生物材料，药物输递，免疫治疗

   

081703-生物化工
085204-材料工程

生物材料科学与工程，药物剂型工程
纳米生物材料科学，药物剂型工程

2003-09--2008-06   浙江大学   博士

   

2020-08~现在, 中国科学院过程工程研究所, 项目研究员
2014-08~2020-08,中国科学院过程工程研究所, 副研究员
2012-05~2014-08,中国科学院过程工程研究所, 助理研究员
2008-07~2011-12,浙江大学, 博士后

   

[1] 张欣, 卢治国, 张田露, 王建泽, 阳俊, 李燕. 一种活性基团修饰的介孔二氧化硅纳米香料及其制备方法. CN: CN113969211A, 2022-01-25.
[2] 张欣, 阳俊, 申奇, 刘瑞瑗. 氧化锌、抗原共载药物纳米疫苗、其制备方法与应用. CN: CN110755607B, 2021-12-28.
[3] 张欣, 卢治国, 王向宇, 张田露, 阳俊. 温度和pH双重响应缓释芳香纳米凝胶、制备方法及应用. CN: CN110982623A, 2020-04-10.
[4] 张欣, 阳俊, 乔晨萌. 一种脂质体核酸疫苗佐剂及其制备方法和应用. CN: CN105106116A, 2015-12-02.
[5] 张欣, 董雅琼, 阳俊. 一种阳离子脂质分子及其制备方法和用途. CN: CN104447365A, 2015-03-25.
[6] 张欣, 董雅琼, 阳俊. 一种阳离子脂质体核酸类药物制剂及其制备方法和应用. CN: CN104352440A, 2015-02-18.
[7] 张欣, 阳俊, 乔晨萌. 一种微胶囊日用香精及其制备方法. CN: CN104293486A, 2015-01-21.
[8] 翁杰, 张欣, 乔晨萌, 阳俊. 一种纳米脂质体食用香精的制备方法. CN: CN103960634A, 2014-08-06.

   

[1] Li, Yan, Ji, Weihong, Peng, Huan, Zhao, Ruichen, Zhang, Tianlu, Lu, Zhiguo, Yang, Jun, Liu, Ruiyuan, Zhang, Xin. Charge-switchable zwitterionic polycarboxybetaine particle as an intestinal permeation enhancer for efficient oral insulin delivery. THERANOSTICS[J]. 2021, 11(9): 4452-4466, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7977443/.
[2] Zhang, Tianlu, Lu, Zhiguo, Wang, Jianze, Shen, Jie, Hao, Qiulian, Li, Yan, Yang, Jun, Niu, Yunwei, Xiao, Zuobing, Chen, Lei, Zhang, Xin. Preparation of mesoporous silica nanoparticle with tunable pore diameters for encapsulating and slowly releasing eugenol. CHINESE CHEMICAL LETTERS[J]. 2021, 32(5): 1755-1758, http://dx.doi.org/10.1016/j.cclet.2020.12.033.
[3] Ji, Weihong, Li, Yan, Peng, Huan, Zhao, Ruichen, Shen, Jie, Wu, Yanyue, Wang, Jianze, Hao, Qiulian, Lu, Zhiguo, Yang, Jun, Zhang, Xin. Self-Catalytic Small Interfering RNA Nanocarriers for Synergistic Treatment of Neurodegenerative Diseases. ADVANCED MATERIALS[J]. 2021, [4] Shen, Jie, Lu, Zhiguo, Wang, Jianze, Hao, Qiulian, Ji, Weihong, Wu, Yanyue, Peng, Huan, Zhao, Ruichen, Yang, Jun, Li, Yan, Shi, Zhuyan, Zhang, Xin. Traceable Nano-Biohybrid Complexes by One-Step Synthesis as CRISPR-Chem Vectors for Neurodegenerative Diseases Synergistic Treatment. ADVANCED MATERIALS[J]. 2021, 33(27): http://dx.doi.org/10.1002/adma.202101993.
[5] Peng, Huan, Ji, Weihong, Zhao, Ruichen, Lu, Zhiguo, Yang, Jun, Li, Yan, Zhang, Xin. pH-sensitive zwitterionic polycarboxybetaine as a potential non-viral vector for small interfering RNA delivery. RSC ADVANCES[J]. 2020, 10(73): 45059-45066, http://dx.doi.org/10.1039/d0ra09359a.
[6] Lu, Zhiguo, Wang, Xiangyu, Zhang, Tianlu, Zhang, Luyao, Yang, Jun, Li, Yan, Shen, Jie, Wang, Jianze, Niu, Yunwei, Xiao, Zuobing, Liu, Guiying, Zhang, Xin. Cationic and temperature-sensitive liposomes loaded with eugenol for the application to silk. CHINESE CHEMICAL LETTERS[J]. 2020, 31(12): 3139-3142, http://lib.cqvip.com/Qikan/Article/Detail?id=7103955078.
[7] Lu, Zhiguo, Zhang, Tianlu, Yang, Jun, Wang, Jianze, Shen, Jie, Wang, Xiangyu, Xiao, Zuobing, Niu, Yunwei, Liu, Guiying, Zhang, Xin. Effect of mesoporous silica nanoparticles-based nano-fragrance on the central nervous system. ENGINEERING IN LIFE SCIENCES[J]. 2020, 20(11): 535-540, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645641/.
[8] Lu, Zhiguo, Wang, Jianze, Qu, Lina, Kan, Guanghan, Zhang, Tianlu, Shen, Jie, Li, Yan, Yang, Jun, Niu, Yunwei, Xiao, Zuobing, Li, Yinghui, Zhang, Xin. Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition. BIOACTIVE MATERIALS[J]. 2020, 5(4): 1127-1137, http://lib.cqvip.com/Qikan/Article/Detail?id=7103847788.
[9] Liu, Ruiyuan, Yang, Jun, Liu, Linying, Lu, Zhiguo, Shi, Zhuyan, Ji, Weihong, Shen, Jie, Zhang, Xin. An "Amyloid-beta Cleaner" for the Treatment of Alzheimer's Disease by Normalizing Microglial Dysfunction. ADVANCED SCIENCE[J]. 2020, 7(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000497900400001.
[10] Peng, Huan, Ji, Weihong, Zhao, Ruichen, Yang, Jun, Lu, Zhiguo, Li, Yan, Zhang, Xin. Exosome: a significant nano-scale drug delivery carrier. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2020, 8(34): 7591-7608, https://www.webofscience.com/wos/woscc/full-record/WOS:000565996500002.
[11] Ruiyuan Liu, Jun Yang, Linying Liu, Zhiguo Lu, Zhuyan Shi, Weihong Ji, Jie Shen, Xin Zhang. An "Amyloid‐β Cleaner" for the Treatment of Alzheimer's Disease by Normalizing Microglial Dysfunction. ADVANCED SCIENCE[J]. 2020, 7(2): n/a-n/a, https://doaj.org/article/3fe6a359cf594caf8352e9939f7de2f6.
[12] Yang, Jun, Shi, Zhuyan, Liu, Ruiyuan, Wu, Yanyue, Zhang, Xin. Combined-therapeutic strategies synergistically potentiate glioblastoma multiforme treatment via nanotechnology. THERANOSTICS[J]. 2020, 10(7): 3223-3239, https://www.webofscience.com/wos/woscc/full-record/WOS:000514452800023.
[13] Zhang, Tianlu, Lu, Zhiguo, Yang, Jun, Wang, Jianze, Shen, Jie, Wang, Xiangyu, Xiao, Zuobing, Niu, Yunwei, Chen, Lei, Zhang, Xin. Chitosan-based nanofragrance with antibacterial function applied to wallpaper. ENGINEERING IN LIFE SCIENCES[J]. 2020, 20(11): 541-546, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645650/.
[14] Shen, Jie, Lu, Zhiguo, Wang, Jianze, Zhang, Tianlu, Yang, Jun, Li, Yan, Liu, Guiying, Zhang, Xin. Advances of Nanoparticles for Leukemia Treatment. ACS BIOMATERIALS SCIENCE & ENGINEERING[J]. 2020, 6(12): 6478-6489, https://www.webofscience.com/wos/woscc/full-record/WOS:000599989300002.
[15] Zhao, Ruichen, Lu, Zhiguo, Yang, Jun, Zhang, Liqun, Li, Yan, Zhang, Xin. Drug Delivery System in the Treatment of Diabetes Mellitus. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY[J]. 2020, 8: https://doaj.org/article/ce1866ea02c84510bbf023ec02e4729f.
[16] Wu, Yanyue, Lu, Zhiguo, Li, Yan, Yang, Jun, Zhang, Xin. Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection. NANOMATERIALS[J]. 2020, 10(8): https://doaj.org/article/fe7a7bee4c6145c8b3809d912b42f6c0.
[17] Zhang, Tianlu, Lu, Zhiguo, Zhang, Luyao, Li, Yan, Yang, Jun, Shen, Jie, Wang, Jianze, Niu, Yunwei, Xiao, Zuobing, Chen, Lei, Zhang, Xin. Preparation of hollow mesoporous silica nanorods for encapsulating and slowly releasing eugenol. CHINESECHEMICALLETTERS[J]. 2020, 31(12): 3135-3138, http://lib.cqvip.com/Qikan/Article/Detail?id=7103955077.
[18] Shen, Qi, Yang, Jun, Liu, Ruiyuan, Liu, Linying, Zhang, Jinchao, Shen, Shigang, Zhang, Xin. Hybrid "clusterbombs' as multifunctional nanoplatforms potentiate brain tumor immunotherapy. MATERIALSHORIZONS[J]. 2019, 6(4): 810-816, http://ir.ipe.ac.cn/handle/122111/28261.
[19] Qiao, Chenmeng, Yang, Jun, Shen, Qi, Liu, Ruiyuan, Li, Yanhui, Shi, Yuanjie, Chen, Jingli, Shen, Yanqin, Xiao, Zuobing, Weng, Jie, Zhang, Xin. Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment. ADVANCED MATERIALS[J]. 2018, 30(18): http://www.irgrid.ac.cn/handle/1471x/1764388.
[20] Yan Li, Jun Yang, Xin Zhang. Small interfering RNA delivery: Challenges and our strategies. NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY, AND MEDICINE. 2018, 14(5): 1862-1863, http://dx.doi.org/10.1016/j.nano.2017.11.326.
[21] Yang Jun, Dong Yaqiong, Zhang Xin. Site-specific drug-releasing polypeptide nanocarriers with enhanced therapeutic efficacy against drug-resistant tumors. MEETING ABSTRACTnull. 2017, 259: E71-, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000407591400120&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[22] Qiao, Chenmeng, Yang, Jun, Shen, Qi, Shen, YanQin, Weng, Jie, Zhang, Xin. RNA Interference-Based Immunomodulation for Glioblastoma Immune Microenvironment: A Review. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY[J]. 2017, 13(8): 891-910, http://www.irgrid.ac.cn/handle/1471x/1763901.
[23] Yang, Jun, Dong, Yaqiong, Zhang, Xin. Site-specific drug-releasing polypeptide nanocarriers with enhanced therapeutic efficacy against drug-resistant tumors. JOURNAL OF CONTROLLED RELEASE[J]. 2017, 259: E71-E71, http://dx.doi.org/10.1016/j.jconrel.2017.03.161.
[24] Chen, Jingli, Yang, Jun, Liu, Ruiyuan, Qiao, Chenmeng, Lu, Zhiguo, Shi, Yuanjie, Fan, Zhanming, Zhang, Zhenzhong, Zhang, Xin. Dual-targeting Theranostic System with Mimicking Apoptosis to Promote Myocardial Infarction Repair via Modulation of Macrophages. THERANOSTICS[J]. 2017, 7(17): 4149-4167, http://www.irgrid.ac.cn/handle/1471x/1763809.
[25] Qiao, Chenmeng, Yang, Jun, Chen, Lei, Weng, Jie, Zhang, Xin. Intracellular accumulation and immunological responses of lipid modified magnetic iron nanoparticles in mouse antigen processing cells. BIOMATERIALS SCIENCE[J]. 2017, 5(8): 1603-1611, http://www.irgrid.ac.cn/handle/1471x/1763706.
[26] Qiao, Chenmeng, Liu, Jiandong, Yang, Jun, Li, Yan, Weng, Jie, Shao, Yiming, Zhang, Xin. Enhanced non-inflammasome mediated immune responses by mannosylated zwitterionic-based cationic liposomes for HIV DNA vaccines. BIOMATERIALS[J]. 2016, 85(APR): 1-17, http://dx.doi.org/10.1016/j.biomaterials.2016.01.054.
[27] Dong, Yaqiong, Yang, Jun, Zhang, Jinchao, Zhang, Xin. Nano-Delivery Vehicles/Adjuvants for DNA Vaccination Against HIV. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY[J]. 2016, 16(3): 2126-2133, http://ir.ipe.ac.cn/handle/122111/21010.
[28] Jun Yang, Yan Li, Tianlu Zhang, Xin Zhang. Development of bioactive materials for glioblastoma therapy. 生物活性材料[J]. 2016, 1(1): 29-38, http://lib.cqvip.com/Qikan/Article/Detail?id=7103845423.
[29] Jun Yang, Yan Li, Shubin Jin, Jing Xu, Paul C Wang, Xing-Jie Liang, Xin Zhang. Engineered biomaterials for development of nucleic acid vaccines. BIOMATERIALS RESEARCH[J]. 2015, 19(1): http://dx.doi.org/10.1186/s40824-014-0025-8.
[30] Li, Yan, Liu, Ruiyuan, Yang, Jun, Shi, Yuanjie, Ma, Guanghui, Zhang, Zhenzhong, Zhang, Xin. Enhanced retention and anti-tumor efficacy of liposomes by changing their cellular uptake and pharmacokinetics behavior. BIOMATERIALS[J]. 2015, 41(FEB): 1-14, http://dx.doi.org/10.1016/j.biomaterials.2014.11.010.
[31] Dong, Yaqiong, Yang, Jun, Liu, Hongmei, Wang, Tianyou, Tang, Suoqin, Zhang, Jinchao, Zhang, Xin. Site-Specific Drug-Releasing Polypeptide Nanocarriers Based on Dual-pH Response for Enhanced Therapeutic Efficacy against Drug-Resistant Tumors. THERANOSTICS[J]. 2015, 5(8): 890-904, http://www.irgrid.ac.cn/handle/1471x/975474.
[32] Li, Yan, Liu, Ruiyuan, Yang, Jun, Ma, Guanghui, Zhang, Zhenzhong, Zhang, Xin. Dual sensitive and temporally controlled camptothecin prodrug liposomes codelivery of siRNA for high efficiency tumor therapy. BIOMATERIALS[J]. 2014, 35(36): 9731-9745, http://dx.doi.org/10.1016/j.biomaterials.2014.08.022.
[33] Liu, Hongmei, Li, Yan, Mozhi, Anbu, Zhang, Liang, Liu, Yilan, Xu, Xia, Xing, Jianmin, Liang, Xingjie, Ma, Guanghui, Yang, Jun, Zhang, Xin. SiRNA-phospholipid conjugates for gene and drug delivery in cancer treatment. BIOMATERIALS[J]. 2014, 35(24): 6519-6533, http://dx.doi.org/10.1016/j.biomaterials.2014.04.033.
[34] Yang, Jun, Liu, Hongmei, Zhang, Xin. Design, preparation and application of nucleic acid delivery carriers. BIOTECHNOLOGY ADVANCES[J]. 2014, 32(4): 804-817, http://dx.doi.org/10.1016/j.biotechadv.2013.11.004.
[35] Liu, Hongmei, Qiao, Chenmeng, Yang, Jun, Weng, Jie, Zhang, Xin. Self-assembling doxorubicin-prodrug nanoparticles as siRNA drug delivery system for cancer treatment: in vitro and in vivo. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2014, 2(35): 5910-5924, http://dx.doi.org/10.1039/c4tb00814f.
[36] Li Yan, Yang Jun, Liu GuiYing, Zhang Xin. The Advance of Gene Delivery Vectors. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2013, 40(10): 998-1007, http://ir.ipe.ac.cn/handle/122111/13678.

   

（ 1 ） 两性离子类脂质药物载体改善肿瘤耐药性的研究, 负责人, 国家任务, 2014-01--2016-12
（ 2 ） 淋巴结靶向的双响应可控释放的杂化多重免疫输递体系用于HIV DNA疫苗的研究, 负责人, 国家任务, 2016-01--2019-12
（ 3 ） 一种微环境响应型的帕金森病纳米免疫治疗系统的研究, 负责人, 国家任务, 2018-01--2021-12
（ 4 ） 金属离子/酶响应型三重协同纳米药物递送体系用于阿尔茨海默病治疗, 负责人, 国家任务, 2021-01--2024-12