白血病的基因组学和表观遗传学

   

0710Z1-基因组学

血液肿瘤基因组学与生物信息学

2004-09--2009-06   中国科学院北京基因组研究所（国家生物信息中心）   研究生，博士学位
2000-09--2004-06   安徽大学   本科，学士学位

研究生学历

理学博士学位

   

2015-01~现在, 中国科学院北京基因组研究所（国家生物信息中心）, 副研究员
2009-07~2014-12,中国科学院北京基因组研究所, 助理研究员

2019-01-01-2019-12-31,国际实验血液学会（ISEH）, 会员
2017-07-01-今,中国抗癌协会肿瘤标志专业委员会, 会员
2015-12-31-2027-12-31,中国研究型医院学会血液病精准诊疗专业委员会, 委员
2015-01-01-2018-12-31,中国科学院青年创新促进会, 会员
2014-12-31-2026-12-31,中国生理学会血液学专业委员会, 会员

基因组信息系统与实践

   

（1） 中国科学院青年创新促进会会员, 院级, 2015

[1] 胡绍燕, 王前飞, 和夫红, 江姝婷, 张永平. CD69用于白血病耐药性诊断及预后的用途. 202310361808.1, 2023-04-06.

   

[1] Yang Xuejing, Lu Yedan, He Fuhong, Hou Fenxia, Xing Caihong, Xu Peiyu, Wang QianFei. Benzene metabolite hydroquinone promotes DNA homologous recombination repair via the NF-κB pathway.. CARCINOGENESIS. 2019, [2] Hu Yixin, Aili Chen, Zheng Xinchang, Lu Jun, He Hailong, Yang Jin, Zhang Ya, Sui Pinpin, Yang Jingyi, He Fuhong, Wang Yi, Xiao Peifang, Liu Xin, Zhou Yinmei, Pei Deqing, Cheng Cheng, Ribeiro Raul C, Hu Shaoyan, Wang Qianfei. Ecological principle meets cancer treatment: treating children with acute myeloid leukemia with low-dose chemotherapy. NATIONAL SCIENCE REVIEW[J]. 2019, 6(3): 469-479, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6579868&detailType=1.
[3] Bu, J, Chen, A, Yan, X, He, F, Dong, Y, Zhou, Y, He, J, Zhan, D, Lin, P, Hayashi, Y, Sun, Y, Zhang, Y, Xiao, Z, Grimes, H L, Wang, Q F, Huang, G. SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia. LEUKEMIA[J]. 2018, 32(4): 890-899, https://www.webofscience.com/wos/woscc/full-record/WOS:000429129100005.
[4] Zhang, Yingchi, Gao, Yufeng, Zhang, Hui, Zhang, Jingliao, He, Fuhong, Hnizda, Ales, Qian, Maoxiang, Liu, Xiaoming, Gocho, Yoshihiro, Pui, ChingHon, Cheng, Tao, Wang, Qianfei, Yang, Jun J, Zhu, Xiaofan, Liu, Xin. PDGFRB mutation and tyrosine kinase inhibitor resistance in Ph-like acute lymphoblastic leukemia. BLOOD[J]. 2018, 131(20): 2256-2261, http://dx.doi.org/10.1182/blood-2017-11-817510.
[5] 和夫红. Chromatin regulator Asxl1 loss and Nf1 halpoinsufficiency cooperate to accelerate myeloid malignancy. Journal of Clinical Investigation. 2018, [6] Jianping Li, Fuhong He, Peng Zhang, Shi Chen, Hui Shi, Yanling Sun, Ying Guo, Hui Yang, Na Man, Sarah Greenblatt, Zhaomin Li, Zhengyu Guo, Yuan Zhou, Lan Wang, Lluis Morey, Sion Williams, Xi Chen, QunTian Wang, Stephen D Nimer, Peng Yu, QianFei Wang, Mingjiang Xu, FengChun Yang. Loss of Asxl2 leads to myeloid malignancies in mice. NATURE COMMUNICATIONS[J]. 2017, 8(1): https://doaj.org/article/d8d0621e6a8f4b58bd9d7e748569e036.
[7] Zhang, Peng, Xing, Caihong, Rhodes, Steven D, He, Yongzheng, Deng, Kai, Li, Zhaomin, He, Fuhong, Zhu, Caiying, Lihn Nguyen, Zhou, Yuan, Chen, Shi, Mohammad, Khalid S, Guise, Theresa A, AbdelWahab, Omar, Xu, Mingjiang, Wang, QianFei, Yang, FengChun. Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cells, Leading to Bohring-Opitz-like Syndrome in Mice. STEM CELL REPORTS[J]. 2016, 6(6): 914-925, http://dx.doi.org/10.1016/j.stemcr.2016.04.013.
[8] 杨雪静, 和夫红, 黄伊子, 闫进, 王前飞. 组蛋白去甲基化酶LSD1抑制剂对MLL-ENL白血病细胞诱导分化的研究. 发育医学电子杂志[J]. 2015, 91-95, http://lib.cqvip.com/Qikan/Article/Detail?id=70898968504849534850484857.
[9] Wang, Qf, Li, Yj, Dong, Jf, Li, B, Kaberlein, J J, Zhang, L, Arimura, F E, Luo, R T, Ni, J, He, F, Wu, J, Mattison, R, Zhou, J, Wang, Cz, Prabhakar, S, Nobrega, M A, Thirman, M J. Regulation of MEIS1 by distal enhancer elements in acute leukemia. LEUKEMIA[J]. 2014, 28(1): 138-146, https://www.webofscience.com/wos/woscc/full-record/WOS:000329441200014.
[10] Hua, Chunlan, Guo, Huidong, Bu, Jiachen, Zhou, Mi, Cheng, Hui, He, Fuhong, Wang, Jinhong, Wang, Xiaomin, Zhang, Yinehi, Wang, Qianfei, Zhou, Jianfeng, Cheng, Tao, Xu, Mingjiang, Yuan, Weiping. Rictor/mammalian target of rapamycin 2 regulates the development of notch1 induced murine T-cell acute lymphoblastic leukemia via forkhead box O3. EXPERIMENTAL HEMATOLOGY[J]. 2014, 42(12): 1031-1040, http://dx.doi.org/10.1016/j.exphem.2014.08.006.
[11] Zhou, J, Wu, J, Li, B, Liu, D, Yu, J, Yan, X, Zheng, S, Wang, J, Zhang, L, Zhang, L, He, F, Li, Q, Chen, A, Zhang, Y, Zhao, X, Guan, Y, Zhao, X, Yan, J, Ni, J, Nobrega, M A, Loewenberg, B, Delwel, R, Valk, P J M, Kumar, A, Xie, L, Tenen, D G, Huang, G, Wang, Qf. PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway. LEUKEMIA[J]. 2014, 28(7): 1436-1448, https://www.webofscience.com/wos/woscc/full-record/WOS:000339705500008.
[12] Zhu, Xiaofan, He, Fuhong, Zeng, Huimin, Ling, Shaoping, Chen, Aili, Wang, Yaqin, Yan, Xiaomei, Wei, Wei, Pang, Yakun, Cheng, Hui, Hua, Chunlan, Zhang, Yue, Yang, Xuejing, Lu, Xin, Cao, Lihua, Hao, Lingtong, Dong, Lili, Zou, Wei, Wu, Jun, Li, Xia, Zheng, Si, Yan, Jin, Zhou, Jing, Zhang, Lixia, Mi, Shuangli, Wang, Xiaojuan, Zhang, Li, Zou, Yao, Chen, Yumei, Geng, Zhe, Wang, Jianmin, Zhou, Jianfeng, Liu, Xin, Wang, Jianxiang, Yuan, Weiping, Huang, Gang, Cheng, Tao, Wang, Qianfei. Identification of functional cooperative mutations of SETD2 in human acute leukemia. NATURE GENETICS[J]. 2014, 46(3): 287-+, http://dx.doi.org/10.1038/ng.2894.
[13] 和夫红. Downregulation of RUNX1/CBFb by MLL fusion proteins enhances hematopoietic stem cell self-renewal. Blood. 2014, [14] Liu, Y, Cheng, H, Gao, S, Lu, X, He, F, Hu, L, Hou, D, Zou, Z, Li, Y, Zhang, H, Xu, J, Kang, L, Wang, Q, Yuan, W, Gao, S, Cheng, T. Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells. LEUKEMIA[J]. 2014, 28(5): 1071-1080, http://dx.doi.org/10.1038/leu.2013.304.
[15] Wu, Gang, Zhu, Jiang, He, Fuhong, Wang, Weiwei, Hu, Songnian, Yu, Jun. Gene and Genome Parameters of Mammalian Liver Circadian Genes (LCGs). PLOS ONE[J]. 2012, 7(10): https://doaj.org/article/59c334508f3f47deb5c33ac9d487cc77.
[16] Wang, Qianfei, Wu, George, Mi, Shuangli, He, Fuhong, Wu, Jun, Dong, Jingfang, Luo, Roger T, Mattison, Ryan, Kaberlein, Joseph J, Prabhakar, Shyam, Ji, Hongkai, Thirman, Michael J. MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome. BLOOD[J]. 2011, 117(25): 6895-6905, https://www.webofscience.com/wos/woscc/full-record/WOS:000291979800021.
[17] Jiang Zhu, Fuhong He, Dapeng Wang, Kan Liu, Dawei Huang, Jingfa Xiao, Jiayan Wu, Songnian Hu, Jun Yu. A Novel Role for Minimal Introns: Routing mRNAs to the Cytosol. PLOS ONE[J]. 2010, 5(4): http://dx.doi.org/10.1371/journal.pone.0010144.
[18] Dapeng Wang, Song Zhang, Fuhong He, Jiang Zhu, Songnian Hu, Jun Yu. How Do Variable Substitution Rates Influence Ka and Ks Calculations?. GENOMICS, PROTEOMICS & BIOINFORMATICS[J]. 2009, 7(3): 116-127, http://lib.cqvip.com/Qikan/Article/Detail?id=32263111.
[19] Zhu, Jiang, He, Fuhong, Hu, Songnian, Yu, Jun. On the nature of human housekeeping genes. TRENDS IN GENETICS[J]. 2008, 24(10): 481-484, http://www.corc.org.cn/handle/1471x/2385100.
[20] Zhu, Jiang, He, Fuhong, Song, Shuhui, Wang, Jing, Yu, Jun. How many human genes can be defined as housekeeping with current expression data?. BMC GENOMICS[J]. 2008, 9(1): 172-172, http://www.corc.org.cn/handle/1471x/2392855.
[21] Zhu, Jiang, He, Fuhong, Wang, Jing, Yu, Jun. Modeling Transcriptome Based on Transcript-Sampling Data. PLOS ONE[J]. 2008, 3(2): http://www.corc.org.cn/handle/1471x/2384448.

（1） 转录组学与精准医学, 转录组学与精准医学, 上海交通大学出版社, 2017-12, 第 5 作者

   

（ 1 ） CD19/CD22双靶点CART免疫治疗下B细胞肿瘤复发的机制研究, 主持, 国家级, 2020-01--2023-12
（ 2 ） 大规模中国人群多组学数据库体系研发与建设, 参与, 部委级, 2020-01--2024-12
（ 3 ） 儿童急性髓系白血病化疗耐药的新靶点与血浆分子标记物研究, 参与, 省级, 2017-07--2020-06
（ 4 ） 组蛋白去甲基化酶LSD1的抑制剂通过调节转录因子治疗MLL白血病的研究, 主持, 国家级, 2015-01--2018-12
（ 5 ） 中国科学院青年创新促进会会员, 主持, 部委级, 2015-01--2018-12
（ 6 ） 肿瘤异质性的基因组和表观遗传机制, 参与, 国家级, 2014-01--2018-08
（ 7 ） 儿童白血病化疗耐药基因突变和新靶标SETD2的功能研究, 参与, 部委级, 2016-01--2017-12
（ 8 ） 药物干预下选择肿瘤细胞增殖的基因组变异与进化规律, 参与, 国家级, 2014-01--2016-12
（ 9 ） 转录因子AML1特异性募集组蛋白修饰酶MLL在白血病发病机制中的作用, 主持, 国家级, 2011-01--2013-12
（ 10 ） 转录因子PU.1调控造血干细胞向粒系和淋巴系前体细胞定向分化的机制研究, 主持, 部委级, 2009-09--2011-08