Fuyi Wang  Ph.D.    Professor   Analytical Chemistry, Bioinorganic Chemistry, Chemical Biology
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Research Areas

         Separation and Identification of Biological Macromolecules
         Design and Molecular basis for mechanism of action of anticancer complexes
         Mass Spectrometry


1983: B.Sc, Central China Normal University
1991: M.Sc. Central China Normal University
1999: Ph. D, Wuhan University


Work Experience

1991-1999: Lecturer / Associate Professor, Central China Normal University
2000-2006: Research Fellow, the University of Edinburgh (UK)
2007-: Professor, Institute of Chemistry, Chinese Academy of Sciences

Teaching Experience

2015 - , Advanced Instrumental Analysis for postgraduates

2016 -, Analytical Chemistry for undergraduates

Honors & Distinctions

The Royal Fellowship (1999), the Royal Society

The Hundred Talents Progam Professorship, CAS


1.        W. Zheng, Y. Zhao*, Q. Luo, Y.  Zhang, K.  Wu, F. Y. Wang*, Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes, Sci China Chem, 2016, 59(10), 1240-1249

2.        Z. Y. Wang, J. Liu, Y. F.  Zhou J. J. Neeway, D. K. Schreiber, J. V. Crum, J. V. Ryan, X. L. Wang, F. Y. Wang,* Z. H. Zhu,* Nanoscale imaging of Li and B in nuclear waste glass, a comparison of ToF-SIMS, NanoSIMS, and APT, Surf. Interface Anal. 2016, DOI 10.1002/sia.6049

3.        L. J. Li, W. Guo, K. Wu,* Y. Zhao, Q. Luo, Q. W. Zhang,* J. A. Liu, S. X. Xiong F. Y.  Wang, Rapid Commun. Mass Spectrom. 2016, 30 (Suppl. 1), 168–172

4.        L. J. Li, W. Guo, K. Wu,* X. L. Wu, L. H. Zhao, Y. Zhao, Q. Luo, Y. Y. Wang, Y. Z. Liu, Q. W. Zhang, F. Y. Wang,* A comparative study on the interactions of human copper chaperone Cox17 with anticancer organoruthenium(II) complexes and cisplatin by mass spectrometry, J. Inorg. Biochem., 2016, 161, 99-106

5.        J. Du, Y. Kang, Y. Zhao,* W. Zheng, Y. Zhang, Yu Lin, Z. Y. Wang, Y. Y. Wang, Q. Luo, Kui Wu, and F. Y. Wang,* Synthesis, Characterization, and in Vitro Antitumor Activity of Ruthenium(II) Polypyridyl Complexes Tethering EGFR-Inhibiting 4-Anilinoquinazolines, Inorg. Chem., 2016, 55, 4595−4605

6.         J. Du, E. L. Zhang, Y. Zhao,* W. Zheng, Y. Zhang, Y. Lin, Z. Y. Wang, Q. Luo, K. Wu, F. Y. Wang*, Discovery of a dual-targeting organometallic ruthenium complex with high activity inducing early stage apoptosis of cancer cells, Metallomics, 2015, 7, 1573-1583 (front cover).

7.        Z. Y. Wang, B. W. Liu, E. W. Zhao, K. Jin, Y. G. Du, J. J. Neeway, J. V. Ryan, D. H. Hu, K. H. L. Zhang, M. Hong, S. Le Guernic, S. Thevuthasan, F. Y. Wang,* Z. H.  Zhu*, Argon Cluster Sputtering Source for ToF-SIMS Depth Profiling of Insulating Materials: High Sputter Rate and Accurate Interfacial Information, , J. Am. Soc. Mass Spectrom., 2015, 26, 1283-1290

8.        Y. Zhang, W. Zheng,* Q. Luo, Y. Zhao, E. L. Zhang, S. Y. Liu, F. Y.  Wang,* Dual-targeting organometallic ruthenium(II) anticancer complexes bearing EGFR-inhibiting 4-anilinoquinazoline ligands, Dalton Trans. 2015, 44, 13100–13111

9.        Y. Lin, Y. D. Huang, W. Zheng, K. Wu, Q. Luo, Y. Zhao, S. X. Xiong, F. Y. Wang,* Quantification of Bindings of Organometallic Ruthenium Complexes to GSTπ by Mass Spectrometry, J. Inorg. Biochem., 2015, 146, 44-51

10.    S. Y. Liu, K. Wu,* W. Zheng, Y. Zhao, Q. Luo, S. X. Xiong, F. Y. Wang,* Identification and Discrimination of Binding Sites of an Organoruthenium Anticancer Complex to Single-Stranded Oligonucleotides by Mass Spectrometry, Analyst, 2014, 139, 4491-4996

11.    W. J. Xia, Z. F. Du, Q. F. Cui, H. Dong, F. Y.Wang*, P. Q. He, Y. C. Tang,* Biosurfactant produced by Novel Pseudomonas sp. WJ6 with 3 Biodegradation of n-Alkanes and Polycyclic Aromatic Hydrocarbons, J. Hazard. Mater. 2014, 276C, 489-498

12.     Z. Y. Wang, K. Jin, Y. W. Zhang, F. Y. Wang,* Z. H. Zhu,* ToF-SIMS depth profiling of insulating samples: interlaced mode or non-interlaced mode, Surf. Interface Anal. 2014, 46, 257-260

13.    B. Jin, X. Zhang, W. Zheng, X. J. Liu, J. Zhou, N. Zhang, F. Y. Wang, D. H. Shangguan,* Dicyanomethylene-Functionalized Squaraine as a Highly Selective Probe for Parallel G-Quadruplexes, Anal. Chem. 2014, 86, 7063−7070

14.    G. J. Zhai, X. Y. Wu, Q. Luo, K. Wu, Y. Zhao, Y. L. Min, J. A. Liu, X. S. Xiong, Y. Q. Feng, L. P. Yang,* F. Y. Wang,* Absolute Quantification of Serum Phosphopeptides by Mass Spectrometry Coupled to Titania Coated Magnetic Mesoporous Silica Microsphere Enrichment, Talanta, 2014, 125, 411–417

15.    L. Y. Ji, W. Zheng, Y. Lin, X. L. Wang, S. , X. Hao, Q. Luo,* X. C. Li, L. Yang, F. Y. Wang,* Novel Ruthenium Complexes Ligated with 4-Anilinoquinazoline Derivatives: Synthesis, Characterisation and Preliminary Evaluation of Biological Activity, Eur. J. Med. Chem. 2014, 77, 110-120

16    Z. F. Du, Q. Luo, L. P. Yang, T. Bing, X. C. Li, W. Guo, K. Wu, Y. Zhao, S. X. Xiong, D. H. Shangguan, F. Y. Wang,* Mass Spectrometric Proteomics Reveals that Nuclear Protein Posi-tive Cofactor PC4 Selectively Binds to Crosslinked DNA by a Trans-platinum Anticancer Complex, J. Am. Chem. Soc. 2014, 136, 2948-2951

17.    Z. Y. Xi, W. Guo, C. L. Tian,* F. Y. Wang,* Y. Z. Liu,* Copper binding modulates the platination of human copper chaperone Atox1 by antitumor trans-platinum complexes, Metallomics 2014, 6, 491-497

18.    B. Jin, X. Zhang, W. Zheng, X. J. Liu, C. Qi, F. Y. Wang, D. H. Shangguan,* Fluorescence Light-Up Probe for Parallel GQuadruplexes, Anal. Chem. 2014, 86, 943−952

19.    Y. Zhao, N. J. Farrer, H. L. Li, J. S. Butler, R. J. McQuitty, A. Habtemariam, F. Y. Wang,* P. J. Sadler,* De Novo Generation of Singlet Oxygen and Ammine Ligands by Photoactivation of A Platinum Anticancer Complex, Angew. Chem. Int. Ed. 2013, 52, 13633 –13637

20.    Z. Y. Xi, W. Guo, C. L. Tian, F. Y.  Wang* and Y. Z. Liu*, Copper binding promotes the interaction of cisplatin with human copper chaperone Atox1, Chem. Commun. 2013, 49, 11197

21.    K. Wu, S. Y. Liu, Q. Luo, W. B. Hu, X. C. Li, F. Y. Wang,* R. H.  Zheng, J. Cui, P. J. Sadler,* J. F. Xiang, Q. Shi, S. X. Xiong, Thymines in single-stranded oligonucleotides and G-quadruplex DNA are competitive with guanines for binding to an organoruthenium anticancer complex, Inorg. Chem. 2013, 52 11332-11342

22.    Y. Lin, Y. D. Huang, W. Zheng, F. Y. Wang,*A. Habtemariam, Q. Luo, X. C. Li, K. Wu, P. J. Sadler, S. X. Xiong, Organometallic ruthenium anticancer complexes inhibit human glutathione-S-transferase p, J. Inorg. Biochem. 2013, 128, 77-84

23.    W. Zheng, Q. Luo, Y. Lin, Y. Zhao, X. L. Wang, Z. F. Du, X. Hao, Y. Yu, S. Lü, L. Y. Ji,  X. C. Li, L. Yang, F. Y. Wang *, Complexation with Organometallic Ruthenium Pharmacophores Enhances the Ability of 4-Anilinoquinazolines Inducing Apoptosis, Chem. Commun. 2013, 49, 10224-10226

24.    Q. Luo, J. H. Cao, D. H. Tang,* D. Y. Wu, Y. Huang, J. F. Xiang, F. Y. Wang*, X. H. Liu, G. Wu, Lipophilic thioguanosine: an anion receptor for cesium fluoride, J. Fluorine Chem. 2013, 150, 67–71

25.    W. Guo, W. Zheng, Q. Luo, X. C. Li, Y. Zhao, S. X. Xiong, F. Y. Wang*, Transferrin serves as a mediator to deliver organometallic ruthenium(II) anticancer complexes into cells, Inorg. Chem. 2013, 52, 5328-5338

26.    G. B. Ge, C. Z. Ai, W. B. Hu, L. L. Zhu, Z. Z. Fang, G. Y. He, Y. L. Liu, F. Y. Wang,* L. Yang,* The role of serum albumin in the metabolism of Boc5: molecular identification, species differences and contribution to plasma metabolism, Eur. J. Pharm. Sci. 2013, 48(1-2), 360-369

27.    K. Wu, W.B. Hu, Q. Luo, X. C. Li, S. X. Xiong, P. J. Sadler,* F. Y. Wang,* Competitive binding sites of a ruthenium arene anticancer complex on oligonucleotides studied by mass spectrometry: ladder-sequencing vs top-down, J. Am. Soc. Mass Spectrom., 2013, 24, 410-420

28.    F. Y. Wang, J. J. Xu, K. Wu, S. K. Weidt, C. L. Mackay, P. R. R. Langridge-Smith, P. J. Sadler,* Competition between glutathione and DNA oligonucleotides for ruthenium(II) arene anticancer complexes, Dalton Trans. 2013, 3188-3195

29.    S. Lü, W. Zheng, L. Y. Ji, Q. Luo*, X. Hao, X. C. Li, F. Y. Wang,* Synthesis, characterization, screening and docking analysis of 4-anilinoquinazoline derivatives as tyrosine kinase inhibitors, Eur. J. Med. Chem., 2013, 76, 84-94

30.    Xianchan Li, Zhilong Zhao, WEnbing Hu, Fuyi Wang,* Interactions between cisplatin and proteins, and their pharmacological implications in Cisplatin: Pharmacology, Clinical Uses and Adverse Effects, Eds: Toshiko Kojima and Yoko Moria, pp75-95, Nove Science Publishers, Inc, U.S.A., 2012

31.    L. Y. Ji, J.-H. Wu, Q. Luo, X. C. Li, W. Zheng, G. J. Zhai, F. Y. Wang,* S. Lü, Y.-Q. Feng,* J. A. Liu, S. X. Xiong, Quantitative Mass Spectrometry Combined with Separation and Enrichment of Phosphopeptides by Titania Coated Magnetic Mesoporous Silica Microspheres for Screening of Protein Kinase Inhibitors, Anal. Chem., 2012, 84, 2284-2291

32.    K Wu, Qun Luo, W.B. Hu, X.C. Li, F.Y. Wang,* S. X. Xiong, P. J. Sadler,* Mechanism of Interstrand Migration of Organoruthenium Anticancer Complexes within a DNA Duplex, Metallomics, 2012, 4, 136-148

33.    S. Lü, Q. Luo, X. Hao, X. C. Li, L. Y. Ji, W. Zheng, F. Y. Wang*, Synthesis and docking study of 2-phenylaminopyrimidine Abl tyrosine kinase inhibitors, Bioorg. Med. Chem. Lett. 2011, 21, 6964-6968

34.    Y. M. Han, Q. Luo, X. Hao, X. C. Li, F. Y. Wang,* W. B. Hu, K. Wu, S. Lü, P. J. Sadler*, reactions of an organoruthenium anticancer complex with 2-mercaptobenzanilide - a model for the active-site cysteine of protein tyrosine phosphatase 1B, Dalton Trans. 2011, 40, 11519-11529

35.    W.B. Hu, Q. Luo, K. Wu, X.C. Li, F.Y. Wang,* Y. Chen, X.Y. Ma, J.P. Wang, J.A. Liu,a S.X. Xiong, P.J.. Sadler*, the anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin, Chem. Commun. 2011, 47, 6006–6008.

36.    W. B. Hu, J. A. Liu, Q. Luo,* Y. M. Han, K. Wu, S. Lv, S. X. Xiong, F. Y. Wang,* Elucidation of the Binding Sites of Sodium Dodecyl Sulfate to b-Lactoglobulin Using Hydrogen/Deuterium Exchange Mass Spectrometry Combined with Docking Simulation, Rapid Commun. Mass Spectrom. 2011, 25, 1429-1436.

37.    G. X. Zhang, W. B. Hu, Z. F. Du, S. Lv, W. Zheng, Q. Luo, X. C. Li, K. Wu, Y. M. Han, F. Y. Wang*, A Comparative Study on Interactions of Cisplatin and Ruthenium Arene Anticancer Complexes with Metallothionein using MALDI-TOF-MS, Intl. J. Mass Spectrom., 2011, 307, 79-84

38.    Q. Luo, D. Y. Wu, S. X. Liu, D. H. Tang,* Y. Huang, X. H. Liu, F. Y. Wang,* R. Y. Wang, G. Wu,* the formation of thymidine-based t-tetramers with remarkable structural and metal ion size effects, Org. Biomol. Chem., 2011, 9,1030-1033

39.    S. Lv, Q. Luo, X. C. Li, K. Wu, J. A. Liu, S. X. Xiong, Y.Q. Feng, F.Y. Wang*, Inhibitor Screening of Protein Kinases Using MALDI-TOF MS Combined with Separation and Enrichment of Phosphopeptides by TiO2 Nanoparticle Deposited Capillary Column, Analyst, 2010, 135, 2858-2863.

40.    H.K. Liu, .J. A. Parkinson, J. Bella, F.Y. Wang, P.J. Sadler,* Penetrative DNA intercalation and G-base selectivity of an organometallic tetrahydroanthracene RuII anticancer complex, Chem. Sci., 2010, 1, 258-270.

41.    D. H. Tang*, D. Y. Wu, Q. Luo, W. B. Hu, F. Y. Wang*, S. X. Liu, X. H. Liu, and Q. H. Fan, single-molecule behavior of dendritic poly(ethylene glycol) structures towards lithium ions, Chem. Eur. J. 2009, 15, 10352-10355.

42.    Y. Wang, F. Li, Y. M. Han, F. Y. Wang, H. Jiang, folding and aggregation of cationic oligo(aryl-triazole)s in aqueous solution, Chem. Eur. J., 2009, 15, 9424-9433.

43.    W. B. Hu, Q. Luo, X. Y. Ma, K. Wu, J. A. Liu, Y. Chen, S. X. Xiong, J. P. Wang, P. J. Sadler, F. Y. Wang,* arene control over thiolate to sulfinate oxidation in albumin by organometallic ruthenium anticancer complexes, Chem. Eur. J. 2009, 15, 6586-6594

44.    F. Y. Wang,* A. Habtemariam, E. P. L. van der Geer, R. J. Deeth, R. Gould, S. Parsons, P. J. Sadler,* synthesis, characterization and reaction pathway for the formation of a GMP adduct of a cytotoxic thiocyanato ruthenium arene complex, J. Biol. Inorg. Chem., 2009, 14, 1065-1076

45.    F.Y. Wang, S. Weidt, J. Xu, C. L. Mackay, P. R. R. Langridge-Smith, P. J. Sadler, identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography Fourier transform ion cyclotron mass spectrometry combined with 18O-labeling, J. Am. Soc. Mass Spectrom. 2008, 19, 544-549

46.    H. K. Liu, S. J. Berners-Price, F. Y. Wang, J. A. Parkinson, J. Xu, J. Bella, P. J. Sadler, diversity in G-selective DNA binding modes for an organometallic ruthenium arene complex, Angew. Chem. Int. Ed. 2006, 45, 8153-8156

47.    H. K. Liu, F. Y. Wang, J. A. Parkinson, J. Bella, P. J. Sadler, ruthenation of duplex and single-stranded d(CGGCCG) by organometallic anticancer complexes, Chem. Eur. J. 2006, 12, 6151-6165

48.    F. Y. Wang, A. Habtemariam, E. P. L. van der Geer, R. Fernández, M. Melchart, R. J. Deeth, R. Aird, S. Guichard, F. P. A. Fabbiani, P. Lozano-Casal, I. D. H. Oswald, D. I. Jodrell, S. Parsons, P. J. Sadler, controlling ligand substitution reactions of organometallic complexes: tuning cancer cell cytotoxicity, Proc. Natl. Acad. Sci. U. S. A. 2005, 102, 18269-18274.

49.    F. Y. Wang, J. Xu, A. Habtemariam, J. Bella, P. J. Sadler, competition between glutathione and guanine for a ruthenium(II) arene anticancer complex: detection of a sulfenato intermediate. J. Am. Chem. Soc. 2005, 127, 17734-17743.

50.    F. Y. Wang, J. Bella, J. A. Parkinson, P. J. Sadler, competitive reactions of a ruthenium arene anticancer complex with histidine, cytochrome c and an oligonucleotide. J. Biol. Inorg. Chem. 2005, 10, 147-55.

51.    I. W. McNae, K. Fishburne, A. Habtemariam, T. M. Hunter, M. Melchart, F. Y. Wang, M. D. Walkinshaw, P. J. Sadler, half-sandwich arene ruthenium(II)-enzyme complex. Chem. Commun. 2004, 1786-1787.

52.    F. Y Wang, H. M. Chen, S. Parsons, I. D. H. Oswald, J. E. Davidson, P. J. Sadler, kinetics of aquation and anation of ruthenium(II) arene anticancer complexes, acidity and X-ray structures of aqua adducts. Chem. Eur. J. 2003, 9, 5810-5820.

53.    H. M. Chen, J. A. Parkinson, O. Novakova, J. Bella, F. Y. Wang, A. Dawson, R. Gould, S. Parsons, V. Brabec, P. J. Sadler, induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers. Proc. Natl. Acad. Sci. U. S. A. 2003, 100, 14623-14628.

54.    F. Y. Wang, B. Hu, Z. C. Jiang, Y. L. Wu, study on the chemical modification of acetylacetone in graphite furnace atomic absorption spectrometry determination of trace aluminium. Anal. Lett. 2002, 35, 2593-2602.

55.    F. Y. Wang, H. M. Chen, J. A. Parkinson, P. D. Murdoch, P. J. Sadler, reactions of a ruthenium(II) arene antitumor complex with cysteine and methionine. Inorg. Chem. 2002, 41, 4509-4523.

56.    F. Y. Wang, Z. C. Jiang, T. Y. Peng, use of polytetrafluoroethylene slurry for silica matrix removal in ETAAS direct determination of trace cobalt and nickel in silicon dioxide powder. J. Anal. At. Spectrom. 1999, 14, 963-966.

57.    F. Y. Wang, Z. C. Jiang, B. Hu,T. Y. Peng, comparative studies on chemical modification of polytetrafluoroethylene slurry in ETV-ICP-AES and ETAAS. J. Anal. At. Spectrom. 1999, 14, 1619-1624.

58.    F. Y. Wang, Z. C. Jiang, direct determination of cadmium in solid biological materials by slurry sampling electrothermal atomic absorption spectrometry with polytetrafluoroethylene as a chemical modifier. Anal. Chim. Acta 1999, 391, 89-94.

Research Projects

    1. NSFC General Project: Chemical Genetic Approach for Deciphering Mechanism of Action of Anticancer Metallodrugs.

    2. 973 Program Project: Investigation of Molecular Basis for Mechanism of Action of Chinese Traditional Medicines.

    3. NSFC Major Project: Development of Super-Resolution & Multi-mode Chemical Imaging System.

    4. NSFC Key Project: Methodology for Investigation of Interactions between Drug-damaged DNA and Proteins.

    5. NSFC Key International Cooperation Project: Methodology for Interactomic Studies of Anticancer Metallodrugs.

    6. NSFC General Project: Mass Spectrometric Studies on Interactions between Anticancer Metallogruds and Serum Proteins.



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