基本信息
尹俊发 男 硕导 生态环境研究中心
电子邮件:jfyin@rcees.ac.cn
通信地址:北京市海淀区双清路18号
邮政编码:100085

研究领域

主要从事环境化学和分析化学领域的研究。近年来的研究包括:DNA损伤的高选择性和高灵敏度检测;功能性分子识别材料及环境纳米材料的研制及应用等。

招生信息


欢迎有分析化学、材料化学和生物化学专业背景的同学报考。
招生专业
083001-环境科学
070302-分析化学
招生方向
功能性分子识别材料及环境纳米材料的研制及应用
DNA损伤的高选择性和高灵敏度检测
用于色谱和毛细管电泳分析的整体分离介质的研制

教育背景

2004-09--2007-06 中国科学院化学研究所 博士
2001-09--2004-06 河北大学化学与环境科学学院、药学院 硕士
1996-09--2000-06 河北大学化学与环境科学学院 学士
学历

研究生

学位
理学博士学位

代表性论著

1. Junfa Yin, Ning Zhang, Hailin Wang*, Liquid chromatography- mass spectrometry for analysis of DNA damages induced by environmental exposure. TrAC-Trends in Analytical Chemistry, 2019, 120: 115645. 

2. Junfa Yin, Shaokun Chen, Ning Zhang, Hailin Wang*. Multienzyme Cascade Bioreactor for a 10 min Digestion of Genomic DNA into Single Nucleosides and Quantitative Detection of Structural DNA Modifications in Cellular Genomic DNA. ACS Applied Materials & Interfaces, 2018, 10, 21883-2189. 

3. Junfa Yin, Ji-Fang-Tong Li, Xing-Hong Li, You-Lin Yang, Zhan-Fen Qin. Bioaccumulation and transfer characteristics of dechlorane plus in human adipose tissue and blood stream and the underlying mechanisms. Science of The Total Environment, 2020, 700, 134391. 

4. Junfa Yin, Tian Xu, Ning Zhang, Hailin Wang*, Three-enzyme cascade bioreactor for rapid digestion of genomic DNA into single nucleosides, Analytical Chemistry, 2016, 88, 7730–7737. 

5. Junfa Yin, Yuanyuan Song, Ning Zhang, Tian Xu, Hailin Wang*,A fluorophore-conjugated ascorbic acid functions for the visualization of sodium vitamin C transporters in living cells, Analytical Methods,2015,7, 9663-9672. 

6. Junfa Yin, Zhixin Wang, Maoyong Song, Chao Zhao, Hailin Wang*, Plastic antibody for DNA damages: Fluorescent imaging of BPDE-dG adducts in genomic DNA. Analyst, 2013, 138, 4958-4966. 

7. Junfa Yin, Zihui Meng, Yishan Zhu, Maoyong Song, Hailin Wang*, Dummy molecularly imprinted polymer for selective screening of trace bisphenols in river water. Analytical Methods, 2011, 3, 173-180. 

8. Junfa Yin*, Yue Cui, Gengliang Yang*, Hailin Wang, Molecularly imprinted nanotubes for enantio-selective drug delivery and controlled release. Chemical Communications, 2010, 46, 7688–7690. 

9Junfa Yin, Zihui Meng, Mingjun Du, Cong Liu, Maoyong Song, Hailin Wang, Pseudo-template molecularly imprinted polymer for selective screening of trace β-lactam antibiotics in river and tap water. Journal of Chromatography A, 2010, 1217, 5420-5426.

10. Junfa Yin, Yuling Song, Zhixin Wang, Hailin Wang, Fabrication and fluorescence imaging of human low-density lipoprotein coatings for highly efficient capillary electrophoresis separation of basic proteins. Electrophoresis, 2009, 30, 1362–1371.

11. Junfa Yin, Lijuan Wang, Xiaoyi Wei, Gengliang Yang, Hailin Wang, p-tert-Butylcalix[8]arene-bonded silica monoliths for liquid chromatography. Journal of Chromatography A, 2008, 1188, 199-207.

12. Junfa Yin, Gengliang Yang*, Hailin Wang, Yi Chen, Macroporous polymer monoliths fabricated by using a metal-organic coordination gel template. Chemical Communications, 2007, 44, 4614–4616.

13. Junfa Yin, Sumin Wang, Guanqun Yang, Gengliang Yang*, Yi Chen, Molecularly imprinted solid-phase extraction for rapid screening of mycophenolic acid in human plasma. Journal of Chromatography B, 2006, 844, 142-147. 
14. Junfa Yin, Gengliang Yang*, Sumin Wang, Yi Chen, Purification and determination of stachyose in Stachys Sieboldii Miq. by high-performance liquid chromatography with evaporative light scattering detection. Talanta, 2006, 70, 208-212.
15. Junfa Yin, Gengliang Yang, Yi Chen, Rapid and efficient chiral separation of nateglinide and its L-enantiomer on monolithic molecularly imprinted polymers. Journal of Chromatography A, 2005, 1090, 68-75. 
16. Junfa Yin, Gengliang Yang*, Yihua Zhang, Haiyan Liu, Yi Chen, Molecular recognition in in-situ nateglinide imprinted chiral stationary phase. Acta Chimica Sinica, 2004, 62, 1922-1926. 
17. Junfa Yin, Gengliang Yang*, Zhiwei Li, Determination of stachyose in Stachys Sieboldii Miq. by high performance liquid chromatography with evaporative light scattering detection. Chinese Journal of Analytical Chemistry, 2003, 31, 1409-1412. 

18. Hua Guo, Lei Zhang, Xu Dong, Gangyi Shen*, Junfa Yin*. Immobilized Multi- Enzyme Cascade Reactor (Review). Progress in Chemistry, 2020, 32: 392-405. 

19. Jianxing Wang, Xiangfang Lin, Lei Su*, Junfa Yin, Tong Shu and Xueji Zhang*, Chemical etching of pH- sensitive aggregationinduced emission- active gold nanoclusters for ultra- sensitive detection of cysteine, Nanoscale, 2019, 11, 294-300. 

20. Weiyi Lai, Jiezhen Mo, Junfa Yin, Cong Lyu, Hailin Wang, Profiling of epigenetic DNA modifications by advanced liquid chromatography-mass spectrometry technologies, TrAC-Trends in Analytical Chemistry, 2019, 110:173-182.

21. Tian Xu, Junfa Yin, Shaokun Chen, Dapeng Zhang, Hailin Wang*. Elevated 8-oxo-7,8-dihydro-2′-deoxyguanosine in genome of T24 bladder cancer cells induced by halobenzoquinones. Journal of Environmental Sciences, 2018, 63, 133-139.

22. Danni Wu, Baodong Liu, Junfa Yin, Tian Xu, Shuli Zhao, Qun Xu, Xi Chen, Hailin Wang*. Detection of 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker of oxidative damage in peripheral leukocyte DNA by UHPLC–MS/MS, Journal of Chromatography B, 2017, 1064, 1–6.

23. Minjie Chen, Junfa Yin, Yong Liang, Shaopeng Yuan, Fengbang Wang,Maoyong Song, Hailin Wang,Oxidative stress and immunotoxicity induced by graphene oxide inzebrafish, Aquatic Toxicology, 2016,174, 54–60. 

24. Maoyong Song*, Fengbang Wang, Luzhe Zeng, Junfa Yin, Hailin Wang, Guibin Jiang, Co-exposure of Carboxyl-Functionalized Single-Walled Carbon Nanotubes and 17α-Ethinylestradiol in Cultured Cells: Effects on Bioactivity and CytotoxicityEnvironmental Science & Technology, 2014, 48, 13978-13984.

25. Song MaoyongZeng LuzheYuan ShaopengYin JunfaWang Hailin*, Jiang GuibinStudy of cytotoxic effects of single-walled carbon nanotubes functionalized with different chemical groups on human MCF7 cells, Chemosphere, 201392, 576-582.

26. Maoyong Song, Luzhe Zeng, Xianjun Hong, Zihui Meng, Junfa Yin, Hailin Wang*, Yong Liang, Polyvinyl Pyrrolidone Promotes DNA Cleavage by a ROS-Independent and Depurination Mechanism. Environmental Science and Technology, 2013, 47, 2886-2891.

27. Bin Han, Chao Zhao, Junfa Yin, Hailin Wang*, High performance aptamer affinity chromatography for single-step selective extraction and screening of basic protein lysozyme. Journal of Chromatography B, 2012, 903, 112-117.

28. Maoyong Song, Shaopeng Yuan, Junfa Yin, Xiaoli Wang, Zihui Meng, Hailin Wang*, Guibin Jiang, Size-Dependent Toxicity of Nano-C-60 Aggregates: More Sensitive Indication by Apoptosis-Related Bax Translocation in Cultured Human Cell. Environmental Science and Technology, 2012, 46, 3457-3464. 

29. Chao Zhao, Ruichuan Yin, Junfa Yin, Dapeng Zhang, Hailin Wang*, Capillary Monolithic Bioreactor of Immobilized Snake Venom Phosphodiesterase for Mass Spectrometry Based Oligodeoxynucleotide Sequencing. Analytical Chemistry, 2012, 84, 1157-1164. 

科研活动

(1)原子转移自由基聚合法制备新型分子印迹纳米膜包覆型毛细管整体柱,主持,国家级,2009-01--2011-12 
(2)纳米材料与技术在水中污染物选择性消除中的应用基础研究,参与,国家级,2009-08--2012-12
(3)松花江水体污染生态风险评估关键技术研究,参与,国家级,2009-07--2012-06 
(4)重大环境污染事件特征污染物实验室检测技术系统,参与,国家级,2008-03--2011-06

工作经历

2007年--至今 中国科学院生态环境研究中心 环境化学与生态毒理学国家重点实验室