龙钢 男 博导 上海巴斯德研究所
电子邮件:glong@ips.ac.cn
通信地址:中科院上海巴斯德所
邮政编码:

招生信息

招生专业:细胞生物学,微生物学
招生专业
071005-微生物学
招生方向
分子病毒学

教育背景

2002-07--2007-03 Wageningen University 博士
1999-09--2002-06 中科院武汉病毒所 硕士
1995-09--1999-06 南昌大学 学士
学历
2002.07-2006.12 博士, 分子病毒学,瓦赫宁恩大学,瓦赫宁恩,荷兰
1999.09-2002.06 硕士, 病毒学, 中科院武汉病毒所,武汉,中国
1995.09-1999.09 学士, 生物工程,南昌大学生物系,南昌,中国

工作经历

2007.07-2012.12 博士后,分子病毒学实验室,海德堡大学,海德堡,德国 
2003.03-2007.07 助理研究员,中科院武汉病毒所,武汉,中国

专利与奖励

2002年,中国科学院院长奖
2007年,Marie Curie Fellowship

出版信息


Zhao F, Zhao T, Deng L, Lv D, Zhang X, Pan X, Xu J, Long G. Visualizing the essential role of complete virion assembly machinery in efficient Hepatitis C virus cell-to-cell transmission by viral infection activated split-intein mediated reporter system (VISI). J Virol. 2016 Nov 16. pii: JVI.01720-16.


Yang ZWang XChi XZhao FGuo JMa PZhong JNiu JPan XLong G. Neglected but Important Role of Apolipoprotein E Exchange in Hepatitis C Virus Infection. J Virol. 2016 Oct 14;90(21):9632-9643.


Zayas M, Long G, Madan V, Bartenschlager R. Coordination of Hepatitis C Virus Assembly by Distinct Regulatory Regions in Nonstructural Protein 5A. PLoS Pathog. 2016  Jan4;12(1):e1005376.


Metz PChiramel AChatel-Chaix LAlvisi GBankhead PMora-Rodriguez RLong G Hamacher-Brady ABrady NRBartenschlager R. Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62. J Virol. 2015 Aug;89(15):8026-41.


Lee JYAcosta EGStoeck IKLong GHiet MSMueller BFackler OTKallis SBartenschlager R.Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins. J Virol. 2014 Nov;88(21):12422-37.


Da Costa DTurek MFelmlee DJGirardi EPfeffer SLong GBartenschlager RZeisel MBBaumert TF. Reconstitution of the entire hepatitis C virus life cycle in nonhepatic cells. J Virol. 2012 Nov;86(21):11919-25.


Da Costa DTurek MFelmlee DJGirardi EPfeffer SLong GBartenschlager RZeisel MBBaumert TF. Reconstitution of the entire hepatitis C virus life cycle in nonhepatic cells. J. Virol. J Virol. 2012 Nov;86(21):11919-25.


Long GHiet MSWindisch MPLee JYLohmann VBartenschlager R. Mouse hepatic cells support assembly of infectious hepatitis C virus particles. Gastroenterology. 2011  Sep;141(3):1057-66. Comments in: Model systems for hepatitis C research: the cup half empty? 2011 Gastroenterology, 141(3):806-9 and Exiting from uncharted territory: Hepatitis C virus assembles in mouse cell lines. 2012 Hepatology, 55(2):645-8.


Merz A*Long G*Hiet MSBrügger BChlanda PAndre PWieland FKrijnse-Locker JBartenschlager R. Biochemical and Morphological properties of hepatitis C virus particles and determination of their lipidome. J Biol Chem. 2011 Jan 28;286(4):3018-32.


Zheng FHuang YLong GSun XWang H.Helicoverpar armigera single nucleocapsid nucleopolyhedrovirus ORF51 is a ChaB homologous gene involved in budded virus production and DNA replication. Virus Res. 2011 Jan;155(1):203-12. 


Pietschmann TZayas MMeuleman PLong GAppel NKoutsoudakis GKallis SLeroux-Roels GLohmann VBartenschlager R. Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations. PLoS Pathog. 2009 Jun;5(6):e1000475.


Long G*Pan X*Vlak JM. Conserved leucines in N-terminal heptad repeat HR1 of envelope fusion protein F of group II nucleopolyhedroviruses are important for correct processing and essential for fusogenicity .J Virol. 2008 Mar;82(5):2437-47.


  Pan XLong GWang RHou SWang HZheng YSun XWestenberg MDeng FWang HVlak JMHu Z. Deletion of a Helicoverpa armigera nucleopolyhedrovirus gene encoding a virion structural protein (ORF107) increases the budded virion titre and reduces in vivo infectivity. J Gen Virol. 2007 Dec;88(Pt 12):3307-16.


  Long GPan XVlak JM. Absence of N-linked glycans from the F2 subunit of the major baculovirus envelope fusion protein F enhances fusogenicity. J Gen Virol. 2007 Feb;88(Pt 2):441-9.


  Long GPan XWestenberg MVlak JM. Functional role of the cytoplasmic tail domain of the major envelope fusion protein of group II baculovirus. J Virol. 2006 Nov;80(22):11226-34.


  Long GPan XKormelink RVlak JM. Functional entry of Baculovirus into insect cells and mammalian cells is dependent on clathrin-mediated endocytosis. J Virol. 2006 Sep;80(17):8830-3.


  Long GWestenberg MWang HVlak JMHu Z. Function, Oligomerization and N-linked glycosylation of the Helicoverpa armigera SNPV envelope fusion protein. J Gen Virol. 2006 Apr;87(Pt 4):839-46.


Dong CLi DLong GDeng FWang HHu Z. Identification of functional domains required for HearNPV P10 filament formation. Virology. 2005 Jul 20;338(1):112-20.


Long GChen XPeters DVlak JMHu Z. Open reading frame 122 of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus encodes a novel structural protein of occlusionderived virions. J Gen Virol. 2003 Jan;84(Pt 1):115-21.

* Co-first authors.


Book Chapter


Bartenschlager, R., G. Long, and D. Moradpour. 2008. Chronic hepatitis C: Portrait of a silent epidemic and the etiologic agent, p95-120. In Olaf, W., and Ulrike, P., (ed), Comparative Hepatitis. ISBN: 978-3-7643-8557-6, A Birkhäuser book.


科研活动

   
科研项目
(1) 丙型肝炎病毒组装,主持,院级级,2013-01--2017-12

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