Organic Chemistry 

Medicinal Chemistry

September 2007 – July 2012

Ph. D. (Medicinal chemistry)

Chengdu Institute of Biology, Chinese Academy of Sciences.

Ph.D. Advisor: Professor: Hua-Wu Shao

September 2007 – July 2008

Department of Chemistry,

University of Science and Technology of China (Co-training student)

September 2003 – July 2007

Bachelor of Medicine (Pharmacy)

Department of Pharmacy, Lanzhou University, China

From September 2019 

Professor 

Chengdu Institute of Biology, Chinese Academy of Sciences (CAS)

March 2016 – March 2019

Postdoctoral Associate 

School of Chemsitry, University of Brsitol, UK

Supervisor: Prof. John F. Bower

December 2012 – March 2016

Postdoctoral Associate 

Laboratoire de Chimie Organique et Médicinale, Université catholique de Louvain, Belgium

Supervisor: Prof. István. E. Markó

July 2012 – October 2012

Research Assistant

Chengdu Institute of Biology, Chinese Academy of Sciences (CAS)

Supervisor: Prof. Hua-Wu Shao

1.       Jian Yang, Demeng Xie, Xiaofeng Ma*, Recent Advances in Chemical Synthesis of Amino Sugars, Molecules, 2023, 28, 4724.

2.       Yinxiang Jian, Peng Liang, Xiaoyan Li, Huawu Shao*, Xiaofeng Ma*, Controllable Transformation of Indoles Using Iodine(III) Reagent, Org. Biomol. Chem. 2023, 21, 179-186.

3.       Xiaoke Zhang, Ya-Zhou Liu, Huawu Shao*, Xiaofeng Ma*, Advances in Atroposelectively De Novo Synthesis of Axially Chiral Heterobiaryl Scaffolds Molecules 2022, 27, 8517.

4.       Hailong Shi, Jian Yang, Yao Cheng, Jinlian Yang, Xiaoxia Lu*, Xiaofeng Ma*, 1, 2-trans-Stereoselective 7-O-Glycosylation of Flavonoids with Unprotected Pyranoses by Mitsunobu Reaction, Chem. Asian J. 2022, 17, e2022001.

5.       Zhongke Shen, Qin Tang, Wei Jiao, Huawu Shao*, Xiaofeng Ma*, One-Pot Synthesis of 2-C-Branched Glycosyl Triazoles by Integrating 1,2-Cyclopropanated Sugar Ring-Opening Azidation and CuAAC Reaction, J. Org. Chem. 2022, 87, 16736-16742.

6.       Amu Wang, Ya-Zhou Liu,Zhongke Shen, Zeen Qiao, Xiaofeng Ma*, Regioselective Synthesis of Pyrazolo[1,5-a]pyridine via TEMPO Mediated [3+2] Annulation-Aromatization of N-Aminopyridines and α,β-Unsaturated Compounds, Org. Lett. 2022, 24, 7, 1454-1459.

7.       Peng Liang, Hang Zhao, Tingting Zhou, Kaiyun Zeng, Wei Jiao, Yang Pan, Yazhou Liu, Dongmei Fang, Xiaofeng Ma*, Huawu Shao*. Rapid Oxidation Indoles into 2-Oxindoles Mediated by PIFA in Combination with n-Bu₄NCl ×H₂O, Adv. Synth. Catal. 2021, 363, 3532-3538.

8.       Xiaofeng Ma*, Yazhou Liu, Le Du, Jingwei Zhou, István E. Markó. Post-functionalization of Dibenzothiophene to Functionalized Biphenyls via a Photoinduced Thia-Baeyer-Villiger Oxidation, Nat. Commun. 2020, 11, 914.

9.       Xiaofeng Ma, Ian R. Hazelden, Thomas Langer, Rachel H. Munday, John F. Bower*. Enantioselective Aza-Heck Cyclizations of N‑(Tosyloxy)carbamates: Synthesis of Pyrrolidines and Piperidines, J. Am. Chem. Soc. 2019, 141, 3356-3360. (Highlight in Synfacts, 2019; 15, 0483).

10.   Xiaofeng Ma, Joshua J. Farndon, Tom A. Young, Natalie Fey, John F. Bower*, A Simple and Broadly Applicable C-N Bond Forming Dearomatization Protocol Enabled by Bifunctional Amino-Reagents, Angew. Chem. Int. Ed. 2017, 56, 14531-14535. (Highlight in Org. Process Res. Dev. 2017, 21, 1873-1883).

11.   Ian R. Hazelden,⁺ Xiaofeng Ma,⁺(⁺并列第一作者) Thomas Langer, John F. Bower*, Diverse N-Heterocyclic Ring Systems via Aza-Heck Cyclizations of N-(Pentafluorobenzoyloxy)sulfonamides, Angew. Chem. Int. Ed. 2016, 55, 11198-11202.

12.   Xiaofeng Ma,* Damien F. Dewez, Le Du, Xiya Luo, István E. Markó, Kevin Lam*, Synthesis of Diketones, Ketoesters and Tetraketones by Electrochemical Oxidative Decarboxylation of Malonic Acid Derivatives: Application to the Synthesis of cis-Jasmone, J. Org. Chem. 2018, 83, 12044-12055.

13.   Xiaofeng Ma, Hodney Lubin, Ágnes Simon, Enikő Ioja, Orsolya Kékesi, Ágota Apáti, Tamás I. Orbán, László Héja, Julianna Kardos, István E. Markó*, Straightforward and Effective Synthesis of γ-Aminobutyric Acid Transporter Subtype 2-Selective Acyl-Substituted Azaspiro[4.5]decanes, Bioorg. Med. Chem. Lett. 2016, 26, 417-423.

14.   Xiaofeng Ma, Xiya Luo, Simon Dochain, Charlotte Mathot, István E. Markó*, Electrochemical Oxidative Decarboxylation of Malonic Acid Derivatives: A Method for the Synthesis of Ketals and Ketones, Org. Lett.2015, 17, 4690-4693. (Featured on Organic Chemistry Portal, https://www.organic- chemistry. org/ abstracts /lit5/128.shtm)

15.   Xiaofeng Ma, Jichao Zhang, Qin Tang, Jun Ke, Wei Zou, Huawu Shao*, Stereospecific [3+2] Cycloaddition of 1,2-Cyclopropanated Sugars and Ketones Catalyzed by SnCl₄: an Efficient Synthesis of Multi-Substituted Perhydrofuro[2,3-b]furans and Perhydrofuro[2,3-b]pyrans, Chem. Commun. 2014, 50, 3505-3508.

16.   Xiaofeng Ma, Qin Tang, Jun Ke, Jichao Zhang, Xinglong Yang, Xudong Shen, Huawu Shao*, A Neighboring Group Participation Strategy: Direct and Highly Diastereoselective Synthesis of 2-Substituted and 2,2-Bisubstituted Perhydrofuro[2,3-b]pyran Derivatives, Org. Biomol. Chem. 2014, 12, 7381-7388.

17.   Xiaofeng Ma, Qin Tang, Jun Ke, Jichao Zhang, Cong Wang, Haibo Wang, Yuxue Li, Huawu Shao*, Straightforward and Highly Diastereoselective Synthesis of 2,2-Disubstituted Perhydrofuro[2,3-b]pyran (and furan) Derivatives Promoted by BiCl₃, Chem. Commun. 2013, 49, 7085-7087 (Highlight in Synfacts, 2013; 9, 1212).

18.   Xiaofeng Ma, Qin Tang, Jun Ke, Xinglong Yang, Jichao Zhang, Huawu Shao*, InCl₃ Catalyzed Highly Diastereoselective [3+2] Cycloaddition of 1,2-Cyclopropanated Sugars with Aldehydes: a Straightforward Synthesis of Persubstituted Bis-Tetrahydrofurans and perhydrofuro [2,3-b]pyrans,Org. Lett. 2013, 15, 5170-5173.

19.   Xiaofeng Ma, Qin Tang, Jun Ke, Haibo Wang, Wei Zou, Huawu Shao*, A Convenient and Highly Stereoselective Method for Synthesis of Octahydropyrano[3,2-b]pyrrole Derivatives, Carbohydr. Res. 2013, 366, 55-62.

20.   Shuaibing Zhang, ⁺ Xiaofeng Ma, ⁺ (⁺并列第一作者) Xiaoqiong Pei, Jingyuan Liu, Huawu Shao, Zhongliu Wu, A Practical High-throughput Screening System for Feruloyl Esterases: Substrate Design and Evaluation, J. Mol. Catal.B-Enzym. 2012, 74, 36-40.

21.   Xiaofeng Ma, Qiang Tian, Qin Tang, Huawu Shao*, A Novel and Highly Stereoselective Synthesis of 2-Substituted Perhydrofuro[2,3-b]pyran Derivatives, Org. Lett. 2011, 13, 4276-4279. 

已指导学生

申忠珂  硕士研究生  078001-药物化学  

现指导学生

张力  博士研究生  100701-药物化学  

李江涛  博士研究生  100701-药物化学  

王阿木  硕士研究生  078001-药物化学  

李小燕  硕士研究生  086002-制药工程  

杨建  博士研究生  100701-药物化学  

简银香  硕士研究生  078001-药物化学  

曾薇  硕士研究生  078001-药物化学  

乔泽恩  博士研究生  100701-药物化学