071010-生物化学与分子生物学
086000-生物与医药
071005-微生物学

线粒体基因组工程
DNA生物合成技术

2008-09--2011-12   浙江大学   博士研究生
2004-09--2007-07   福建师范大学   硕士研究生
2000-09--2004-07   福建师范大学   本科

   

2019-09~现在, 中国科学院天津工业生物技术研究所, 副研究员
2012-05~2019-09,康奈尔大学, 博士后
2007-07~2008-09,湖南科技学院, 专任教师

[1] Xiaoxian Guo, Weilin Xu, Weiping Zhang, Cuiping Pan, Anna E ThalackerMercer, Hongxiang Zheng, Zhenglong Gu. High-frequency and functional mitochondrial DNA mutations at the single-cell level. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022, 120(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910596/.
[2] Wang, Yiqin, Guo, Xiaoxian, Hong, Xiumei, Wang, Guoying, Pearson, Colleen, Zuckerman, Barry, Clark, Andrew G, OBrien, Kimberly O, Wang, Xiaobin, Gu, Zhenglong. Association of mitochondrial DNA content, heteroplasmies and inter-generational transmission with autism. NATURECOMMUNICATIONS[J]. 2022, 13(1): http://dx.doi.org/10.1038/s41467-022-30805-7.
[3] Lu, Xiaoyun, Li, Jinlong, Li, Congyu, Lou, Qianqian, Peng, Kai, Cai, Bijun, Liu, Ying, Yao, Yonghong, Lu, Lina, Tian, Zhenyang, Ma, Hongwu, Wang, Wen, Cheng, Jian, Guo, Xiaoxian, Jiang, Huifeng, Ma, Yanhe. Enzymatic DNA Synthesis by Engineering Terminal Deoxynucleotidyl Transferase. Acs Catalysis[J]. 2022, 12(5): 2988-2997, [4] Wang, Yiqin, Guo, Xiaoxian, Ye, Kaixiong, Orth, Michael, Gu, Zhenglong. Accelerated expansion of pathogenic mitochondrial DNA heteroplasmies in Huntington's disease. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2021, 118(30): [5] Yang, Qiaoyu, Guo, Xiaoxian, Liu, Yuwan, Jiang, Huifeng. Biocatalytic C-C Bond Formation for One Carbon Resource Utilization. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2021, 22(4): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918591/.
[6] Li, Xiangchen, Cheng, Jian, Liu, Xiaonan, Guo, Xiaoxian, Liu, Yuqian, Fan, Wenjing, Lu, Lina, Ma, Yanhe, Liu, Tao, Tao, Shiheng, Jiang, Huifeng. Origin and Evolution of Fusidane-Type Antibiotics Biosynthetic Pathway through Multiple Horizontal Gene Transfers. GENOME BIOLOGY AND EVOLUTION[J]. 2020, 12(10): 1830-1840, http://dx.doi.org/10.1093/gbe/evaa163.
[7] 彭凯, 逯晓云, 程健, 刘莹, 江会锋, 郭晓贤. DNA合成、组装与纠错技术研究进展. 合成生物学[J]. 2020, 1(6): 697-708, http://lib.cqvip.com/Qikan/Article/Detail?id=7103713718.
[8] Guo, Xiaoxian, Wang, Yiqin, Zhang, Ruoyu, Gu, Zhenglong. STAMP: a multiplex sequencing method for simultaneous evaluation of mitochondrial DNA heteroplasmies and content. NAR GENOMICS AND BIOINFORMATICS[J]. 2020, 2(4): http://dx.doi.org/10.1093/nargab/lqaa065.
[9] Liu, Xiaonan, Cheng, Jian, Zhu, Xiaoxi, Zhang, Guanghui, Yang, Shengchao, Guo, Xiaoxian, Jiang, Huifeng, Ma, Yanhe. De Novo Biosynthesis of Multiple Pinocembrin Derivatives in Saccharomyces cerevisiae. ACS SYNTHETIC BIOLOGY[J]. 2020, 9(11): 3042-3051, https://www.webofscience.com/wos/woscc/full-record/WOS:000592986800018.
[10] Guo Xiaoxian, Ruoyu Zhang, Yudong Li, Zhe Wang, Olena P. Ishchuk, Khadija M. Ahmad, Josephine Wee, Jure Piskur, Joshua A. Shapiro, Gu, Zhenglong. Understand the Genomic Diversity and Evolution of Fungal Pathogen Candida glabrata by analyzing the Genetic Variations Genome-wide. Methods[J]. 2019, 176: 82-90, [11] Wang, Zhe, Sun, Xuepeng, Wee, Josephine, Guo, Xiaoxian, Gu, Zhenglong. Novel insights into global translational regulation through Pumilio family RNA-binding protein Puf3p revealed by ribosomal profiling. CURRENT GENETICS[J]. 2019, 65(1): 201-212, https://www.webofscience.com/wos/woscc/full-record/WOS:000456958800024.
[12] Kothapalli, Kumar S D, Park, Hui Gyu, Guo, Xiaoxian, Sun, Xuepeng, Zou, James, Hyon, Stephanie S, Qin, Xia, Lawrence, Peter, RanRessler, Rinat R, Zhang, Ji Yao, Gu, Zhenglong, Brenna, J Thomas. A novel FADS2 isoform identified in human milk fat globule suppresses FADS2 mediated Delta 6-desaturation of omega-3 fatty acids. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS[J]. 2018, 138: 52-59, http://dx.doi.org/10.1016/j.plefa.2018.06.004.
[13] Cheng, Jian, Guo, Xiaoxian, Cai, Pengli, Cheng, Xiaozhi, Piskur, Jure, Ma, Yanhe, Jiang, Huifeng, Gu, Zhenglong. Parallel Evolution of Chromatin Structure Underlying Metabolic Adaptation. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2017, 34(11): 2870-2878, https://www.webofscience.com/wos/woscc/full-record/WOS:000416178700010.
[14] Zhang, Ruoyu, Nakahira, Kiichi, Guo, Xiaoxian, Choi, Augustine M K, Gu, Zhenglong. Very Short Mitochondrial DNA Fragments and Heteroplasmy in Human Plasma. SCIENTIFIC REPORTS[J]. 2016, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000387008200001.
[15] Sun, Xuepeng, Wang, Zhe, Guo, Xiaoxian, Li, Hongye, Gu, Zhenglong. Coordinated Evolution of Transcriptional and Post-Transcriptional Regulation for Mitochondrial Functions in Yeast Strains. PLOS ONE[J]. 2016, 11(4): https://doaj.org/article/20b20a623ebc4994acc6a537e4e38ec1.
[16] Wang, Zhe, Sun, Xuepeng, Zhao, Yi, Guo, Xiaoxian, Jiang, Huifeng, Li, Hongye, Gu, Zhenglong. Evolution of Gene Regulation during Transcription and Translation. GENOME BIOLOGY AND EVOLUTION[J]. 2015, 7(4): 1155-1167, http://124.16.173.210/handle/834782/1482.
[17] Chen, Zhigang, Li, Jingkai, Wang, Wei, Guo, Xiaoxian, Li, Yongquan, Mao, Xuming, Chen, Xinyu, Guan, Wenjun. Mutations adjacent to the end of transmembrane helices 6 and 7 independently affect drug efflux capacity of yeast ABC transporter Pdr5p. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES[J]. 2014, 1838(3): 932-939, https://www.webofscience.com/wos/woscc/full-record/WOS:000331661800023.
[18] Ahmad, Khadija M, Kokosar, Janez, Guo, Xiaoxian, Gu, Zhenglong, Ishchuk, Olena P, Piskur, Jure. Genome structure and dynamics of the yeast pathogen Candida glabrata. FEMS YEAST RESEARCHnull. 2014, 14(4): 529-535, http://dx.doi.org/10.1111/1567-1364.12145.
[19] Jiang, Huifeng, Guo, Xiaoxian, Xu, Lin, Gu, Zhenglong. Rewiring of Posttranscriptional RNA Regulons: Puf4p in Fungi as an Example. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2012, 29(9): 2169-2176, http://dx.doi.org/10.1093/molbev/mss085.
[20] Guo, Xiaoxian, Li, Jingkai, Wang, Tanjun, Liu, Zhenhua, Chen, Xin, Li, Yudong, Gu, Zhenglong, Mao, Xuming, Guan, Wenjun, Li, Yongquan. A Mutation in Intracellular Loop 4 Affects the Drug-Efflux Activity of the Yeast Multidrug Resistance ABC Transporter Pdr5p. PLOS ONE[J]. 2012, 7(1): https://doaj.org/article/6438c171d6654021b74b6c19179b3d6a.
[21] Wenjun Guan, Huifeng Jiang, Xiaoxian Guo, Eugenio Mancera, Lin Xu, Yudong Li, Lars Steinmetz, Yongquan Li, Zhenglong Gu. Antagonistic Changes in Sensitivity to Antifungal Drugs by Mutations of an Important ABC Transporter Gene in a Fungal Pathogen. PLOS ONE[J]. 2010, 5(6): http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201903250010551LS.

   

（ 1 ） 酶法DNA 合成技术研究, 主持, 国家级, 2020-01--2021-12