基本信息
胡晗华  男  博导  中国科学院水生生物研究所
电子邮件: hanhuahu@ihb.ac.cn
通信地址: 武汉市武昌区东湖南路7号
邮政编码: 430072

招生信息

   
招生专业
071004-水生生物学
招生方向
藻类学,硅藻生物学

教育背景

1996-09--2001-07   中国科学院水生生物研究所   理学博士
学历
-- 研究生
学位
-- 博士

工作经历

   
工作简历
2008-01~2010-01,巴黎高师(école normale supérieure, Paris), 访问学者/博士后
2004-04~现在, 中国科学院水生生物研究所, 副研究员/研究员
2002-01~2004-03,中国科学院过程工程研究所, 博士后
2001-08~2004-02,厦门大学, 讲师

专利与奖励

   
专利成果
( 1 ) 一种可提高微藻缩醛磷脂含量的方法及RNA干扰片段, 发明专利, 2021, 第 1 作者, 专利号: CN112280685A

( 2 ) 含有支链氨基酸的培养基及其在培养三角褐指藻中的应用, 发明专利, 2020, 第 1 作者, 专利号: CN110819536B

( 3 ) 塔玛亚历山大藻的高密度培养方法, 发明专利, 2006, 第 1 作者, 专利号: CN1724636A

出版信息

   
发表论文
(1) Zeaxanthin epoxidase is involved in the carotenoid biosynthesis and light-dependent growth of the marine alga Nannochloropsis oceanica, BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS, 2023, 第 4 作者
(2) CRISPR/Cas9-Mediated Genome Editing via Homologous Recombination in a Centric Diatom Chaetoceros muelleri, ACS SYNTHETIC BIOLOGY, 2023, 通讯作者
(3) NmrA acts as a positive regulator of nitrate assimilation in Phaeodactylum tricornutum, ALGAL RESEARCH, 2023, 通讯作者
(4) Pyruvate orthophosphate dikinase is required for the acclimation to high bicarbonate concentrations in Phaeodactylum tricornutum, ALGAL RESEARCH, 2023, 通讯作者
(5) Editorial: Metabolic Regulation of Diatoms and Other Chromalveolates, FRONTIERS IN PLANT SCIENCE, 2022, 第 2 作者
(6) CGI-58 Protein Acts as a Positive Regulator of Triacylglycerol Accumulation in Phaeodactylum tricornutum, JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2022, 通讯作者
(7) The Transition Toward Nitrogen Deprivation in Diatoms Requires Chloroplast Stand-By and Deep Metabolic Reshuffling, FRONTIERS IN PLANT SCIENCE, 2022, 第 5 作者
(8) Multiplexed CRISPR/Cas9 editing of the long-chain acyl-CoA synthetase family in the diatom Phaeodactylum tricornutum reveals that mitochondrial ptACSL3 is involved in the synthesis of storage lipids, NEW PHYTOLOGIST, 2022, 第 7 作者
(9) PDAT regulates PE as transient carbon sink alternative to triacylglycerol in Nannochloropsis, PLANT PHYSIOLOGY, 2022, 通讯作者
(10) Metabolic engineering of the oleaginous alga Nannochloropsis for enriching eicosapentaenoic acid in triacylglycerol by combined pulling and pushing strategies, METABOLIC ENGINEERING, 2022, 第 5 作者
(11) Impaired photoprotection in Phaeodactylum tricornutum KEA3 mutants reveals the proton regulatory circuit of diatoms light acclimation, NEW PHYTOLOGIST, 2022, 其他(合作组作者)
(12) Lipid production is more than doubled by manipulating a diacylglycerol acyltransferase in algae, GLOBAL CHANGE BIOLOGY BIOENERGY, 2021, 第 4 作者
(13) High-efficiency transformation of a centric diatom Chaetoceros muelleri by electroporation with a variety of selectable markers, ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, 2021, 通讯作者
(14) ∆6 fatty acid elongase is involved in eicosapentaenoic acid biosynthesis via the ω6 pathway in the marine alga Nannochloropsis oceanica, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2021, 第 4 作者
(15) A genomics approach reveals the global genetic polymorphism, structure, and functional diversity of ten accessions of the marine model diatom Phaeodactylum tricornutum, THE ISME JOURNAL, 2020, 通讯作者
(16) Amino Acid Catabolism During Nitrogen Limitation in Phaeodactylum tricornutum, FRONTIERS IN PLANT SCIENCE, 2020, 通讯作者
(17) Screening of High Temperature-Tolerant Oleaginous Diatoms, JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2020, 通讯作者
(18) Screening High CO2-Tolerant Oleaginous Microalgae from Genera Desmodesmus and Scenedesmus, APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2020, 通讯作者
(19) High efficiency transformation by electroporation of the freshwater alga Nannochloropsis limnetica, WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2019, 通讯作者
(20) Knockdown of carbonate anhydrase elevates Nannochloropsis productivity at high CO2 level, METABOLIC ENGINEERING, 2019, 第 8 作者
(21) Acetylome Profiling Reveals Extensive Lysine Acetylation of the Fatty Acid Metabolism Pathway in the Diatom Phaeodactylum tricornutum, MOLECULAR & CELLULAR PROTEOMICS, 2018, 第 4 作者
(22) Enhanced triacylglycerol production in the diatom Phaeodactylum tricornutum by inactivation of a Hotdog-fold thioesterase gene using TALEN-based targeted mutagenesis, BIOTECHNOLOGY FOR BIOFUELS, 2018, 第 6 作者
(23) 湖泊微拟球藻高含油突变株的构建及筛选, CONSTRUCTION OF OIL-RICH MUTANTS IN NANNOCHLOROPSIS LIMNETICA, 水生生物学报, 2018, 通讯作者
(24) Identification of the triacylglycerol lipase in the chloroplast envelope of the diatom Phaeodactylum tricornutum, ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, 2018, 通讯作者
(25) Producing Designer Oils in Industrial Microalgae by Rational Modulation of Co-evolving Type-2 Diacylglycerol Acyltransferases, MOLECULAR PLANT, 2017, 第 9 作者
(26) The peculiar carbon metabolism in diatoms, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2017, 通讯作者
(27) RNAi-based targeted gene knockdown in the model oleaginous microalgae Nannochloropsis oceanica, PLANT JOURNAL, 2017, 通讯作者
(28) A type-I diacylglycerol acyltransferase modulates triacylglycerol biosynthesis and fatty acid composition in the oleaginous microalga, Nannochloropsis oceanica, BIOTECHNOLOGY FOR BIOFUELS, 2017, 第 5 作者
(29) 3-Hydroxyisobutyryl-CoA hydrolase involved in isoleucine catabolism regulates triacylglycerol accumulation in Phaeodactylum tricornutum, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2017, 通讯作者
(30) Knockdown of phosphoenolpyruvate carboxykinase increases carbon flux to lipid synthesis in Phaeodactylum tricornutum, ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, 2016, 通讯作者
(31) 不同氮源及CO2浓度下湖泊微拟球藻的生长及产油特性分析, EFFECTS OF NITROGEN SOURCES AND CO2 LEVELS ON THE GROWTH AND OIL ACCUMULATION IN NANNOCHLOROPSIS LIMNETICA, 水生生物学报, 2015, 通讯作者
(32) 微藻高CO_2耐受机制及其在生物减碳领域的应用, High-CO_2 tolerance mechanisms in microalgae and application to biomitigation, 哈尔滨工业大学学报, 2015, 通讯作者
(33) High-efficiency nuclear transformation of the diatom Phaeodactylum tricornutum by electroporation, MARINE GENOMICS, 2014, 通讯作者
(34) Metabolic engineering of microorganisms to produce omega-3 very long-chain polyunsaturated fatty acids, PROGRESS IN LIPID RESEARCH, 2014, 第 5 作者
(35) Methylcrotonyl-CoA Carboxylase Regulates Triacylglycerol Accumulation in the Model Diatom Phaeodactylum tricornutum, PLANT CELL, 2014, 通讯作者
(36) 海洋富油微拟球藻 Nannochloropsis gaditana CCAP849/5的转化及外源基因整合方式, Transformation of marine oleaginous alga Nannochloropsis gaditana CCAP849/5 and heterologous gene integration, 热带海洋学报, 2014, 第 2 作者
(37) 异味物质β-环柠檬醛降解菌的分离和鉴定, ISOLATION AND IDENTIFICATION OFβ-CYCLOCITRAL DEGRADING BACTERIA, 水生生物学报, 2014, 第 4 作者
(38) Effect of silicate and inorganic carbon availability on the growth and competition of a diatom and two red tide dinoflagellates, PHYCOLOGIA, 2014, 通讯作者
(39) High-efficiency nuclear transformation of the oleaginous marine Nannochloropsis species using PCR product, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2014, 通讯作者
(40) 微拟球藻属对盐度的耐受及其产油特性分析, STUDY ON THE SALINITY TOLERANCE AND OIL ACCUMULATION IN NANNOCHLOROPSIS, 水生生物学报, 2013, 通讯作者
(41) Role of two phosphohexomutase genes in glycogen synthesis in Synechocystis sp PCC6803, CHINESE SCIENCE BULLETIN, 2013, 第 2 作者
(42) Screening high oleaginous Chlorella strains from different climate zones, BIORESOURCE TECHNOLOGY, 2013, 通讯作者
(43) 利用蓝藻生物报告体检测水体中可利用铁的研究, IRON-DEPENDENT CYANOBACTERIAL BIOREPORTER FOR MEASURING FE BIOAVAILABILITY IN FRESHWATER ENVIRONMENTS, 水生生物学报, 2012, 通讯作者
(44) 高产油小球藻的筛选及其油脂分析, SCREENING AND LIPID ANALYSES OF HIGH OLEAGINOUS CHLORELLA SPECIES, 水生生物学报, 2012, 通讯作者
(45) A high sensitivity iron-dependent bioreporter used to measure iron bioavailability in freshwaters, FEMS MICROBIOLOGY LETTERS, 2012, 通讯作者
(46) Temperature responses of growth, photosynthesis, fatty acid and nitrate reductase in Antarctic and temperate Stichococcus, EXTREMOPHILES, 2012, 通讯作者
(47) Scenedesmus sp NJ-1 isolated from Antarctica: a suitable renewable lipid source for biodiesel production, World Journal of Microbiology & Biotechnology, 2012, 通讯作者
(48) Microalgae as platforms for production of recombinant proteins and valuable compounds: progress and prospects (Review), JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2011, 第 2 作者
(49) Evolution and metabolic significance of the urea cycle in photosynthetic diatoms, NATURE, 2011, 第 9 作者
(50) Competition of bloom-forming marine phytoplankton at low nutrient concentrations, JOURNAL OF ENVIRONMENTAL SCIENCES, 2011, 通讯作者
(51) 氯化铁和聚丙烯酰胺絮凝剂WT652对三角褐指藻的絮凝作用, FLOCCULATION OF PHAEDACTYLUM TRICORNUTUM INDUCED BY FERRIC CHLORIDE AND POLYACRYLAMIDE FLOCCULANT WT652, 水生生物学报, 2010, 第 2 作者
(52) Regulation of inorganic carbon acquisition by nitrogen and phosphorus levels in the Nannochloropsis sp., WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2010, 通讯作者
(53) 产蜡酯聚球藻PCC7002的构建, SYNECHOCOCCUS SP. PCC7002 ENGINEERED FOR WAX ESTER PRODUCTION, 水生生物学报, 2010, 通讯作者
(54) 利用抑制差减杂交技术分离三角褐指藻在缺氮条件下上调表达的基因, Separation of the up-regulated genes under nitrogen starvation from Phaeodactylum tricornutum by suppression subtractive hybridization technology, 遗传, 2009, 通讯作者
(55) Enhanced expression of antifreeze protein genes drives the development of freeze tolerance in an Antarctica isolate of Chlorella vulgaris, PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL, 2009, 第 4 作者
(56) Potential impact of stress activated retrotransposons on genome evolution in a marine diatom, BMC GENOMICS, 2009, 第 4 作者
(57) Impacts of CO2 enrichment on growth and photosynthesis in freshwater and marine diatoms, CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2008, 通讯作者
(58) Alternative cold response modes in Chlorella (Chlorophyta, Trebouxiophyceae) from Antarctica, PHYCOLOGIA, 2008, 通讯作者
(59) Nitrite utilization by Chaetoceros muelleri under elevated CO2 concentration, WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2008, 通讯作者
(60) Hydrodynamics in an expanded bed of large size ion-exchange resin, and natural product adsorption, JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 2007, 第 3 作者
(61) Analysis of steric mass-action model for protein adsorption equilibrium onto porous anion-exchange adsorbent, CHEMICAL ENGINEERING SCIENCE, 2006, 第 2 作者
(62) Fe^3+对铜绿微囊藻生长和光合作用的影响, Effects of Fe^3+ on growth and photosynthesis of microcystis aeruginosa, 北京化工大学学报:自然科学版, 2006, 第 4 作者
(63) Nitrate and phosphate supplementation to increase toxin production by the marine dinoflagellate Alexandrium tamarense, MARINE POLLUTION BULLETIN, 2006, 通讯作者
(64) CO2对微拟球藻(Nannochloropsis sp.)利用有机碳和光合作用的影响, Effects of CO2 on the Organic Carbon Utilization and Photosynthesis of Nannochloropsis sp., 植物生理学通讯, 2006, 通讯作者
(65) Improvement in growth and toxin production of Alexandrium tamarense by two-step culture method, JOURNAL OF APPLIED PHYCOLOGY, 2006, 通讯作者
(66) Response of growth and fatty acid compositions of Nannochloropsis sp to environmental factors under elevated CO2 concentration, BIOTECHNOLOGY LETTERS, 2006, 通讯作者
(67) Photosynthetic inorganic carbon utilization of gametophytes and sporophytes of Undaria pinnatifida (Phaeophyceae), PHYCOLOGIA, 2006, 通讯作者
(68) 铜绿微囊藻生物钟蛋白KaiA的自身相互作用研究, SELF-INTERACTION OF CIRCADIAN CLOCK PROTEIN KAIA OF MICROCYSTIS AERUGINOSA IN YEAST TWO HYBRIDIZATION SYSTEM, 水生生物学报, 2005, 第 5 作者
(69) Growth promotion of vegetative gametophytes of Undaria pinnatifida by blue light, BIOTECHNOLOGY LETTERS, 2005, 第 3 作者
(70) Positive effects of continuous low nitrate levels on growth and photosynthesis of Alexandrium tamarense (Gonyaulacales, Dinophyceae), PHYCOLOGICAL RESEARCH, 2005, 通讯作者
(71) Fe^3+对浮游颤藻生长和光合作用的影响, 水生生物学报, 2005, 通讯作者
(72) 通过氮浓度调节塔玛亚历山大藻毒素产量的初步研究, A Preliminary Study of Improvement in Toxin Production of Alexandrium tamarense by Regulation of Nitrate Concentrations, 过程工程学报, 2005, 第 1 作者
(73) 通气量和CO_2对Nannochloropsis sp.在光生物反应器中的生长和EPA合成的影响, 过程工程学报, 2004, 第 2 作者
(74) Growth characteristics and eicosapentaenoic acid production by Nannochloropsis sp in mixotrophic conditions, BIOTECHNOLOGY LETTERS, 2004, 第 2 作者
(75) 不同氮磷水平下微小原甲藻对营养盐的吸收及光合特性, 过程工程学报, 2004, 通讯作者
(76) Improved use of organic phosphate by Skeletonema costatum through regulation of Zn2+ concentrations, BIOTECHNOLOGY LETTERS, 2004, 通讯作者
(77) 不同氮磷水平下中肋骨条藻对营养盐的吸收及光合特性, 应用与环境生物学报, 2004, 第 1 作者
(78) 塔玛亚历山大藻对氮和磷的吸收及其生长特性, 应用生态学报, 2003, 通讯作者
(79) 有机碳源对产EPA微藻(Nannochloropsis sp.)生长及光合作用的影响, 过程工程学报, 2003, 第 2 作者
(80) Growth and photosynthesis limitation of marine red tide alga Skeletonema costatum by low concentrations of Zn2+, BIOTECHNOLOGY LETTERS, 2003, 通讯作者
(81) Optimization of growth and fatty acid composition of a unicellular marine picoplankton, Nannochloropsis sp., with enriched carbon sources, BIOTECHNOLOGY LETTERS, 2003, 第 1 作者
(82) 测定浮游植物中色素的高效液相色谱与二极管阵分光光度计联用的方法, 植物生理学通讯, 2003, 第 1 作者
(83) 微小原甲藻的生长及其对锌限制的响应, 应用生态学报, 2003, 通讯作者
(84) 一种海生超微型黄藻的色素蛋白复合体, 水生生物学报, 2003, 第 1 作者
(85) 多甲藻素在一种海生黄藻中的存在, 海洋与湖沼, 2001, 第 1 作者
(86) CO2深度倍增对牟氏角毛藻生长和光合作用的影响, 水生生物学报, 2001, 第 1 作者
(87) 一种海生黄藻的氨基酸和脂肪酸组成, 应用与环境生物学报, 1999, 第 1 作者

科研活动

   
科研项目
( 1 ) 逆境下三角褐指藻LTR反转录转座子的活动规律及其生态意义, 负责人, 国家任务, 2010-01--2012-12
( 2 ) 适于荒漠地区养殖的产油微藻的筛选, 负责人, 境内委托项目, 2010-01--2012-12
( 3 ) 微藻能源规模化制备的科学基础 子课题——能源微藻优良藻种(株)选育, 负责人, 国家任务, 2011-01--2015-12
( 4 ) 适应规模化培养能源微藻的选育, 负责人, 研究所自主部署, 2011-01--2012-12
( 5 ) 中国产油微藻调查 子课题——东北三省产油微藻调查, 负责人, 国家任务, 2012-05--2017-04
( 6 ) 三角褐指藻耐高温基因筛选及其性状改良, 负责人, 研究所自主部署, 2013-03--2013-11
( 7 ) 三酰甘油酯酶(TGL)在三角褐指藻中的功能及其对油脂积累和生长的调控研究, 负责人, 国家任务, 2016-01--2019-12
( 8 ) 磷脂:甘油二酯脂酰基转移酶在三角褐指藻油脂积累中的作用, 负责人, 研究所自主部署, 2015-01--2015-11
( 9 ) 三角褐指藻中非典型C4途径及其生理功能, 负责人, 国家任务, 2018-01--2020-12
( 10 ) 三角褐指藻中外膜定位C4途径相关酶的功能, 负责人, 研究所自主部署, 2017-07--2019-06
( 11 ) 磷脂:甘油二酯脂酰基转移酶(PDAT)调控海洋微藻碳流分配及缩醛磷脂合成的分子机制, 负责人, 国家任务, 2020-01--2023-12
( 12 ) 三角褐指藻质体溶血磷脂酸酰基转移酶ATS1/2的鉴定及其调控细胞油脂合成的机制研究, 负责人, 中国科学院计划, 2021-01--2021-12
( 13 ) 海洋硅藻脂质合成机制及其与二氧化碳固定的关系研究, 负责人, 中国科学院计划, 2023-01--2025-12
( 14 ) 合成生物智能设计与构建——亚细胞体系设计与构建——线粒体设计和构建, 负责人, 中国科学院计划, 2021-06--2022-05
( 15 ) 构建具有简化线粒体与融合线粒体替代氧化路径质体的高效固碳硅藻, 负责人, 国家任务, 2024-01--2027-12
参与会议
(1)硅藻适应高CO2 浓度的分子机制   中国植物生理与植物分子生物学2023年全国学术年会暨成立六十周年庆祝大会   2023-04-26
(2)三角褐指藻甘油三酯积累和分解代谢机制   中国海洋湖沼学会藻类学分会换届大会暨第二十次学术讨论会   2019-11-22
(3)Triacylglycerol accumulation and catabolism in Phaeodactylum tricornutum   2019-07-14

指导学生

已指导学生

何晨柳  硕士研究生  071004-水生生物学  

查士红  硕士研究生  071004-水生生物学  

徐进  硕士研究生  071004-水生生物学  

黄伟超  硕士研究生  071004-水生生物学  

代志刚  硕士研究生  071004-水生生物学  

张春叶  硕士研究生  071004-水生生物学  

杨娟  硕士研究生  085238-生物工程  

万秀  硕士研究生  085238-生物工程  

张玲香  硕士研究生  071004-水生生物学  

李小龙  硕士研究生  071004-水生生物学  

杨娟  博士研究生  071004-水生生物学  

陈怡雯  硕士研究生  071004-水生生物学  

杨欢  硕士研究生  085238-生物工程  

于晨  博士研究生  071004-水生生物学  

黄腾  博士研究生  071004-水生生物学  

舒琴  硕士研究生  071004-水生生物学  

殷文秀  博士研究生  071004-水生生物学  

现指导学生

李晨杰  博士研究生  071004-水生生物学  

张言言  硕士研究生  086000-生物与医药  

王驰绎  硕士研究生  071004-水生生物学  

郝夏晖  博士研究生  071004-水生生物学  

黄琴  硕士研究生  071004-水生生物学  

胡朝文  博士研究生  071004-水生生物学