基本信息
姜学军 男 博导 微生物研究所
电子邮件:jiangxj@im.ac.cn
通信地址:中国科学院微生物研究所 北京朝阳区北辰西路1号院3号
邮政编码:100101

研究领域

细胞自噬和表皮生长因子受体(EGFR)信号转导通路;真菌次级代谢产物与哺乳类细胞自噬和死亡

自噬是细胞的三种死亡方式之一。它是指细胞内的溶酶体降解自身细胞器和其他大分子的过程。自噬主要降解长半衰期蛋白,也是细胞能够完整降解细胞器的唯一途径。当细胞在缺乏营养或发生应激反应时,可增加细胞自噬的发生。细胞自噬参与体内多种生理、病理过程,如:代谢平衡、器官发育、肿瘤、免疫、神经退行性病变、心脑血管疾病、病原体入侵等。本研究组主要以微生物来源的小分子化合物开展以下方面的研究:(1)小分子化合物对EGFR受体及其他信号通路的影响;(2)该类化合物引起细胞自噬、凋亡、坏死的机理以及三者间的关系;(3)该类化合物抗医源性微生物、抗肿瘤的可能性。上述研究旨在认识该类小分子物质作用机理的基础上,从中寻找并开发高效低毒的新型抗肿瘤和治疗其他疾病的药物。

学习经历

1995-1998 北京大学医学部,博士;
1992-1995 青岛大学医学院,硕士;
1980-1983 山东省菏泽医学专科学校。
工作经历
2009- 中国科学院微生物研究所,研究员
2005-2006 美国科罗拉多大学医学中心,高级访问学者;
2003-2009 中国科学院微生物研究所,副研究员;
2000-2002 美国科罗拉多大学医学中心,博士后;
1999-2000 美国犹他大学医学院,博士后;
1998-1999 日本名古屋市立大学医学院,博士后;
1989-1992 山东省章丘市人民医院;
1983-1988 山东济钢明水耐火材料厂职工医院;

指导学生

已指导学生

岳晓婧  硕士研究生  071010-生物化学与分子生物学  

张蔚  硕士研究生  071010-生物化学与分子生物学  

闫金国  硕士研究生  071010-生物化学与分子生物学  

现指导学生

金昕  硕士研究生  071010-生物化学与分子生物学  

袁栋栋  硕士研究生  071010-生物化学与分子生物学  

学术兼职

北京大学泌尿外科研究所客座教授;
AUTOPHAGY 审稿人;
BIOCHEMICAL PHARMACOLOGY 审稿人;
中国男科学 编委;

代表性论文

1. Nan Zhang, Yali Chen, Ruixuan Jiang, Erwei Li, Xiuling Chen, Zhijun Xi, Yinglu Guo, Xingzhong Liu, Yuguang Zhou, Yongsheng Che and Xuejun Jiang. PARP and RIP 1 are required for autophagy induced by 11'-deoxyverticillin A, which precedes caspase-dependent apoptosis. Autophagy. 2011, 7:6, 1-15.
2. Xuejun Jiang. Animal genes identification and mTOR signaling reactivation in Autophagy. Protein&Cell. 2010. 8:699-701. (News and views).
3. Yuan Yao, Gang Wang, Zhe Li, Bing Yan, Yinglu Guo, Xuejun Jiang, and Zhijun Xi. Mitochondrially localized EGFR is independent of its endocytosis and associates with cell viability. Acta Biochimica et Biophysica Sinica 2010, 42: 763–770 (correspondence author)
4. Yan J, Yang H, Wang G, Sun L, Zhou Y, Guo Y, Xi Z, Jiang X. Autophagy augmented by troglitazone is independent of EGFR transactivation and correlated with AMP-activated protein kinase signaling. Autophagy. 2010; 6: 67-73.(IF:6.8)(correspondence author)
5. Zhou Z, Jiang X, Liu D, Fang Z, Hu X, Yan J, Wang M, Gao GF. Autophagy is involved in influenza A virus replication. Autophagy. 2009; 5(3): 321-328. (IF:6.8)(co-first author)
6. Yue X, Song W, Zhang W, Chen L, Xi Z, Xin Z, Jiang X. Mitochondrially localized EGFR is subjected to autophagic regulation and implicated in cell survival. Autophagy. 2008;4(5):641-9. (correspondence author)
7. Li M, Jiang X, Liu D, Na Y, Gao GF, Xi Z. Autophagy protects LNCaP cells under androgen deprivation conditions. Autophagy. 2008;4(1):54-60. (co-first author)
8. Xuejun Jiang Alexander Sorkin. Epidermal Growth Factor Receptor Internalization through Clathrin-coated Pits requires Cbl RING finger and Proline-rich domains but not receptor Polyubiquitylation. Traffic, 2003; 4:529-543.(IF:6.2)
9. Xuejun Jiang, Alexander Sorkin. Coordinated Traffic of Grb2 and Ras during Epidermal Growth Factor Receptor Endocytosis Visualized in Living Cells. Mol. Biol. Cell, 2002; 13: 1522-1535. (IF: 8.6)
10. Xuejun Jiang, Fangtian Huang, Andriy Marusyk, Alexander Sorkin. Grb2 Regulates Internalization of EGF Receptors through Clathrin-coated Pits. Mol. Biol. Cell, 2003; 14: 585-570. (IF:8.6)
11. Jiang XJ, Feng T, Chang LS, Kong XT, Wang G, Zhang ZW, Guo YL. Expression of osteopontin mRNA in normal and stone forming rat kidney. Urol.Res., 1998; 26(6):389-394
12. F Huang, D Kirkpatrick, X Jiang, S Gygi, A Sorkin. Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol. Cell, 2006, 21(6):737-48.
13. Fangtian Huang, Xuejun Jiang, Alexander Sorkin. Tyrosine phosphorylation of the β2 subunit of clathrin adaptor complex AP-2 reveals the role of a di-leucine motif in the EGFR receptor trafficking. J Biol Chem, 2003;278:43411-7.
14. Li X, Yang X, Xu Y, Jiang X, Li X, Nan F, Tang H. Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor gamma. Cell Res. 2009; 6: 720-732.

出版信息

   
发表论文
(1) PARP and RIP 1 are required for autophagy induced by 11-deoxyverticillin A, which precedes caspase-dependent apoptosis. Autophagy. ,Autophagy,2011,通讯作者
(2) Mitochondrially localized EGFR is independent of its endocytosis and associates with cell viability,Acta Biochimica et Biophysica Sinica ,2010,通讯作者
(3) Autophagy augmented by troglitazone is independent of EGFR transactivation and correlated with AMP-activated protein kinase signaling. ,Autophagy,2010,通讯作者
(4) Animal genes identification and mTOR signaling reactivation in Autophagy. ,Protein and Cell,2010,第1作者
(5) Autophagy is involved in influenza A virus replication., Autophagy,2009,第1作者
(6) Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor gamma,Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor gamma,2009,第4作者
(7) Autophagy protects LNCaP cells under androgen deprivation conditions,Autophagy ,2008,第1作者
(8) Mitochondrially localized EGFR is subjected to autophagic regulation and implicated in cell survival.,Autophagy ,2008,通讯作者
(9) Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain,Mol. Cell,2006,第3作者
(10) Grb2 Regulates Internalization of EGF Receptors through Clathrin-coated Pits,Molecular Biology of the Cell (IF: 8.6) ,2003,第1作者
(11) Tyrosine phosphorylation of the β2 subunit of clathrin adaptor complex AP-2 reveals the role of a di-leucine motif in the EGFR receptor trafficking,Tyrosine phosphorylation of the β2 subunit of clathrin adaptor complex AP-2 reveals the role of a di-leucine motif in the EGFR receptor trafficking,2003,第2作者
(12) Epidermal growth factor receptor internalization through clathrin-coated pits requires Cbl RING finger and proline-rich domains but not receptor polyubiquitylation,Traffic (IF:6.2),2003,第1作者
(13) Coordinated Traffic of Grb2 and Ras during Epidermal Growth Factor Receptor Endocytosis Visualized in Living Cells,Molecular Biology of the Cell (IF: 8.6) ,2002,第1作者
(14) Expression of osteopontin mRNA in normal and stone forming rat kidney,Urol.Res.,1998,第1作者
发表著作