General

Dr. Li Wang

Associate professor

Dalian Institute of Chemical Physics, Chinese Academy of Science

Address: 457 Zhongshan Road, Group DNL2003, 116023

Email: wlhws@dicp.ac.cn

Telephone: 86-411-84379396


Research Areas

Analytical Chemistry

Medicinal Chemistry


Education

Ph.D. 2003-2007  Analytical Chemistry    Dalian Institute of Chemical Physics, Chinese Academy of  Sciences

M.S. 1998-2001   Medicinal Chemistry     Henan University of Traditional Chinese Medicine

B.S.  1994-1998  Chinese Pharmacy        Henan University of Traditional Chinese Medicine

Experience

   
Work Experience

  • Establishment of twenty quality criteria for toxic compounds originated from Traditional Chinese Medicine.Financial supported by Scientific and Technological Major Special Project of China (2014ZX09304307-001-006, Topic Leader, 2014-2016).

  • Discovering three highly active anticancer compounds isolated from Stellera chamaejasme. Financial supported by Scientific and Technological Major Special Project (2013ZX09301307-004, Topic Leader, 2013-2015).

  • High sensitive analysis of rat plasma, urine, and CSF samples dozed Gastrodia elata, based on UPLC-TOF/MS and UPLC-LFD. Financial supported by National Natural Science Foundation of China. (81001629, Project Leader, 2010-2013).

  • Isolation of 25 meaningful trace compounds from Traditional Chinese Medicine in an amount of 10-30 g with their purity higher than 98%. Financial supported by Scientific and Technological Major Special Project (2009ZX09502-023, Topic Leader, 2009-2010).

Publications

   
Papers

  1. Z. X. Wang, Y. Qu, L. Wang, X. Z. Zhang, H. B. Xiao, Ultra-high performance liquid chromatography with linear ion trap-Orbitrap hybrid mass spectrometry combined with a systematic strategy based on fragment ions for the rapid separation and characterization of components in Stellera chamaejasme extracts.Journal of Separation Science, 2016, 39 (7): 1379-1388.

  2. C. Tang, L. Wang, X. Liu, M. Cheng, H. Xiao, Chemical fingerprint and metabolic profile analysis of ethyl acetate fraction of Gastrodia elata by ultra performance liquid chromatography/quadrupole-time of flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci, 2016, 1011: 233-9.

  3. C. Tang, L. Wang, X. Liu, M. Cheng, H. Xiao, Pharmacokinetic study of Gastrodia elata in rats. Anal Bioanal Chem, 2015, 407 (29): 8903-10.

  4. C. Tang, L. Wang, X. Liu, M. Cheng, Y. Qu, H. Xiao, Comparative pharmacokinetics of gastrodin in rats after intragastric administration of free gastrodin, parishin and Gastrodia elata extract. J Ethnopharmacol, 2015, 176: 49-54.

  5. C. Tang, L. Wang, J. Li, X. Liu, M. Cheng, H. Xiao, Analysis of the metabolic profile of parishin by ultra-performance liquid chromatography/quadrupole-time of flight mass spectrometry. Biomed Chromatogr, 2015, 29 (12): 1913-20.

  6. Chunlan Tang, Li Wang, Mengchun Cheng, Xiaozhe Zhang, Xiaoyan Liu, Hongbin Xiao, Rapid and sensitive analysis of parishin and its metabolites in rat plasma using ultra high performance liquid chromatography-fluorescence detection. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 2014, 973: 104-109.

  7. Rongjie Zhuo, Liangxiao Zhang, Li Wang, Guoshun Shan, Qianxu Yang, Xiaoyan Yuan, Hongbin Xiao, Rapid simultaneous quantitative determination of terpenoids in Tripterygium wilfordii Hook F by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Analytical Methods, 2013, 5 (8): 2046-2052.

  8. QianXu Yang, Li Wang, LiangXiao Zhang, HongBin Xiao, Baohuoside I production through enzyme hydrolysis and parameter optimization by using response surface and subset selection. Journal of Molecular Catalysis B-Enzymatic, 2013, 90: 132-138.

  9. Li Wang, Hongbin Xiao, Li Yang, Zhengtao Wang, Two new phenolic glycosides from the rhizome of Gastrodia elata. Journal of Asian Natural Products Research, 2012, 14 (5): 457-462.

  10. Aihua Zuo, Li Wang, Hongbin Xiao, Limin Li, Yuhong Liu, Jinhai Yi, Identification of the absorbed components and metabolites in rat plasma after oral administration of Rhizoma Chuanxiong decoction by HPLC-ESI-MS/MS. Journal of Pharmaceutical and Biomedical Analysis, 2011, 56 (5): 1046-1056.

  11. Yujia Lei, Li Wang, Mengchun Cheng, Hongbin Xiao, Identification of major metabolites in rat urine and plasma of N-6-(4-hydroxybenzyl) adenine riboside by LC/MS/MS. Biomedical Chromatography, 2011, 25 (3): 344-352.

Research Interests

1. High sensitive analyis for active metablites

2. Elucidation of neuroprotective mechanism