General
Research Areas
RNA modification
Bioinformatics
Anti-tumor therapies
Stem cells and tissue regeneration
Education
2003-2007 USTC, Biology
2007-2012 IGDB-CAS, Bioinformatics PhD
Experience
2017-Now BIG CAS, PI
2012-2017 UChicago, Postdoc
Publications
(1) N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription, Science, 2020
(2) Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells, Nature, 2019
(3) Highly Efficient Base Editing in Staphylococcus aureus Using an Engineered CRISPR RNA-guided Cytidine Deaminase, Chemical Science, 2018
(4) Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer, Cell Research, 2018
(5) Nm-seq maps 2-O-methylation sites in human mRNA with base precision, Nature Methods, 2017
(6) A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations, Molecular Cell, 2016
(7) Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale, Nature Methods, 2015
(8) Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics, Cell Research, 2015
(9) Evolution of Alu elements toward enhancers, Cell Reports, 2014
(10) Stress‐associated H3K4 methylation accumulates during postnatal development and aging of rhesus macaque brain, Aging Cell, 2012
(11) Ab initio identification of transcription start sites in the Rhesus macaque genome by histone modification and RNA-Seq, Nucleic acids research, 2011
(2) Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells, Nature, 2019
(3) Highly Efficient Base Editing in Staphylococcus aureus Using an Engineered CRISPR RNA-guided Cytidine Deaminase, Chemical Science, 2018
(4) Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer, Cell Research, 2018
(5) Nm-seq maps 2-O-methylation sites in human mRNA with base precision, Nature Methods, 2017
(6) A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations, Molecular Cell, 2016
(7) Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale, Nature Methods, 2015
(8) Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics, Cell Research, 2015
(9) Evolution of Alu elements toward enhancers, Cell Reports, 2014
(10) Stress‐associated H3K4 methylation accumulates during postnatal development and aging of rhesus macaque brain, Aging Cell, 2012
(11) Ab initio identification of transcription start sites in the Rhesus macaque genome by histone modification and RNA-Seq, Nucleic acids research, 2011