感染免疫学

免疫系统在病原体感染后的免疫应答反应特征及控制感染的作用机制研究。目前的研究重点包括：NK细胞及杀伤性CD4 T细胞在流感病毒感染中的免疫应答特征及作用机制；结核感染中的细胞免疫学研究。

071005-微生物学
071010-生物化学与分子生物学

病毒免疫学；肿瘤免疫学； 流行病学

1998-09--2003-07   中科院遗传与发育生物学研究所   理学博士
1990-09--1994-06   兰州大学   理学学士

研究生

博士

   

2010-02~2012-06,福克斯蔡斯癌症研究中心, Staff Scientist
2008-06~2010-02,福克斯蔡斯癌症研究中心, Research Associate
2003-08~2008-06,福克斯蔡斯癌症研究中心, 博士后
1994-08~1998-08,陕西航天制药厂, 助理工程师

2013-10-01-今,中国微生物学会病毒学专业委员会, 第一届青年委员会副主任委员

免疫学及生物物理学
细胞免疫学
分子病毒学

   

（1） WJ Avery followship, , 研究所（学校）, 2007
（2） Gordon Research conferences travel award, , 其他, 2007
（3） 研究生奖学金, , 研究所（学校）, 2002

[1] 方敏, 顾秀玲, 张毓凡, 姜威, 卢娇, 顾光磊. 一种痘病毒人源单克隆抗体及其应用. CN: CN113861285A, 2021-12-31.
[2] 方敏, 王浩宇, 段学锋, 秦天, 卢娇, 姜威. 一种检测嗜肺军团菌毒力的方法. CN: CN108660179B, 2020-11-20.
[3] 方敏, 姜威, 徐赫男, 顾秀玲, 李凯莉. UBL7蛋白质及其编码基因在抗病毒感染中的应用. CN: CN111714617A, 2020-09-29.
[4] 方敏, 李凯莉, 王滔, 徐赫男, 姜威, 李晶, 刘文军, 段学锋. 一种可检测热原的单克隆细胞系的制备方法. CN: CN108707626A, 2018-10-26.
[5] 方敏, 王浩宇, 段学锋, 秦天, 卢娇, 姜威. 一种检测嗜肺军团菌毒力的方法. CN: CN108660179A, 2018-10-16.
[6] 孟颂东, 方敏, 彭善鑫, 王静, 李长菲. 微RNA mmu-mir-487b-5p及类似物的应用和表达该微RNA载体的应用. CN: CN108374011A, 2018-08-07.
[7] 方敏, 孟颂东, 王静, 彭善鑫, 魏松涛. 微RNA hsa-mir-593-5p及其类似物的应用和表达该微RNA载体的应用. CN: CN108359725A, 2018-08-03.
[8] 方敏, 孟颂东, 王静, 彭善鑫, 魏松涛. 微RNA hsa-mir-127-3p及其类似物，以及表达该微RNA载体的应用. CN: CN108342388A, 2018-07-31.
[9] 孟颂东, 方敏, 彭善鑫, 王静, 李长菲. 微RNA hsa-mir-1-3p及其类似物的应用，和表达该微RNA载体的应用. CN: CN108113995A, 2018-06-05.
[10] 孟颂东, 方敏, 彭善鑫, 王静, 李长菲. 微RNA hsa-mir-486-5p及其类似物的应用和表达该微RNA载体的应用. CN: CN108079007A, 2018-05-29.
[11] 方敏, 周凯, 王静, 朱莉, 方俊. Csad蛋白及其编码基因在抗流感病毒中的应用. CN: CN107287178A, 2017-10-24.
[12] 方敏, 姜威, 顾秀玲, 王东方, 李凯莉. 一种抗体融合蛋白及其制备方法与应用. CN: CN106467576A, 2017-03-01.
[13] 方敏, 赵文明, 朱莉. SLD5蛋白及其编码基因在抗流感病毒中的应用. CN: CN106084025A, 2016-11-09.

   

[1] Gu, Xiuling, Zhang, Yufan, Jiang, Wei, Wang, Dongfang, Lu, Jiao, Gu, Guanglei, Qin, Chengfeng, Fang, Min. Protective Human Anti-Poxvirus Monoclonal Antibodies Are Generated from Rare Memory B Cells Isolated by Multicolor Antigen Tetramers. VACCINES[J]. 2022, 10(7): [2] Xinjun Liu, Jian Zhao, Xiaopeng Li, Fengxue Lao, Min Fang, Marco Carlo Merlano, Vita Golubovskaya. Design Strategies and Precautions for Using Vaccinia Virus in Tumor Virotherapy. Vaccines[J]. 2022, 10(9): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504998/.
[3] Gu, Xiuling, Zhang, Yufan, Jiang, Wei, Wang, Dongfang, Lu, Jiao, Gu, Guanglei, Qin, Chengfeng, Fang, Min. Protective Human Anti-Poxvirus Monoclonal Antibodies Are Generated from Rare Memory B Cells Isolated by Multicolor Antigen Tetramers. VACCINES[J]. 2022, 10(7): [4] Xinjun Liu, Jian Zhao, Xiaopeng Li, Fengxue Lao, Min Fang, Marco Carlo Merlano, Vita Golubovskaya. Design Strategies and Precautions for Using Vaccinia Virus in Tumor Virotherapy. Vaccines[J]. 2022, 10(9): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504998/.
[5] He, Wanxue, Xiao, Kun, Fang, Min, Xie, Lixin. Immune Cell Number, Phenotype, and Function in the Elderly with Sepsis. AGING AND DISEASEnull. 2021, 12(1): 277-296, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801284/.
[6] Lu, Jiao, Li, Shan, Li, Xiaopeng, Zhao, Wenming, Duan, Xuefeng, Gu, Xiuling, Xu, Jianqiao, Yu, Bolan, Sigal, Luis J, Dong, Zhongjun, Xie, Lixin, Fang, Min. Declined miR-181a-5p expression is associated with impaired natural killer cell development and function with aging. AGING CELL[J]. 2021, 20(5): http://dx.doi.org/10.1111/acel.13353.
[7] He, Wanxue, Xiao, Kun, Xu, Jiaruo, Guan, Wei, Xie, Sheling, Wang, Kaifei, Yan, Peng, Fang, Min, Xie, Lixin. Recurrent Sepsis Exacerbates CD4(+) T Cell Exhaustion and Decreases Antiviral Immune Responses. FRONTIERS IN IMMUNOLOGY[J]. 2021, 12: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946831/.
[8] Chen, Kui, Wang, Yujiao, Liang, Haojun, Huang, Huan, Liang, Yuelan, Zhang, Jiaxin, Chang, Yanan, Li, Juan, Fang, Min, Xing, Gengmei. Fullerenols boosting the therapeutic effect of anti-CD47 antibody to trigger robust anti-tumor immunity by inducing calreticulin exposure. NANO TODAY[J]. 2021, 37: http://dx.doi.org/10.1016/j.nantod.2020.101070.
[9] He, Wanxue, Xiao, Kun, Fang, Min, Xie, Lixin. Immune Cell Number, Phenotype, and Function in the Elderly with Sepsis. AGING AND DISEASEnull. 2021, 12(1): 277-296, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801284/.
[10] Lu, Jiao, Li, Shan, Li, Xiaopeng, Zhao, Wenming, Duan, Xuefeng, Gu, Xiuling, Xu, Jianqiao, Yu, Bolan, Sigal, Luis J, Dong, Zhongjun, Xie, Lixin, Fang, Min. Declined miR-181a-5p expression is associated with impaired natural killer cell development and function with aging. AGING CELL[J]. 2021, 20(5): http://dx.doi.org/10.1111/acel.13353.
[11] He, Wanxue, Xiao, Kun, Xu, Jiaruo, Guan, Wei, Xie, Sheling, Wang, Kaifei, Yan, Peng, Fang, Min, Xie, Lixin. Recurrent Sepsis Exacerbates CD4(+) T Cell Exhaustion and Decreases Antiviral Immune Responses. FRONTIERS IN IMMUNOLOGY[J]. 2021, 12: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946831/.
[12] Chen, Kui, Wang, Yujiao, Liang, Haojun, Huang, Huan, Liang, Yuelan, Zhang, Jiaxin, Chang, Yanan, Li, Juan, Fang, Min, Xing, Gengmei. Fullerenols boosting the therapeutic effect of anti-CD47 antibody to trigger robust anti-tumor immunity by inducing calreticulin exposure. NANO TODAY[J]. 2021, 37: http://dx.doi.org/10.1016/j.nantod.2020.101070.
[13] Wang, Qihui, Song, Hao, Cheng, Hao, Qi, Jianxun, Nam, Gol, Tan, Shuguang, Wang, Junzhi, Fang, Min, Shi, Yi, Tian, Zhigang, Cao, Xuetao, An, Zhiqiang, Yan, Jinghua, Gao, George F. Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2020, 17(9): 966-975, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609294/.
[14] Li, Xiaopeng, Zhou, Jiayi, Fang, Min, Yu, Bolan. Pregnancy immune tolerance at the maternal-fetal interface. INTERNATIONAL REVIEWS OF IMMUNOLOGYnull. 2020, 39(6): 247-263, https://www.webofscience.com/wos/woscc/full-record/WOS:000545215300001.
[15] Wang, Qihui, Song, Hao, Cheng, Hao, Qi, Jianxun, Nam, Gol, Tan, Shuguang, Wang, Junzhi, Fang, Min, Shi, Yi, Tian, Zhigang, Cao, Xuetao, An, Zhiqiang, Yan, Jinghua, Gao, George F. Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2020, 17(9): 966-975, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609294/.
[16] Li, Xiaopeng, Zhou, Jiayi, Fang, Min, Yu, Bolan. Pregnancy immune tolerance at the maternal-fetal interface. INTERNATIONAL REVIEWS OF IMMUNOLOGYnull. 2020, 39(6): 247-263, https://www.webofscience.com/wos/woscc/full-record/WOS:000545215300001.
[17] Fang, Min, Zhu, Li, Zhao, Wenming. Influenza virus M1 interacts with SLD5 to block host cell cycle and inhibit lung epithelial regeneration. JOURNAL OF IMMUNOLOGYnull. 2019, 202(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000524982500377.
[18] Peng He, Chuanfang Zhao, Jiao Lu, Yang Zhang, Min Fang, Yuguo Du. Synthesis of 5-Thio-α-GalCer Analogueswith Fluorinated Acyl Chain on Lipid Residue and Their BiologicalEvaluation. ACS Medicinal Chemistry Letters. 2019, 10(2): 221-225, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378668/.
[19] He, Peng, Zhao, Chuanfang, Lu, Jiao, Zhang, Yang, Fang, Min, Du, Yuguo. Synthesis of 5-Thio-alpha-GalCer Analogues with Fluorinated Acyl Chain on Lipid Residue and Their Biological Evaluation (vol 10, pg 221, 2019). ACS MEDICINAL CHEMISTRY LETTERS. 2019, 10(3): 394-394, [20] He, Peng, Zhao, Chuanfang, Lu, Jiao, Zhang, Yang, Fang, Min, Du, Yuguo. Synthesis of 5-Thio-alpha-GalCer Analogues with Fluorinated Acyl Chain on Lipid Residue and Their Biological Evaluation. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2019, 10(2): 221-225, [21] Zhu, Li, Zhao, Wenming, Lu, Jiao, Li, Shan, Zhou, Kai, Jiang, Wei, Duan, Xuefeng, Fu, Lifeng, Yu, Bolan, Cai, Kathy Q, Gao, George Fu, Liu, Wenjun, Fang, Min. Influenza virus matrix protein M1 interacts with SLD5 to block host cell cycle. CELLULAR MICROBIOLOGY[J]. 2019, 21(8): http://dx.doi.org/10.1111/cmi.13038.
[22] Wang, Dongfang, Gu, Xiuling, Liu, Xinjun, Liu, Xiaoman, Wang, Bin, Lao, Fengxue, Fang, Min. "Acquired" NKG2D Ligand Stimulates NK Cell-mediated Tumor Immunosurveillance. JOURNAL OF IMMUNOTHERAPY[J]. 2019, 42(6): 189-196, [23] Fang, Min, Zhu, Li, Zhao, Wenming. Influenza virus M1 interacts with SLD5 to block host cell cycle and inhibit lung epithelial regeneration. JOURNAL OF IMMUNOLOGYnull. 2019, 202(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000524982500377.
[24] Peng He, Chuanfang Zhao, Jiao Lu, Yang Zhang, Min Fang, Yuguo Du. Synthesis of 5-Thio-α-GalCer Analogueswith Fluorinated Acyl Chain on Lipid Residue and Their BiologicalEvaluation. ACS Medicinal Chemistry Letters. 2019, 10(2): 221-225, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378668/.
[25] He, Peng, Zhao, Chuanfang, Lu, Jiao, Zhang, Yang, Fang, Min, Du, Yuguo. Synthesis of 5-Thio-alpha-GalCer Analogues with Fluorinated Acyl Chain on Lipid Residue and Their Biological Evaluation (vol 10, pg 221, 2019). ACS MEDICINAL CHEMISTRY LETTERS. 2019, 10(3): 394-394, [26] He, Peng, Zhao, Chuanfang, Lu, Jiao, Zhang, Yang, Fang, Min, Du, Yuguo. Synthesis of 5-Thio-alpha-GalCer Analogues with Fluorinated Acyl Chain on Lipid Residue and Their Biological Evaluation. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2019, 10(2): 221-225, [27] Zhu, Li, Zhao, Wenming, Lu, Jiao, Li, Shan, Zhou, Kai, Jiang, Wei, Duan, Xuefeng, Fu, Lifeng, Yu, Bolan, Cai, Kathy Q, Gao, George Fu, Liu, Wenjun, Fang, Min. Influenza virus matrix protein M1 interacts with SLD5 to block host cell cycle. CELLULAR MICROBIOLOGY[J]. 2019, 21(8): http://dx.doi.org/10.1111/cmi.13038.
[28] Wang, Dongfang, Gu, Xiuling, Liu, Xinjun, Liu, Xiaoman, Wang, Bin, Lao, Fengxue, Fang, Min. "Acquired" NKG2D Ligand Stimulates NK Cell-mediated Tumor Immunosurveillance. JOURNAL OF IMMUNOTHERAPY[J]. 2019, 42(6): 189-196, [29] Wang, Dongfang, Gu, Xiuling, Liu, Xiaoman, Wei, Songtao, Wang, Bin, Fang, Min. NK cells inhibit anti-Mycobacterium bovis BCG T cell responses and aggravate pulmonary inflammation in a direct lung infection mouse model. CELLULAR MICROBIOLOGY[J]. 2018, 20(7): https://www.webofscience.com/wos/woscc/full-record/WOS:000434636700001.
[30] Wang Haoyu, Lu Jiao, Li Kaili, Ren Hongyu, Shi Yi, Qin Tian, Duan Xuefeng, Fang Min. The virulence of Legionella pneumophila is positively correlated with its ability to stimulate NF-B activation. FUTURE MICROBIOLOGY[J]. 2018, 13(11): 1247-1259, http://www.corc.org.cn/handle/1471x/2201262.
[31] Wang, Bin, Zhang, Yufan, Jiang, Wei, Zhu, Li, Li, Kaili, Zhou, Kai, Dai, Dongsheng, Chang, Shan, Fang, Min. GALNT3 inhibits NF-kappa B signaling during influenza A virus infection. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2018, 503(4): 2872-2877, http://www.corc.org.cn/handle/1471x/2202262.
[32] Fang, Min, Wang, Dongfang, Gu, Xiuling, Liu, Xiaoman, Wei, Songtao, Wang, Bin. NK cells inhibit anti-M.bovis BCG T cell responses by lysing BCG-infected macrophages and aggravating pulmonary inflammation. JOURNAL OF IMMUNOLOGYnull. 2018, 200(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000459977701338.
[33] Wong, Eric, Xu, RenHuan, Rubio, Daniel, Lev, Avital, Stotesbury, Colby, Fang, Min, Sigal, Luis J. Migratory Dendritic Cells, Group 1 Innate Lymphoid Cells, and Inflammatory Monocytes Collaborate to Recruit NK Cells to the Virus-Infected Lymph Node. CELL REPORTS[J]. 2018, 24(1): 142-154, http://dx.doi.org/10.1016/j.celrep.2018.06.004.
[34] Lu, Jiao, Duan, Xuefeng, Zhao, Wenming, Wang, Jing, Wang, Haoyu, Zhou, Kai, Fang, Min. Aged Mice are More Resistant to Influenza Virus Infection due to Reduced Inflammation and Lung Pathology. AGING AND DISEASE[J]. 2018, 9(3): 358-373, http://www.corc.org.cn/handle/1471x/2201328.
[35] Min Fang. The virulence of L. pneumophila is positively correlated with its ability to stimulate NF-κB activation. Future Microbiol. 2018, [36] Zhu Li, Dai Dongsheng, Fang Min, Zhang Yufan, Jiang Wei, Wang Bin, Li Kaili, Chang Shan, Zhou Kai. Galnt3 inhibits nf-κb signaling during influenza a virus infection.. Biochemical & biophysical research communications[J]. 2018, Vol.503 no.4(4): 2872-2877, http://www.corc.org.cn/handle/1471x/2204359.
[37] Bin Wang, Yufan Zhang, Wei Jiang, Li Zhu, Kaili Li, Kai Zhou, Dongsheng Dai, Shan Chang, Min Fang. GALNT3 inhibits NF-κB signaling during influenza A virus infection. Biochemical and Biophysical Research Communications. 2018, 503(4): 2872-2877, http://www.corc.org.cn/handle/1471x/2204359.
[38] Peng, Shanxin, Wang, Jing, Wei, Songtao, Li, Changfei, Zhou, Kai, Hu, Jun, Ye, Xin, Yan, Jinghua, Liu, Wenjun, Gao, George F, Fang, Min, Meng, Songdong. Endogenous Cellular MicroRNAs Mediate Antiviral Defense against Influenza A Virus. MOLECULAR THERAPY-NUCLEIC ACIDS[J]. 2018, 10(C): 361-375, http://dx.doi.org/10.1016/j.omtn.2017.12.016.
[39] Wang, Haoyu, Lu, Jiao, Li, Kaili, Ren, Hongyu, Shi, Yi, Qin, Tian, Duan, Xuefeng, Fang, Min. The virulence of Legionella pneumophila is positively correlated with its ability to stimulate NF-kappa B activation. FUTURE MICROBIOLOGY[J]. 2018, 13(11): 1247-1259, [40] Li, Kaili, Xu, Henan, Jiang, Wei, Li, Jing, Liu, Wenjun, Wang, Tao, Fang, Min. Development and characterization of stable reporter cells for fast and sensitive detection of pyrogen. ANALYTICAL BIOCHEMISTRY[J]. 2018, 557: 69-76, http://www.corc.org.cn/handle/1471x/2202095.
[41] Wang, Dongfang, Gu, Xiuling, Liu, Xiaoman, Wei, Songtao, Wang, Bin, Fang, Min. NK cells inhibit anti-Mycobacterium bovis BCG T cell responses and aggravate pulmonary inflammation in a direct lung infection mouse model. CELLULAR MICROBIOLOGY[J]. 2018, 20(7): https://www.webofscience.com/wos/woscc/full-record/WOS:000434636700001.
[42] Wang Haoyu, Lu Jiao, Li Kaili, Ren Hongyu, Shi Yi, Qin Tian, Duan Xuefeng, Fang Min. The virulence of Legionella pneumophila is positively correlated with its ability to stimulate NF-B activation. FUTURE MICROBIOLOGY[J]. 2018, 13(11): 1247-1259, http://www.corc.org.cn/handle/1471x/2201262.
[43] Wang, Bin, Zhang, Yufan, Jiang, Wei, Zhu, Li, Li, Kaili, Zhou, Kai, Dai, Dongsheng, Chang, Shan, Fang, Min. GALNT3 inhibits NF-kappa B signaling during influenza A virus infection. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2018, 503(4): 2872-2877, http://www.corc.org.cn/handle/1471x/2202262.
[44] Fang, Min, Wang, Dongfang, Gu, Xiuling, Liu, Xiaoman, Wei, Songtao, Wang, Bin. NK cells inhibit anti-M.bovis BCG T cell responses by lysing BCG-infected macrophages and aggravating pulmonary inflammation. JOURNAL OF IMMUNOLOGYnull. 2018, 200(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000459977701338.
[45] Wong, Eric, Xu, RenHuan, Rubio, Daniel, Lev, Avital, Stotesbury, Colby, Fang, Min, Sigal, Luis J. Migratory Dendritic Cells, Group 1 Innate Lymphoid Cells, and Inflammatory Monocytes Collaborate to Recruit NK Cells to the Virus-Infected Lymph Node. CELL REPORTS[J]. 2018, 24(1): 142-154, http://dx.doi.org/10.1016/j.celrep.2018.06.004.
[46] Lu, Jiao, Duan, Xuefeng, Zhao, Wenming, Wang, Jing, Wang, Haoyu, Zhou, Kai, Fang, Min. Aged Mice are More Resistant to Influenza Virus Infection due to Reduced Inflammation and Lung Pathology. AGING AND DISEASE[J]. 2018, 9(3): 358-373, http://www.corc.org.cn/handle/1471x/2201328.
[47] Min Fang. The virulence of L. pneumophila is positively correlated with its ability to stimulate NF-κB activation. Future Microbiol. 2018, [48] Zhu Li, Dai Dongsheng, Fang Min, Zhang Yufan, Jiang Wei, Wang Bin, Li Kaili, Chang Shan, Zhou Kai. Galnt3 inhibits nf-κb signaling during influenza a virus infection.. Biochemical & biophysical research communications[J]. 2018, Vol.503 no.4(4): 2872-2877, http://www.corc.org.cn/handle/1471x/2204359.
[49] Bin Wang, Yufan Zhang, Wei Jiang, Li Zhu, Kaili Li, Kai Zhou, Dongsheng Dai, Shan Chang, Min Fang. GALNT3 inhibits NF-κB signaling during influenza A virus infection. Biochemical and Biophysical Research Communications. 2018, 503(4): 2872-2877, http://www.corc.org.cn/handle/1471x/2204359.
[50] Peng, Shanxin, Wang, Jing, Wei, Songtao, Li, Changfei, Zhou, Kai, Hu, Jun, Ye, Xin, Yan, Jinghua, Liu, Wenjun, Gao, George F, Fang, Min, Meng, Songdong. Endogenous Cellular MicroRNAs Mediate Antiviral Defense against Influenza A Virus. MOLECULAR THERAPY-NUCLEIC ACIDS[J]. 2018, 10(C): 361-375, http://dx.doi.org/10.1016/j.omtn.2017.12.016.
[51] Wang, Haoyu, Lu, Jiao, Li, Kaili, Ren, Hongyu, Shi, Yi, Qin, Tian, Duan, Xuefeng, Fang, Min. The virulence of Legionella pneumophila is positively correlated with its ability to stimulate NF-kappa B activation. FUTURE MICROBIOLOGY[J]. 2018, 13(11): 1247-1259, [52] Li, Kaili, Xu, Henan, Jiang, Wei, Li, Jing, Liu, Wenjun, Wang, Tao, Fang, Min. Development and characterization of stable reporter cells for fast and sensitive detection of pyrogen. ANALYTICAL BIOCHEMISTRY[J]. 2018, 557: 69-76, http://www.corc.org.cn/handle/1471x/2202095.
[53] Duan, Xuefeng, Li, Shihua, Wong, Gary, Wang, Dongfang, Wang, Haoyu, Lu, Jiao, Bi, Yuhai, Lu, Xuancheng, Shi, Yi, Yan, Jinghua, Fang, Min, Gao, George Fu. Natural killer cells are activated and play a protective role against ZIKA virus infection in mice. SCIENCE BULLETIN. 2017, 62(14): 982-984, http://www.corc.org.cn/handle/1471x/2158652.
[54] Min Fang. Changes of peripheral lymphocyte subsets and cytokine environment during ageing and deteriorating gastrointestinal tract health status. Oncotarget. 2017, [55] Wang, Jing, Yang, Guodong, Wang, Dongfang, Liu, Kuiliang, Ma, Yongchao, Liu, Hong, Wu, Jing, Fang, Min. Changes of peripheral lymphocyte subsets and cytokine environment during aging and deteriorating gastrointestinal tract health status. ONCOTARGET[J]. 2017, 8(37): 60764-60777, https://www.webofscience.com/wos/woscc/full-record/WOS:000409254200004.
[56] Duan, Xuefeng, Lu, Jiao, Wang, Haoyu, Liu, Xiaofei, Wang, Jing, Zhou, Kai, Jiang, Wei, Wang, Yingchun, Fang, Min. Bidirectional factors impact the migration of NK cells to draining lymph node in aged mice during influenza virus infection. EXPERIMENTAL GERONTOLOGY[J]. 2017, 96: 127-137, http://www.corc.org.cn/handle/1471x/2157157.
[57] Li, Jing, Lu, Jiao, Zhang, Shuang, Wang, Jing, Wang, Haoyu, Liu, Fei, Fang, Min, Duan, Xuefeng, Liu, Wenjun. Differential immune response of influenza A virus-infected dendritic cells and association with autophagy. FUTURE VIROLOGY[J]. 2017, 12(11): 635-649, http://www.corc.org.cn/handle/1471x/2158902.
[58] Duan, Xuefeng, Li, Shihua, Wong, Gary, Wang, Dongfang, Wang, Haoyu, Lu, Jiao, Bi, Yuhai, Lu, Xuancheng, Shi, Yi, Yan, Jinghua, Fang, Min, Gao, George Fu. Natural killer cells are activated and play a protective role against ZIKA virus infection in mice. SCIENCE BULLETIN. 2017, 62(14): 982-984, http://www.corc.org.cn/handle/1471x/2158652.
[59] Min Fang. Changes of peripheral lymphocyte subsets and cytokine environment during ageing and deteriorating gastrointestinal tract health status. Oncotarget. 2017, [60] Wang, Jing, Yang, Guodong, Wang, Dongfang, Liu, Kuiliang, Ma, Yongchao, Liu, Hong, Wu, Jing, Fang, Min. Changes of peripheral lymphocyte subsets and cytokine environment during aging and deteriorating gastrointestinal tract health status. ONCOTARGET[J]. 2017, 8(37): 60764-60777, https://www.webofscience.com/wos/woscc/full-record/WOS:000409254200004.
[61] Duan, Xuefeng, Lu, Jiao, Wang, Haoyu, Liu, Xiaofei, Wang, Jing, Zhou, Kai, Jiang, Wei, Wang, Yingchun, Fang, Min. Bidirectional factors impact the migration of NK cells to draining lymph node in aged mice during influenza virus infection. EXPERIMENTAL GERONTOLOGY[J]. 2017, 96: 127-137, http://www.corc.org.cn/handle/1471x/2157157.
[62] Li, Jing, Lu, Jiao, Zhang, Shuang, Wang, Jing, Wang, Haoyu, Liu, Fei, Fang, Min, Duan, Xuefeng, Liu, Wenjun. Differential immune response of influenza A virus-infected dendritic cells and association with autophagy. FUTURE VIROLOGY[J]. 2017, 12(11): 635-649, http://www.corc.org.cn/handle/1471x/2158902.
[63] Zhou, Kai, Wang, Jing, Li, An, Zhao, Wenming, Wang, Dongfang, Zhang, Wei, Yan, Jinghua, Gao, George Fu, Liu, Wenjun, Fang, Min. Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection. JOURNAL OF IMMUNOLOGY[J]. 2016, 196(4): 1842-1854, https://www.webofscience.com/wos/woscc/full-record/WOS:000369632300041.
[64] George Fu Gao, Wenming Zhao, Jing Wang, Wei Zhang, Min Fang, Jinghua Yan, An Li, Kai Zhou, Wenjun Liu, Dongfang Wang. Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection. American Association of Immunologists. 2016, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902029607152ZK.
[65] Hussain, Muhammad Ramzan Manwar, Hoessli, Daniel C, Fang, Min. N-acetylgalactosaminyltransferases in cancer. ONCOTARGET[J]. 2016, 7(33): 54067-54081, http://www.corc.org.cn/handle/1471x/2374912.
[66] Jiang, Wei, Sheng, Chunjie, Gu, Xiuling, Liu, Dong, Yao, Chen, Gao, Shijuan, Chen, Shuai, Huang, Yinghui, Huang, Wenlin, Fang, Min. Suppression of Rac1 Signaling by Influenza A Virus NS1 Facilitates Viral Replication. SCIENTIFIC REPORTS[J]. 2016, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000388162100001.
[67] Zhou, Kai, Wang, Jing, Li, An, Zhao, Wenming, Wang, Dongfang, Zhang, Wei, Yan, Jinghua, Gao, George Fu, Liu, Wenjun, Fang, Min. Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection. JOURNAL OF IMMUNOLOGY[J]. 2016, 196(4): 1842-1854, https://www.webofscience.com/wos/woscc/full-record/WOS:000369632300041.
[68] George Fu Gao, Wenming Zhao, Jing Wang, Wei Zhang, Min Fang, Jinghua Yan, An Li, Kai Zhou, Wenjun Liu, Dongfang Wang. Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection. American Association of Immunologists. 2016, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902029607152ZK.
[69] Hussain, Muhammad Ramzan Manwar, Hoessli, Daniel C, Fang, Min. N-acetylgalactosaminyltransferases in cancer. ONCOTARGET[J]. 2016, 7(33): 54067-54081, http://www.corc.org.cn/handle/1471x/2374912.
[70] Jiang, Wei, Sheng, Chunjie, Gu, Xiuling, Liu, Dong, Yao, Chen, Gao, Shijuan, Chen, Shuai, Huang, Yinghui, Huang, Wenlin, Fang, Min. Suppression of Rac1 Signaling by Influenza A Virus NS1 Facilitates Viral Replication. SCIENTIFIC REPORTS[J]. 2016, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000388162100001.
[71] Jingjing Bi, Jing Wang, Kai Zhou, Yuancheng Wang, Min Fang, Yuguo Du. Synthesis and Biological Activities of 5-Thio-α-GalCers. ACS Medicinal Chemistry Letters. 2015, 6(4): 476-480, [72] Min Fang. Natural Killer Cells are involved in Thymic Atrophy induced by Influenza A Virus Infection. J Gen Virol. 2015, [73] Fang, Min, Sigal, Luis J. Protective CD8(+) T cell memory without help. ONCOTARGETnull. 2015, 6(30): 28529-28530, https://www.webofscience.com/wos/woscc/full-record/WOS:000363183200009.
[74] Nair, Savita, Fang, Min, Sigal, Luis J. The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15R alpha treatment. AGING CELL[J]. 2015, 14(2): 180-190, https://www.webofscience.com/wos/woscc/full-record/WOS:000350659900004.
[75] Fang, Min, Remakus, Sanda, Roscoe, Felicia, Ma, Xueying, Sigal, Luis J. CD4(+) T Cell Help Is Dispensable for Protective CD8(+) T Cell Memory against Mousepox Virus following Vaccinia Virus Immunization. JOURNAL OF VIROLOGY[J]. 2015, 89(1): 776-783, https://www.webofscience.com/wos/woscc/full-record/WOS:000347176100065.
[76] Bi, Jingjing, Wang, Jing, Zhou, Kai, Wang, Yuancheng, Fang, Min, Du, Yuguo. Synthesis and Biological Activities of 5-Thio-alpha-GalCers. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2015, 6(4): 476-480, http://dx.doi.org/10.1021/acsmedchemlett.5b00046.
[77] Duan, Xuefeng, Lu, Jiao, Zhou, Kai, Wang, Jing, Wu, Jihua, Gao, George Fu, Fang, Min. NK-cells are involved in thymic atrophy induced by influenza A virus infection. JOURNAL OF GENERAL VIROLOGY[J]. 2015, 96: 3223-3235, https://www.webofscience.com/wos/woscc/full-record/WOS:000367206200006.
[78] Jingjing Bi, Jing Wang, Kai Zhou, Yuancheng Wang, Min Fang, Yuguo Du. Synthesis and Biological Activities of 5-Thio-α-GalCers. ACS Medicinal Chemistry Letters. 2015, 6(4): 476-480, [79] Min Fang. Natural Killer Cells are involved in Thymic Atrophy induced by Influenza A Virus Infection. J Gen Virol. 2015, [80] Fang, Min, Sigal, Luis J. Protective CD8(+) T cell memory without help. ONCOTARGETnull. 2015, 6(30): 28529-28530, https://www.webofscience.com/wos/woscc/full-record/WOS:000363183200009.
[81] Nair, Savita, Fang, Min, Sigal, Luis J. The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15R alpha treatment. AGING CELL[J]. 2015, 14(2): 180-190, https://www.webofscience.com/wos/woscc/full-record/WOS:000350659900004.
[82] Fang, Min, Remakus, Sanda, Roscoe, Felicia, Ma, Xueying, Sigal, Luis J. CD4(+) T Cell Help Is Dispensable for Protective CD8(+) T Cell Memory against Mousepox Virus following Vaccinia Virus Immunization. JOURNAL OF VIROLOGY[J]. 2015, 89(1): 776-783, https://www.webofscience.com/wos/woscc/full-record/WOS:000347176100065.
[83] Bi, Jingjing, Wang, Jing, Zhou, Kai, Wang, Yuancheng, Fang, Min, Du, Yuguo. Synthesis and Biological Activities of 5-Thio-alpha-GalCers. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2015, 6(4): 476-480, http://dx.doi.org/10.1021/acsmedchemlett.5b00046.
[84] Duan, Xuefeng, Lu, Jiao, Zhou, Kai, Wang, Jing, Wu, Jihua, Gao, George Fu, Fang, Min. NK-cells are involved in thymic atrophy induced by influenza A virus infection. JOURNAL OF GENERAL VIROLOGY[J]. 2015, 96: 3223-3235, https://www.webofscience.com/wos/woscc/full-record/WOS:000367206200006.
[85] Ma YongChao, Fang Min. Immunosenescence and age-related viral diseases. SCIENCE CHINA-LIFE SCIENCES[J]. 2013, 56(5): 399-405, https://www.webofscience.com/wos/woscc/full-record/WOS:000318308100003.
[86] Min Fang. Natural Killer cells in Innate Defense against Infective Pathogens. Journal of Clinical & Cellular Immunology. 2013, [87] Ma YongChao, Fang Min. Immunosenescence and age-related viral diseases. SCIENCE CHINA-LIFE SCIENCES[J]. 2013, 56(5): 399-405, https://www.webofscience.com/wos/woscc/full-record/WOS:000318308100003.
[88] Min Fang. Natural Killer cells in Innate Defense against Infective Pathogens. Journal of Clinical & Cellular Immunology. 2013, [89] Fang, Min, Siciliano, Nicholas A, Hersperger, Adam R, Roscoe, Felicia, Hu, Angela, Ma, Xueying, Shamsedeen, Ahamed R, Eisenlohr, Laurence C, Sigal, Luis J. Perforin-dependent CD4(+) T-cell cytotoxicity contributes to control a murine poxvirus infection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2012, 109(25): 9983-9988, https://www.webofscience.com/wos/woscc/full-record/WOS:000306061400066.
[90] Fang, Min, Siciliano, Nicholas A, Hersperger, Adam R, Roscoe, Felicia, Hu, Angela, Ma, Xueying, Shamsedeen, Ahamed R, Eisenlohr, Laurence C, Sigal, Luis J. Perforin-dependent CD4(+) T-cell cytotoxicity contributes to control a murine poxvirus infection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2012, 109(25): 9983-9988, https://www.webofscience.com/wos/woscc/full-record/WOS:000306061400066.
[91] Fang, Min, Orr, Mark T, Spee, Pieter, Egebjerg, Thomas, Lanier, Lewis L, Sigal, Luis J. CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease. IMMUNITY[J]. 2011, 34(4): 579-589, http://dx.doi.org/10.1016/j.immuni.2011.02.015.
[92] Fang, Min, Orr, Mark T, Spee, Pieter, Egebjerg, Thomas, Lanier, Lewis L, Sigal, Luis J. CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease. IMMUNITY[J]. 2011, 34(4): 579-589, http://dx.doi.org/10.1016/j.immuni.2011.02.015.
[93] Orr, Mark T, Wu, Jun, Fang, Min, Sigal, Luis J, Spee, Pieter, Egebjerg, Thomas, Dissen, Erik, Fossum, Sigbjorn, Phillips, Joseph H, Lanier, Lewis L. Development and Function of CD94-Deficient Natural Killer Cells. PLOS ONE[J]. 2010, 5(12): https://www.webofscience.com/wos/woscc/full-record/WOS:000284939600030.
[94] Min Fang. Age-dependent susceptibility to a viral disease due to decreased NK cell numbers and trafficking. J Exp Med. 2010, [95] Orr, Mark T, Wu, Jun, Fang, Min, Sigal, Luis J, Spee, Pieter, Egebjerg, Thomas, Dissen, Erik, Fossum, Sigbjorn, Phillips, Joseph H, Lanier, Lewis L. Development and Function of CD94-Deficient Natural Killer Cells. PLOS ONE[J]. 2010, 5(12): https://www.webofscience.com/wos/woscc/full-record/WOS:000284939600030.
[96] Min Fang. Age-dependent susceptibility to a viral disease due to decreased NK cell numbers and trafficking. J Exp Med. 2010, [97] Fang, Min, Lanier, Lewis L, Sigal, Luis J. A role for NKG2D in NK cell-mediated resistance to poxvirus disease. PLOS PATHOGENS[J]. 2008, 4(2): https://doaj.org/article/a9593830f6dc4d13a12dbb179373d012.
[98] MacFarlane, Alexander W, Yamazaki, Tetsuo, Fang, Min, Sigal, Luis J, Kurosaki, Tomohiro, Campbell, Kerry S. Enhanced NK-cell development and function in BCAP-deficient mice. BLOOD[J]. 2008, 112(1): 131-140, https://www.webofscience.com/wos/woscc/full-record/WOS:000257199300025.
[99] Fang, Min, Lanier, Lewis L, Sigal, Luis J. A role for NKG2D in NK cell-mediated resistance to poxvirus disease. PLOS PATHOGENS[J]. 2008, 4(2): https://doaj.org/article/a9593830f6dc4d13a12dbb179373d012.
[100] MacFarlane, Alexander W, Yamazaki, Tetsuo, Fang, Min, Sigal, Luis J, Kurosaki, Tomohiro, Campbell, Kerry S. Enhanced NK-cell development and function in BCAP-deficient mice. BLOOD[J]. 2008, 112(1): 131-140, https://www.webofscience.com/wos/woscc/full-record/WOS:000257199300025.
[101] Xu, RenHuan, Fang, Min, KleinSzanto, Andres, Sigal, Luis J. Memory CD8(+) T cells are gatekeepers of the lymph node draining the site of viral infection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2007, 104(26): 10992-10997, https://www.webofscience.com/wos/woscc/full-record/WOS:000247641900045.
[102] Xu, RenHuan, Fang, Min, KleinSzanto, Andres, Sigal, Luis J. Memory CD8(+) T cells are gatekeepers of the lymph node draining the site of viral infection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2007, 104(26): 10992-10997, https://www.webofscience.com/wos/woscc/full-record/WOS:000247641900045.
[103] Min Fang, Luis J Sigal. Direct CD28 Costimulation Is Required for CD8+ T Cell-Mediated Resistance to an Acute Viral Disease in a Natural Host. American Association of Immunologists. 2006, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902029448109ZK.
[104] Fang, M, Cheng, H, Dai, ZP, Bu, ZM, Sigal, LJ. Immunization with a single extracellular enveloped virus protein produced in bacteria provides partial protection from a lethal orthopoxvirus infection in a natural host. VIROLOGY[J]. 2006, 345(1): 231-243, http://dx.doi.org/10.1016/j.virol.2005.09.056.
[105] Min Fang, Luis J Sigal. Direct CD28 Costimulation Is Required for CD8+ T Cell-Mediated Resistance to an Acute Viral Disease in a Natural Host. American Association of Immunologists. 2006, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902029448109ZK.
[106] Fang, M, Cheng, H, Dai, ZP, Bu, ZM, Sigal, LJ. Immunization with a single extracellular enveloped virus protein produced in bacteria provides partial protection from a lethal orthopoxvirus infection in a natural host. VIROLOGY[J]. 2006, 345(1): 231-243, http://dx.doi.org/10.1016/j.virol.2005.09.056.
[107] Min Fang, Luis J Sigal. Antibodies and CD8+ T Cells Are Complementary and Essential for Natural Resistance to a Highly Lethal Cytopathic Virus. American Association of Immunologists. 2005, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902026551981ZK.
[108] Min Fang, Luis J Sigal. Antibodies and CD8+ T Cells Are Complementary and Essential for Natural Resistance to a Highly Lethal Cytopathic Virus. American Association of Immunologists. 2005, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902026551981ZK.
[109] Min Fang, Rui Zhao, Zhi Yang, Zhong Zhang, Hua Li, Xue-Tao Zhang, Qing Lin, Hua-Liang Huang. Characterization of an anti-human ovarian carcinoma×anti-human CD3 bispecific single-chain antibody with an albumin-original interlinker. Gynecologic Oncology. 2004, 92(1): 135-146, http://dx.doi.org/10.1016/j.ygyno.2003.10.032.
[110] Min Fang, Rui Zhao, Zhi Yang, Zhong Zhang, Hua Li, Xue-Tao Zhang, Qing Lin, Hua-Liang Huang. Characterization of an anti-human ovarian carcinoma×anti-human CD3 bispecific single-chain antibody with an albumin-original interlinker. Gynecologic Oncology. 2004, 92(1): 135-146, http://dx.doi.org/10.1016/j.ygyno.2003.10.032.

（ 1 ） 研究小鼠鼠痘病毒感染中的NK细胞反应, Studying NK cell responses to ectromelia virus infections in mice, Humana Press, 2012-05, 第 1 作者

   

（ 1 ） 青年****, 主持, 国家级, 2012-06--2015-05
（ 2 ） 免疫学, 主持, 国家级, 2014-01--2016-12
（ 3 ） NK细胞随衰老出现发育分化缺陷的分子机制研究, 主持, 国家级, 2014-01--2017-12
（ 4 ） 宿主免疫细胞对流感等重要病毒应答的蛋白质分子基础, 主持, 国家级, 2015-01--2019-12
（ 5 ） 宿主调控病毒复制机制的研究, 参与, 国家级, 2014-01--2018-12

（1）Swift and strong NK cell responses protect 129 mice against high dose influenza virus infection   Kai Zhou, Jing Wang, An Li, Wenming Zhao, Dongfang Wang, Wei Zhang, Jinghua Yan, George Fu Gao, Wenjun Liu, Min Fang   2015-05-02
（2）Identify the melocular mechamisms that regulate defective NK cell development in aged mice   Min Fang   2015-02-28

现指导学生

王静  博士研究生  071010-生物化学与分子生物学  

顾秀玲  硕士研究生  085238-生物工程  

王东方  博士研究生  071010-生物化学与分子生物学  

王斌  硕士研究生  085238-生物工程  

卢娇  博士研究生  071010-生物化学与分子生物学  

徐赫男   硕士研究生  085238-生物工程  

彭齐  博士研究生  071010-生物化学与分子生物学  

朱莉  博士研究生  071010-生物化学与分子生物学