基本信息
胡蕴菲  女  博导  中国科学院精密测量科学与技术创新研究院
电子邮件: huyunfei@wipm.ac.cn
通信地址: 湖北省武汉市武昌区小洪山西30号中国科学院精密测量科学与技术创新研究院波谱楼
邮政编码:

招生信息

   
招生专业
070302-分析化学
招生方向
生物大分子核磁共振

教育背景

2005-09--2010-07   北京大学   博士
2001-09--2005-07   北京大学   学士

工作经历

   
工作简历
2019-06~现在, 中国科学院武汉精密测量科学与技术创新研究院, 研究员
2018-06~2019-06,苏州大学, 教授
2012-07~2018-06,北京大学, 副研究员
2010-07~2012-07,北京大学, 博士后

出版信息

   
发表论文
(1) Mechanisms of chaperones as active assistant/protector for proteins: Insights from NMR studies, Chin. J. Chem., 2020, 第 1 作者
(2) Backbone 1H, 13C and 15N resonance assignments of the proteasome lid subunit Rpn12 from Saccharomyces cerevisiae, Biomol. NMR Assign., 2020, 第 3 作者
(3) NMR 1H, 13C, 15N Backbone and side chain resonance assignment of the N-terminal domain of yeast proteasome lid subunit Rpn5, Biomol. NMR Assign., 2019, 第 3 作者
(4) Structural basis and mechanism of the unfolding-induced activation of HdeA, a bacterial acid response chaperone, J. Biol. Chem., 2019, 通讯作者
(5) 1H, 13C and 15N resonance assignments of the second peptidyl-prolyl isomerase domain of chaperone SurA from Escherichia coli, Biomol. NMR Assign., 2019, 通讯作者
(6) Conformational complexity and dynamics in a muscarinic receptor revealed by NMR spectroscopy, Mol. Cell, 2019, 第 2 作者
(7) Residue selective 15N CEST and CPMG experiments for studies of millisecond timescale protein dynamics, J. Magn. Res., 2018, 第 5 作者
(8) Solution structure of the N-terminal domain of proteasome lid subunit Rpn5, Biochem. Biophys. Res. Commun., 2018, 通讯作者
(9) Intra- and inter-protein couplings of backbone motions underlie protein thiol-disulfide exchange cascade, Sci. Rep., 2018, 通讯作者
(10) Characterizations of the interactions between Escherichia coli periplasmic chaperone HdeA and its native substrates during acid stress, Biochemistry, 2017, 通讯作者
(11) Solution structure of yeast Rpn9: Insights into proteasome lid assembly., J. Biol. Chem., 2015, 第 1 作者
(12) A hybrid mechanism for the Synechocystis arsenate reductase revealed by structural snapshots during arsenate reduction, J. Biol. Chem., 2015, 通讯作者
(13) HdeB chaperone activity is coupled to its intrinsic dynamic properties, Sci. Rep., 2015, 通讯作者
(14) Structural basis for TatA oligomerization: An NMR study of Escherichia coli TatA dimeric structure, PLoS One, 2014, 第 2 作者
(15) Solution structure of the TatB component of the twin-arginine translocation system, Biochim. Biophys. Acta., 2014, 通讯作者
(16) Chitin-induced dimerization activates a plant immune receptor, Science, 2012, 第 4 作者
(17) Structures of Anabaena calcium-binding protein CcbP: Insights into Ca2+ signaling during heterocyst differentiation, J. Biol. Chem., 2011, 第 1 作者
(18) Solution NMR structure of the TatA component of the twin-arginine protein transport system from Gram-positive bacterium Bacillus subtilis., J. Am. Chem. Soc., 2010, 第 1 作者
(19) Conformational fluctuations coupled to the thiol-disulfide transfer between thioredoxin and arsenate reductase in Bacillus subtilis, J. Biol. Chem., 2007, 第 2 作者
(20) Solution tructures and backbone dynamics of a flavodoxin MioC from Escherichia coli in both apo- And holo-forms: implications for cofactor binding and electron transfer, J. Biol. Chem., 2006, 第 1 作者

科研活动

   
科研项目
( 1 ) 细胞中生物大分子结构与相互作用的谱学测量, 参与, 国家级, 2020-01--2024-12
( 2 ) 肠道菌抗酸性分子伴侣HdeA和HdeB的结构、动力学和活化的分子机理研究, 主持, 国家级, 2014-01--2017-12
( 3 ) 黄素氧还蛋白结构、动力学和功能的核磁共振研究, 主持, 国家级, 2012-01--2012-12
参与会议
(1)Molecular basis for proteasome lid assembly via PCI domains revealed by structures and interactions of yeast Rpn9   第五届海峡两岸磁共振研讨会   2015-01-18
(2)Structures and dynamics of bacterial flavodoxins   太平洋地区国际化学大会   2010-12-15