1. Biopeptides: Peptides released from proteins in vivo or in vitro exhibit various physiological activities. My research interest is to investigate peptides activities and profiles in the food processing and gastrointestinal tract by peptidomics method. We presented the integrated approach of LC/MS/MS and bioinformation to identify bioactive peptides from protein hydrolysates. ACE inhibitory peptides, DPP-IV inhibitory peptides have been identified from deer plasma, bee pollen and milk proteins respectively. The present research focuses on peptidiomic study of yogurt proteins after simulated gastrointestinal digestion by LC/MS/MS.

2. Functional Food and Nutriceuticals: In this research field, my interesting is developing the method of extracting bioactive compounds from herb and producing bioactive peptides from proteins. The producing procedure of deer plasma peptides by enzymatic hydrolysis has been applied industrially. The deer plasma peptides have been used as commercial nutraceuticals.

Welcome the graduates majored in biochemical engineering, food, chemistry,pharmacy and related direction.

1988-09--1992-07 Dalian University of Technology (Dalian, China)，B. Sc.

1992-09--1995-03 Dalian University of Technology (Dalian, China)，M. Sc. 

                              Major: Biochemical Engineering

1997-09--2001-03 Dalian Institute of Chemical Physics, Chinese Academy of Sciences (Dalian, China),Ph.D. 

                              Major: Analytical Chemistry

（1） Preparation and application of a kind of ACE inhibitor, first prize, 2016
（2） Research of deer functional components and industrialization, second prize,  2015
（3） Capillary electrophoresis in life science, first prize, 2002

Journal Articles:

1. Peptide profiling and the bioactivity character of yogurt in the simulated gastrointestinal digestion，Yan Jin*, Yang Yu, Yanxia Qi, Fangjun Wang, Jiaze yan, Hanfa Zou*, Journal fo Peoteomics，2016，141: 24-46

2.     Screening and identification of DPP-IV inhibitory peptides from deer skin hydrolysates by an integrated approach of LC–MS/MS and in silico analysis, Yan Jin,*, Jiaze Yan, Yang Yu, Yanxia Qi, Journal of Functional Foods, 2015, 18: 344–357

3.     Application of reversed-phase liquid chromatography-tandem mass spectrometry in the identification of protein and bioactivity peptides from rape bee pollen, GUO Jing, Yan Jize, Guo Ming, Jin Yan*, Chinese Journal of Chromatography, 2014.3:284-289

4.     Analysis of proteins in the extracts of Physalis alkekengi L．var．franchetii ( Mast.) Makino using nanoflow reversed-phase liquid chromatography tandem mass spectrometry, Yu Haiyang, Yan Jiaze, Guo Ming, Jin Yan*, Chinese Journal of Chromatography, 2013,4:362-366

5.     Screening Bioactive Protein and Peptides in Animal Medicine of Chinese Materia Medica by Proteomics and Peptidomics, Jin Yan*, Liu Xiaoyan, Zou Hanfa, Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology, 2011, 12(1)：162-164

6.     Epoxidation of cyclohexene catalyzed by the vanadium bromoperoxidase from coralline officinalis, Yu Yao, Jin Yan, Wu Peichun, Zhang Wei, Chinese Journal of Catalysis, 2007, 28(10):915-918

7.     Halichondria sulfonic acid, a new HIV-1 inhibitory guanidino-sulfonic acid, and halistanol sulfate isolated from the marine sponge Halichondria rugosa Ridley & Dendy. Yan Jin, Serge Fotso, Yongtang Zheng, Madhumati Sevvana, Hartmut Laatsch and Wei Zhang, Natural Product Research，2006，20 (12): 1129-1135

8.     Actinoalloteichus hymeniacidon. sp. nov., a novel actinomycete isolated from marine sponge Hymeniacidon perleve., Zhang H.T., Zheng W., Huang J.Y., Luo H., Jin Y., Zhang W., Liu Z.H.,Huang Y.International Journal of Systematic and Evolutionary Microbiology, 2006, 56: 2309－2312

9.  Phylogenetic Diversity of Marine Sponge Hymeniacidon perleve endocellular bacteria. Jin Yan, Guo Peng-fei, Sun Li-ming, Yu Xing-ju, Zhang Wei    Acta Microbiologica Sinica，2006，46(6)：875－878

10.  Bromoperoxidase activity in three species of marine algae and the characterization of vanadium bromoperoxidase from Corallina officinalis

Jin Yan, Zhang Jin-you, Wu Pei-chun, Zhang Wei, Zhao Xing-wen

Journal of Fishery Sciences ofChina, 2007, 14(3): 482-487

11.  The Structure, Function and Biosynthesis of Cyclic Lipopeptidic Biosurfactants. Hou Hong-Man, Jin Yan, Jin Mei-Fang, Yu Xing-Ju, Zhang Wei, Microbiology, 2006，33：122－128

12.  Two Bioactive aldisine alkaloids isolated from marine sponge axinella sp. in the south China sea. Zhang Hao, Jin Yan, Zhang Wei, Journal of Chinese Medicinal Materials, 2006, 29(12): 1299-1301

13.      Potential of Co-culture Induction in Antibiotics Discovery from Bacteria-associated with Marine Sponge Hymeniacidon perleve. Guo Pengfei, Jin Yan, Zhang Haitao, Yu Xingju, Zhang Wei. Microbiology, 2006, 33(1): 33-37

14.  A method for screening HIV-1 reverse transcriptase inhibitors from crude natural product extract. Hu Zheng, Jin Yan, Yuan Jing-li, Wang Gui-lan, Zhang Wei, Deng Mai-cun. Chinese Pharmacological Bulletin, 2006, 22(5): 639-640

15.  Filtered removal of residual diets in controlled aquaculture system by marine sponge Hymeniacidon perleve. Fu Wan-tao, Zhang Wei, Jin Mei-fang, Yu Xing-ju, JIN Yan, ZhangXi-chang.Marine Environmental Science, 2006, 25(3): 29-32

16.  16S rDNA-RFLP analysis of actinomycetes associated with marine sponge Hymeniacidon perleve. Hai-tao Zhang, Yan Jin, Xing-ju Yu, Wei  Zhang. Acta Microbiologica Sinica，2005, 45(6)，828-831

17.      Recent Advances in Chromatography Coupled Bioassay for Screening Bioactive Natural Products. Yan Jin, Wei Zhang, Zheng Hu, Meifang Jin, Xingju Yu. Chinese Journal of Chromatography, 2004, 22(6): 616-619

18.  Analysis of Low-Polarity Constituents of Reniochalina sp. By Gas Chormatography-Mass Spectrometry. Xiaoyan Yan, Yan Jin, Xingju Yu, Wei Zhang, Meifang Jin. Chinese Journal of Chromatography, 2004, 22(6): 652-654

19.  Bacteria Diversity Associated with the Marine Sponge Hymeniacidon perleve in China Yellow Sea. Junyi Xu, Yan Jin, Xingju Yu, Meifang Jin, Wei Zhang.Acta Microbiologica Sinica, 2004, 44(5): 576-579

20.  Isolation, Identification and Bioactivity Screening of Stremptomyces pseudogriselus Associated with Marine Sponge Hymeniacidon perleve. Haitao Zhang, Yan Jin, Peichun Wu, Wei Zhang. Microbiology, 2004, 31(5): 60-64

21.  Electrophoretic Migration Behavior of DNA Fragments in Polymer Solution. Yan Jin, Bingcheng Lin, Yingsing Fung. Electrophoresis, 2001, 22: 2150-2156

22.  A Collision Model for DNA Separation by Capillary Electrophoresis in Dilute Polymer Solution. Yan Jin, Bing-cheng Lin, Ying-sing Fung. Fresenius’ Journal of Analytical Chemistry, 2001, 370: 1015－1022

23.  DNA Behavior in Three Polymer Solution Regions. Yan Jin, Bingcheng Lin, Yingsing Fung. Chinese Journal of Chromatograph, 2001, 19(1): 60-63

24.  DNA Separation in HPMC-Glucose Matrix by Capillary Electrophoresis. Yan Jin, Bingcheng Lin, Yingsing Fung. Chinese Journal of Analytical Chemistry, 2001, 29(5): 502－506

25.  DNA Separation in Polymer Solution by Capillary Electrophoresis. Yan Jin, Bingcheng Lin. Chinese Journal of Analytical Chemistry, 2000, 28(1): 111~117

26.  Studies of ethanol fermentation using a fusant SPSC flocs-description of flocs, growth and ethanol fermentation kinetics. Bai Fengwu, Jin Yan, Feng Pusun, He Xiuliang. Chinese Journal of Biotechnology, 1999, 15(4): 455-460

27.  Studies of ethanol fermentation using fusant SPSC flocs. Jin Yan, Bai Fengwu, Feng Pusun. Acta Microbiologica Sinica, 1996, 86(2),115－120

28.  Analysis of tumor inhibition gene P16 point mutation by capillary electrophoresis. Yuan Xiaolin, Zhang Xiulin, Jin Yan, Lin Bingcheng. Chinese Journal of Laboratory Medicine, 2000, 23(6): 370

    (1)  Hanfa Zou, Yan Jin, Shuyou Tang, The application of bioactive peptides from deer plasma on antihypertensive nutraceuticals. China’s Patent: ZL20081001205 7.8

(2)  Hanfa Zou, Yan Jin, Shuyou Tang, The producing procedure of bioactive compounds from deer blood. China’s Patent: ZL200710159035.X

(3)  Hanfa Zou, Yan Jin, Shuyou Tang, The method of producing antiogensin converting enzyme (ACE) inhibitory peptides. China’s Patent: ZL200710159029.9

(4)  Yan Jin, Wei Zhang, Xingju Yu, Meifang Jin, A novel compound, Guanidino Sulfonic Acid, isolated from marine sponge Halichondria rugosa Ridley&Dendy. China Patent: 10050754.4 (2004)

(5)  Yan Jin, Yongtang Zheng, Jianhua Wang, Wei Zhang, Halichondria Sulfonic Acid, a novel anti-HIV-1 inhibitory. Patent No: 10082873.8 (2004)

(6)Wei Zhang, Jingli Yuan, Zheng Hu, Yan Jin, Guilan Wang, Xingju Yu, Meifang Jin, A method for screening anti-AIDS bioactive compounds. China’s Patent: 200510047612.7

(7  Yan Jin, Wei Zhang, Jinyou Zhang, A method for isolating and purification bromoperoxidase from marcoalgae, China’s Patent:: 200610046052.8

Peptidomics, New technologies and methods of screening bioactive peptides

已指导学生

于瑶  硕士研究生  081703-生物化工  

刘晓艳  硕士研究生  070302-分析化学  

董浩  硕士研究生  085238-生物工程  

陈津  博士研究生  070302-分析化学  

刘哲益  博士研究生  070302-分析化学  

李吉楠  博士研究生  070302-分析化学  

刘忠山  博士研究生  070302-分析化学  

现指导学生

李亚楠  博士研究生  070302-分析化学  

毛家维  博士研究生  070302-分析化学  

王钟毓  硕士研究生  070302-分析化学