基本信息
鞠建华  男  博导  中国科学院南海海洋研究所
电子邮件: jju@scsio.ac.cn
通信地址: 广州市新港西路164号标本楼405室
邮政编码: 510301

教育背景

1995-09--2000-07   北京协和医学院/中国医学科学院   研究生/博士,天然药物化学
1991-09--1995-07   山东大学 药学院   本科/学士,药学

教授课程

生物有机化学

个人简介

鞠建华,男,1972年生,理学博士,研究员,博士生导师,中国科学院大学岗位教授。中国科学院热带海洋生物资源与生态重点实验室主任,广东省海洋药物重点实验室主任。2014年获得国家杰出青年科学基金同年入选科技部创新人才推进计划中青年科技创新领军人才2016年入选国家万人计划科技创新领军人才和广东特支计划南粤百杰杰出人才主要从事海洋微生物活性次级代谢产物的发现、生物合成和抗感染、抗肿瘤创新药物研发工作从海洋微生物中发现了具有抗感染、抗肿瘤等活性天然产物800余个,开发了海洋微生物的组合生物合成和异源表达技术,阐明了18种特征活性代谢产物的生物合成机制,揭示了咔啉碱合成酶、Dieckmann缩合酶、别异亮氨酸异构酶、细胞色素P450氧化酶、L-半乳糖变构酶等26种新颖生物合成酶的催化功能,筛选出3个自主产权的抗结核杆菌感染、抗胶质瘤和抗白血病候选海洋药物。主持国家科技部863计划重点课题、NSFC-广东联合基金重点项目、国家海洋经济创新发展区域示范专项课题、广东省自然科学基金团队和中科院科技创新交叉团队项目等20余项。获得第五届施维雅青年药物化学奖(2002)第七届药明康德生命化学研究奖(2013)。中国微生物学会海洋微生物专业委员会副主任委员,广东药学会药物化学专业委员会副主任委员,中国药学会海洋药物专业委员会委员,热带海洋学报副主编Chin. J. Chem.青年编委,中国海洋药物编委。在Nat. Chem. Biol., Nature Commun., PNAS, J. Am. Chem. Soc., Angew. Chem. Int. Ed., Org. lett., Antimicrob. Agents Chemother., J. Nat. Prod.等国内外学术刊物发表论文162篇(其中SCI论文110篇),论文被SCI引用超过3000(H=32),多篇论文被Nature Chemical Biology, Faculty of 1000, Science-PerspectivesGlobal Medical Discovery等作为研究亮点评述,被自然指数中国增刊评为2014年广州个体科研产出领先者,获授权专利18项,参与撰写专著4

  工作经历:

2008.03—中国科学院南海海洋研究所,中国科学院热带海洋生物资源与生态重点实验室,广东省海洋药物重点实验室,研究员,博士生导师,中国科学院大学岗位教授;

2003.03—2008.02美国威斯康星麦迪逊大学 (University of Wisconsin-Madison) 药学院,研究助理(Research Associate)助理研究员(Assistant Researcher)

2000.08—2003.03中国医学科学院/北京协和医学院药用植物研究所,助理研究员、副研究员,硕士生导师。

研究领域:

本学科组以海洋微生物为研究对象,以海洋微生物活性次级代谢产物的生物学功能及其形成机制为拟解决的关键科学问题。主要从特殊海洋环境中(深海沉积物、珊瑚礁生态系统、不同深度的海水层、特色海洋生物等)分离、培养、鉴定海洋放线菌、真菌和细菌;综合运用微生物学、天然产物化学、细菌遗传学、分子生物学、生物信息学、生物化学和药理学等多学科专业技能,从海洋微生物中筛选发现新的生物活性物质,发掘新的生物合成途径、新型酶催化反应机理,利用代谢工程、组合生物合成和合成生物学技术手段构建新结构衍生物,并对具有自主产权、有前景的化合物进行成药性评价和药物开发,具体包括以下内容:

(1) 海洋微生物活性次级代谢产物的发现(Marine Bioactive Natural Products Discovery)。利用化学生态学原理和多种发酵培养技术,从海洋微生物中筛选、分离和鉴定结构新颖、活性显著的生物活性物质。研究海洋微生物产生的活性物质在特定海洋生态系统中的化学防御机理,发现生理活性显著药效活性物质,为开发具有我国独立知识产权的创新药物提供先导化合物。

(2) 海洋微生物复杂活性天然产物的代谢工程和组合生物合成(Metabolic Engineering and Combinatorial Biosynthesis of Complex Bioactive Natural Products)。包括:抗生素生物合成基因簇的克隆、序列测定和生物信息学分析;重要活性化合物产生菌全基因组的序列测定及其功能基因研究;新的生物合成途径的发现及其调控机制;基因阻断、置换、重组或异源表达构建工程菌,产生非天然的天然产物或提高目标天然产物的产量;利用基因克隆、蛋白表达、纯化手段,对酶促反应机理和动力学进行表征,发掘新型酶促反应催化剂;重要活性天然产物的体外全生物合成(in vitro total biosynthesis),体外构建重要天然产物的生物合成途径,用生物酶快速合成天然产物衍生物库。

(3) 抗感染、抗肿瘤海洋药物的成药性评价和药物研发(Anti-infective and Anti-tumor Drug Development)。对通过发现和生物合成技术改造获得的化合物进行构效关系研究,筛选出结构新颖、活性显著、具有自主知识产权的化合物进行体内药效、安全性、质量标准、药代和药剂学等临床前研究,开发抗感染、抗肿瘤海洋药物。

代表性论文

2018:

1.         Li, Q.;* Ding,W.; Yao, Z.; Tu, J.; Wang, L.; Huang,H.; Li, S.; Ju, J.* AbmV catalyzes tandem ether installation and hydroxylation during neoabyssomicin/abyssomicin biosynthesis. Org. Lett. 2018, 20, 4854-4857.

2.         Qin, X.; Xie, Y.; Huang, H.; Chen, Q.; Ma, J.; Li, Q.; Ju, J.* Enzymatic synthesis of GDP-b-L-fucofuranose by MtdL and Hyg20. Org. Lett. 2018, 20, 1015-1018.

3.         Huang, H.; Song, Y.; Li, X.; Wang, X.; Ling, C.; Qin, X.; Zhou, Z.; Li, Q.; Wei, X.; Ju, J.* Abyssomicin monomers and dimers from the marine-derived Streptomyces koyangensis SCSIO 5802. J. Nat. Prod. 2018, 81, 1892-1898.

4.         Zhang, C.; Sun, C.; Gui, C.; Wang, L.; Huang, H.; Li, Q.; Ju, J.* Biosynthetic Baeyer–Villiger chemistry enables access to two anthracene scaffolds from a single gene cluster in deep sea-derived Streptomyces olivaceus SCSIO T05. J. Nat. Prod. 2018, 81, 1570-1577.

5.         Gui, C.; Yuan, J.; Mo, X.; Huang, H.; Zhang, S.; Gu, Y. C.; Ju, J.* Cytotoxic anthracycline metabolites from a recombinant Streptomyces. J. Nat. Prod. 2018, 81, 1278-1289.

6.         Sun, C.; Zhang, C.; Qin, X.; Wei, X.; Liu, Q.; Li, Q.; Ju, J.* Genome mining of Streptomyces olivaceus SCSIO T05: discovery of olimycins A and B and assignment of absolute configurations. Tetrahedron, 2018, 74, 199-203.

7.         Sun, J.; Shao, J.; Song, Y.; Sun, C.; Li, Q.; Lu, L.; Hu, Y.; Zhang, H.;* Ju, J.* Borrelidins F–I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89. Bioorg. & Med. Chem. 2018, 26, 1488-1494.

8.         Li, Y.; Zhang, C.; Liu, C.; Ju, J.;* Ma, J.* Genome sequencing of Streptomyces atratus SCSIO ZH16 and activation production of nocardamine via metabolic engineering. Front Microbiol., 2018, 9:1269,  doi:10.3389/fmicb.2018.01269

9.         Gui, C.; Liu, Y.; Zhou, Z.; Zhang, S.; Hu, Y.; Gu, Y-C.; Huang, H.;* Ju, J.* Angucycline glycosides from mangrove-derived Streptomyces diastaticus subsp. SCSIO GJ056. Mar. Drugs. 2018, 16, 185; doi:10.3390/md16060185.

10.     Tu, J.; Li, S.; Chen, J.; Song, Y.; Fu, S.; Ju, J.; Li, Q.* Characterization and heterologous expression of the gene cluster for neoabyssomincins and abyssomincins biosynthesis from Streptomyces koyangensis SCSIO 5802. Microb. Cell Fact. 2018, 17(1):28. doi: 10.1186/s12934-018-0875-1.

11.     Deng, Y.; Kang, D.; Qiu, L.; Shi, J.; Zhou,W.; Sun, A.; Ju, J.; Zhu, X.; Shen, B.;* Duan, Y.;* Huang,  Y.* The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin. MedChemComm. 2018, 9, 789-794.

12.     Hou, L.; Huang, H.; Li, H.; Wang, S.; Ju, J.; Li, W.* Overexpression of a type III PKS gene affording novel violapyrones with enhanced anti-influenza A virus activity. Microb. Cell Fact. 2018, 17(1):61 (doi: 10.1186/s12934-018-0908-9).

13.     Lai, Z.; Yu, J.; Ling, H.; Song, Y.; Yuan, J.; Ju, J.; Tao, Y.;* Huang, H.* Grincamycins I - K, cytotoxic angucycline glycosides derived from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. Planta Med. 2018, 84, 201-207.

14.     Zhang, S.; Gui, C.; Shao, M.; Kumar, S.; Huang, H.;* Ju, J.* Antimicrobial tunicamycin derivatives from the deep sea-derived Streptomyces xinghaiensis SCSIO S15077. Nat. Prod. Res. 2018, doi:10.1080/14786419.2018.1493736.

15.     Xie, Y.; Li, Q.; Qin, X.; Ju, J. ;* Ma, J.* Enhancement of himastatin bioproduction via inactivation of atypical repressors in Streptomyces hygroscopicus. 2018, Metabolic Engineering Communications, in press.

 

2017:

16.     Zhu, Q.; Chen, Q.; Song, Y.; Huang, H.; Li, J.; Ma, J.; Li, Q.; Ju, J.* Deciphering the sugar biosynthetic pathway and tailoring steps of nucleoside antibiotic A201A unveils a GDP-L-galactose mutase. Proc. Natl. Acad. Sci. U.S.A. 2017114, 4948-4953.

17.     Ma, J.;* Huang, H.; Xie, Y.; Liu, Z.; Zhao, J.; Zhang, C.; Jia, Y.; Zhang, Y.; Zhang, H.; Zhang, T.; Ju, J.* Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents. Nat. Commun. 2017, 8(1), 391(doi: 10.1038/s41467-017-00419-5).

18.     Gui, C.; Mo, X.; Gu, Y.-C.; Ju, J.* Elucidating the sugar tailoring steps in the cytorhodin biosynthetic pathway. Org. Lett. 2017, 19, 5617-5620.

19.     Gui, C.; Zhang, S.; Zhu, X.; Ding, W.; Huang, H.; Gu, Y.C.; Duan, Y.; Ju, J.* Antimicrobial spirotetronate metabolites from marine-derived Micromonospora harpali SCSIO GJ089. J. Nat. Prod. 2017, 80, 1594-1603.

20.     Luo, M.; Cui, Z.; Huang, H.; Song, X.; Sun, A.; Dang, Y.; Lu, L*; Ju, J.* Amino Acid Conjugated Anthraquinones from the Marine-derived Fungus Penicillium sp. SCSIO sof101. J. Nat. Prod. 2017, 80, 1668-1673.

21.     Xie, Y.; Ma, J.; Qin, X.; Li, Q.; Ju, J.* Identification and utilization of two important transporters: SgvT1 and SgvT2, for griseoviridin and viridogrisein biosynthesis in Streptomyces griseoviridis. Microb. Cell Fact. 2017, 16(1):177 (doi:10.1186/s12934-017-0792-8).

22.     Song, Y.; Li, Q.; Qin, F.; Sun, C.; Liang, H.; Wei, X.; Wong, N.-K.; Ye, L.; Zhang, Y.; Shao, M.; Ju, J.* Neoabyssomicins A–C, polycyclic macrolactones from the deep-sea derived Streptomyces koyangensis SCSIO 5802. Tetrohedron, 2017, 73, 5366-5372.

23.     Chen. E; Chen, Q.; Chen, S.; Xu, B.; Ju, J.*; Wang, H.* Discovery and biosynthesis of mathermycin from marine-derived Marinactinospora thermotolerans SCSIO 00652. Appl. Environ. Microbiol. 2017, 83(15), pii: e00926-17 (doi: 10.1128/AEM.00926-17).

24.     Li, H.; Huang, H.; Hou, L.; Ju, J.; Li, W.* Discovery of antimycin-type depsipeptides from a wbl gene mutant strain of deep sea-derived Streptomyces somaliensis SCSIO ZH66 and their effects on pro-inflammatory cytokine production. Front Microbiol. 2017, 8, 678.

25.     Zhu, X.; Duan, Y.; Cui, Z.; Wang, Z.; Li, Z.; Zhang, Y.; Ju, J.; Huang, H.* Cytotoxic rearranged angucycline glycosides from deep sea-derived Streptomyces lusitanus SCSIO LR32. J. Antibiot. 2017, 70, 819-822.

26.     Mo, X.*; Shi, C.; Gui, C.; Zhang, Y.; Ju, J.; Wang, Q.* Identification of nocamycin biosynthetic gene cluster from Saccharothrix syringae NRRL B-16468 and generation of new nocamycin derivatives by manipulating gene cluster. Microb. Cell Fact. 2017, 16(1):100.

27.     Li, X.; Xia, Z.; Tang, J.; Wu, J.; Tong, J.; Li, M.; Ju, J.; Chen, H.; Wang, L.* Identification and biological evaluation of secondary metabolites from marine derived fungi-Aspergillus sp. SCSIOW3, cultivated in the presence of epigenetic modifying agents. Molecules, 2017, 22(8), pii: E1302 (doi: 10.3390/molecules22081302).

 

2016:

28.     Li, Q.; Qin, X.; Liu, J.; Gui, C.; Wang, B.; Li, J.; Ju, J.* Deciphering the biosynthetic origin of L-allo-isoleucine. J. Am. Chem. Soc. 2016, 138, 408-415 (Highlighted in JACS Spotlights, 2016, 138, 461; Hot off the Press in Natural Products Reports, 2016, 33, 530).

29.     Luo, M.; Tang, G.; Ju, J.; Lu, L.; Huang, H.* A new diketopiperazine derivative from a deep sea-derived Streptomyces sp. SCSIO 04496. Nat. Prod. Res. 2016, 30, 138-143.

30.     Huang, H.; Li, H.; Qiu, Y.; Hou, L.; Ju, J.; Li, W.* A new dioic acid from a wbl gene mutant of deep sea-derived Streptomyces somaliensis SCSIO ZH66. Mar Drugs. 2016, 14(10). pii: E184.

31.     Huang, H.; Hou, L.; Li, H.; Qiu, Y.; Ju, J.; Li, W.* Activation of a plasmid-situated type III PKS gene cluster by deletion of a wbl gene in deepsea-derived Streptomyces somaliensis SCSIO ZH66. Microb. Cell Fact. 2016, 15(1):116.

 

2015

32.     Liu, J.; Wang, B.; Li, H.; Xie, Y.; Li, Q.; Qin, X.; Zhang, X.; Ju, J.* Biosynthesis of the anti-infective marformycins featuring pre-NRPS assembly line N-formylation and O-methylation and post-assembly line C-hydroxylation chemistries. Org. Lett. 2015, 17, 1509-1512 (Hot off the Press in Natural Product Reports).

33.     Gui, C.; Li, Q.; Mo, X.; Qin, X.; Ma, J; Ju, J.* Discovery of a new family of Dieckmann cyclases essential to tetramic acid and pyridone-based natural products biosynthesis. Org. Lett. 2015, 17, 628-631.

34.     Li, Q,; Song, X.; Qin, X,; Zhang, X.; Sun, A.; Ju, J.* Identification of the biosynthetic gene cluster for the anti-infective desotamides and production of a new analogue in a heterologous host. 2015, J. Nat. Prod. 2015, 78, 944-948.

35.     Song, Y.; Liu, G.; Li, J.; Huang, H.; Zhang, X.; Zhang, H.,* Ju, J.* Cytotoxic and antibacterial angucycline- and prodigiosin- analogues from the deep-sea derived Streptomyces sp. SCSIO 11594. Mar. Drugs, 2015, 13, 1304-1316.

36.     Medema, M.H.; et al; Xie, Y.; et al; Ju, J.; et al, Glöckner, F.O.* Minimum Information about a Biosynthetic Gene cluster. Nat. Chem. Biol. 2015, 11, 625-631.

37.     Huang SX, Yun BS, Ma M, Basu HS, Church DR, Ingenhorst G, Huang Y, Yang D, Lohman JR, Tang GL, Ju J, Liu T, Wilding G, Shen B.* Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species. Proc. Natl. Acad. Sci. USA. 2015, 112, 8278-8283.

38.     Zhang, Y.; Huang, H.; Xu, S.; Wang, B.; Ju, J; Tan, H.; Li, W.* Activation and enhancement of fredericamycin A production in deepsea-derived Streptomyces somaliensis SCSIO ZH66 by using ribosome engineering and response surface methodology. Microb. Cell Fact. 2015, 14, 64.

 

2014:

39.     Song,Y.; Li, Q.; Liu, X.; Chen, Y.; Zhang, Y.; Sun, A.; Zhang, W.; Zhang, J.; Ju, J.* Cyclic hexapeptides from the deep South China Sea-derived Streptomyces scopuliridis SCSIO ZJ46 active against pathogenic Gram-positive bacteria. J. Nat. Prod. 2014, 77, 1937-1941.

40.     Xie, Y.; Li, Q.; Song, Y.; Ma, J.; Ju, J* Involvement of SgvP in carbon–sulfur bond formation during griseoviridin biosynthesis. ChemBioChem, 2014, 15, 1183-1189 (commented by Faculty of 1000).

41.     Ji C., Chen Q., Li Q.,Huang H., Song Y., Ma J, Ju J.* Chemoenzymatic synthesis of new β-carboline derivatives using McbA, an ATP-dependent amide synthetase. Tetrahedron Lett. 2014, 55, 4901-4904.

42.     Mo X., Li Q., Ju J.* Naturally occurring tetramic acid products: isolation, structure elucidation and biological activity. RSC Advances. 2014, 4, 50566-50593.

43.     Zhou X., Huang H., Li J., Song Y., Jiang R., Liu J., Zhang S., Hua Y.,* Ju J.* New anti-infective cycloheptadepsipeptide congeners and absolute stereo-chemistry from the deep sea-derived Streptomyces drozdowiczii SCSIO 10141. Tetrehedron, 2014, 70, 7795-7801.

44.     Seo, J.W.; Ma, M.; Kwong, T.; Ju, J.; Lim, S.K.; Jiang, H.; Lohman, J.R.; Yang, C.; Cleveland, J.; Zazopoulos, E.; Farnet, C.M.; Shen, B.* Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues. Biochemistry. 2014, 53(49):7854-7865.

45.     Wang, H.; Zhang, H.; Mi, Y.; Ju, J.; Chen, Q.; Zhang, H.* Expression, crystallization and preliminary X-ray analysis of McbB, a multifunctional enzyme involved in β-carboline skeleton biosynthesis. Acta Crystallogr F Struct Biol Commun. 2014, 70(Pt 10), 1402-145.

 

2013:

46.     Chen, Q.; Ji, C.; Song, Y.; Huang, H.; Ma, J.; Tian, Xi.; Ju, J* Discovery of McbB, a novel enzyme catalyzing the β-Carboline skeleton construction in the marinacarboline biosynthetic pathway. Angew. Chem. Int. Ed., 2013, 52, 9980-9984 (commented by Faculty of 1000)

47.     Zhang, Y.; Huang, H.; Chen, Q.; Luo, M.; Sun, A.; Song, Y.; Ma, J.; Ju, J.* Identification of the grincamycin gene cluster unveils divergent roles for GcnQ in different hosts, tailoring the L-rhodinose moiety. Org. Lett. 2013, 15, 3254-3257.

48.     Wang, B.; Song, Y.; Luo, M.; Chen, Q.; Ma, J.; Huang, H.; Ju, J.* Biosynthesis of 9-methylstreptimidone involves a new decarboxylative step for polyketide terminal diene formation. Org. Lett. 2013, 15, 1278-1281.

49.     Song, Y.; Huang, H.; Chen, Y.; Ding, J.; Zhang, Y.; Sun, A.; Zhang, W.; Ju, J.* Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406. J. Nat. Prod. 2013, 76, 2263-2268.

50.     Zhang, Y.; Zhou, X.; Huang, H.; Tian, X.; Song, Y.; Zhang, S.; Ju, J.* 03219A, a new Δ8,9-pregnene isolated from Streptomyces sp. SCSIO 03219 obtained from a South China Sea sediment. J. Antibiot. 2013, 66, 327-331.

51.     Zhang, H.; Chen, J.; Wang, H.; Xie, Y.; Ju, J.; Yan, Y.; Zhang, H.* Structural analysis of HmtT and HmtN involved in the tailoring steps of himastatin biosynthesis. FEBS Lett. 2013, 587, 1675-1680.

52.     Ma, M.; Kwong, T.; Lim, S.-K.; Ju, J.; Lohman, J. R.; Shen, B.* Post-polyketide synthase steps in iso-migrastatin biosynthesis, featuring tailoring enzymes with broad substrate specificity. J. Am. Chem. Soc., 2013, 135, 2489-2492.

 

2012:

53.     Mo, X.; Ma, J.; Huang, H.; Wang, B.; Song, Y.; Zhang, S.; Zhang, C.; Ju, J.* D11,12-double bond formation in tirandamycin biosynthesis is atypically catalyzed by TrdE, a glycoside hydrolase family enzyme. J. Am. Chem. Soc. 2012, 134, 2844-2847 (highlighted in Nat. Chem. Biol. 2012, 8, 320).

54.     Zhu,Q.; Li, J.; Ma, J.;Luo, M.;Wang, B.; Huang, H.; Tian, X.; Li, W.; Zhang, S.; Zhang, C.; Ju, J.* Discovery and engineered overproduction of antimicrobial nucleoside antibiotic A201A from deep sea marine actinomycete Marinactinospora thermotolerans SCSIO 00652. Antimicrob. Agents. Chemother. 2012, 56, 110-114.

55.     Xie, Y.; Wang, B.; Liu, J.; Zhou, J.; Ma, J.; Huang, H.; Ju, J.* Identification of the biosynthetic gene cluster and regulatory cascade for the synergistic antibacterial antibiotics griseoviridin and viridogrisein in Streptomyces griseoviridis. ChemBioChem, 2012, 13, 2745-2757 (highlighted as an an inside cover).

56.     Ma, J.; Zuo, D.; Song, Y.; Huang, H.; Yao, Y.; Li, W.; Zhang, C.; Ju, J.* Characterization of a single gene cluster that is responsible for methylpendolmycin and pendolmycin biosynthesis in the deep sea bacterium Marinactinospora thermotolerans. ChemBioChem, 2012, 13, 547-552.

57.     Huang, H.; Yang, T.; Ren, X.; Liu, J.; Song,Y.; Sun, A.; Ma, J.; Zhang, Y.; Huang, C.; Zhang, C.; Ju, J.* Cytotoxic angucycline class glycosides from the deep sea actinomycete Streptomyces lusitanus SCSIO LR32. J. Nat. Prod. 2012, 75, 202-208.

58.     Chen, Z.; Song, Y.; Chen, Y.; Huang, H.; Zhang, W.; Ju, J.* Cyclic heptapeptides, codyheptapeptides C–E, from marine-derived fungus Acremonium persicinum SCSIO 115. J. Nat. Prod., 2012, 75, 1215-1219

59.     Huang, H.; Wang, F.; Luo, M.; Chen, Y.; Song, Y.; Wang, B.; Ma, J.; Zhang, W.; Zhang, S.; Ju, J.* Halogenated anthranquinones from the deep sea-derived fungus Aspergillus sp. SCSIO F063.  2012, J. Nat Prod. 75, 1346-1352.

60.     Zhou, X.; Huang, H.; Chen, Y.; Tan, J.; Song, Y.; Zou, J.; Tian, X.; Hua, Y.; Ju, J.* Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60-L scale fermentation of the deep sea-derived marinactinospora thermotolerans SCSIO 00652. J. Nat Prod. 2012, 75, 2251-2255.

61.     Chen, Z.; Zheng, Z.; Huang, H.; Song, Y.; Zhang, X.; Ma, J.; Wang, B.; Zhang C.; Ju, J.* Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp. SOF07. Bioorg. Med. Chem. Lett., 2012, 22, 3332-3335.

 

2011:

62.     Ma, J.; Wang, Z.; Huang, H.; Zuo, D.; Luo, M.; Wang, B.; Sun, A.; Cheng, Y.; Zhang, C.; Ju, J.* Biosynthesis of himastatin: Assembly line and characterization of three cytochrome P450 enzymes involved in the post-tailoring oxidative steps. Angew. Chem. Int. Ed. 2011, 50, 7797-7802 (commented by Faculty of 1000).

63.     Mo, X.; Huang, H.; Ma, J.; Wang, Z.; Wang, B.; Zhang, S.; Zhang, C.; Ju J.* Characterization of TrdL as a 10-hydroxy dehydrogenase and generation of new analogues from a tirandamycin biosynthetic pathway. Org. Lett., 2011, 13, 2212-2215.

64.     Huang, H.; Yao, Y.; He, Z.; Yang, T.; Ma, J.; Tian, X.; Li, Y.; Huang, C.; Chen, X.; Li, W.; Zhang, S.; Zhang, C.; Ju, J.* Antimalarial b-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate. J. Nat. Prod. 2011, 74, 2122-2127 (highlighted by Global Medical Discovery).

65.     Mo, X.; Wang, Z.; Wang, B.; Ma, J.; Huang, H.; Tian, X.; Zhang, S.; Zhang, C.; Ju, J.* Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomyces sp. SCSIO1666. Biochem. Biophy. Res. Commun., 2011, 406, 341-347. 

66.     Chen, Z.; Huang, H; Chen, Y.; Wang, Z.; Ma, J.; Wang, B.; Zhang, W.; Zhang, C.; Ju, J.*  New cytochalasins from the marine-derived fungus Xylaria sp. SCSIO 156. Helv. Chim. Acta. 2011, 94, 1671-1676.

67.     Huang, Y.; Huang, S. X.; Ju, J.; Tang, G.; Liu, T.; Shen, B.* Characterization of the lnmKLM genes unveiling key intermediates for b-alkylation in leinamycin biosynthesis. Org. Lett., 2011, 13, 498-501.

Other representative publications

68.     Schneider-Poetsch, T.; Ju, J.; Eyler, D. E.; Dang, Y.; Bhat, S.; Merrick, W. C.; Green, R.; Shen, B.; Liu, J. O*. Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nat. Chem. Biol. 2010, 6, 209-217.

69.     Ju, J.; Rajski, S.R.; Lim S.K.; Seo, J.W.; Peters, N.R.; Hoffmann, F.M., Shen, B.* Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration. J. Am. Chem. Soc. 2009, 131, 1370-1371.

70.     Ju, J.;# Li, W.;# (co-first-author) Yuan, Q.; Peters, N.R.; Hoffmann, F.M., Rajski, S.R.; Osada, H.; Shen, B.* Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity. Org. Lett., 2009, 11, 1639-1642.

71.     Ju, J.; Rajski, S.R.; Lim, S.K.; Seo, J.W.; Peters, N.R.; Hoffmann, F.M., Shen, B*. Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency. Bioorg. Med. Chem. Lett. 2008, 18, 5951-5954.

72.     Kennedy, D.R.; Ju, J.; Shen, B.; Beerman, T.A.* Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses. Proc. Natl. Acad. Sci. U.S.A., 2007, 104, 17632-17637.

73.     Ju, J.; Seo, J.-W.; Her, Y.; Lim, S.-K; Shen, B*. New lactimidomycin congeners shed insight into lactimidomycin biosynthesis in Streptomyces amphibiosporus. Org. Lett., 2007, 9, 5183-5186.

74.     Ju, J.; Lim, S.-K; Jiang, H.; Seo, J.-W.; Her, Y.; Shen, B*. Thermolysis of isomigrastatin and its congeners via [3,3]-sigmatropic rearrangement: a new route to the synthesis of migrastatin and its analogues. Org. Lett., 2006, 8, 5865-5868.

75.     Ju, J.; Lim, S.K.; Jiang, H.; Seo, J.W.; Shen, B.* Isomigrastatin congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424 scaffolds. J. Am. Chem Soc. 2005, 127, 11930-11931.

76.     Ju, J.; Lim, S.K.; Jiang, H.; Shen, B.* Migrastatin and dorrigocins are shunt metabolites of iso-migrastatin. J. Am. Chem. Soc. 2005, 127:1622-1623.

77.     Ju, J.; Ozanick, S.G.; Shen, B.; Thomas, M.G.* Conversion of (2S)-arginine to (2S, 3R)-capreomycidine by VioC and VioD from the viomycin biosynthetic pathway of Streptomyces sp. strain ATCC11861. ChemBioChem, 2004, 5:1281-1285.

78.     Ju, J.; Zhou, L.; Lin, G.; Liu, D.; Wang, L.; Yang, J. Studies on constituents of triterpene acids from Eriobotrya japonica and their anti-inflammatory and antitussive effects. Chin. Pharm. J. 2003, 38, 752-757.

79.     Ju, J.*; Liu, D.; Lin, G.; Xu, X.; Han, B.; Yang, J*. Tu, G.; Ma, L.; Beesiosides A-F, Six new cycloartane triterpene glycosides from Beesia calthaefoliaJ. Nat. Prod., 2002, 65, 42-47.

80.     Ju, J.*; Liu, D.; Lin, G.; Zhang, Y.; Yang, J.*; Lu, Y.; Gong N.; Zheng, Q. Beesiosides G, H, and J-N, Seven new cycloartane triterpene glycosides from Beesia calthifoliaJ. Nat. Prod., 2002, 65, 147-152.

81.     Ju, J.; Liu, D.; Lin, G.; Xu, X.; Yang, J.*; Tu, G.; Ma, L. New triterpenic glucoside from Beesia calthaefolia (Maxim.) Ulbr. native toChina. Acta Botanica Sinica 2001, 43, 983-987.

82.     Ju, J.; Yang, J.; Li, J.; Xiao, P. Cypripediquinone A, a new phenanthraquinone from Cypripedium macranthum (Orchidaceae ). Chin. Chem. Lett. 2000, 11(1), 37-38.

83.     Ju, J.; Yu, J. Studies on chemical constituents of seeds of Desmos chinensis Lour. China Journal of Chinese Materia Medica. 1999, 24, 418-421.

代表性专利

1.         鞠建华,黄洪波,姚月良,等。 β-咔啉生物碱及其在制备抗疟疾药物中的应用(授权专利号:ZL 201110132680.9)。

2.         鞠建华,姚月良,田新朋,等。 一种海洋链霉菌以及利用该菌制备替达霉素AB的方法(授权专利号:ZL 201010565028.1)

3.         鞠建华,周俊勇,黄洪波,等。一种海洋链霉菌及利用其制备星形孢菌素和K-252d的方法(授权专利号ZL 201110065140.3)

4.         鞠建华, 陈子明, 黄洪波,等。霉酚酸衍生物ABC及其在制备免疫抑制药物中的应用(授权专利号:ZL 201110404515.4)

5.         鞠建华, 朱清华, 李军等。一种核苷类抗生素A201A高产菌株及其构建方法(授权专利号ZL 201110340905.X)

6.         鞠建华, 黄洪波, 任香梅,等。一类角环素类化合物及其在制备抗肿瘤药物中的应用(授权专利号:ZL 201110421665.6)

7.         鞠建华,谢运昌。绿灰霉素和绿灰霉素的生物合成基因簇及其应用(授权专利号:ZL201210284937.7)

8.         鞠建华,张云,黄洪波,等。一种格瑞克霉素和P-1894B的生物合成基因簇及其应用(授权专利号:ZL 201310118576.3)

9.         鞠建华,周潇,黄洪波,等。抗生素Tetrathiazomycin A及其制备方法和在制备抗肿瘤药物中的应用(授权专利号:ZL 201210230665.3)

10.     鞠建华,陈奇,纪昌涛。一种海洋咔啉生物碱的生物合成基因簇及其应用PCT专利申请号:201310224447.2)。

11.     鞠建华,宋永相,黄洪波,等。一类吩嗪化合物及其在制备抗肿瘤药物中的应用(授权专利:ZL 201310304568.8

12.     鞠建华,宋永相,黄洪波,等。一类萘醌倍半萜化合物及其在制备抗肿瘤或抗菌药物中的应用(授权专利:ZL 201310304510.3

13.     鞠建华,丁杰,宋永相。一种生物碱类化合物的制备方法及其在制备抑制钙离子通道药物中的应用(授权专利:ZL 201310367331.4)

14.     鞠建华、宋永相、黄洪波、张云。两个环六肽化合物及其在制备抗菌药物中的应用(授权专利:ZL 201310322638.2

15.     张幸, 罗明和, 鞠建华。一种吲哚-3-甲醛类化合物的制备方法和应用(授权专利:ZL 201410641080.9)

16.     鞠建华,张幸,桂春。一种海洋链霉菌及其应用(授权专利:ZL 201510073450.8)

17.     鞠建华, 宋永相, 李洁, 黄洪波。一类角环素化合物及其在制备抗肿瘤或抗菌药物中的应用(授权专利:ZL 201510053130.6)

主要在研课题

1.         NSFC-广东联合基金重点项目:南海海洋放线菌中抗感染环肽药物先导化合物的发现、优化与评价(U1501223),2016.01-2019.12,主持、在研;

2.         国家杰出青年科学基金项目:天然药物化学(81425022)2015.01-2019.12,主持、在研;

3.         广东省自然科学基金团队项目:海洋放线菌抗肿瘤药物研究与开发(2016A030312014), 2016.01-2019.12,主持、在研。

团队成员

1. 学科组团队成员。研究员1名:马俊英(华南农业大学博士,分子生物学);副研究员3名:黄洪波(中山大学博士,天然药物化学),宋永相(中山大学博士,天然药物化学),李青连(北京协和医学院博士,分子生物学);助理研究员3名:谢运昌(中国科学院大学博士,分子生物学),秦湘静(中山大学博士,结构生物学),孙长利(中国科学院大学博士,天然药物化学)。现在读博士生5名,硕士生5名,联合培养硕博士生4名。已培养毕业硕博士研究生14名(其中3人获得国家奖学金),联合培养毕业研究生5人。

2.硕士/博士研究生和博士后。招生专业一:海洋生物学(方向1:海洋微生物代谢工程、海洋生物技术;方向2:海洋微生物天然药物化学);招生专业二:生物工程。每年9月份接受教育部双一流高校,原985、211工程院校生命科学(生物科学、生物技术)、化学和药学专业推荐免试直博生和推荐免试硕士生各1名,接受联合培养硕士/博士研究生。