新型污染物的环境行为、毒性效应与健康风险

新型污染物的环境行为、毒性效应与健康风险

070302-分析化学

环境分析化学，环境毒理学

2012-09--2016-01   中国科学院大连化学物理研究所   理学博士
2009-09--2012-07   郑州大学化学系   理学硕士
2005-09--2009-07   郑州大学化学系   理学学士

博士研究生

理学博士

   

2018-06~现在, 中国科学院大连化学物理研究所, 副研究员
2016-02~2018-06,中国科学院大连化学物理研究所, 助理研究员

   

（ 1 ） 一种特定代谢通路中代谢物的仪器检测方法, 发明专利, 2021, 第 3 作者, 专利号: CN112903880A

（ 2 ） 一种测定雾霾期间颗粒物质量浓度粒径分布的方法, 专利授权, 2021, 第 4 作者, 专利号: CN110715881B

（ 3 ） 一种精确定量非暴露式气管滴注装置, 实用新型, 2020, 第 1 作者, 专利号: CN210019779U

（ 4 ） 一种雾霾相关多环芳烃毒性评价方法, 发明专利, 2020, 第 4 作者, 专利号: CN110736791A

（ 5 ） 一种用于非暴露式气管滴注的实验鼠固定装置, 实用新型, 2019, 第 1 作者, 专利号: CN209827080U

（ 6 ） 一种基于代谢组学的短链氯化石蜡斑马鱼胚胎毒性效应的研究方法, 发明专利, 2019, 第 4 作者, 专利号: CN109900884A

（ 7 ） 一种基于代谢组学技术的有机污染物低剂量联合暴露毒性效应评估方法, 发明专利, 2019, 第 4 作者, 专利号: CN109880877A

（ 8 ） 一种细胞内小分子代谢物的鉴定方法, 发明专利, 2019, 第 3 作者, 专利号: CN109870498A

（ 9 ） 一种PM2.5颗粒对人肺细胞内自由基代谢通路影响的评估方法, 发明专利, 2019, 第 3 作者, 专利号: CN109839498A

（ 10 ） 代谢组学方法对二噁英类化合物的毒性作用进行评估, 发明专利, 2018, 第 2 作者, 专利号: CN108226307A

（ 11 ） 一种贴壁细胞中游离氨基酸和脂肪酸的提取及分析方法, 发明专利, 2018, 第 1 作者, 专利号: CN105842364B

（ 12 ） 一种环境化学品对大鼠甲状腺系统影响的测定方法, 发明专利, 2018, 第 3 作者, 专利号: CN107937551A

（ 13 ） 一种基于代谢组学技术的有机污染物细胞毒性作用机制的研究方法, 发明专利, 2018, 第 4 作者, 专利号: CN107643390A

（ 14 ） 一种短链氯化石蜡对细胞能量代谢通路影响的测定方法, 发明专利, 2017, 第 1 作者, 专利号: CN105842443B

（ 15 ） 一种微量细胞培养液中离脂肪酸的测定方法, 发明专利, 2017, 第 3 作者, 专利号: CN106324165A

（ 16 ） 一种贴壁细胞内小分子代谢产物检测分析的前处理方法, 发明专利, 2017, 第 4 作者, 专利号: CN106324159A

（ 17 ） 一种有机污染物细胞代谢毒性的评估方法, 发明专利, 2015, 第 3 作者, 专利号: CN105021716A

[1] Ahmad, Zia, Li, Yun, Yang, Jiajia, Geng, Ningbo, Fan, Yun, Gou, Xiaoyi, Sun, Qingye, Chen, Jiping. A Membrane-Supported Bifunctional Poly(amidoxime-ethyleneimine) Network for Enhanced Uranium Extraction from Seawater and Wastewater. JOURNAL OF HAZARDOUS MATERIALS[J]. 2022, 425: http://dx.doi.org/10.1016/j.jhazmat.2021.127995.
[2] Ning, Cuiping, Gao, Yuan, Yu, Haoran, Zhang, Haijun, Geng, Ningbo, Cao, Rong, Chen, Jiping. FT-ICR mass spectrometry for molecular characterization of water-insoluble organic compounds in winter atmospheric fine particulate matters. JOURNAL OF ENVIRONMENTAL SCIENCES[J]. 2022, 111: 51-60, http://dx.doi.org/10.1016/j.jes.2020.12.0171001-0742.
[3] Luo, Yun, Zhang, Baoqin, Geng, Ningbo, Sun, Shuai, Song, Xiaoyao, Chen, Jiping, Zhang, Haijun. Transcriptomics and metabolomics analyses provide insights into the difference in toxicity of benzoapyrene and 6-chlorobenzoapyrene to human hepatic cells. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2022, 812: http://dx.doi.org/10.1016/j.scitotenv.2021.152242.
[4] Yun Luo, Baoqin Zhang, Ningbo Geng, Shuai Sun, Xiaoyao Song, Jiping Chen, Haijun Zhang. Insights into the hepatotoxicity of pyrene and 1-chloropyrene using an integrated approach of metabolomics and transcriptomics. Science of the Total Environment. 2022, 829: [5] Song, Xiaoyao, Liu, Jianhui, Geng, Ningbo, Shan, Yichu, Zhang, Baoqin, Zhao, Baofeng, Ni, Yuwen, Liang, Zhen, Chen, Jiping, Zhang, Lihua, Zhang, Yukui. Multi-omics analysis to reveal disorders of cell metabolism and integrin signaling pathways induced by PM2.5. JOURNAL OF HAZARDOUS MATERIALS[J]. 2022, 424: http://dx.doi.org/10.1016/j.jhazmat.2021.127573.
[6] Mila, A, Cao, Rong, Geng, Ningbo, Zhu, Xiuhua, Chen, Jiping. Characteristics of PAHs, PCDD/Fs, PCBs and PCNs in atmospheric fine particulate matter in Dalian, China. CHEMOSPHERE[J]. 2022, 288: [7] Shuai Sun, Haijun Zhang, Yun Luo, Cuicui Guo, Xindong Ma, Jingfeng Fan, Jiping Chen, Ningbo Geng. Occurrence, accumulation, and health risks of heavy metals in Chinese market baskets. Science of the Total Environment[J]. 2022, 829: [8] Yubing Dai, Shuai Sun, Yun Li, Jiajia Yang, Chengbin Zhang, Rong Cao, Haijun Zhang, Jiping Chen, Ningbo Geng. Residual levels and health risk assessment of rare earth elements in Chinese resident diet: A market-based investigation. Science of the Total Environment[J]. 2022, 828: [9] Gong, Yufeng, Zhang, Keke, Geng, Ningbo, Wu, Minghuo, Yi, Xianliang, Liu, Renyan, Challis, Jonathan K, Codling, Garry, Xu, Elvis Genbo, Giesy, John P. Molecular mechanisms of zooplanktonic toxicity in the okadaic acid- producing dinoflagellate Prorocentrum lima. ENVIRONMENTAL POLLUTION[J]. 2021, 279: http://dx.doi.org/10.1016/j.envpol.2021.116942.
[10] 孙帅, 耿柠波, 郭崔崔, 张保琴, 卢宪波, 张海军, 陈吉平. 我国东部沿海地区蔬菜中重金属累积分布特征及居民膳食暴露评估. 环境科学[J]. 2021, https://nxgp.cnki.net/kcms/detail?v=3uoqIhG8C46NmWw7YpEsKHTPvOGrUOOqX1coEOzL8AGFJVKR-prsWOoNWmaWbdUyROBLfp6EXpF4Wu6SmXXMIvng_9D-fE5m&uniplatform=NZKPT.
[11] Ningbo Geng, Xiaoyao Song, Rong Cao, Yun Luo, Mila A, Zhengang Cai, Kejie Yu, Yuan Gao, Yuwen Ni, Haijun Zhang, Jiping Chen. The effect of toxic components on metabolomic response of male SD rats exposed to fine particulate matter. Environmental Pollution[J]. 2021, 272: [12] Chen, Qiliang, Lian, Xiaolong, An, Jingjing, Geng, Ningbo, Zhang, Haijun, Challis, Jonathan K, Luo, Yun, Liu, Yaxin, Su, Guanyong, Xie, Yuwei, Li, Yingwen, Liu, Zhihao, Shen, Yanjun, Giesy, John P, Gong, Yufeng. Life Cycle Exposure to Environmentally Relevant Concentrations of Diphenyl Phosphate (DPhP) Inhibits Growth and Energy Metabolism of Zebrafish in a Sex-Specific Manner. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2021, 55(19): 13122-13131, [13] Geng, Ningbo, Luo, Yun, Cao, Rong, Song, Xiaoyao, Li, Fang, Wang, Feidi, Gong, Yufeng, Xing, Liguo, Zhang, Haijun, Chen, Jiping. Effect of short-chain chlorinated paraffins on metabolic profiling of male SD rats. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2021, 750: http://dx.doi.org/10.1016/j.scitotenv.2020.141404.
[14] Zhang, Meng, Liu, Yonggang, Zhao, Hao, Tao, Jianli, Geng, Ningbo, Li, Wei, Zhai, Yunpu. Pd Anchored on a Phytic Acid/Thiourea Polymer as a Highly Active and Stable Catalyst for the Reduction of Nitroarene. ACS APPLIED MATERIALS & INTERFACES[J]. 2021, 13(17): 19904-19914, http://dx.doi.org/10.1021/acsami.0c23007.
[15] Gong, Yufeng, Geng, Ningbo, Zhang, Haijun, Luo, Yun, Giesy, John P, Sun, Shuai, Wu, Ping, Yu, Zhengkun, Chen, Jiping. Exposure to short-chain chlorinated paraffins inhibited PPAR alpha-mediated fatty acid oxidation and stimulated aerobic glycolysis in vitro in human cells. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2021, 772: http://dx.doi.org/10.1016/j.scitotenv.2021.144957.
[16] Luo, Yun, Geng, Ningbo, Zhang, Baoqin, Chen, Jiping, Zhang, Haijun. Effects of harvesting and extraction methods on metabolite recovery from adherently growing mammalian cells. ANALYTICAL METHODS[J]. 2020, 12(19): 2491-2498, https://www.webofscience.com/wos/woscc/full-record/WOS:000536687300008.
[17] 耿柠波, 任晓倩, 张海军, 曹蓉, 宋肖垚, 罗云, 张保琴, 陈吉平. 蛋白质组学在环境毒理学中的研究进展. 生态毒理学报[J]. 2020, 15(4): 88-98, http://lib.cqvip.com/Qikan/Article/Detail?id=7103198160.
[18] Xia, Kexue, Cao, Rong, Gao, Yuan, Li, Yun, Ni, Yuwen, Wang, Shuqiu, Geng, Ningbo, Song, Boyu, Ren, Yong, Zhang, Yichi, Chen, Jiping, Zhang, Haijun. Mass balance and elimination mechanism of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) during the kraft pulping process. JOURNAL OF HAZARDOUS MATERIALS[J]. 2020, 398: http://dx.doi.org/10.1016/j.jhazmat.2020.122819.
[19] Yufeng Gong, Haijun Zhang, Ningbo Geng, Xiaoqian Ren, John P Giesy, Yun Luo, Liguo Xing, Ping Wu, Zhengkun Yu, Jiping Chen. Short-chain chlorinated paraffins (SCCPs) disrupt hepatic fatty acid metabolism in liver of male rat via interacting with peroxisome proliferator-activated receptor α (PPARα). Ecotoxicology and Environmental Safety. 2019, 181: 164-171, http://dx.doi.org/10.1016/j.ecoenv.2019.06.003.
[20] Ning, Cuiping, Gao, Yuan, Zhang, Haijun, Yu, Haoran, Wang, Lei, Geng, Ningbo, Cao, Rong, Chen, Jiping. Molecular characterization of dissolved organic matters in winter atmospheric fine particulate matters (PM2.5) from a coastal city of northeast China. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2019, 689: 312-321, http://dx.doi.org/10.1016/j.scitotenv.2019.06.418.
[21] Ren, Xiaoqian, Geng, Ningbo, Zhang, Haijun, Wang, Feidi, Gong, Yufeng, Song, Xiaoyao, Luo, Yun, Zhang, Baoqin, Chen, Jiping. Comparing the disrupting effects of short-, medium- and long-chain chlorinated Paraffins on cell viability and metabolism. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2019, 685: 297-307, http://dx.doi.org/10.1016/j.scitotenv.2019.05.388.
[22] Fan, Yun, Ren, Meihui, Zhang, Haijun, Geng, Ningbo, Li, Yun, Zhang, Ning, Zhao, Liang, Gao, Yuan, Chen, Jiping. Levels and fingerprints of chlorinated aromatic hydrocarbons in fly ashes from the typical industrial thermal processes: Implication for the co-formation mechanism. CHEMOSPHERE[J]. 2019, 224: 298-305, http://cas-ir.dicp.ac.cn/handle/321008/165484.
[23] Geng, Ningbo, Ren, Xiaoqian, Gong, Yufeng, Zhang, Haijun, Wang, Feidi, Xing, Liguo, Cao, Rong, Xu, Jiazhi, Gao, Yuan, Giesy, John P, Chen, Jiping. Integration of metabolomics and transcriptomics reveals short-chain chlorinated paraffin-induced hepatotoxicity in male Sprague-Dawley rat. ENVIRONMENT INTERNATIONAL[J]. 2019, 133: [24] Cao, Rong, Zhang, Haijun, Zhao, Lijuan, Zhang, Yichi, Geng, Ningbo, Teng, Man, Zou, Lili, Gao, Yuan, Ni, Yuwen, Fu, Qiang, Chen, Jiping. Hazy Weather-Induced Variation in Environmental Behavior of PCDD/Fs and PBDEs in Winter Atmosphere of A North China Megacity. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2018, 52(15): 8173-8182, https://www.webofscience.com/wos/woscc/full-record/WOS:000441477600015.
[25] Wang, Feidi, Zhang, Haijun, Geng, Ningbo, Ren, Xiaoqian, Zhang, Baoqin, Gong, Yufeng, Chen, Jiping. A metabolomics strategy to assess the combined toxicity of polycyclic aromatic hydrocarbons (PAHs) and short-chain chlorinated paraffins (SCCPs). ENVIRONMENTAL POLLUTION[J]. 2018, 234: 572-580, http://cas-ir.dicp.ac.cn/handle/321008/168678.
[26] Gong, Yufeng, Zhang, Haijun, Geng, Ningbo, Xing, Liguo, Fan, Jingfeng, Luo, Yun, Song, Xiaoyao, Ren, Xiaoqian, Wang, Feidi, Chen, Jiping. Short-chain chlorinated paraffins (SCCPs) induced thyroid disruption by enhancement of hepatic thyroid hormone influx and degradation in male Sprague Dawley rats. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2018, 625: 657-666, http://cas-ir.dicp.ac.cn/handle/321008/168812.
[27] 王菲迪, 张海军, 耿柠波, 任晓倩, 张保琴, 宫玉峰, 陈吉平. 短链氯化石蜡（SCCPs）和多环芳烃（PAHs）联合暴露对HepG2细胞抗氧化系统的影响. 生态毒理学报[J]. 2018, 13(5): 218-225, http://lib.cqvip.com/Qikan/Article/Detail?id=676839032.
[28] Ren, Xiaoqian, Zhang, Haijun, Geng, Ningbo, Xing, Liguo, Zhao, Yu, Wang, Feidi, Chen, Jiping. Developmental and metabolic responses of zebrafish (Danio rerio) embryos and larvae to short-chain chlorinated paraffins (SCCPs) exposure. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2018, 622: 214-221, http://cas-ir.dicp.ac.cn/handle/321008/168840.
[29] Cao, Rong, Zhang, Haijun, Geng, Ningbo, Fu, Qiang, Teng, Man, Zou, Lili, Gao, Yuan, Chen, Jiping. Diurnal variations of atmospheric polycyclic aromatic hydrocarbons (PAHs) during three sequent winter haze episodes in Beijing, China. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2018, 625: 1486-1493, http://cas-ir.dicp.ac.cn/handle/321008/168720.
[30] Shi, Leimeng, Gao, Yuan, Zhang, Haijun, Geng, Ningbo, Xu, Jiazhi, Zhan, Faqiang, Ni, Yuwen, Hou, Xiaohong, Chen, Jiping. Concentrations of short- and medium-chain chlorinated paraffins in indoor dusts from malls in China: Implications for human exposure. CHEMOSPHERE[J]. 2017, 172: 103-110, http://cas-ir.dicp.ac.cn/handle/321008/169502.
[31] 罗云, 张保琴, 任晓倩, 王菲迪, 耿柠波, 张海军, 陈吉平. 氯代多环芳烃的污染现状及毒性研究进展. 生态毒理学报[J]. 2017, 12(3): 120-134, http://lib.cqvip.com/Qikan/Article/Detail?id=673313982.
[32] Wang, Feidi, Zhang, Haijun, Geng, Ningbo, Zhang, Baoqin, Ren, Xiaoqian, Chen, Jiping. New Insights into the Cytotoxic Mechanism of Hexabromocyclododecane from a Metabolomic Approach. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2016, 50(6): 3145-3153, http://cas-ir.dicp.ac.cn/handle/321008/171142.
[33] Li, Fang, Jin, Jing, Tan, Dongqin, Wang, Longxing, Geng, Ningbo, Cao, Rong, Gao, Yuan, Chen, Jiping. Hexabromocyclododecane and tetrabromobisphenol A in sediments and paddy soils from Liaohe River Basin, China: Levels, distribution and mass inventory. JOURNAL OF ENVIRONMENTAL SCIENCES[J]. 2016, 48: 209-217, http://cas-ir.dicp.ac.cn/handle/321008/169776.
[34] Geng, Ningbo, Zhang, Haijun, Xing, Liguo, Gao, Yuan, Zhang, Baoqin, Wang, Feidi, Ren, Xiaoqian, Chen, Jiping. Toxicokinetics of short-chain chlorinated paraffins in Sprague-Dawley rats following single oral administration. CHEMOSPHERE[J]. 2016, 145: 106-111, http://cas-ir.dicp.ac.cn/handle/321008/171382.
[35] Li, Fang, Jin, Jing, Gao, Yuan, Geng, Ningbo, Tan, Dongqin, Zhang, Haijun, Ni, Yuwen, Chen, Jiping. Occurrence, distribution and source apportionment of polychlorinated naphthalenes (PCNs) in sediments and soils from the Liaohe River Basin, China. ENVIRONMENTAL POLLUTION[J]. 2016, 211: 226-232, http://cas-ir.dicp.ac.cn/handle/321008/170600.
[36] 白皓, 高媛, 朱秀华, 陈吉平, 耿柠波, 徐甲知, 马新东. 环境空气中短链氯化石蜡研究进展. 生态毒理学报[J]. 2016, 11(2): 80-88, http://lib.cqvip.com/Qikan/Article/Detail?id=669701519.
[37] 耿柠波, 张海军, 王菲迪, 任晓倩, 张保琴, 陈吉平. 代谢组学技术在环境毒理学研究中的应用. 生态毒理学报[J]. 2016, 11(3): 26-35, http://lib.cqvip.com/Qikan/Article/Detail?id=670046649.
[38] 耿柠波, 张海军, 张保琴, 王菲迪, 任晓倩, 陈吉平. 短链氯化石蜡暴露对HepG2细胞代谢的影响. 生态毒理学报. 2015, 10(4): 115-122, http://lib.cqvip.com/Qikan/Article/Detail?id=666183752.
[39] 耿柠波. 短链氯化石蜡的代谢动力学及其毒性效应的代谢组学评价. 2015, [40] Geng, Ningbo, Zhang, Haijun, Zhang, Baoqin, Wu, Ping, Wang, Feidi, Yu, Zhengkun, Chen, Jiping. Effects of Short-Chain Chlorinated Paraffins Exposure on the Viability and Metabolism of Human Hepatoma HepG2 Cells. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2015, 49(5): 3076-3083, http://cas-ir.dicp.ac.cn/handle/321008/146080.
[41] Wang, Jia, Geng, Ning Bo, Xu, Yi Fei, Zhang, Wen Ding, Tang, Xiao Yan, Zhang, Rui Qin. PAHs in PM2.5 in Zhengzhou: concentration, carcinogenic risk analysis, and source apportionment. ENVIRONMENTAL MONITORING AND ASSESSMENT[J]. 2014, 186(11): 7461-7473, https://www.webofscience.com/wos/woscc/full-record/WOS:000343051400036.
[42] Geng, Ningbo, Wang, Jia, Xu, Yifei, Zhang, Wending, Chen, Chun, Zhang, Ruiqin. PM2.5 in an industrial district of Zhengzhou, China: Chemical composition and source apportionment. PARTICUOLOGY[J]. 2013, 11(1): 99-109, http://dx.doi.org/10.1016/j.partic.2012.08.004.
[43] 张海军, 高媛, 马新东, 耿柠波, 张亦弛, 陈吉平. 短链氯化石蜡（SCCPs）的分析方法、环境行为及毒性效应研究进展. 中国科学：化学[J]. 2013, 43(3): 255-, http://159.226.238.44/handle/321008/119548.

（1） 环境化学前沿(第二辑), 科学出版社, 2019-08, 第 其他 作者

   

（ 1 ） 氯化石蜡对肝脏能量代谢的干扰效应及作用机制研究, 负责人, 国家任务, 2021-01--2024-12
（ 2 ） 基于代谢组学解析大气细颗粒物对呼吸系统损伤的分子机制, 负责人, 国家任务, 2017-01--2019-12
（ 3 ） 基于蛋白质组和代谢组动态变化分析的大气细颗粒物健康效应研究新方法, 参与, 国家任务, 2016-01--2019-12
（ 4 ） 高分辨质谱技术鉴定大气细颗粒有机组分及其呼吸系统损伤, 参与, 国家任务, 2017-01--2019-12
（ 5 ） 代谢组学策略探究PM2.5关键 毒作用组分对抑癌基因P53依赖的代谢毒性及其分子机制, 参与, 国家任务, 2019-01--2021-12

（1）基于转录组与代谢组研究SCCPs对大鼠的毒性效应   第十届全国环境化学大会   2019-08-19
（2）基于代谢组与转录组研究短链氯化石蜡对大鼠的肝毒性   第五届全国生态毒理学研讨会   2018-04-25