电子邮件: huj@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号生物物理研究所
邮政编码: 100101
研究领域
工作经历
工作经历
2013 -- 今 中国科学院生物物理研究所 研究员
2008 -- 2012 南开大学 教授
2005 -- 2008 美国哈佛医学院 博士后
学术兼职
中国细胞生物学会细胞结构与细胞行为分会常务委员
中国细胞生物学会青年工作委员会常务委员
中国生物物理学会膜与细胞生物物理专业委员会副主任
发表论文
2021
FIT2 organizes lipid droplet biogenesis with ER tubule-forming proteins and septins.
Chen F, Yan B, Ren J, Lyu R, Wu Y, Guo Y, Li D, Zhang H, Hu J.
J Cell Biol. 2021 May 3;220(5):e201907183.
PMID: 33861319
Endoplasmic reticulum composition and form: Proteins in and out.
Sun S, Tang X, Guo Y, Hu J.
Curr Opin Cell Biol. 2021 Feb 18;71:1-6.
PMID: 33611096 Review.
2020
Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1.
Yan L, Qi Y, Ricketson D, Li L, Subramanian K, Zhao J, Yu C, Wu L, Sarsam R, Wong M, Lou Z, Rao Z, Nunnari J, Hu J.
Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4061-4070.
PMID: 32041880
STIM1 interacts with termini of Orai channels in a sequential manner.
Niu L, Wu F, Li K, Li J, Zhang SL, Hu J, Wang Q.
J Cell Sci. 2020 Feb 27:jcs.239491.
PMID: 32107289
Structural insights into G domain dimerization and pathogenic mutation of OPA1.
Yu C, Zhao J, Yan L, Qi Y, Guo X, Lou Z, Hu J, Rao Z.
J Cell Biol. 2020 Jul 6;219(7):e201907098.
PMID: 32379273
A Plasmodium homolog of ER tubule-forming proteins is required for parasite virulence.
Shi X, Hai L, Govindasamy K, Gao J, Coppens I, Hu J, Wang Q, Bhanot P.
Mol Microbiol. 2020 May 20.
PMID: 32432369
Self-Association of Purified Reconstituted ER Luminal Spacer Climp63
Zhao J and Hu J.
Front Cell Dev Biol. 2020 June 16.
PMID: 32612999
“At last in” the physiological roles of the tubular ER network
Lv L, Niu L, Hu J.
Biophys Rep. 2020;6(4): 105-114.
Review.
Mitochondrial Fusion: The Machineries In and Out.
Gao S, Hu J.
Trends Cell Biol. 2021 Jan;31(1):62-74.
PMID: 33092941 Review.
2019
Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites.
Liu X, Guo X, Niu L, Li X, Sun F, Hu J, Wang X, Shen K.
Nat Commun. 2019 Feb 4;10(1):568.
PMID: 30718476
Atlastin-mediated membrane tethering is critical for cargo mobility and exit from the endoplasmic reticulum.
Niu L, Ma T, Yang F, Yan B, Tang X, Yin H, Wu Q, Huang Y, Yao ZP, Wang J, Guo Y, Hu J.
Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14029-14038.
PMID: 31239341
Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset.
Li YJ, Cao YL, Feng JX, Qi Y, Meng S, Yang JF, Zhong YT, Kang S, Chen X, Lan L, Luo L, Yu B, Chen S, Chan DC, Hu J, Gao S.
Nat Commun. 2019 Oct 29;10(1):4914.
PMID: 31664033
Mycobacterial dynamin-like protein IniA mediates membrane fission.
Wang M, Guo X, Yang X, Zhang B, Ren J, Liu A, Ran Y, Yan B, Chen F, Guddat LW, Hu J, Li J, Rao Z.
Nat Commun. 2019 Aug 29;10(1):3906.
PMID: 31467269
Reciprocal regulation between lunapark and atlastin facilitates ER three-way junction formation.
Zhou X, He Y, Huang X, Guo Y, Li D, Hu J.
Protein Cell. 2019 Jul;10(7):510-525.
PMID: 30498943
Calumenin-1 Interacts with Climp63 to Cooperatively Determine the Luminal Width and Distribution of Endoplasmic Reticulum Sheets.
Shen B, Zheng P, Qian N, Chen Q, Zhou X, Hu J, Chen J, Teng J.
iScience. 2019 Dec 20;22:70-80.
PMID: 31751826
2018
Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales.
Guo Y, Li D, Zhang S, Yang Y, Liu JJ, Wang X, Liu C, Milkie DE, Moore RP, Tulu US, Kiehart DP, Hu J, Lippincott-Schwartz J, Betzig E, Li D.
Cell. 2018 Nov 15;175(5):1430-1442.e17.
PMID: 30454650
LEM4 confers tamoxifen resistance to breast cancer cells by activating cyclin D-CDK4/6-Rb and ERα pathway.
Gao A, Sun T, Ma G, Cao J, Hu Q, Chen L, Wang Y, Wang Q, Sun J, Wu R, Wu Q, Zhou J, Liu L, Hu J, Dong JT, Zhu Z.
Nat Commun. 2018 Oct 9;9(1):4180.
PMID: 30301939
DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.
Zheng P, Chen Q, Tian X, Qian N, Chai P, Liu B, Hu J, Blackstone C, Zhu D, Teng J, Chen J.
Cell Res. 2018 Aug;28(8):833-854.
PMID: 30030520
Structural basis for GTP hydrolysis and conformational change of MFN1 in mediating membrane fusion.
Yan L, Qi Y, Huang X, Yu C, Lan L, Guo X, Rao Z, Hu J, Lou Z.
Nat Struct Mol Biol. 2018 Mar;25(3):233-243.
PMID: 29483649
Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL.
Wu Y, Li X, Jia J, Zhang Y, Li J, Zhu Z, Wang H, Tang J, Hu J.
Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2762-E2771.
PMID: 29507230
Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies.
Qiu X, Lei Y, Yang P, Gao Q, Wang N, Cao L, Yuan S, Huang X, Deng Y, Ma W, Ding T, Zhang F, Wu X, Hu J, Liu SL, Qin C, Wang X, Xu Z, Rao Z.
Nat Microbiol. 2018 Mar;3(3):287-294.
PMID: 29379207
Sec61β facilitates the maintenance of endoplasmic reticulum homeostasis by associating microtubules.
Zhu Y, Zhang G, Lin S, Shi J, Zhang H, Hu J.
Protein Cell. 2018 Jul;9(7):616-628.
PMID: 29168059
2017
Sequences flanking the transmembrane segments facilitate mitochondrial localization and membrane fusion by mitofusin.
Huang X, Zhou X, Hu X, Joshi AS, Guo X, Zhu Y, Chen Q, Prinz WA, Hu J.
Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9863-E9872.
PMID: 29093165
Quantitative proteomics reveal proteins enriched in tubular endoplasmic reticulum of Saccharomyces cerevisiae.
Wang X, Li S, Wang H, Shui W, Hu J.
Elife. 2017 Mar 13;6:e23816.
PMID: 28287394
Atlastin regulates store-operated calcium entry for nerve growth factor-induced neurite outgrowth.
Li J, Yan B, Si H, Peng X, Zhang SL, Hu J.
Sci Rep. 2017 Feb 27;7:43490.
PMID: 28240257
2016
The Vici Syndrome Protein EPG5 Is a Rab7 Effector that Determines the Fusion Specificity of Autophagosomes with Late Endosomes/Lysosomes.
Wang Z, Miao G, Xue X, Guo X, Yuan C, Wang Z, Zhang G, Chen Y, Feng D, Hu J, Zhang H.
Mol Cell. 2016 Sep 1;63(5):781-95.
PMID: 27588602
Fusion of the endoplasmic reticulum by membrane-bound GTPases.
Hu J, Rapoport TA.
Semin Cell Dev Biol. 2016 Dec;60:105-111.
PMID: 27269373 Review.
Shaping the Endoplasmic Reticulum into a Social Network.
Zhang H, Hu J.
Trends Cell Biol. 2016 Dec;26(12):934-943.
PMID: 27339937 Review.
Identification of endoplasmic reticulum-shaping proteins in Plasmodium parasites.
Sun S, Lv L, Yao Z, Bhanot P, Hu J, Wang Q.
Protein Cell. 2016 Aug;7(8):615-20.
PMID: 27484902
A Comprehensive Analysis of Plasmodium Circumsporozoite Protein Binding to Hepatocytes.
Zhao J, Bhanot P, Hu J, Wang Q.
PLoS One. 2016 Aug 25;11(8):e0161607.
PMID: 27560376
A family of membrane-shaping proteins at ER subdomains regulates pre-peroxisomal vesicle biogenesis.
Joshi AS, Huang X, Choudhary V, Levine TP, Hu J, Prinz WA.
J Cell Biol. 2016 Nov 21;215(4):515-529.
PMID: 27872254
Structures of human mitofusin 1 provide insight into mitochondrial tethering.
Qi Y, Yan L, Yu C, Guo X, Zhou X, Hu X, Huang X, Rao Z, Lou Z, Hu J.
J Cell Biol. 2016 Dec 5;215(5):621-629.
PMID: 27920125
2015
Junjie Hu: Shape-shifting in the endoplasmic reticulum.
Hu J, Powell K.
J Cell Biol. 2015 Jun 8;209(5):626-7.
PMID: 26056135
Human atlastin GTPases mediate differentiated fusion of endoplasmic reticulum membranes.
Hu X, Wu F, Sun S, Yu W, Hu J.
Protein Cell. 2015 Apr;6(4):307-311.
PMID: 25773277
Cis and trans interactions between atlastin molecules during membrane fusion.
Liu TY, Bian X, Romano FB, Shemesh T, Rapoport TA, Hu J.
Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1851-60.
PMID: 25825753
Comparison of human and Drosophila atlastin GTPases.
Wu F, Hu X, Bian X, Liu X, Hu J.
Protein Cell. 2015 Feb;6(2):139-46.
PMID: 25407413
Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy.
Wu F, Watanabe Y, Guo XY, Qi X, Wang P, Zhao HY, Wang Z, Fujioka Y, Zhang H, Ren JQ, Fang TC, Shen YX, Feng W, Hu J, Noda NN, Zhang H.
Mol Cell. 2015 Dec 17;60(6):914-29.
PMID: 26687600
Structures of the yeast dynamin-like GTPase Sey1p provide insight into homotypic ER fusion.
Yan L, Sun S, Wang W, Shi J, Hu X, Wang S, Su D, Rao Z, Hu J, Lou Z.
J Cell Biol. 2015 Sep 14;210(6):961-72.
PMID: 26370501
2013
Homotypic fusion of endoplasmic reticulum membranes in plant cells.
Zhang M, Hu J.
Front Plant Sci. 2013 Dec 18;4:514.
PMID: 24385977 Review.
Structural insight into Golgi membrane stacking by GRASP65 and GRASP55 proteins.
Feng Y, Yu W, Li X, Lin S, Zhou Y, Hu J, Liu X.
J Biol Chem. 2013 Sep 27;288(39):28418-27.
PMID: 23940043
ROOT HAIR DEFECTIVE3 family of dynamin-like GTPases mediates homotypic endoplasmic reticulum fusion and is essential for Arabidopsis development.
Zhang M, Wu F, Shi J, Zhu Y, Zhu Z, Gong Q, Hu J.
Plant Physiol. 2013 Oct;163(2):713-20.
PMID: 23922269
Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.
Zheng H, Zhou MH, Hu C, Kuo E, Peng X, Hu J, Kuo L, Zhang SL.
J Biol Chem. 2013 Apr 19;288(16):11263-72.
PMID: 23447534
2012
Molecular basis for sculpting the endoplasmic reticulum membrane.
Lin S, Sun S, Hu J.
Int J Biochem Cell Biol. 2012 Sep;44(9):1436-43.
PMID: 22640864 Review.
Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion.
Liu TY, Bian X, Sun S, Hu X, Klemm RW, Prinz WA, Rapoport TA, Hu J.
Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):E2146-54.
PMID: 22802620
The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae.
Anwar K, Klemm RW, Condon A, Severin KN, Zhang M, Ghirlando R, Hu J, Rapoport TA, Prinz WA.
J Cell Biol. 2012 Apr 16;197(2):209-17.
PMID: 22508509
生物膜曲度形成机制的探讨
生物物理学报. 2012
Sun S, Hu J
2011
Weaving the web of ER tubules.
Hu J, Prinz WA, Rapoport TA.
Cell. 2011 Dec 9;147(6):1226-31.
PMID: 22153070 Review.
Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes.
Bian X, Klemm RW, Liu TY, Zhang M, Sun S, Sui X, Liu X, Rapoport TA, Hu J.
Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):3976-81.
PMID: 21368113
Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91.
Zhang SL, Yeromin AV, Hu J, Amcheslavsky A, Zheng H, Cahalan MD.
Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17838-43.
PMID: 21987804
内质网膜形态维持的分子机制
生命科学. 2011
Sui X, Hu J
2009
Mechanisms shaping the membranes of cellular organelles.
Shibata Y, Hu J, Kozlov MM, Rapoport TA.
Annu Rev Cell Dev Biol. 2009;25:329-54.
PMID: 19575675
A class of dynamin-like GTPases involved in the generation of the tubular ER network.
Hu J, Shibata Y, Zhu PP, Voss C, Rismanchi N, Prinz WA, Rapoport TA, Blackstone C.
Cell. 2009 Aug 7;138(3):549-61.
PMID: 19665976
2008
The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum.
Shibata Y, Voss C, Rist JM, Hu J, Rapoport TA, Prinz WA, Voeltz GK.
J Biol Chem. 2008 Jul 4;283(27):18892-904.
PMID: 18442980
Membrane proteins of the endoplasmic reticulum induce high-curvature tubules.
Hu J, Shibata Y, Voss C, Shemesh T, Li Z, Coughlin M, Kozlov MM, Rapoport TA, Prinz WA.
Science. 2008 Feb 29;319(5867):1247-50.
PMID: 18309084
2006
Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS.
Hu J, Hubbard SR.
J Mol Biol. 2006 Aug 4;361(1):69-79.
PMID: 16824542
Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK.
Marciniak SJ, Garcia-Bonilla L, Hu J, Harding HP, Ron D.
J Cell Biol. 2006 Jan 16;172(2):201-9.
PMID: 16418533
2005
Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins.
Hu J, Hubbard SR.
J Biol Chem. 2005 May 13;280(19):18943-9.
PMID: 15737992
Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14.
Depetris RS, Hu J, Gimpelevich I, Holt LJ, Daly RJ, Hubbard SR.
Mol Cell. 2005 Oct 28;20(2):325-33.
PMID: 16246733
2003
Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor.
Hu J, Liu J, Ghirlando R, Saltiel AR, Hubbard SR.
Mol Cell. 2003 Dec;12(6):1379-89.
PMID: 14690593
科研活动
科研项目:
1. 胞生物自噬过程中膜的构建于融合,参与,国家级,2015-01--2018-12
2. 中组部青年拔尖人才,主持,国家级,2014-01--2015-12
3. RHD3影响内质网形态和根毛生长的分子机制,主持,国家级,2012-01--2015-12
4. 美国霍华德休斯国际青年科学家奖基金,主持,其他级,2012-01--2016-12
5. 嵌膜GTP酶影响内质网结构的分子机制,主持,国家级,2010-01--2012-12
6. 生物膜形态发生及维持的分子机制,主持,国家级,2010-01--2014-12
参与会议:
1. “Membrane Shaping and Remodeling by Proteins” May 21-23, 2010 (第一届蛋白质介导的膜塑形与重装”国际学术研讨会) 会议组织者
2. “Membrane Shaping and Remodeling by Proteins” May 16-19,2013 (第二届蛋白质介导的膜塑形与重装”国际学术研讨会)会议组织者
3. EMBO work shop—cell cellfusion.2013, invited speaker.
报告题目:Mechanistic insight into mitofusin-mediated membrane fusion
4. IUPAB2014国际生物物理大会
报告题目:Homotypic membrane fusion by dynamin-like GTPases
招生信息
招生专业:细胞生物学
招生方向:内质网形态与功能
所获荣誉
2. 美国霍华德休斯医学院(HHMI)国际青年科学家奖 2012
3. 中国科学报社 第三届“青年科学之星”称号 2012
4. 天津青年五四奖章 2012
5. 国家自然科学基金委杰出青年基金 2013
6. 中组部青年拔尖人才 2014
7. 入选**** B类 2015