提升机制研究. 2015年中国化工学会年会论文集null. 2015, http://ir.ipe.ac.cn/handle/122111/20422.
[37] 朱凯, 赵岚. 葡聚糖接枝型高载量抗体介质的载量提升机制. 2015年中国化工学会年会论文集null. 2015, http://ir.ipe.ac.cn/handle/122111/20421.
[38] 张晨旭, 李强, 黄永东, 赵岚, 张荣月, 巩方玲, 宋翠, 苏志国, 袁其朋, 马光辉. 聚二乙烯基苯微球介质制备及其在奥曲肽层析分离中的应用. 过程工程学报[J]. 2015, 15(3): 482-488, http://www.irgrid.ac.cn/handle/1471x/1047926.
[39] Rongyue Zhang, Qiang Li, Dekun Ji, Yiting Pan, Bo Xu, Yongdong Huang, Lan Zhao. Preparation of a novel polymer monolith with high loading capacity by grafting block poly(PEGA–mPEGA) for high-efficiency solid phase synthesis. REACTIVE AND FUNCTIONAL POLYMERS. 2015, 94: 63-69, http://dx.doi.org/10.1016/j.reactfunctpolym.2015.08.002.
[40] 张静飞, 赵岚, 黄永东, 张志刚, 马光辉, 苏志国. 葡聚糖接枝型高载量金属螯合介质的制备与性能. 过程工程学报[J]. 2015, 15(1): 111-118, http://www.irgrid.ac.cn/handle/1471x/945751.
[41] Zhao, Lan, Liu, Yongdong, Wang, Yinjue, Huang, Yongdong, Li, Xiunan, Li, Yan, Ma, Guanghui, Su, Zhiguo. Determination of leakage from antibody adsorbent: composition analysis and pH effect. BIOMEDICAL CHROMATOGRAPHY[J]. 2013, 27(9): 1089-1091, http://ir.ipe.ac.cn/handle/122111/13762.
[42] Zhao, Lan, Liu, Yongdong, Huang, Yongdong, Li, Xiunan, Wang, Yinjue, Li, Yan, Ma, Guanghui, Su, Zhiguo. Deliberate manipulation of the surface hydrophobicity of an adsorbent for an efficient purification of a giant molecule with multiple subunits. JOURNAL OF SEPARATION SCIENCE[J]. 2011, 34(22): 3186-3193, http://www.irgrid.ac.cn/handle/1471x/735896.
[43] Huang, Yongdong, Bi, Jingxiu, Zhao, Lan, Ma, Guanghui, Su, Zhiguo. Regulation of protein multipoint adsorption on ion-exchange adsorbent and its application to the purification of macromolecules. PROTEIN EXPRESSION AND PURIFICATION[J]. 2010, 74(2): 257-263, http://dx.doi.org/10.1016/j.pep.2010.07.002.
[44] Zhou, Weibin, Bi, Jingxiu, Zhao, Lan, Wang, Yangmu, Li, Yan, Huang, Yongdong, Ma, Guanghui, Su, Zhiguo. A highly efficient hydrophobic interaction chromatographic absorbent improved the purification of hepatitis B surface antigen (HBsAg) derived from Hansenula polymorpha cell. PROCESS BIOCHEMISTRY[J]. 2007, 42(5): 751-756, http://dx.doi.org/10.1016/j.procbio.2007.01.003.
[45] 李瑞红, 李岩, 闭静秀, 赵岚, 周卫斌, 黄永东, 张焱, 孙李靖, 王化军, 苏志国. 间臂和丁基密度对疏水层析分离纯化重组乙肝病毒表面抗原的影响. 生物工程学报[J]. 2007, 23(4): 692-699, http://lib.cqvip.com/Qikan/Article/Detail?id=25148470.
[46] 王阳木, 闭静秀, 赵岚, 周卫斌, 李岩, 黄永东, 张焱, 林海, 苏志国. 一种新型的琼脂糖疏水层析介质开发及其在重组乙肝表面抗原(CHO-HBsAg)分离纯化中的应用. 生物工程学报[J]. 2006, 22(2): 278-, http://lib.cqvip.com/Qikan/Article/Detail?id=21482916.
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科研活动

   
科研项目
( 1 ) 类病毒颗粒组合层析一体化介质的制备与性能研究, 主持, 国家级, 2014-01--2016-12
( 2 ) 生物技术药物分离介质的研发和合成工艺, 主持, 国家级, 2013-10--2017-09
( 3 ) 生物分离-生物催化反应的集成, 参与, 国家级, 2012-11--2014-11
( 4 ) 快流速高载量抗体纯化介质设计与应用基础研究, 参与, 国家级, 2015-01--2018-12
( 5 ) 层析介质开发, 主持, 院级, 2015-01--2015-12
参与会议
(1)High Performance Agarose-based Chromatography Media for Bioseparation   2015-10-27
(2)Preparation of Agarose Beads with a Controllable Pore Structure   2014-11-07
(3)Regulation of spacer length and ligand density for improved vaccine purification by hydrophobic interaction chromatography   2009-09-25