基本信息
王晋辉  男  博导  生命科学学院
电子邮件: wangjinhui@ucas.ac.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码: 100101
部门/实验室:生命科学学院

研究领域

神经科学,生理学

招生信息

记忆细胞和环路的工作原理

招生专业
071006-神经生物学
招生方向
记忆细胞工作原理
抑郁症神经环路机制
神经细胞及突触信息编码的分子机制

教育背景

1989-08--1992-07   中国科学院上海生理研究所   博士
学历
中国科学院上海生理研究所 -- 研究生
学位
中国科学院上海生理研究所 -- 博士

工作经历

   
工作简历
2003-12~2025-09,中国科学院生物物理研究所;中国科学院大学, 研究员;特聘教授 博导
1999-08~2004-08,University of Kansas, Assistant professor (tenure-track), 博导
社会兼职
2010-08-01-今,中国心理生理学会理事,
2010-05-31-今,中国神经药理学会常务理事,

教授课程

人体生理学 (H)
高等生理学
人体生理学
神经生物学
高级生理学
生理学
普通生理学
生物物理学系列讲座
神经生理学

专利与奖励


奖励信息
(1) 国家杰出青年基金, , 国家级, 2003
(2) 中国科学院百人计划, , 部委级, 2003

出版信息

   
发表论文
(1) mRNA and miRNA profiles in the nucleus accumbens are related to fear memory and anxiety induced by physical or psychological stress, Journal of Psychiatric Research, 2019-08, 通讯作者
(2) Coactivations of barrel and piriform cortices induce their mutual synapse innervations and recruit associative memory cells, Brain Research, 2019-07, 通讯作者
(3) microRNA and mRNA profiles in the amygdala are relevant to fear memory induced by physical or psychological stress, Journal of Neurophysiology, 2019-06, 通讯作者
(4) Searching basic units of memory traces: Associative memory cells, F1000 Research, 2019-04, 第 1 作者
(5) microRNA and mRNA profiles in the amygdala are associated with stress-induced depression and resilience in juvenile mice, Psychopharmacology, 2019-02, 通讯作者
(6) microRNA and mRNA profiles in ventral tegmental area relevant to stress-induced depression and resilience, Progress in Neuropsychopharmacology & Biological Psychiatry, 2018-05, 通讯作者
(7) Cell-specific plasticity associated with integrative memory of triple sensory signals in the barrel cortex, Oncotarget, 2018-03, 通讯作者
(8) microRNA and mRNA profiles in nucleus accumbens underlying depression versus resilience in response to chronic stress, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2018-02, 通讯作者
(9) Associative memory cells and their working principle in the brain, F1000Research, 2018, 通讯作者
(10) Barrel Cortical Neuron Integrates Triple Associated Signals for Their Memory Through Receiving Epigenetic-Mediated New Synapse Innervations, Cerebral Cortex, 2017, 通讯作者
(11) Synapse Innervation and Associative Memory Cell Are Recruited for Integrative Storage of Whisker and Odor Signals in the Barrel Cortex through miRNA-Mediated Processes, Frontiers in Cellular Neuroscience, 2017, 通讯作者
(12) GABAergic neurons in nucleus accumbens are correlated to resilience and vulnerability to chronic stress for major depression, Oncotarget, 2017, 通讯作者
(13) Associative memory cells: Formation, function and perspectives, F1000Research, 2017, 通讯作者
(14) Functional compatibility between Purkinje cell axon branches and their target neurons in the cerebellum., Oncotarget, 2017, 通讯作者
(15) Associative memory extinction is accompanied by decayed plasticity at motor cortical neurons and persistent plasticity at sensory cortical neurons, Frontiers in Cellular Neuroscience, 2017, 通讯作者
(16) Piriform cortical glutamatergic and GABAergic neurons express coordinated plasticity for whisker-induced odor recall, Oncotarget, 2017, 通讯作者
(17) Coordinated plasticity among glutamatergic and GABAergic neurons and synapses in the barrel cortex is correlated to learning efficiency, Frontiers in Cellular Neuroscience, 2017, 通讯作者
(18) Activity-induced spontaneous spikes in GABAergic neurons suppress seizure discharges: an implication of computational modeling., Oncotarget, 2017, 通讯作者
(19) Activity strengths of cortical glutamatergic and GABAergic neurons are correlated with transgenerational inheritance of learning ability, Oncotarget, 2017, 通讯作者
(20) PKC and CaMK-II inhibitions coordinately rescue ischemia-induced GABAergic neuron dysfunction., Oncotarget, 2017, 通讯作者
(21) Associations of Unilateral Whisker and Olfactory Signals Induce Synapse Formation and Memory Cell Recruitment in Bilateral Barrel Cortices: Cellular Mechanism for Unilateral Training Toward Bilateral Memory, Front Cell Neurosci., 2016, 通讯作者
(22) Coordinated Plasticity between Barrel Cortical Glutamatergic and GABAergic Neurons during Associative Memory, Neural Plasticity, 2016, 通讯作者
(23) Molecular mechanism for stress-induced depression assessed by sequencing miRNA and mRNA in medial prefrontal cortex., PLoS One, 2016, 通讯作者
(24) Incoordination among subcellular compartments is associated to depression-like behavior induced by chronic mild stress, International Journal of Neuropsychopharmacology, 2016, 通讯作者
(25) Impaired GABA synthesis, uptake and release are associated with depression-like behaviors induced by chronic mild stress., Translational Psychiatry, 2016, 通讯作者
(26) Reward memory relieves anxiety-related behavior through synaptic strengthening and protein kinase C in dentate gyrus., Hippocampus, 2016, 通讯作者
(27) Glucocorticoid Induces Incoordination between Glutamatergic and GABAergic Neurons in the Amygdala, PLoS One, 2016, 通讯作者
(28) Neuron-specific mechanisms for epilepsy self-termination, Molecular & Cellular Epilepsy, 2015, 通讯作者
(29) Acidosis-induced dysfunction of cortical GABAergic neurons through astrocyte-related excitotoxicity, PLoS One, 2015, 通讯作者
(30) Reward memory relieves anxiety-related behavior through synaptic strengthening and protein kinase C in dentate gyrus, Hippocampus, 2015, 通讯作者
(31) A portion of inhibitory neurons in human TLE are functionally upregulated: an endogenous mechanism for seizure termination. , CNS Neuroscience and Therapeutics, 2015, 通讯作者
(32) Neurons in the barrel cortex turn into processing whisker and odor signals: a cellular mechanism for the storage and retrieval of associative signals., Frontier in Cellular Neuroscience., 2015, 通讯作者
(33) Essential role of axonal VGSC inactivation in time-dependent deceleration and unreliability of spike propagation at cerebellar Purkinje cells., Molecular Brain, 2014, 通讯作者
(34) The coupling features of electrical synapses modulate neuronal synchrony in hypothalamic superachiasmatic nucleus. , Brain Research, 2014, 通讯作者
(35) Input-dependent subcellular localization of spike initiation between soma and axon at cortical pyramidal neurons., Molecular Brain, 2014, 通讯作者
(36) Voltage-independent sodium channels emerge for an expression of activity-induced spontaneous spikes in GABAergic neurons, Molecular Brain, 2014, 通讯作者
(37)  Protein kinase C is essential for kainate-induced anxiety-like behavior and glutamatergic synapse upregulation in prefrontal cortex. , CNS Neuroscience and Therapeutics, 2014, 通讯作者
(38) Upregulation of excitatory neurons and downregulation of inhibitory neurons in barrel cortex are associated with loss of whisker inputs., Molecular Brain, 2013, 通讯作者
(39) Frequency-dependent reliability of spike propagation is function of axonal voltage-gated sodium channels in cerebellar Purkinje cells., Cerebellum, 2013, 通讯作者
(40) Barrel cortical neurons and astrocytes coordinately respond to an increased whisker stimulus frequency., Molecular Brain, 2012, 通讯作者
(41) mGluR activation improves network asynchrony and GABAergic synapse attenuation in the amygdala: Implication for anxiety-like behavior in DAB/2 mice., Molecular Brain, 2012, 通讯作者
(42) The functional upregulation of piriform cortex is associated with cross-modal plasticity in loss of whisker tactile inputs., PloS One, 2012, 通讯作者
(43) Upregulation of transmitter release probability improves a conversion of synaptic analogue signals into neuronal digital spikes., Molecular Brain, 2012, 通讯作者
(44) Physiological synaptic signals initiate sequential spikes at soma of cortical pyramidal neurons, Molecular Brain, 2011, 通讯作者
(45)  Quantal Glutamate Release Is Essential for Reliable Neuronal Encodings in Cerebral Networks, PLoS ONE, 2011, 通讯作者
(46) Ca2+ and acidosis synergistically lead to the dysfunction of cortical GABAergic neurons during ischemia. , Biochemical and Biophysical Research Communications, 2010, 通讯作者
(47) Axons Amplify Somatic Incomplete Spikes into Uniform Amplitudes in Mouse Cortical Pyramidal Neurons., PLoS ONE, 2010, 通讯作者
(48) Upregulation of barrel GABAergic neurons is associated with cross-modal plasticity in olfactory deficit., PLoS ONE, 2010, 通讯作者
(49) Intracellular Ca2+ regulates spike encoding at cortical GABAergic neurons and cerebellar Purkinje cells differently., Biochemical and Biophysical Research Communications , 2009, 通讯作者
(50) Real-time neuronal homeostasis by coordinating VGSC intrinsic properties., Biochemical and Biophysical Research Communications , 2009, 通讯作者
(51) The postnatal development of intrinsic properties and spike encoding at cortical GABAergic neurons., Biochemical and Biophysical Research Communications, 2009, 通讯作者
(52) Gain and fidelity of transmission patterns at cortical excitatory unitary synapses improve spike encoding. , Journal of Cell Science, 2008, 第 1 作者
(53) Homeostasis established by coordination of subcellular compartment plasticity improves spike encoding., Journal of Cell Science, 2008, 通讯作者
(54)  Ischemia deteriorates the spike encoding of rat cerebellar Purkinje cells by raising intracellular Ca2+. , Biochemical and Biophysical Research Communications, 2008, 通讯作者
(55) Afterhyperpolarization improves spike programming through lowering threshold potentials and refractory periods mediated by voltage-gated sodium channels., Biochemical and Biophysical Research Communications, 2006, 通讯作者
(56) Sodium channel-mediated intrinsic mechanisms underlying the di?erences of spike programming among GABAergic neurons., Biochemical and Biophysical Research Communications, 2006, 通讯作者
(57) The intrinsic mechanisms underlying the maturation of programming sequential spikes at cerebellar Purkinje cells., Biochemical and Biophysical Research Communications, 2006, 通讯作者
(58) The refractory periods and threshold potentials of sequential spikes measured by whole-cell recording., Biochemical and Biophysical Research Communications , 2006, 通讯作者
(59) The postnatal development of refractory periods and threshold potentials at cerebellar Purkinje neurons., Brain Research, 2006, 通讯作者
(60) Differential modulation of glutamatergic and cholinergic synapses by calcineurin in hippocampal CA1 fast-spiking interneurons., Brain Research, 2004, 通讯作者
(61) Calcium signal- dependent multigrade-plasticity of neuronal excitability developed postnatally., Journal of Neurobiology, 2004, 通讯作者
(62) Ca2+/CaM signal pathway up-regulates GABA synaptic function through cytoskeleton-mediated mechanisms. , Neuroscience, 2004, 通讯作者
(63) Short-term cerebral ischemia causes the dysfunction of interneurons and more excitation of pyramidal neurons in rats., Brain Research Bulletin, 2003, 通讯作者
(64) Ca2+/CaM signal pathway up-regulates glutamatergic synaptic function on non-pyramidal fast-spiking neurons in hippocampal CA1., Journal of Physiology (London), 2001, 通讯作者
(65)  Postsynaptic calcineurin activity down-regulates synaptic transmission by weakening intracellular Ca2+ signaling mechanisms in hippocampal CA1 neurons. , Journal of Neuroscience, 1997, 第 1 作者
(66) Attenuation of paired-pulse facilitation associated with synaptic potentiation mediated by postsynaptic mechanisms., Journal of Neurophysiology, 1997, 第 1 作者
(67) Cellular and molecular bases of memory: synaptic and neuronal plasticity, Journal of Clinic Neurophysiology, 1997, 第 1 作者
(68) Shared calcium signaling pathways in the induction of long-term potentiation and synaptic disinhibition in CA1 pyramidal cell dendrites. , Journal of Neurophysiology, 1996, 第 1 作者
(69) Regulation of synaptic facilitation by postsynaptic Ca2+ -CaM signaling pathway in rat hippocampal CA1 neurons., Journal of Neurophysiology, 1996, 第 1 作者
(70) The balance between postsynaptic Ca2+-dependent protein kinases and phosphates controlling synaptic strength. , Learning and Memory, 1996, 第 1 作者
(71) Postsynaptic injection of Ca2+/CaM induces synaptic potentiation requiring CaM-KII and PKC activity, Neuron, 1995, 第 1 作者
(72) Inhibition of phosphatase 2B prevents expression of hippocampal long-term potentiation, NeuroReport, 1994, 第 1 作者
(73) Postsynaptic protein kinase C essential to both induction and maintenance of long-term potentiation in hippocampal CA1 region., Proc. Natl. Acad. Sci. USA, 1992, 第 1 作者
发表著作
(1) Associative Memory Cells: Basic Units of Memory Traces, Springer Nature, 2019-09, 第 1 作者

科研活动

   
科研项目
( 1 ) 中枢神经损伤修复与功能重建中胶质细胞的作用及意义, 参与, 国家级, 2011-01--2015-08
( 2 ) 额叶和海马环路发育调控的分子机理, 主持, 国家级, 2010-01--2013-12
( 3 ) 跨膜式神经可塑性动物模型在改善认知障碍中的机理和应用, 主持, 国家级, 2012-01--2015-12
( 4 ) 奖励性记忆改善焦虑的细胞分子基础研究, 主持, 国家级, 2015-01--2018-12
( 5 ) MDD神经环路异常及形成机制, 主持, 国家级, 2013-01--2017-08
( 6 ) 用新信息记忆的动物模型研究认知障碍病理机制和防治策略, 主持, 国家级, 2017-01--2020-12
( 7 ) 抑郁症亚型诊断及其防治疗效监测的生物标志物研究, 参与, 国家级, 2016-09--2020-12
( 8 ) 增强大脑联合记忆细胞形成与维护拟改善认知障碍的研究, 主持, 国家级, 2020-01--2023-12
参与会议
(1)Associative memory extinction is accompanied by decays of associative memory cells and their plasticity at motor cortex but not sensory cortex   2017-11-11
(2)Synapse formation and memory cell recruitment for associative memory   2016-11-12
(3)Neuron-specific mechanisms for unilateral learning and bilateral memory recalls   2015-10-17
(4)Cortical glutamatergic and GABAergic neurons learn to encode odor signal through their coordinated plasticity    2014-11-14
(5)Neurons in barrel cortex turn into processing whisker and odor signals: a novel form of associative learning   2013-11-08
(6)Functional compatibility between Purkinje cell axon branches and their target neurons in the cerebellum   2012-10-12
(7)Anxiety-associated network asynchrony and GABAergic synapse attenuation in amygdala are improved by mGluR1.5 activation   Fengyu Zhang, Bei Liu, Zhuofen Lei and Jinhui Wang   2011-11-12
(8)Soma as a source to encode neuronal digital signals   J. H. WANG   2010-10-17
(9)How is neuronal homeostasis maintained   J. H. WANG   2009-10-19
(10)Axon facilitates the propagation of sequential spikes toward terminals to secure synaptic transmission   J. H. WANG   2008-11-15
(11)Ischemia deteriorates the spike encoding of cerebellar Purkinje cells via raising intracellular Ca2+   J. H. WANG   2007-11-05
(12)Sodium channel-mediated intrinsic mechanisms navigate the programming of sequential spikes   J. H. WANG   2006-10-17

合作情况

   
项目协作单位
   

指导学生

已指导学生

陈欣  博士研究生  071011-生物物理学  

余建东  博士研究生  071011-生物物理学  

王明辉  博士研究生  071010-生物化学与分子生物学  

葛荣靖  博士研究生  071006-神经生物学  

赵君  博士研究生  071006-神经生物学  

杨志来  博士研究生  071006-神经生物学  

雷卓凡  博士研究生  071006-神经生物学  

温波  博士研究生  071006-神经生物学  

钱浩  博士研究生  071006-神经生物学  

卢炜  博士研究生  071006-神经生物学  

高子龙  博士研究生  071006-神经生物学  

魏忠杰  硕士研究生  071006-神经生物学  

现指导学生

郭莉  博士研究生  071006-神经生物学  

吴瑞祥  博士研究生  071006-神经生物学  

肖华娟  博士研究生  071006-神经生物学  

许杨  博士研究生  071010-生物化学与分子生物学  

崔田亮  硕士研究生  071011-生物物理学  

姜震  硕士研究生  085238-生物工程  

张赟  博士研究生  071009-细胞生物学