基本信息
陆瑶  男  硕导  中国科学院大连化学物理研究所
电子邮件: luyao@dicp.ac.cn
通信地址: 辽宁省大连市中山路457号
邮政编码: 116023

研究领域

1. 高通量同一单细胞多时间点动态分析以及多种不同参数的分析方法 ;

2. 高通量智能数字液滴微反应器系统用于单细胞操控;

3. 肿瘤的体外、个体化单细胞分析及其临床应用;

4. 基于微流控芯片的快速、高灵敏分析

教育背景

2003-09--2010-07   中科院大连化物所   硕博连读
1999-09--2003-07   安徽大学   学士

研究成果

2020

    1.  Meimei Liu, Meihua Jin,  Linmei Li, Yahui Ji,  Fengjiao Zhu,  Yong Luo,  Tingjiao Liu,  Bingcheng Lin,  Yao Lu* 

         PDMS Microwell Stencil Based Multiplexed Single‐Cell Secretion Analysis. Proteomics, 2020, 1900231.

2019

    1.  Yahui Ji, Dongyuan Qi, Linmei Li, Haoran Su, Xiaojie Li, Yong Luo, Bo Sun, Fuyin Zhang, Bingcheng Lin, Tingjiao  Liu*,  

         Yao Lu* Multiplexed Profiling of Single-cell Extracellular Vesicles Secretion. PNAS, 2019, 116 (13) 5979-5984.

    2.  Zhuo Chen#, Yao Lu#*, Kerou Zhang, Yang Xiao, Jun Lu, Rong Fan* Multiplexed, sequential secretion analysis of the  same 

         single cells reveals distinct effector response dynamics dependent on the initial basal state. Advanced Science, 2019,  6, 1801361 (Highlighted as Inside Cover).

    3.  Jun Ma#, Shiqiang Yan#, Chunyue Miao, Linmei Li, Weiwei Shi, Xianming Liu,  Yong Luo, Tingjiao Liu, Bingcheng Lin, 

         Wenming Wu,*, Yao Lu* Paper Microfluidics for Cell Analysis. Advanced Healthcare Materials, 2019, 8, 1801084.

2018

    1. Ruihan Bai, Linmei Li, Meimei Liu, Shiqiang Yan, Chunyue Miao, Ruijun Li, Yong Luo, Tingjiao Liu, Bingcheng  Lin, Yibing Ji*, and Yao Lu* 
        Paper Based 3D Scaffold for Multiplexed Single Cell Secretomic Analysis. Analytical Chemistry, 2018,  90 (9), pp 5825–5832.
    2. Linmei Li, Shiqiang Yan, Bingcheng Lin, Qihui Shi*, Yao Lu* 
        Single-Cell Proteomics for Cancer  Immunotherapy, Advances in Cancer Research, 2018.
    3. Yueyang Qu, Fan An, Yong Luo*, Yao Lu, Tingjiao Liu, Weijie Zhao, Bingcheng Lin. 
        A nephron model for study of    drug-induced acute kidney injury and assessment of drug-induced nephrotoxicity. Biomaterials, 2018, 155, 41-53.

2017

  1. Yao Lu, Liu Yang, Wei Wei*, Qihui Shi* Microchip-Based Single-Cell Functional Proteomics for BiomedicalApplications. Lab on a Chip, 2017, Mar 29;17(7):1250-1263. 

  2. Shimeng Fang, Hongzhu Tian, Xiancheng Li, Dong Jin, Xiaojie Li, Jing Kong, Chun Yang, Xuesong Yang, Yao Lu, Yong Luo, Bingcheng Lin, Weidong Niu*, Tingjiao Liu* Clinical application of a microfluidic chip for immunocapture and quantification of circulating exosomes to assist breast cancer diagnosis and molecular classification. PLoS One. 2017 Apr 3;12(4):e0175050. doi: 10.1371/journal.pone.0175050. eCollection 2017.

  3. 高志刚, 郑婷婷, 邓九, 李晓瑞, 曲玥阳, 陆瑶, 刘婷娇, 罗勇*, 赵伟杰, 林炳承 基于便携拉曼光谱仪和双层纸芯片的头发皮质醇超高灵敏检测 化学学报(Acta Chim. Sinica), 2017, 75, 355-359

 

2016

  1. Kun Zou, Zhigang Gao, Quanfeng Deng, Yong Luo, Lijuan Zou, Yao Lu, Weijie Zhao and Bingcheng Lin Picomolar detection of carcinoembryonic antigen in whole blood using microfluidics and surface-enhanced Raman spectroscopy. Electrophoresis, 2016, 37(5-6):786-9.  

 

Before 2016 

  1. Qiong Xue†, Yao Lu†, Markus R. Eisele, Endah S. Sulistijo, Nafeesa Khan, Rong Fan*, and Kathryn Miller-Jensen* Analysis of single cell secretion reveals a role for paracrine signaling in coordinating macrophage response to TLR4 stimulation. Science Signaling, 2015, 8(381), ra59.

  2. Yao Lu†, Qiong Xue†, Markus Eisele, Endah Sulistijo, Kara Brower, Lin Han, El-ad David Amir, Dana Pe’er, Kathryn Miller-Jensen* & Rong Fan* Highly multiplexed profiling of single-cell effector functions reveals deep functional heterogeneity in response to pathogenic ligands. PNAS, 2015, 112 (7), E607-E615.

  3. Yao Lu†, Jonathan J. Chen†, Luye Mu, Qiong Xue, Yu Wu, Pei-Hsun Wu, Jie Li, Alexander O. Vortmeyer, Kathryn Miller-Jensen, Denis Wirtz, and Rong Fan* High-Throughput Secretomic Analysis of Single Cells to Assess Functional Cellular Heterogeneity. Analytical Chemistry 2013, 85 (4), 2548–2556

  4. Yao Lu, Bingcheng Lin*, Jianhua Qin*. Patterned Paper as a Low-cost, Flexible Substrate for Rapid Prototyping PDMS Microdevices via “liquid molding” . Analytical Chemistry 2011, 83 (5), 1830–1835

  5. Yao Lu, Weiwei Shi, Jianhua Qin*, Bingcheng Lin*. Fabrication And Characterization of Paper Based Microfluidics Prepared in Nitrocellulose Membrane By Wax Printing. Analytical Chemistry 2010, 82, 329–335 

  6. Yao Lu, Weiwei Shi, Lei Jiang, Jianhua Qin*, Bingcheng Lin*. Rapid prototyping of paper-based microfluidics with wax for low-cost, portable bioassay . Electrophoresis 2009, 30, 1497–1500

  7. Yao Lu, Weiwei Shi, Jianhua Qin*, Bingcheng Lin*. Low cost, portable detection of gold nanoparticle-labeled microfluidic immunoassay with camera cell phone. Electrophoresis 2009, 30, 579–582 (selected by editor as Fast Track)

  8. Lei Jiang, Yao Lu, Zhongpeng Dai, Minhao Xie, Bingcheng Lin*.  Mini-electrochemical Detector for Microchip Electrophoresis. Lab Chip 2005, 5(9), 930-934

  9. Lei Jiang, Xuening Jiang, Yao Lu, Zhongpeng Dai, Minhao Xie, Jianhua Qin*, Bingcheng Lin*. Development of a universal serial bus-powered mini-high-voltage power supply for microchip electrophoresis. Electrophoresis 2007, 28(8), 1259–1264.

  10. Weiwei Shi, Hui Wen, Yao Lu, Yang Shi, Bingcheng Lin*,Jianhua Qin* Droplet Microfluidics for Characterizing the Neurotoxin-induced Responses in Individual Caenorhabditis elegans. Lab Chip, 2010, 10, 2855 – 2863

  11. Wu Y, Lu Y, Chen WQ, Fu JP & Fan R*. In silico experimentation of glioma microenvironment development and anti-tumor therapy. PLoS Computational Biology, 8(2), 1002355 (2012).

  12. Lee SK*, Kim GS, Wu Y, Kim DJ, Lu Y, Kwak M, Han L, Hyung JH, Seol JK, Sander C, Gonzalez A, Li J, Fan R*. Nanowire Substrate-Based Laser Scanning Cytometry for Quantitation of Circulating Tumor Cells. Nano Letters, 12(6), 2697-2704(2012)

  13. Minsuk Kwak, Luye Mu, Yao Lu, Jonathan Chen, Yu Wu, Kara Brower and Rong Fan*. Single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interaction. Frontiers in Oncology, 2013; 3: 10

  14. Meltem Elitas†, Kara Brower†, Yao Lu, Jonathan J. Chen and Rong Fan* A Microchip Platform for Interrogating Tumor-Immune Cell Communication at the Single-Cell Level. Lab on a Chip 14 (18), 3582-3588

  15. Mao, Lin†; Shen, Li†; Chen, Jiahui; Wu, Yu; Kwak, Minsuk; Lu, Yao; Xue, Qiong; Pei, Jia; Zhang, Lei; Yuan, Guangyin; Fan, Rong; Ge, Junbo; Ding, Wen-Jiang Enhanced bioactivity of Mg-Nd-Zn-Zr alloy achieved with nanoscale MgF2 surface for vascular stent application ACS applied materials & interfaces, 7 (9), 5320–5330.

工作经历

2015年10月-至今            中科院大连化物所单细胞分析研究组组长

201410月—20159       耶鲁大学生物医学工程系Associate Research Scientist            

201010月—20149       耶鲁大学生物医学工程系Postdoctoral Associate