General

Hongchang Li, is a senior principal investigator at the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, graduated from Beijing Normal University with bachelor degree in 1999, obtained a PhD degree from Institute of Genetics and Developmental Biology Chinese Academy of Sciences in 2006, worked as a postdoctoral fellow at Purdue University between 2006 and 2010. Dr. Li has developed strong expertise in genetics, molecular biology, cell biology and biochemistry and made great contribution to research in cell cycle control and asymmetric cell division. Currently, he is focused on discovery of carcinogenesis mechanisms using cell biological and biochemistry technologies. The research field includes cancer signaling pathways and cell division control. The long-term goal is to discover and develop novel antitumor drugs. 

部门/实验室:医药所

Research Areas

cancer signaling pathways,cell cycle control,endocytic trafficking, chemical biology


Education

1995-1999  Beijing Normal University, Bachelor

1999-2006  Institutes of Genetics and Developmental Biology, CAS, Ph.D

Experience

   
Work Experience

2006-2010, Biochemistry Department, Purdue University, USA, Postdoc 

2010-2011, Sichuan University, Professor

2011-      Shenzhen Institutes of Advanced Technology, CAS

Teaching Experience

Experiment in Biochemistry

Progression in Chemical Biology

Publications

1) Haishan Zhang Ximing ShaoYin PengYanning TengKonda Mani SaravananHuiling ZhangHongchang LiYanjie Wei.(2019) A novel machine learning based approach for iPS progenitor cell identification, Plos Comput Biol, 15 (12), e1007351 

 

2) Ke Liu, Lijing Fang, Haiyan Sun, Zhengyin Pan, Jianchao Zhang, Juntao Chen, Ximing Shao, Wei Wang, Yuanyan Tan, Zhihao Ding, Lijiao Ao, Chunlei, Wu, Xiaoqi Liu, Huashun Li, Rui Wang, Wu Su1, and Hongchang Li* (2018)Targeting Polo-like Kinase 1 by a Novel Pyrrole-imidazole Polyamide-Hoechst Conjugate Suppresses Tumor Growth in vivo­. Mol Cancer Ther.17(5) 988-1002 

3Ximing Shao, Zhihao Ding, Ming Zhao, Ke Liu, Haiyan Sun, Juntao Chen, Xianming Liu, Yuzhen Zhang, Yang Hong, Huashun Li* & Hongchang Li*. (2017) Mammalian Numb protein antagonizes Notch by controlling postendocytic trafficking of the Notch ligand Delta-like 4. J Biol Chem.  2017 Dec 15;292(50):20628-20643

4)Haiyan Sun, Yi Liu, Lei Zhang, Ximing Shao, Ke Liu, Zhihao Ding, Xianming Liu, Changan Jiang , Huashun Li, Hongchang Li. (2017) Numb positively regulates autophagic flux via regulating lysosomal Function. Biochem Biophys Res Commun. 2017 Sep 23;491(3):780-786.

5)Zhenyin Pan, Chunlei Wu, Wei Wang, Zhehong ChengKe Liu, Hongchang Li, Lijin Fang, Wu Su. (2017)Total Synthesis and Stereochemical Assignment of Gymnopeptides A and B. Org Lett. 2017 Sep 1;19(17):4420-4423.

6).Wenyu Qian, Yang Hong, Minyan Zhu, Liang Zhou, Hongchang Li, Huashun Li. (2017)  Deletion of Numb/Numblike in glutamatergic neurons leads to anxiety-like behavior in mice. Brain Research 1665 (2017) 36–49

7Jianchao Zhang, Ximing Shao, Haiyan Sun, Ke Liu, Zhihao Ding, Juntao Chen, Lijing Fang, Wu Su, Yang Hong, Huashun Li* and Hongchang Li*. (2016) NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling. Oncotarget, 2016, 2016, , 7(38):61036-53  

8Run Lei , Ke Zhang , Ke Liu, Ximing Shao, Zhihao Ding, Fudi Wang, Yang Hong, Minyan Zhu, Hongchang Li,* and Huashun Li*. (2016) Transferrin Receptor Facilitates TGF- and BMP Signaling Activation to Control Craniofacial Morphogenesis. Cell death and Disease, 2016, Jun 30;7(6):e2282

9Ximing Shao, Yi Liu, Qian Yu, Zhihao Ding, Wenyu Qian, Lei Zhang, Jianchao Zhang, Nan Jiang, Linfei Gui, Zhiheng Xu, Yang Hong, Yifan Ma, Yanjie Wei, Xiaoqing Liu, Changan Jiang, Minyan Zhu, Hongchang Li* & Huashun Li*. (2016) Numb Regulates Vesicular Docking for Homotypic Fusion of Early Endosomes via Membrane Recruitment of Mon1b. Cell Research, 26(5):593-612

 

10Run Lei, Ke Zhang,Yanxia Wei,Min Chen,LeeS.Weinstein,Yang Hong, Minyan Zhu, Hongchang Li*,Huashun Li*. (2016) G-Protein α-Subunit Gsα Is Required for Craniofacial Morphogenesis. PLoS ONE  9;11(2):e0147535

 

11Ke Liu, Run Lei, Qiong Li, Xin-Xin Wang, Qian Wu, Peng An, Jianchao Zhang, Minyan Zhu, Zhiheng Xu, Yang Hong, Fudi Wang, Ying Shen, Hongchang Li,* & Huashun Li*. (2016) Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity.  Scientific Reports 16;6:21019.

 

12Ximing Shao, Ke Liu, Yi Fan, Zhihao Ding, Min Chen, Minyan Zhu, Lee S Weinstein, Hongchang Li*, Huashun Li*. (2015) Gαs Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize VE-cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity. Journal of genetics and Genomics, 4211):613-624

 

13Ke Liu, Quan Lin, Yanxia Wei, Renbing He, Ximing Shao, Zhihao Ding, Jianchao Zhang, Minyan Zhu, Lee S. Weinstein, Yang Hong, Hongchang Li *, Huashun Li*. (2015) Gas regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression. Neuroscience Letters 597 97103

 

14Hongchang Li, Shawn Liu, Xiaoming Yang, Yun Wang, Bing Song, and Xiaoqi Liu. (2010) Plk1 phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase. Proc Natl Acad Sci USA. 107 (33), 14633-14638.(Featured in faculty of 1000,  http://f1000.com/prime/4916968; Incorporated in the book, Intracellular Membranes: Advances in Research and application:2011 Edition Scholarly Brief, 59-60)

 

15Hongchang Li, Shawn Liu, Xiaoming Yang, Yingmin Wang, Yun Wang, Jerrold R. Turner, and Xiaoqi Liu. (2010) Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore-microtubule attachments. Embo J. 29, 2953-2965.

 

16Xiaoming Yang*, Hongchang Li*, X.Shawn Liu, Anping Deng, and Xiaoqi Liu. (2009) CDC2-mediated phosphorylation of CLIP-170 is essential for its inhibition of centrosome reduplication. J. Biol. Chem. 284, 28775-28782 (*, contributed equally)

 

17Hongchang Li, Yun Wang, and Xiaoqi Liu. (2008) Plk1-dependent phosphorylation regulates functions of DNA Topoisomerase IIa in cell cycle progression. J. Biol. Chem. 283, 6209-6221 


Research Interests

Molecular mechanisms of carcinogenesis and tumor drug development 

Students

已指导学生

孙海燕  博士研究生  071010-生物化学与分子生物学  

现指导学生

李梅青  博士研究生  071010-生物化学与分子生物学  

李艳艳  博士研究生  071010-生物化学与分子生物学  

张海山  硕士研究生  085211-计算机技术  

Honors & Distinctions

Selected as “Shenzhen Peacock Plan Talents” in 2012