基本信息
黄宇彬 男 博导 长春应化所
电子邮件:ybhuang@ciac.jl.cn
联系电话:0431-85262769
手机号码:
通信地址:长春市人民大街5625号
邮政编码:130022

研究领域

生物医用高分子,生物可降解高分子,高性能聚乳酸材料,人造红血球,高分子药物,肿瘤靶向药物,内毒素清除材料,生物粘合剂,功能化多糖蛋白质材料

教育背景

   
学历

1993年,吉林大学化学系,高分子专业,学士
1999年,中科院长春应化所,高分子专业,理学博士

学位

理学博士

出国学习工作
1997-1998 日本早稻田大学理工学部应用化学系,国际交流
2000-2006 日本早稻田大学理工学研究中心,博士后,副教授

工作经历

   
工作简历
2000-2001 日本文部省科学技术振兴事业团, JST博士后研究员
2001-2002 日本厚生省人间科学振兴财团,博士后研究员
2002-2003 日本厚生省公定书协会,博士后研究员
2002-2006 日本庆应大学医学部,客座讲师
2003-2005 日本早稻田大学理工学研究中心,专任讲师
2005-2006 日本早稻田大学理工学研究中心,副教授
2006-now   中国科学院长春应用化学研究所,高分子物理与化学国家重点实验室,研究员,博士生导师,中国科学院“****”获得者

专利与奖励

   
专利成果
 
1. 一种生物降解的键合了血红蛋白分子的纳米粒子及制法,黄宇彬、景遐斌、石全、吴猛、陈学思,申请号200810050914.3,公开号101306196A。
2. Solid phase membrane useful as artificial skin, coating agent, cell sheet, contains surface modified serum albumin covalently bonded with polyethylene glycol, or surface-modified serum albumin-metal porphyrin complex, Tsuchida E., Komatsu T., Huang Y., Patent No.: WO2007091350-A1; JP2007209543-A.
3. Surface modified serum-albumin-metalloporphyrin composite for use in oxygen infusion solution, comprises metalloporphyrin contained in serum albumin, and has polyoxyethylene covalently bonded to surface of serum albumin molecule, Tsuchida E., Komatsu T., Huang Y., Patent No.: WO2006016561-A1; JP2006045173-A; EP1792917-A1; US2007142290-A1.
4. 表面修飾血清アルブミン-金属ポルフィリン複合体、およびそれを含有する酸素輸液(特願2004-232519)/ 土田英俊、小松晃之、黄 宇彬 2004年,已公告;
5. 脱酸素装置(NP3442751)(Hb小胞体の脱酸素化装置)/ 土田英俊、武岡真司、黄 宇彬 2001年,已授权。
6. Huang Yubin, Ding Mengxian, Gao Lianxun. “Synthesis of the Catalyst for the Polymerization of Oxirance”, Chinese patent (1996), CN 1 23526.8 已授权。
7. 一种生物降解高分子-多西紫杉醇键合药及其制备方法, 景遐斌、谢志刚、陈学思、郑勇辉、柳时、庄秀丽、黄宇彬,申请号200610131693.3,公开号CN101007174-A
8. 含有肉桂酰氧基的环状脂肪族碳酸酯及其聚合物的制备方法,景遐斌、胡秀丽、陈学思、谢志刚、莫国军、黄宇彬、庄秀丽,申请号200710055794.1
9. 可生物降解的两亲性嵌段共聚物-紫杉醇前药及其冻干粉的制备方法,景遐斌、胡秀丽、陈学思、谢志刚、柳时、郑勇辉、黄宇彬,申请号200710055797.5
10. 具有靶向功能的高分子阿霉素键合药纳米胶囊及其制备方法,景遐斌;胡秀丽;吕常海;陈学思;黄宇彬;郑勇辉;柳 时,申请号200810050408.4
11. 高分子键合阿霉素药、其纳米胶囊及制备方法,景遐斌;胡秀丽;吕常海;陈学思;黄宇彬;郑勇辉;柳 时,申请号200810050407.X
12. 脂肪族聚酯-聚氨基酸Y型三臂嵌段共聚物及合成方法,景遐斌;孙 静;陈学思;石 全;谢志刚;黄宇彬,申请号 200710300335.5
13. 环状脂肪族碳酸酯单体、其聚合物及制备方法,景遐斌;胡秀丽;陈学思;谢志刚;黄宇彬;郑勇辉,申请号200710193597.6
14. 一种具有活性表面的聚谷氨酸酯微球及制备方法, 黄宇彬、郭金山、景遐斌、陈学思,申请号200810051584.x
15. 可生物降解的载有血红蛋白的聚肽囊泡及其制备方法,景遐斌、孙静、黄宇彬、石全、陈学思,申请号200810051615.1
16. 一种环酯类化合物聚合催化剂及制备方法和用法,黄宇彬、景遐斌、原宇平、陈学思,申请号200910066800.2

出版信息

   
发表论文
1.      Mao Z, Guo J, Bai S, Nguyan TL, Xia H, Huang Y*, Mulvaney P, Wang D*, Hydrogen-bond-selective phase transfer of nanoparticles across liquid/gel interfaces, Angew. Chem. Int. Ed., 2009, 48, 4953-4956.
2.      Sun J, Huang Y, Shi Q, Chen X, and Jing X, Oxygen carrier based on hemoglobin/poly(L-lysine)-block-poly(L-phenylanaline) vesicles, Langmuir, 2009, DOI: 10.1021/la901194k.
3.      Guo J, Huang Y, Jing X, Chen X, Synthesis and characterization of functional poly (γ-benzyl-L-glutamate) (PBLG) as a hydrophobic precursor, Polymer, 50, 2847-55, 2009.
4.     Horinouchi H, Yamamoto H, Komatsu T, Huang Y, Tsuchida E, Kobayashi K. Enhanced radiation response of a solid tumor with the artificial oxygen carrier albumin-heme, Cancer Sci., 99(6), 1274-8, 2008.
5.      Nakagawa A., Komatsu T, Huang Y, Lu, G, Tsuchida E,  O-2-Binding albumin thin films: solid membranes of poly(ethylene glycol)-conjugated human serum albumin incorporating iron porphyrin, Bioconjugate Chemistry, 18(5), 1673-77, 2007.
6.       Komatsu T; Huang Y; Wakamoto S; Abe H; Fujihara M; Azuma H; Ikeda H; Yamamoto H; Horinouchi H; Kobayashi K; Tsuchida E.  Influence of O(2)-carrying plasma hemoprotein "albumin-heme" on complement system and platelet activation in vitro and physiological responses to exchange transfusion, Journal of Biomedical Materials Research, 81(4), 821-6, 2007.
7.      Komatsu T., Huang Y., Wang RM, Nakagawa A., Yamamoto H., Horinouchi H., Kobayashi K., and Tsuchida E., Poly(ethylene glycol)-conjugated Albumin-heme: Solution properties and functions as O2-carrying plasma expander, Artificial Blood, 14(2), 47-54, 2006.
8.      Huang Y., Komatsu T., Yamamoto H., Horinouchi H., Kobayashi K. and Tsuchida E., PEGylated albumin-heme as an oxygen-carrying plasma expander: exchange transfusion into acute anemia rat model, Biomaterials, 27(25), 4477-83,2006.
9.      Huang Y., Komatsu T., Wang R.-M., Nakagawa A. and Tsuchida E., “Poly(ethyleneglycol) conjugated human serum albumin including iron porphyrins: surface modification improves the O2-transporting ability”, Bioconjugate Chemistry, 17(2), 393-398, 2006.
10. Huang Y, Tsuchida E. “Structure, property and oxygen-binding ability of a polyoxyethylene-modified albumin-heme hybrid”, Biorheology, 42(1-2),145,2005.
11. Huang Y., Komatsu T., Yamamoto H., Horinouchi H., Kobayashi K., Tsuchida E., “Exchange Transfusion with entirely synthetic red cell substitute “albumin-heme” into rats: physiological responses and blood biochemical tests”, Journal of Biomedical Materials Research, 71A, 63-69, 2004.
12. Huang Y., Komatsu T., Yamamoto H., Horinouchi H., Kobayashi K., Tsuchida E., “Safety evaluation of synthetic O2-carrier as a red cell substitute by blood biochemical tests and histopathological observations”, ASAIO J., 50, 525-529, 2004.
13. Huang Y., Komatsu T., and Tsuchida E., “Compatibility of albumin-based O2-carrier (albumin-heme) with blood cell in vitro ”, Journal of Biomedical Materials Research 66A, 292-297, 2003.
14. Huang Y., Komatsu T., and Tsuchida E., “Microcalorimetry investigation of synthetic hemoprotein (albumin-heme)”, Polymers for Advanced Technologies, 14, 729-732, 2003.
15. Huang Y., Takeoka S., Sakai H., Abe H., Hirayama J., Ikebuchi K., and Tsuchida E., “Completely deoxygenation from a hemoglobin solution by an electrochemical method and heat treatment for virus inactivation”, Biotechnology Progress, 18, 101-107, 2002.
16. Huang Y., Komatsu T., and Tsuchida E., “Recent progress on the research of artificial blood”, Chinese Journal of Applied Chemistry, 21(11), 1081-1086, 2004.
17. Huang Y., Takeoka S., and Tsuchida E., “Reduction of oxygen bound with hemoglobin with electrolytic method using hydrogen gas in phosphate-bufferred solution”, Chinese Journal of Applied Chemistry, 19, 307-309, 2002.
18. Komatsu T., Yamamoto H., Huang Y., Horinouchi H., Kobayashi K., Tsuchida E., “Exchange transfusion with synthetic oxygen-carrying plasma protein “albumin-heme” into an acute anemia rat model after seventy-percent hemodilution”, Journal of Biomedical Materials Research, 71A,644-651,2004.
19. Tsuchida E., Sakai H., Komatsu T., Takeoka S., Huang Y., Sou K., Nakagawa A., Teramura Y., Izumi Y., Watanabe M., Horinouchi H., Kobayashi K., “Oxygen infusioins (hemoglobin-vesicles and albumin-hemes) based on nano-molecular sciences”, Polym. Adv. Technol., 16, 73-83, 2005.
20. Tsuchida E, Komatsu T., Wu Y., and Huang Y., “Human serum albumin incorporating synthetic heme: a novel O2-carrying hemoprotein”, Chinese Journal of Applied Chemistry, 18, 316-321, 2001.
21. Huang Y., Gao L., and Ding M., “Polymerization of styrene oxide catalyzed by diethyzinc/-pinene oxide system”, J. Polym. Sci., Part A: Polymer Chem., 37, 4640-4645, 1999.
22. Huang Y., Takeoka S., and Tsuchida E., “Synthesis of polysaccharide-protein”, Chinese Journal of Applied Chemisttry, 16, 109-111,1999.
发表著作
1.      Komatsu T., Huang Y., Horinouchi H., Kobayashi K., and Tsuchida E., “Albumin-heme: A synthetic heme-based oxygen carrier”, in book: Blood Sustitutes, Chapter 46, pp 532-539, Robert M. Winslow (Eds), Academic Press, Elsevier, 2006.
2.      Kobayashi K., Horinouchi H., Watanabe M., Izumi Y., Teramura Y., Nakagawa A., Huang Y., Sou K., Sakai H., Komatsu T., Takeoka S., Tsuchida E., “Safety and efficacy of hemoglobin-vesicles and albumin-hemes”, in book: Artificial Oxygen Carrier-Its Frontline, Keio University International Symposia for Life Sciences and Medicine Vol. 12, pp. 1-21, Kobayashi K., Tsuchida E., Horinouchi Hirohisa (Eds), Elsevier Science (Tokyo, 2005).

科研活动

   
科研项目
  1. 一步法聚乳酸纺丝工艺与技术,科技部国家高技术研究发展计划863专题项目;
    2.   肿瘤细胞特异性靶向高分子纳米胶束的合成与穿膜效应,国家自然科学基金委面上项目
    3.   智能性可生物降解高分子材料的制备与医学应用探索,国家自然科学基金委重点项目;
  4. 键合血红蛋白的可降解纳米胶束,国家自然科学基金委面上项目;
  5. 红血球替代物聚合物/血红蛋白胶束(胶囊),973
纳米专项;
  6. 高性能聚乳酸材料的合成与应用研究,院知识创新工程重要方向、****项目;
  7. 吉林省生物活性功能化材料科技创新中心建设,省科技厅科技基础平台建设 重点项目。
参与会议
1.  Polymer-drug conjugates and their targeting(邀请报告),International Workshop on Biomacromolecules 2008, Stockholm, Sweden, June 1-4, 2008.
2.  Polymer-drug conjugates and their targetingFifth China-Japan-Korea (Asia 3) Foresight Joint Symposium on Gene Therapy, Pohang, Korea, June 11-13, 2008.
3.  PEG-PLA Nano-particles Conjugating with Hemoglobin Molecules as Oxygen-carrier, 第三届国际高分子化学学术讨论会PC2008, Hefei, China, June 15-19, 2008.
4.  可降解纳米胶束键合血红蛋白的研究,中国化学会第26届学术年会,天津,7月13日-16日,2008。
5.  具有生物活性的聚乳酸类医用材料(邀请报告),第二届中国科学院应用化学学术研讨会, Changchun, China, Sep. 23-25, 2008.
6.  Synthesis of biomedical materials using biodegradable copolymers,2nd Sino-German Frontiers of Chemistry Symposium, Beijing, China, Oct.5-8, 2008.
7.  Synthesis of biomedical materials using biodegradable copolymers,The third international symposium on integrated molecular/materials Engineering, Xi-an China, Nov.5-9, 2008.
8.  PEG-PLA Nano-particles Conjugating with Hemoglobin Molecules as Oxygen-carrier(邀请报告),Sixth China-Jpaan-Korea (Asia 3) Foresight Joint Symposium on Gene Therapy, Sanya, China, Nov 26-29, 2008.
9.  Albumin-Heme: Completely Synthetic Red Blood Cell Substitute(邀请报告),Third China-Jpaan-Korea (Asia 3) Foresight Joint Symposium on Gene Therapy, Daejeon, Korea, May 7-9, 2007.
 10.  高分子键合药与高分子药物学(邀请报告),高分子科学青年学者研讨会,上海,8月5日-8日,2007。
 11. Biodegradable polymer with bioactive units as the biomedical material(邀请报告), 2007 China-Korea Bilateral Symposium on Polymer Materials, Dalian, China, August 9-11, 2007.
 12.  壳聚糖-白蛋白pH敏感型水凝胶的合成和性能研究,2007年全国高分子学术论文报告会,成都,10月9日-13日,2007。
 13. Poly(ethyleneglycol)-modified albumin-heme hybrid-Structure, property and oxygen-binding ability,11th International Symposium for Blood Substitutes, Beijing, China, Oct.18th-21st, 2007.
 14. Synthesis of biomedical materials using biodegradable polymers bound with bioactive units,9th International Symposium Polymers for Advanced Technologies, Shanghai, China, Oct.22nd-25th, 2007.
 15. Albumin-Heme: Completely Synthetic Red Blood Cell Substitute(邀请报告),Third China-Jpaan-Korea (Asia 3) Foresight Joint Symposium on Gene Therapy, Tokyo, Japan, Dec 5-9, 2007

指导学生

郭金山  博士研究生  070305-高分子化学与物理  80037-长春应用化学研究所

吴苏红  硕士研究生  070305-高分子化学与物理  80037-长春应用化学研究所

陈高  硕士研究生  070305-高分子化学与物理  80037-长春应用化学研究所

周东方  硕士研究生  070305-高分子化学与物理  80037-长春应用化学研究所

王亮燕  硕士研究生  070305-高分子化学与物理  80037-长春应用化学研究所

李太行  博士研究生  070305-高分子化学与物理  80037-长春应用化学研究所

魏英  博士研究生  070305-高分子化学与物理  80037-长春应用化学研究所

邝慧慧  硕士研究生  070305-高分子化学与物理  80037-长春应用化学研究所