General
   

Research Areas

RNA modification

Bioinformatics

Anti-tumor therapies

Stem cells and tissue regeneration


Education

2003-2007 USTC, Biology

2007-2012 IGDB-CAS, Bioinformatics PhD

Experience

2017-Now     BIG CAS,   PI

2012-2017     UChicago, Postdoc

Publications

(1) N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription, Science, 2020
(2) Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells, Nature, 2019
(3) Highly Efficient Base Editing in Staphylococcus aureus Using an Engineered CRISPR RNA-guided Cytidine Deaminase, Chemical Science, 2018
(4) Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer, Cell Research, 2018
(5) Nm-seq maps 2-O-methylation sites in human mRNA with base precision, Nature Methods, 2017
(6) A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations, Molecular Cell, 2016
(7) Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale, Nature Methods, 2015
(8) Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics, Cell Research, 2015
(9) Evolution of Alu elements toward enhancers, Cell Reports, 2014
(10) Stress‐associated H3K4 methylation accumulates during postnatal development and aging of rhesus macaque brain, Aging Cell, 2012
(11) Ab initio identification of transcription start sites in the Rhesus macaque genome by histone modification and RNA-Seq, Nucleic acids research, 2011