基本信息
狄翠霞  女  硕导  中国科学院近代物理研究所
电子邮件: dicx@impcas.ac.cn
通信地址: 甘肃省兰州市南昌路509号
邮政编码: 730000

研究领域

研究方向:肿瘤、DNA损伤修复、选择性剪接、DNA甲基化、凋亡、新药筛选

招生信息

   
招生专业
071011-生物物理学
招生方向
DNA损伤修复,表观遗传,转录组学、蛋白组学
基因选择性剪接
辐射增敏药物的筛选

教育背景

2014-07--2014-08   日本的国立放射医学综合研究所   合作研究学者
2008-09--2010-08   德国癌症研究中心(DKFZ)   博士后
2003-09--2008-05   兰州大学生命科学学院   理学博士
1999-09--2003-06   甘肃农业大学生命科学学院   理学学士
学历
   
学位

理学博士

工作经历

201211月~至今

中国科学院近代物理研究所

副研究员

硕士生导师

201010月~201210

中国科学院近代物理研究所

助理研究员

20089月~201010

德国癌症研究中心(DKFZ

博士后

工作简历
2012-10~现在, 中国科学院近代物理研究所, 副研究员
2010-10~2012-10,中国科学院近代物理研究所, 助理研究员
社会兼职
   

教授课程

   

专利与奖励

   
奖励信息
(1) 西部首个斑马鱼模式动物平台建设及在放射生物学研究中的应用, 二等奖, 省级, 2014
(2) 难治性肿瘤新辐射技术的应用基础研究, 三等奖, 省级, 2014
专利成果
   

出版信息

1.       Cuixia DiLu Han, Hong Zhang, Shuai Xu, Aihong MAO, et al. Dially disulfide attenuated carbon ion irradiation-induced apoptosis in mouse testis through changing the ratio of Tap73/ΔNp73 via mitochondrial pathway. Scientific reports. 2015. DOI:10.1038/srep16020. IF: 5.58

2.       Cuixia DiChao Sun, Hongyan Li, Jing Si, Hong Zhang et al. Diallyl disulfide enhances carbon ion beams–induced apoptotic cell death in cervical cancer cells through regulating Tap73 /ΔNp73. Cell Cycle. 2015. 14(23):3725-33.IF: 4.57

3.       Cuixia Di, Lina Yang, Hong Zhang, Xiaofei Ma, Xin Zhang,et al. Mechanisms, function and clinical applications of DNp73. Cell Cycle. 2013,12(12):1861-67.IF: 4.57

4.       Cuixia Di, Lina Yang, Hong Zhang, Lizhe An, Xin Zhang, Xiaofei Ma et al. Anti-Apoptotic ΔNp73 Degraded by Ionizing Irradiation of Different LET in Hela Cells. GENE. 2013,515(1):208-13.IF: 2.341

5.       Cuixia Di, Hong Zhang, Zhenglong Sun, Honglei Jia, Lina Yang,et al. Spatial Distribution of Polygalacturonase-Inhibiting proteins in Arabidopsis and Their Expression Induced by Stemphylium solani infection. GENE. 2013,515(1):208-13.IF: 2.341

6.       Cuixia Di, Ming Li, Feng Long, Muqun Bai, Yajie liu, et al. Molecular cloning, functional analysis and localization of a novel gene encoding PGIPin Chorispora bungeana. Planta.2009,23(1):169-178.IF: :3.26

7.       Cuixia Di, Manxiao Zhang, Shijian Xu, Tuo Cheng, Lizhe An. Role of Poly-galacturonase Inhibiting Protein in Plant Defense. Critical Reviews in Microbiology. 2006, 32(2):91-100.IF: 6.02

8.       Hongyan Li, Hong Zhang, Cuixia Di, et al. Comparative proteomic profiling and possible toxicological mechanism of acute injury induced by carbon ion radiation in pubertal mice testes. Reproductive Toxicology.2015, 58:45-53. IF: 3.23

9.       Aihong Mao, Yang Liu, Hong Zhang, Cuixia Di, et al. MicroRNA Expression and Biogenesis in Cellular Response to Ionizing Radiation. DNA and Cell Biology. 2014, 33(10).· IF: 2.06

10.    Mao A, Liu Y, Wang Y, Zhao Q, Zhou X, Sun C, Di Cuixia, Si J, Gan L, Zhang H. miR-449a enhances radiosensitivity through modulating pRb/E2F1 in prostate cancer cells. Tumour Biol. 2015, 33(10): 667-679

11.    Zhou xin, Yupei Wang, Jing Si, Rong Zhou, Lu Gan. Cuixia DiLaser controlled singlet oxygen generation in mitochondria to promote mitochondrial DNA replication in vitro. Scitific reports .2015,18;5:16925.IF: 5.58

12.    Sun C, Wang ZH, Liu Y, Liu YY, Li HY, Cuixia Di, et al. Carbon Ion Beams Induce Hepatoma Cell Death by NADPH Oxidase-mediated Mitochondrial Damage. Journal of Cellular Physiology. 2014, 229(1): 100-107

13.    Yuanyuan Liu, Yang liu, Hong Zhang, Chao Sun , Queyue Zhao, Cuixia Di, et al. Effects of carbon-ion beam irradiation on the angiogenic response in lung adenocarcinoma A549 cells. Cell Biology International. 2014, 38(11): 1304-1310

14.    Li HY, Xie Y, Zhang H, Liu Y, Sun C, Liu YY, Di CuiXia, Miao GY, Zhang X,Zhou X, Ma XF, Xu S, Gan L. Simulated microgravity conditions and carbonion irradiation-induced spermatogenic cells apoptosis and sperm DNA damage. Biomedical and Environmental Sciences. 2013, 26(9): 726-734

15.    Li HY, Zhang H, Xie Y, He YX, Miao GY, Yang LN, Di Cuixia, He Y. Proteomicanalysis for testis of mice exposed to carbon ion radiation. Mutat Res. 2013, 755:148-155

16.    Si Jing, Zhang Hong, Wang Zhenhua, Wu Zhenhua, Lu Jiang, Di Cuixia, Zhou Xin. Effects of 12C6+ ion radiation and ferulic acid on the zebrafish (Danio rerio) embryonic oxidative stress response and gene expression. Mutant research. 2013.745-746.IF: 2.85

17.    Wu Z, Wang X, Yang R, Liu Y, Zhao W, Si J, Ma X, Sun C, Liu Y, Tan Y, Liu W, Zhang X, Di Cuixia, Wang Z, Zhang H, Zhang Z. Effects of carbon ion beam irradiation on lung injury and pulmonary fibrosis in mice. Exp Ther Med. 2013. 5(3):771-776. IF: 0.85

Yang Liu, Luwei Zhang, Yuanyuan Liu,  Chao sun,· Hong Zhang, Guoying Miao, Cui Xiao Di. DNA-PKcs Deficiency Inhibits Glioblastoma Cell-Derived Angiogenesis After Ionizing Radiation. Journal of cellular physiology.2014, 230(5):1094-103.

18.    Yajie Liu · Zhiguang Zhao · Jing Si · Cuixia Di .Brassinosteroids alleviate chilling-induced oxidative damage by enhancing antioxidant defense system in suspension cultured cells of Chorispora bungeana.Plant Growth Regulation. 2009. 59(3):207-214

19.    Yong Zhang. Tong-Wen Yang. Li-Jing Zhang. Teng-Guo Zhang. Cuixia Di. Isolation and Expression Analysis of Two ColdInducible Genes Encoding Putative CBF Transcription Factors from Chinese Cabbage. Journal of Integrative Plant Biology. 2006. 48(7):848 - 856.  

20.    缪国英, 张红, 卢启明, 李鸿岩,狄翠霞,郭逸潇. 重离子对人胃癌细胞DNA错配修复基因MSH2表达的影响. 2015, 32(1):110-4.

21. 韩璐,狄翠霞,毛爱红,颜家玮,张红. 离子通道TRPV1阻滞剂capsazepine 诱导人肝癌HepG2细胞凋亡机制研究.中华肿瘤防治杂志,22(10), pp103, 2015.

22. 韩璐,张红,狄翠霞,谢漪,刘圆圆.离子通道与肿瘤关系研究现状.生理科学进展,2014,453):225-229.

23. 赵邱越 ,王振华 ,谢漪 ,许帅, 狄翠霞,张红. 姜黄素对重离子辐射损伤小鼠睾丸组织的防护作用研究.原子核物理评论. 2014, 31(1):101-5.

24. 许帅,张红,刘阳,赵邱越,狄翠霞. 二烯丙基二硫对荷S180肉瘤小鼠的辐射增敏效应. 激光生物学报. 201322(02): 119-124

25. 杨立娜, 张红, 狄翠霞, 张秋宁,王小虎. 集簇性DNA损伤在辐射研究中的进展.原子核物理评论,29(2), pp196,2012

26.    无细胞蛋白质芯片的制备及其应用. 中国生物化学与分子生物学报.2012

27. 狄翠霞, 张红, 王振华. p73变异体研究现状及其在肿瘤放疗中的应用前景. 原子核物理评论, 29(1) , pp103, 2012

28. 狄翠霞, 张红,杨立娜,王小虎. 无细胞蛋白质芯片的制备及其应用. 中国生物化学与分子生物学报. 28(1), pp28, 2012

Diallyl disulfide attenuated carbon ion
   

科研活动

   
科研项目
( 1 ) 辐射诱导的p73 变异体对肿瘤细胞凋亡的调控作用, 主持, 国家级, 2013-01--2015-12
( 2 ) 胃癌新标志物的筛选和应用, 主持, 国家级, 2012-01--2014-12
( 3 ) 胃癌新标志物的筛选及应用, 主持, 省级, 2012-01--2014-12
( 4 ) 线粒体:放射性脑损伤的受害者还是施害者?, 参与, 国家级, 2012-01--2014-12
( 5 ) 胃癌新标志物的筛选和应用, 主持, 国家级, 2015-08--2018-07
参与会议
(1)基因的选择性剪接和辐射肿瘤生物学   第十四次中国暨国际生物物理大会   狄翠霞,张红   2015-11-16
(2)Anti-apoptotic DeltaNp73 degraded by ionizing radiation of diferent LET in human cervical carcinoma HeLa cells    国际质子治疗协作委员会(PTCOG)第51届年会   狄翠霞,张红   2013-05-17
(3)Analysis of protein isoforms that are relevant to diagnostics and   Cuixia Di, Mohamed Saiel Saeed Alhamdani, Christoph Schr?der and J?rg D. Hoheisel   2010-11-25
(4)Transgenic Technologies and society   Cuixia Di   2009-11-06

合作情况

   
项目协作单位
   

指导学生