基本信息
丁侃 男 博导 上海药物研究所
电子邮件:kding@mail.shcnc.ac.cn
通信地址:上海浦东张江祖冲之路555号
邮政编码:201203

研究领域

    运用有机化学、细胞生物学、分子生物学,中药学等化学与生物学交叉学科手段,进行生物体内多糖、寡糖、蛋白聚糖结构与功能研究,在此基础上致力于重大疾病的药物研发。

招生信息

   
招生专业
100706-药理学
100701-药物化学
招生方向


教育背景

   
学历
-- 研究生
学位
-- 博士

专利与奖励

   
专利成果
[1] 丁侃. 一种天葵子糖肽、其制备方法及用途. CN202310023083.5, 2023-01-05.
[2] 丁侃. 一种月季花中新均一多糖的制备及其在抗纤维化药物中的应用. CN202211651073.8, 2022-12-21.
[3] 丁侃. 铁皮石斛花中新聚糖的制备及其调节肠道菌群的新应用. CN202211651085.0, 2022-12-21.
[4] 丁侃. 一种芫花新聚糖的制备及其新用途. CN202211651316.8, 2022-12-21.
[5] 丁侃. 海藻硫酸多糖及其制备方法和用途. CN202211624541.2, 2022-12-16.
[6] 丁侃. 一种栀子多糖及其制备方法及用途. CN202210314228.2, 2022-03-28.
[7] 丁侃. 一种合欢花非均一多糖,其制备方法及用途. CN202210215654.0, 2022-03-07.
[8] 丁侃. 丁香多糖、其制备方法及应用. CN202111230082.5, 2021-10-21.

出版信息

   
发表论文
[1] Pan, Haoyu, Chen, Xia, Wang, PeiPei, Peng, Junfeng, Li, Judong, Ding, Kan. Effects of Nemacystus decipiens polysaccharide on mice with antibiotic associated diarrhea and colon inflammation. FOOD & FUNCTION[J]. 2023, 14(3): 1627-1635, [2] Jiang, Lan, Zhang, Tianji, Lu, Hongzhong, Li, Saijuan, Lv, Kangjie, Tuffour, Alex, Zhang, Lixin, Ding, Kan, Li, JinPing, Li, Hongmei, Liu, Xueting. Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing. SYNTHETIC AND SYSTEMS BIOTECHNOLOGYnull. 2023, 8(1): 11-19, http://dx.doi.org/10.1016/j.synbio.2022.10.002.
[3] Saijuan Li, Tingting Li, Binqiang Wang, Chang Wen, Meixia Li, Kan Ding. A structure defined pectin SA02B from Semiaquilegia adoxoides is metabolized by human gut microbes. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2023, 234: http://dx.doi.org/10.1016/j.ijbiomac.2023.123673.
[4] Sun, Chuanxin, Chen, Xia, Yang, Shangpo, Jin, Can, Ding, Kan, Chen, Chang. LBP1C-2 from Lycium barbarum alleviated age-related bone loss by targeting BMPRIA/BMPRII/Noggin. CARBOHYDRATE POLYMERS[J]. 2023, 310: http://dx.doi.org/10.1016/j.carbpol.2023.120725.
[5] Liao, Wenfeng, Hu, Xiaodong, Du, Zhenyun, Wang, Peipei, Ding, Kan. A homogalacturonan from Lonicera japonica Thunb. disrupts angiogenesis via epidermal growth factor receptor and Delta-like 4 associated signaling. GLYCOCONJUGATE JOURNAL[J]. 2022, 39(6): 725-735, [6] Li, Saijuan, Jin, Can, Gao, Pengcheng, Zhou, Wanqi, Xiao, Rongrong, Zhang, Zhenqiang, Liao, Wenfeng, Ding, Kan. A Novel Pectin-Like Glycopeptide Isolated from the Fruit of Fructus Mori Impedes Aggregation and Production of A beta(42). JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2022, 70(32): 9908-9918, [7] Hu, Chaoyu, Wu, Shengjie, He, Fei, Cai, Deqin, Xu, Zhuojia, Ma, Wenjing, Liu, Yating, Wei, Bangguo, Li, Tiehai, Ding, Kan. Convergent Synthesis and Anti-Pancreatic Cancer Cell Growth Activity of a Highly Branched Heptadecasaccharide from Carthamus tinctorius. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, 61(32): http://dx.doi.org/10.1002/anie.202202554.
[8] Li Yan, Yang Qingran, Yang Chi, Ding Kan, Xu Guangzhou. Evaluation of the predominant bacteria and proinflammatory cytokine expressions in odontogenic cysts. ACTA BIOCHIMICA ET BIOPHYSICA SINICA[J]. 2022, 54(3): 409-411, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7254917&detailType=1.
[9] Li, Bingbing, Hong, Ying, Gu, Yu, Ye, Shengjie, Hu, Kaili, Yao, Jian, Ding, Kan, Zhao, Aihua, Jia, Wei, Li, Houkai. Functional Metabolomics Reveals that Astragalus Polysaccharides Improve Lipids Metabolism through Microbial Metabolite 2-Hydroxybutyric Acid in Obese Mice. ENGINEERING[J]. 2022, 9(2): 111-122, https://doaj.org/article/c446843590b445c89e60a80ae5d3fd53.
[10] Huang, Lulin, Zeng, Hui, Jin, Can, Ma, Xiaonan, Zhang, Yiwen, Huang, Chunfan, Du, Zhenyun, Ding, Kan. Sulfated galactoglucan impedes xenografted lung cancer cell growth by blocking angiogenesis via binding BMPRs. CARBOHYDRATE POLYMERS[J]. 2022, 289: http://dx.doi.org/10.1016/j.carbpol.2022.119412.
[11] Zhang, Shihai, Pei, Rongjuan, Li, Meixia, Su, Haixia, Sun, Hao, Ding, Yaqi, Su, Minbo, Huang, Chunfan, Chen, Xia, Du, Zhenyun, Jin, Can, Zang, Yi, Li, Jia, Xu, Yechun, Chen, Xinwen, Zhang, Bo, Ding, Kan. Cocktail polysaccharides isolated from Ecklonia kurome against the SARS-CoV-2 infection. CARBOHYDRATE POLYMERS[J]. 2022, 275: 118779-118779, http://dx.doi.org/10.1016/j.carbpol.2021.118779.
[12] Huang, Chunfan, Jing, Xiaoqi, Wu, Qianhu, Ding, Kan. Novel pectin-like polysaccharide from Panax notoginseng attenuates renal tubular cells fibrogenesis induced by TGF-beta. CARBOHYDRATE POLYMERS[J]. 2022, 276: http://dx.doi.org/10.1016/j.carbpol.2021.118772.
[13] Pan, HaoYu, Zhang, ChunQian, Zhang, XiuQi, Zeng, Hui, Dong, ChunHong, Chen, Xia, Ding, Kan. A galacturonan from Dioscorea opposita Thunb. regulates fecal and impairs IL-1 and IL-6 expression in diarrhea mice. GLYCOCONJUGATE JOURNAL[J]. 2022, 39(1): 131-141, http://dx.doi.org/10.1007/s10719-022-10053-z.
[14] Zhang, L, Wang, P, Qin, Y, Cong, Q, Shao, C, Du, Z, Ni, X, Li, P, Ding, K. RN1, a novel galectin-3 inhibitor, inhibits pancreatic cancer cell growth in vitro and in vivo via blocking galectin-3 associated signaling pathways. ONCOGENE[J]. 2017, 36(9): 1297-1308, https://www.webofscience.com/wos/woscc/full-record/WOS:000395861300013.
[15] Cong, Qifei, Chen, Huanjun, Liao, Wenfeng, Xiao, Fei, Wang, Peipei, Qin, Yi, Dong, Qun, Ding, Kan. Structural characterization and effect on anti-angiogenic activity of a fucoidan from Sargassum fusiforme. CARBOHYDRATE POLYMERS[J]. 2016, 136: 899-907, http://dx.doi.org/10.1016/j.carbpol.2015.09.087.
[16] Lin Liyan, Wang Peipei, Du Zhenyun, Wang Wucheng, Cong Qifei, Zheng Changping, Jin Can, Ding Kan, Shao Chenghao. Structural elucidation of a pectin from flowers of Lonicera japonica and its antipancreatic cancer activity. INTERNATIONALJOURNALOFBIOLOGICALMACROMOLECULES[J]. 2016, [17] Kan Ding. A fucoidan from Nemacystus decipiens disrupts angiogenesis through targeting BMP4. Carbohydr. Polym. 2016, [18] Kan Ding. microRNA-149 targets caspase-2 in glioma progression. Oncotarget. Oncotarget. 2016, [19] Chen, Huanjun, Cong, Qifei, Du, Zhenyun, Liao, Wenfeng, Zhang, Lei, Yao, Yanli, Ding, Kan. Sulfated fucoidan FP08S2 inhibits lung cancer cell growth in vivo by disrupting angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/VEGF signaling. CANCER LETTERS[J]. 2016, 382(1): 44-52, http://dx.doi.org/10.1016/j.canlet.2016.08.020.
[20] Kan Ding. WSS25, a sulfated polysaccharide, inhibits RANKL-inducted osteoclast formation through blocking SMAD/ID1 signaling. Acta Pharmacol Sin. 2015, [21] Qin, Yi, Ke, Jiyuan, Gu, Xin, Fang, Jianping, Wang, Wucheng, Cong, Qifei, Li, Jie, Tan, Jinzhi, Brunzelle, Joseph S, Zhang, Chenghai, Jiang, Yi, Melcher, Karsten, Li, Jinping, Xu, H Eric, Ding, Kan. Structural and Functional Study of D-Glucuronyl C5-epimerase. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2015, 290(8): 4620-4630, http://dx.doi.org/10.1074/jbc.M114.602201.
[22] Zheng, Changping, Dong, Qun, Chen, Huanjun, Cong, Qifei, Ding, Kan. Structural characterization of a polysaccharide from Chrysanthemum morifolium flowers and its antioxidant activity. CARBOHYDRATE POLYMERS[J]. 2015, 130: 113-121, http://dx.doi.org/10.1016/j.carbpol.2015.05.004.
[23] Wang, Peipei, Zhang, Lei, Yao, Jian, Shi, Yikang, Li, Ping, Ding, Kan. An arabinogalactan from flowers of Panax notoginseng inhibits angiogenesis by BMP2/Smad/Id1 signaling. CARBOHYDRATE POLYMERS[J]. 2015, 121: 328-335, http://dx.doi.org/10.1016/j.carbpol.2014.11.073.
[24] Xiao, F, Qiu, H, Cui, H, Ni, X, Li, J, Liao, W, Lu, L, Ding, K. MicroRNA-885-3p inhibits the growth of HT-29 colon cancer cell xenografts by disrupting angiogenesis via targeting BMPR1A and blocking BMP/Smad/Id1 signaling. ONCOGENE[J]. 2015, 34(15): 1968-1978, https://www.webofscience.com/wos/woscc/full-record/WOS:000352725600011.
[25] Xiong, Xiuming, Chen, Zhaoqiang, Cossins, Benjamin P, Xu, Zhijian, Shao, Qiang, Ding, Kai, Zhu, Weiliang, Shi, Jiye. Force fields and scoring functions for carbohydrate simulation. CARBOHYDRATE RESEARCH[J]. 2015, 401: 73-81, http://dx.doi.org/10.1016/j.carres.2014.10.028.
[26] Zheng, Changping, Dong, Qun, Du, Zhenyun, Wang, Peipei, Ding, Kan. Structural elucidation of a polysaccharide from Chrysanthemum morifolium flowers with anti-angiogenic activity. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2015, 79: 674-680, http://dx.doi.org/10.1016/j.ijbiomac.2015.04.026.
[27] Shen, Xiaokun, Xie, Bojian, Ma, Zhaosheng, Yu, Wenjie, Wang, Wenmin, Xu, Dong, Yan, Xinqiang, Chen, Beibei, Yu, Longyao, Li, Jicheng, Chen, Xiaobing, Ding, Kan, Cao, Feilin. Identification of novel long non-coding RNAs in triple-negative breast cancer. ONCOTARGET[J]. 2015, 6(25): 21730-21739, https://www.webofscience.com/wos/woscc/full-record/WOS:000360969200080.
[28] Ying Wang, Xiaokun Shen, Wenfeng Liao, Jianping Fang, Xia Chen, Qun Dong, Kan Ding. A heteropolysaccharide, l-fuco-d-manno-1,6-α-d-galactan extracted from Grifola frondosa and antiangiogenic activity of its sulfated derivative. CARBOHYDRATE POLYMERS. 2014, 101: 631-641, http://dx.doi.org/10.1016/j.carbpol.2013.09.085.
[29] Shi, Lei, Dong, Qun, Ding, Kan. Structure elucidation and immunomodulatory activity in vitro of a xylan from roots of Cudrania tricuspidata. FOOD CHEMISTRY[J]. 2014, 152: 291-296, http://dx.doi.org/10.1016/j.foodchem.2013.11.091.
[30] Cong, Qifei, Shang, Mingsheng, Dong, Qun, Liao, Wenfeng, Xiao, Fei, Ding, Kan. Structure and activities of a novel heteroxylan from Cassia obtusifolia seeds and its sulfated derivative. CARBOHYDRATERESEARCH[J]. 2014, 393: 43-50, http://dx.doi.org/10.1016/j.carres.2014.04.016.
[31] Peipei Wang, Wenfeng Liao, Jianping Fang, Qin Liu, Jian Yao, Minghua Hu, Kan Ding. A glucan isolated from flowers of Lonicera japonica Thunb. inhibits aggregation and neurotoxicity of Aβ42. CARBOHYDRATE POLYMERS. 2014, 110: 142-147, http://dx.doi.org/10.1016/j.carbpol.2014.03.060.
[32] Kan Ding. Proteoglycans and Glycosaminoglycans in Misfolded Proteins Formation in Alzheimer’s Disease. Protein Pept Lett. Protein Pept Lett. 2014, [33] Kan Ding. Glce regulates PC12 cell neuritogenesis induced by nerve growth factor through activating Smad/Id3 signaling. Biochem J. 2014, [34] Cong, Qifei, Xiao, Fei, Liao, Wenfeng, Dong, Qun, Ding, Kan. Structure and biological activities of an alginate from Sargassum fusiforme, and its sulfated derivative. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2014, 69: 252-259, http://dx.doi.org/10.1016/j.ijbiomac.2014.05.056.
[35] Liu, Hailing, Zhou, Ling, Shi, Songshan, Wang, Ying, Ni, Xinyan, Xiao, Fei, Wang, Shunchun, Li, Ping, Ding, Kan. Oligosaccharide G19 inhibits U-87 MG human glioma cells growth in vitro and in vivo by targeting epidermal growth factor (EGF) and activating p53/p21 signaling. GLYCOBIOLOGY[J]. 2014, 24(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000339418000008.
[36] Xiao, Fei, Qiu, Hong, Zhou, Ling, Shen, Xiaokun, Yang, Liping, Ding, Kan. WSS25 inhibits Dicer, downregulating microRNA-210, which targets Ephrin-A3, to suppress human microvascular endothelial cell (HMEC-1) tube formation. GLYCOBIOLOGY[J]. 2013, 23(5): 524-535, https://www.webofscience.com/wos/woscc/full-record/WOS:000316964600003.
[37] Liu, HanWei, Yu, XiuZhu, Padula, Daniele, Pescitelli, Gennaro, Lin, ZhiWei, Wang, Fei, Ding, Kai, Lei, Ming, Gao, JinMing. Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: Absolute configuration, and their estrogenic and anti-proliferative activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2013, 59: 265-273, http://dx.doi.org/10.1016/j.ejmech.2012.11.003.
[38] Wang, Ying, Fang, Jianping, Ni, Xinyan, Li, Jie, Liu, Qin, Dong, Qun, Duan, Jinyou, Ding, Kan. Inducement of Cytokine Release by GFPBW2, a Novel Polysaccharide from Fruit Bodies of Grifola frondosa, through Dectin-1 in Macrophages. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2013, 61(47): 11400-11409, https://www.webofscience.com/wos/woscc/full-record/WOS:000327812500020.
[39] Zhang Xiaoman, Liao Wenfeng, Cong Qifei, Dong Qun, Ding Kan. Isolation and Structural Characterization of the Polysaccharides of Cortex Mori radices. ACTA CHIMICA SINICA[J]. 2013, 71(5): 722-728, https://www.webofscience.com/wos/woscc/full-record/WOS:000320011200005.
[40] Kan Ding. Structure of a β-glucan from Grifola frondosa and its antitumor effect by activating Dectin-1/Syk/NF-κB signaling. Glycoconj J. 2012, [41] Qun Dong, Ying Wang, Lei Shi, Jian Yao, Jie Li, Fangli Ma, Kan Ding. A novel water-soluble β-d-glucan isolated from the spores of Ganoderma lucidum. CARBOHYDRATE RESEARCH. 2012, 353: 100-105, http://dx.doi.org/10.1016/j.carres.2012.02.029.
[42] Liu, Yang, Fang, Jianping, Cai, Haiyan, Xiao, Fei, Ding, Kan, Hu, Youhong. Identification and synthesis of substituted pyrrolo2,3-dpyrimidines as novel firefly luciferase inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2012, 20(18): 5473-5482, http://dx.doi.org/10.1016/j.bmc.2012.07.035.
[43] Feng, Chao, Li, Jie, Ruan, Jinlan, Ding, Kan. MicroRNA-125a inhibits cell growth by targeting glypican-4. GLYCOCONJUGATE JOURNAL[J]. 2012, 29(7): 503-511, https://www.webofscience.com/wos/woscc/full-record/WOS:000308356000005.
[44] Chen, Xia, Xiao, Fei, Wang, Ying, Fang, Jianping, Ding, Kan. Structure-activity relationship study of WSS25 derivatives with anti-angiogenesis effects. GLYCOCONJUGATE JOURNAL[J]. 2012, 29(5-6): 389-398, https://www.webofscience.com/wos/woscc/full-record/WOS:000307763900016.
[45] Fang Jianping, Liu Yang, Li Jie, Liao Wenfeng, Hu Youhong, Ding Kan. A novel small molecule, HK-156, inhibits lipopolysaccharide-induced activation of NF-κB signaling and improves survival in mouse models of sepsis. ACTA PHARMACOLOGICA SINICA[J]. 2012, 33(9): 1204-,  http://dx.doi.org/10.1038/aps.2012.56.
[46] Yu, Qianming, Yan, Jun, Wang, Shunchun, Ji, Lili, Ding, Kan, Vella, Cherelyn, Wang, Zhengtao, Hu, Zhibi. Antiangiogenic effects of GFP08, an agaran-type polysaccharide isolated from Grateloupia filicina. GLYCOBIOLOGY[J]. 2012, 22(10): 1343-1352, http://www.corc.org.cn/handle/1471x/2298991.
[47] Shang, Mingsheng, Zhang, Xiaoman, Dong, Qun, Yao, Jian, Liu, Qin, Ding, Kan. Isolation and structural characterization of the water-extractable polysaccharides from Cassia obtusifolia seeds. CARBOHYDRATE POLYMERS[J]. 2012, 90(2): 827-832, http://dx.doi.org/10.1016/j.carbpol.2012.06.007.
[48] Xiao-fen LV, Si-han CHEN, Jie LI, Jian-ping FANG, Yue-wei GUO, Kan DING. Lobolide, a diterpene, blockades the NF-κB pathway and p38 and ERK MAPK activity in macrophages in vitro. 中国药理学报:英文版[J]. 2012, 33(10): 1293-, http://lib.cqvip.com/Qikan/Article/Detail?id=43458973.
[49] Cao, Bin, Wang, Yong, Ding, Kan, Neamati, Nouri, Long, YaQiu. Synthesis of the pyridinyl analogues of dibenzylideneacetone (pyr-dba) via an improved Claisen-Schmidt condensation, displaying diverse biological activities as curcumin analogues. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2012, 10(6): 1239-1245, https://www.webofscience.com/wos/woscc/full-record/WOS:000299342200015.
[50] Cui, Hengxiang, Shao, Chenghao, Liu, Qin, Yu, Wenjie, Fang, Jianping, Yu, Weishi, Ali, Amjad, Ding, Kan. Heparanase enhances nerve-growth-factor-induced PC12 cell neuritogenesis via the p38 MAPK pathway. BIOCHEMICAL JOURNAL[J]. 2011, 440: 273-282, https://www.webofscience.com/wos/woscc/full-record/WOS:000298222200011.
[51] Chen, Xia, Cao, Dianxiu, Zhou, Ling, Jin, Hongying, Dong, Qun, Yao, Jian, Ding, Kan. Structure of a polysaccharide from Gastrodia elata Bl., and oligosaccharides prepared thereof with anti-pancreatic cancer cell growth activities. CARBOHYDRATE POLYMERS[J]. 2011, 86(3): 1300-1305, http://dx.doi.org/10.1016/j.carbpol.2011.06.029.
[52] Wu, GuangWei, Gao, JinMing, Shi, XinWei, Zhang, Qiang, Wei, ShaoPeng, Ding, Kan. Microbial Transformations of Diosgenin by the White-Rot Basidiomycete Coriolus versicolor. JOURNAL OF NATURAL PRODUCTS[J]. 2011, 74(10): 2095-2101, https://www.webofscience.com/wos/woscc/full-record/WOS:000296206500009.
[53] Xu, Yuxia, Dong, Qun, Qiu, Hong, Ma, ChungWah, Ding, Kan. A homogalacturonan from the radix of Platycodon grandiflorum and the anti-angiogenesis activity of poly-/oligogalacturonic acids derived therefrom. CARBOHYDRATE RESEARCH[J]. 2011, 346(13): 1930-1936, http://dx.doi.org/10.1016/j.carres.2011.05.011.
[54] Kan Ding. Silencing of hHS6ST2 inhibits progression of pancreatic cancer through inhibition of Notch signaling. Biochem J. 2011, [55] Dong, Qun, Liu, Xuan, Yao, Jian, Dong, Xiaotang, Ma, Chao, Xu, Yuxia, Fang, Jinian, Ding, Kan. Structural characterization of a pectic polysaccharide from Nerium indicum flowers. PHYTOCHEMISTRY[J]. 2010, 71(11-12): 1430-1437, http://dx.doi.org/10.1016/j.phytochem.2010.05.019.
[56] Xu, Yuxia, Dong, Qun, Qiu, Hong, Cong, Renhuai, Ding, Kan. Structural Characterization of an Arabinogalactan from Platycodon grandiflorum Roots and Antiangiogenic Activity of Its Sulfated Derivative. BIOMACROMOLECULES[J]. 2010, 11(10): 2558-2566, http://ir.simm.ac.cn/handle/153631/1958.
[57] Duan, Jinyou, Chen, Vincent L, Dong, Qun, Ding, Kan, Fang, Jinian. Chemical structure and immunoinhibitory activity of a pectic polysaccharide containing glucuronic acid from the leaves of Diospyros kaki. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2010, 46(5): 465-470, http://dx.doi.org/10.1016/j.ijbiomac.2010.03.014.
[58] Duan, Jinyou, Dong, Qun, Ding, Kan, Fang, Jinian. Characterization of a Pectic Polysaccharide from the Leaves of Diospyros kaki and Its Modulating Activity on Lymphocyte Proliferation. BIOPOLYMERS[J]. 2010, 93(7): 649-656, http://ir.simm.ac.cn/handle/153631/2020.
[59] Kan Ding. A Polysaccharides, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart. Glycobiology. 2010, [60] Qiu, Hong, Yang, Bo, Pei, ZhiChao, Zhang, Zhang, Ding, Kan. WSS25 Inhibits Growth of Xenografted Hepatocellular Cancer Cells in Nude Mice by Disrupting Angiogenesis via Blocking Bone Morphogenetic Protein (BMP)/Smad/Id1 Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2010, 285(42): 32638-32646, http://dx.doi.org/10.1074/jbc.M110.105544.
[61] Ma, Zhaocheng, Wang, Jianguo, Zhang, Lina, Zhang, Yufeng, Ding, Kan. Evaluation of water soluble beta-D-glucan from Auricularia auricular-judae as potential anti-tumor agent. CARBOHYDRATE POLYMERS[J]. 2010, 80(3): 977-983, http://ir.simm.ac.cn/handle/153631/2057.
[62] Kan Ding. WSS45, a sulfated α-D-glucan compound, strongly interfere with Dengue 2 virus infection in vitro. Acta Pharmacologica Sinica. 2010, [63] Kan Ding. Study on antitumor activity of a water-soluble hyperbranched polysaccharide and its sulfated derivatives. ACTAPOLYMERICASINIC. 2009, [64] Hu, Ke, Liu, Qin, Wang, Shunchun, Ding, Kan. New oligosaccharides prepared by acid hydrolysis of the polysaccharides from Nerium indicum Mill and their anti-angiogenesis activities. CARBOHYDRATE RESEARCH[J]. 2009, 344(2): 198-203, http://dx.doi.org/10.1016/j.carres.2008.10.019.
[65] Zhang, Zhang, Wang, Shuo, Qiu, Hong, Duan, Chaohui, Ding, Kan, Wang, Zhengtao. Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo. CANCER LETTERS[J]. 2009, 286(2): 223-231, http://dx.doi.org/10.1016/j.canlet.2009.05.023.
[66] Kan Ding. Structure and chain conformation of a (1→6)-a-D-glucan from the root of Puerarialobata (Willd.) Ohwi and the antioxidant activity of its sulfated derivative. Carbohydr Polym. 2008, [67] Dong, Qun, Yao, Han, Fang, Jinian, Ding, Kan. Structural characterization and immunological activity of two cold-water extractable polysaccharides from Cistanche deserticola Y. C. Ma. CARBOHYDRATE RESEARCH[J]. 2007, 342(10): 1343-1349, http://dx.doi.org/10.1016/j.carres.2007.03.017.
[68] Blondeau, Nicolas, Lai, Yushuan, Tyndall, Sarah, Popolo, Margherita, Topalkara, Kamil, Pru, James K, Zhang, Ling, Kim, HyungHwan, Liao, James K, Ding, Kan, Waeber, Christian. Distribution of sphingosine kinase activity and mRNA in rodent brain. JOURNAL OF NEUROCHEMISTRY[J]. 2007, 103(2): 509-517, https://www.webofscience.com/wos/woscc/full-record/WOS:000250384500008.
[69] Kan Ding. Separation, Purification and Structure Characterization of a Polysaccharide from Roots of Cudrania tricuspidata(Carr.). Bur. Chem. J. Chin. Univ.-Chin. 2007, [70] Kan Ding. Structure elucidation and sulfated derivatives preparation of two alpha-glycan from Gstrodia elata Bl. and their anti-dengue virus bioactivities. Carbohydr Res. 2007, [71] Kan Ding. Structure investigation of two neutral polysaccharides isolated from rhizome of Polygonatum sibiricum. Carbohydr Polym. 2007, [72] Kan Ding. Monodispersed Fe-Pt Nanoparticles for Biomedical Application. J. Appl. Phys. 2005, [73] Ding, K, LopezBurks, M, SanchezDuran, JA, Korc, M, Lander, AD. Growth factor-induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells. JOURNAL OF CELL BIOLOGY[J]. 2005, 171(4): 729-738, [74] Kan Ding. Fransson LA The heparan sulfate-specific epitope 10E4 is NO-sensitive and partly inaccessible in glypican-1. Glycobiology. 2004, [75] Kan Ding. Characterization of a rhamnogalacturonan and xyloglycan from Nerium indicum and their activities on PC12 pheochromocytoma cells. J Nat Prod. 2003, [76] Ding, K, Mani, K, Cheng, F, Belting, M, Fransson, LA. Copper-dependent autocleavage of glypican-1 heparan sulfate by nitric oxide derived from intrinsic nitrosothiols. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2002, 277(36): 33353-33360, http://dx.doi.org/10.1074/jbc.M203383200.
[77] Cheng, F, Mani, K, van den Born, J, Ding, K, Belting, M, Fransson, LA. Nitric oxide-dependent processing of heparan sulfate in recycling S-nitrosylated glypican-1 takes place in caveolin-1-containing endosomes. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2002, 277(46): 44431-44439, https://www.webofscience.com/wos/woscc/full-record/WOS:000179272000114.
[78] Ding, K, Sandgren, S, Mani, K, Belting, M, Fransson, LA. Modulations of glypican-1 heparan sulfate structure by inhibition of endogenous polyamine synthesis - Mapping of spermine-binding sites and heparanase, heparin lyase, and nitric oxide/nitrite cleavage sites. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2001, 276(50): 46779-46791, http://dx.doi.org/10.1074/jbc.M105419200.
[79] Ding, K, Jonsson, M, Mani, K, Sandgren, S, Belting, M, Fransson, LA. N-unsubstituted glucosamine in heparan sulfate of recycling glypican-1 from suramin-treated and nitrite-deprived endothelial cells - Mapping of nitric oxide/nitrite-susceptible glucosamine residues to clustered sites near the: Core protein. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2001, 276(6): 3885-3894, http://dx.doi.org/10.1074/jbc.M005238200.
[80] Ding, K, Lin, G, Ho, YP, Cheng, TY, Li, P. Prederivatization and high-performance liquid chromatographic analysis of alkaloids of bulbs of Fritillaria. JOURNAL OF PHARMACEUTICAL SCIENCES[J]. 1996, 85(11): 1174-1179, http://dx.doi.org/10.1021/js960211v.
[81] Shen Xiaokun, Fang Jianping, Lv Xiaofen, Pei Zhicao, Wang Ying, Jiang Songshan, Ding Kan. Heparin Impairs Angiogenesis through Inhibition of MicroRNA-10b *. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 286(30): 26616-26627, http://dx.doi.org/10.1074/jbc.M111.224212.

指导学生

已指导学生

方建平  博士研究生  100720-药物设计学  

吕晓芬  博士研究生  100701-药物化学  

邱宏  博士研究生  100701-药物化学  

陈霞  硕士研究生  077901-药物化学  

沈孝坤  博士研究生  100706-药理学  

现指导学生

廖文锋  硕士研究生  077906-药理学  

王滢  博士研究生  100701-药物化学  

秦毅  硕士研究生  077906-药理学  

肖斐  博士研究生  100706-药理学  

王武成  硕士研究生  077901-药物化学