We are interested in the molecular and cellular functions of peripheral immune system in CNS injury and degenerative diseases, specially focus on infiltrating monocyte in mediating the immune response post ischemic stroke and inflammaging in the induction of AD. As immune response is a double-edged sword in neuronal death and regeneration post injury, understanding and fine tuning the balance between proinflammatory and anti-inflammatory responses provides new strategies for the relief of neural injury and promotion of regeneration. Aging is the key risking factor for neuronal degenerative diseases, accumulated distortions in the aged immune system lead to the interruption of immune niche in CNS and finally disturb the immune-protective effect of glial cells on neuronal survival. Thus, it is of great importance to find out the mechanism of inflammaging in the induction and progression of CNS degeneration.

Additionally, we will also investigate the role of neural circuitry regulations on immune system in homeostasis and immune disease progression. The innervation of sympathetic and parasympathetic nerves in immune organs provide controlling hubs for CSN in regulating immune activities. However, the detailed neural circuitry and molecular mechanisms of how CNS directing immune system still remains mysteries.

We are always looking for motivated students who have good trainings in biology，zoology，medicine or other natural science background and willing to join us with great interest on neuroimmunology topics.

2009-2014 Ph.D., Division of Molecular Neurobiology, German Cancer Research Center / University of Heidelberg, Heidelberg, Germany

2006-2009 M.S., Institute of Neuroscience, Second Military Medical University, Shanghai, China

2000-2004 B.S., Faculty of Biotechnology, Tianjin University of Science and Technology, Tianjin, China

2015-2017  Postdoc, Division of Molecular Neurobiology, German Cancer Research Center, Heidelberg, Germany

Principles of Neural Science, section name: Immune the CNS, 2019 at BCBDI, SIAT, CAS

1.     Gülcüler Balta, Gülce S., Cornelia Monzel, Susanne Kleber, Joel Beaudouin, Emre Balta, Thomas Kaindl, Si Chen, Liang Gao, Meinolf Thiemann, Christian R. Wirtz, Yvonne Samstag, Motomu Tanaka and Ana Martin-Villalba. 3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival. Cell Reports 29 (8): 2295-2306.e6. doi:10.1016/j.celrep.2019.10.054.

2.     Dehler, Sascha, Wilson Pak-Kin Lou, Liang Gao, Maxim Skabkin, Sabrina Dällenbach, Andreas Neumann, and Ana Martin-Villalba. 2018. “An Immune-CNS Axis Activates Remote Hippocampal Stem Cells Following Spinal Transection Injury.” Frontiers in Molecular Neuroscience 11 (December): 1–12. doi:10.3389/fnmol.2018.00443.

3.     Liang Gao, Gülce Sila Gülcüler, Lieke Golbach, Helena Block, Alexander Zarbock, and Ana Martin-Villalba^*. 2016. “Endothelial Cell-Derived CD95 Ligand Serves as a Chemokine in Induction of Neutrophil Slow Rolling and Adhesion.” eLife 5 (OCTOBER2016): 1–20. doi:10.7554/eLife.18542.

4.     Liang Gao^#, David Brenner^#, Enric Llorens-Bobadilla, Gonzalo Saiz-Castro, Tobias Frank, Peter Wieghofer, Oliver Hill, Meinolf Thiemann, Saoussen Karray, Marco Prinz, Jochen H. Weishaupt, and Ana Martin-Villalba^*. 2015. “Infiltration of Circulating Myeloid Cells through CD95L Contributes to Neurodegeneration in Mice.” The Journal of Experimental Medicine 212 (4): 469–80. doi:10.1084/jem.20132423.

5.     Liang Gao, Li Cao, Yang Qiu, Zhida Su, Geoffrey Burnstock, Zhenghua Xiang, and Cheng He^*. 2010. “Blocking P2X Receptors Can Inhibit the Injury-Induced Proliferation of Olfactory Epithelium Progenitor Cells in Adult Mouse.” International Journal of Pediatric Otorhinolaryngology 74 (7). Elsevier Ireland Ltd: 747–51. doi:10.1016/j.ijporl.2010.03.030.

6.     Zhida Su, Yimin Yuan, Li Cao, Yanling Zhu, Liang Gao, Yang Qiu, and Cheng He^*. 2010. “Triptolide Promotes Spinal Cord Repair by Inhibiting Astrogliosis and Inflammation.” Glia 58 (8): 901–15. doi:10.1002/glia.20972.

7.     Zhida Su, Yimin Yuan, Jingjing Chen, Li Cao, Yanling Zhu, Liang Gao, Yang Qiu, and Cheng He^*. 2009. “Reactive Astrocytes in Glial Scar Attract Olfactory Ensheathing Cells Migration by Secreted TNF-Alpha in Spinal Cord Lesion of Rat.” PloS One 4 (12): e8141. doi:10.1371/journal.pone.0008141.

现指导学生

徐帆  硕士研究生  071006-神经生物学