基本信息
胡俊杰 男 博导 其它

电子邮件huj@ibp.ac.cn
通信地址:北京市朝阳区大屯路15号中科院生物物理研究所10号楼
邮政编码:100101 
实验室主页
hu-lab.org/

研究领域

     本实验室主要研究内质网等重要细胞器的形态与功能。内质网是一个广泛连续的膜网络,承担了蛋白合成、脂类合成和钙存储等重要功能。内质网的形态主要包括片状和管状,然而这些不同形态的膜结构如何在同一膜系统内形成,我们还知之甚少。前期研究发现一组膜蛋白reticulons和DP1/Yop1p参与了管状内质网的成形,这些膜蛋白只在管状内质网中存在,他们的过表达和敲除都会影响内质网的形态。我们纯化了两个成管膜蛋白,并发现他们在体外与脂肪重组后能形成管状膜结构。我们最近又发现嵌膜GTP酶atlastin等参与了内质网管状网络的形成,这些蛋白的缺失或突变导致内质网分叉减少,也能引起遗传性痉挛性截瘫。我们还通过结构解析等实验手段,剖析了atlastin介导膜融合的可能机制。总体来说,我们将采用细胞生物学,生物化学及结构生物学等多种方法深入研究内质网塑形和重装的分子机制,内质网的形态与功能的关联,以及与内质网功能相关的疾病。

学习经历

   
学习经历
2001 -- 2005  美国纽约大学 博士
1996 -- 2000  复旦大学 学士

工作经历

   
工作经历
2015 -- 今        中国科学院大学 岗位教授
2013 -- 今        中国科学院生物物理研究所 研究员
2008 -- 2012   南开大学 教授
2005 -- 2008   美国哈佛医学院 博士后

学术兼职
中国细胞生物学会细胞信号转导分会秘书
中国细胞生物学会细胞结构与细胞行为分会常务委员
中国细胞生物学会青年工作委员会常务委员
中国生物物理学会膜与细胞生物物理专业委员会副主任

发表论文

Structures of the yeast dynamin-like GTPase Sey1p provide insight into homotypic ER fusion. The Journal of Cell Biology.
Liming Yan, Sha Sun, Wei Wang, Juanming Shi, Xiaoyu Hu, Shiyan Wang, Dan Su, Zihe Rao, Junjie Hu, and Zhiyong Lou 

Cis and trans interactions between atlastin molecules during membrane fusion. Proceedings of the National Academy of Sciences of the United States of America. 2015
Liu Tina Y, Bian Xin, Romano, Fabian B, Shemesh, Tom  Rapoport, Tom A, Hu  Junjie 

Human atlastin GTPases mediate differentiated fusion of endoplasmic reticulum membranes. Protein & cell. 2015
Hu, Xiaoyu, Wu, Fuyun, Sun, Sha, Yu, Wenying, Hu, Junjie 

Comparison of human and Drosophila atlastin GTPases. Protein & cell. 2015
Wu, Fuyun, Hu, Xiaoyu, Bian, Xin, Liu, Xinqi, Hu, Junjie 

Homotypic fusion of endoplasmic reticulum membranes in plant cells. Frontiers in plant science. 2014
Zhang, Miao, Hu, Junjie 

ROOT HAIR DEFECTIVE3 family of dynamin-like GTPases mediates homotypic endoplasmic reticulum fusion and is essential for Arabidopsis development. Plant physiology. 2014
Zhang, Miao, Wu, Fuyun, Shi, Juanming, Zhu, Yimeng, Zhu, Zhengmao, Gong, Qingqiu, Hu, Junjie 

Structural insight into Golgi membrane stacking by GRASP65 and GRASP55 proteins. The Journal of biological chemistry. 2013
Feng, Yanbin, Yu, Wenying, Li, Xinxin, Lin, Shaoyu, Zhou, Ying, Hu, Junjie, Liu, Xinqi 

Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation. The Journal of biological chemistry. 2013
Zheng, Hongying, Zhou, Meng-Hua, Hu, Changlong, Kuo, Enoch, Peng, Xu, Hu, Junjie, Kuo, Lih, Zhang, Shenyuan L 

Molecular basis for sculpting the endoplasmic reticulum membrane. The international journal of biochemistry & cell biology. 2012
Lin, Shaoyu, Sun, Sha, Hu, Junjie 

Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion. Proceedings of the National Academy of Sciences of the United States of America. 2012
Liu, Tina Y, Bian, Xin, Sun, Sha, Hu, Xiaoyu, Klemm, Robin W, Prinz, William A, Rapoport, Tom A, Hu, Junjie 

生物膜曲度形成机制的探讨 生物物理学报. 2012
Sun, Sha, Hu, Junjie 

内质网膜形态维持的分子机制 生命科学. 2011
Sui, Xuewu, Hu, Junjie 

Weaving the web of ER tubules. Cell. 2011
Hu, Junjie, Prinz, William A, Rapoport, Tom A 

Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91. Proceedings of the National Academy of Sciences of the United States of America. 2011
Zhang, Shenyuan L, Yeromin, Andriy V, Hu, Junjie, Amcheslavsky, Anna, Zheng, Hongying, Cahalan, Michael D 

Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes. Proceedings of the National Academy of Sciences of the United States of America. 2011
Bian, Xin, Klemm, Robin W, Liu, Tina Y, Zhang, Miao, Sun, Sha, Sui, Xuewu, Liu, Xinqi, Rapoport, Tom A, Hu, Junjie 

Mechanisms shaping the membranes of cellular organelles. Annual review of cell and developmental biology. 2009
Shibata, Yoko, Hu, Junjie, Kozlov, Michael M, Rapoport, Tom A 

A class of dynamin-like GTPases involved in the generation of the tubular ER network. Cell. 2009
Hu, Junjie, Shibata, Yoko, Zhu, Peng-Peng, Voss, Christiane, Rismanchi, Neggy, Prinz, William A, Rapoport, Tom A, Blackstone, Craig 

The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum. The Journal of biological chemistry. 2008
Shibata, Yoko, Voss, Christiane, Rist, Julia M, Hu, Junjie, Rapoport, Tom A, Prinz, William A, Voeltz, Gia K 

Membrane proteins of the endoplasmic reticulum induce high-curvature tubules. Science. 2008
Hu, Junjie, Shibata, Yoko, Voss, Christiane, Shemesh, Tom, Li, Zongli, Coughlin, Margaret, Kozlov, Michael M, Rapoport, Tom A, Prinz, William A 

Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS. Journal of molecular biology. 2006
Hu, Junjie, Hubbard, Stevan R 

Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK. The Journal of cell biology. 2006
Marciniak, Stefan J, Garcia-Bonilla, Lidia, Hu, Junjie, Harding, Heather P, Ron, David 

Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14. Molecular cell. 2005
Depetris, Rafael S, Hu, Junjie, Gimpelevich, Ilana, Holt, Lowenna J, Daly, Roger J, Hubbard, Stevan R 

Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins. The Journal of biological chemistry. 2005
Hu, Junjie, Hubbard, Stevan R 

Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Molecular cell. 2003
Hu, Junjie, Liu, Jun, Ghirlando, Rodolfo, Saltiel, Alan R, Hubbard, Stevan R 

科研活动



科研项目:

1.  胞生物自噬过程中膜的构建于融合,参与,国家级,2015-01--2018-12 
2.  中组部青年拔尖人才,主持,国家级,2014-01--2015-12
3.  RHD3影响内质网形态和根毛生长的分子机制,主持,国家级,2012-01--2015-12
4.  美国霍华德休斯国际青年科学家奖基金,主持,其他级,2012-01--2016-12
5.  嵌膜GTP酶影响内质网结构的分子机制,主持,国家级,2010-01--2012-12
6.  生物膜形态发生及维持的分子机制,主持,国家级,2010-01--2014-12

参与会议:

1. “Membrane Shaping and Remodeling by Proteins”   May 21-23, 2010 (第一届蛋白质介导的膜塑形与重装”国际学术研讨会) 会议组织者
2. “Membrane Shaping and Remodeling by Proteins”  May 16-19,2013 (第二届蛋白质介导的膜塑形与重装”国际学术研讨会)会议组织者 
3. EMBO work shop—cell cellfusion.2013, invited speaker. 
报告题目:Mechanistic insight into mitofusin-mediated membrane fusion 
4. IUPAB2014国际生物物理大会
报告题目:Homotypic membrane fusion by dynamin-like GTPases


招生信息


招生专业:细胞生物学

招生方向:内质网形态与功能

所获荣誉

1. Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes.入选中国百篇最具影响国际学术论文 2011
2. 美国霍华德休斯医学院(HHMI)国际青年科学家奖 2012
3. 中国科学报社 第三届“青年科学之星”称号 2012
4. 天津青年五四奖章 2012
5. 国家自然科学基金委杰出青年基金 2013
6. 中组部青年拔尖人才 2014
7. 入选百人计划 B类 2015