有机化学、药物化学、糖化学

   

070303-有机化学
100701-药物化学

糖化学
不对称催化
有机合成、药物合成

2007-09--2012-07   中国科学院成都生物研究所天然产物研究中心   理学博士
2003-09--2007-07   兰州大学 药学院   医学学士

2019-09~现在, 中国科学院成都生物研究所天然产物研究中心, 研究员
2016-03~2019-03,英国布里斯托大学化学系, 博士后
2012-12~2016-03,比利时天主教鲁汶大学化学与药物化学系, 博士后
2012-07~2012-10,中国科学院成都生物研究所天然产物研究中心, 研究助理

2019-09~现在, 中国科学院成都生物研究所天然产物研究中心, 研究员
2016-03~2019-03,英国布里斯托大学化学系, 博士后
2012-12~2016-03,比利时天主教鲁汶大学化学与药物化学系, 博士后
2012-07~2012-10,中国科学院成都生物研究所天然产物研究中心, 项目聘用

   

（ 1 ） 一种 2-硝基-2-烯吲哚糖碳苷类化合物及其合成方法与应用, 发明专利, 2023, 第 1 作者, 专利号: 2023107668588

（ 2 ） 一种吲哚糖碳苷类大环化合物及其制备方法与应用, 发明专利, 2023, 第 1 作者, 专利号: 2023106916985

（ 3 ） 一种4-氮杂吲哚啉类化合物及其合成方法与应用, 发明专利, 2023, 第 1 作者, 专利号: 202310032248.5

（ 4 ） 吲哚糖苷类化合物及吡咯糖苷类化合物及合成方法与应用, 发明专利, 2022, 第 1 作者, 专利号: 202211581675.0

（ 5 ） 调节雌激素受体合成活性的吡唑并吡啶衍生物, 发明专利, 2021, 第 1 作者, 专利号: 2021107866683

（ 6 ） 一种二苯并c,e1,2氧硫杂环己烷-6-氧化物类化合物的转化方法, 发明专利, 2020, 第 1 作者, 专利号: CN110683940A

（ 7 ） 一种立体选择性制备吡喃衍生物的方法, 发明专利, 2011, 第 2 作者, 专利号: CN102180923A

   

[1] Yang Jian, Demeng Xie, Ma Xiaofeng. Recent Advances in Chemical Synthesis of Amino Sugars. Molecules[J]. 2023, 28: 4724-, https://www.mdpi.com/1420-3049/28/12/4724.
[2] Jian, Yinxiang, Liang, Peng, Li, Xiaoyan, Shao, Huawu, Ma, Xiaofeng. Controllable transformation of indoles using iodine(iii) reagent. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2023, 21(1): 179-186, [3] Wang Yong-Qiang, Chen Wei-Ting, Liu Xia, Zhu Hua, Qiao Xuan, Wang Yuzhi, Ma Xiaofeng. Development of a Safe, Efficient and Scalable Process for the Synthesis of Midazolam Hydrochloride. Org. Process Res. Dev.[J]. 2023, 27(12): 2374-2384, https://doi.org/10.1021/acs.oprd.3c00327.
[4] Liang, Junxiu, Ya-Zhou Liu, Wang Amu, Wu Yanchao, Ma Xiaofeng, Li Huijin. Dearomatization of Halonaphthols via an Intermolecular [4+1] Spiroannulation with in situ Formed Aza-Ortho-Quinone Methides. Chin. J. Org. Chem.[J]. 2023, 43(11): 3888-3899, http://sioc-journal.cn/Jwk_yjhx/EN/10.6023/cjoc202303029.
[5] Jian Yang, Shanqiao Wei, Jinzhong Zhao, Wei Zeng, Huawu Shao, Xiaofeng Ma. An environmentally benign protocol for the synthesis of sugar 1,2-orthoesters in poly(ethylene glycol) dimethyl ether (DMPE). CARBOHYDRATE RESEARCH. 2023, 534: http://dx.doi.org/10.1016/j.carres.2023.108902.
[6] Hu Xiaofang, Qiao Zenen, Zhang Li, Zhao, Jinzhong, Ya-Zhou Liu, Zhang Jiangang, Ma Xiaofeng. One-pot Cascade Synthesis of Dibenzothiophene-based Heterobiaryls from Dibenzothiophene-5-oxide. Org. Biomol. Chem.[J]. 2023, 21: 9123-9127, DOI https://doi.org/10.1039/D3OB01468A.
[7] Shi Hailong, Yang Jinlian, Qiao Zenen, Lingyu Li, Liu Gang, Dai Qi, Xu Li, Jiao Wei, Zhang Guolin, Wang Fei, Lu Xiaoxia, Ma Xiaofeng. Design, Synthesis and Structure–Activity Relationship Studies on Erianin Analogues as Pyruvate Carboxylase (PC) Inhibitors Against Hepatocellular Carcinoma Cells. Org. Biomol. Chem.[J]. 2023, 21: 7005-7017, https://doi.org/10.1039/D3OB01114C.
[8] Zhang Guoqing, Tang Senling, Yang Chunmei, Cheng Yongjie, Xiang Ling, Shao Huawu, Ma Xiaofeng, Zhang Fan, Jiao Wei. Synthesis of 2,2-Disubstituted Perhydrofuro[2,3-b]-pyran Derivatives containing Indole catalyzed by BF3.Et2O. ASIAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2022, [9] Shi Hailong, Yang Jian, Cheng Yao, Lu Xiaoxia, Ma Xiaofeng. 1, 2‐trans‐Stereoselective 7‐O‐Glycosylation of Flavonoids with Unprotected Pyranoses by Mitsunobu Reaction. CHEMISTRYANASIANJOURNAL[J]. 2022, https://onlinelibrary.wiley.com/doi/10.1002/asia.202200120.
[10] Wang Amu, Liu Ya-Zhou, Shen Zhongke, Qiao Zeen, Ma Xiaofeng. Regioselective Synthesis of Pyrazolo[1,5-a]pyridine via TEMPO Mediated [3+2] Annulation-Aromatization of N-Aminopyridines and α,β-Unsaturated Compounds. Organic Letters[J]. 2022, https://pubs.acs.org/doi/10.1021/acs.orglett.2c00035.
[11] Shen, Zhongke, Tang Qin, Jiao, Wei, Shao, Huawu, Ma, Xiaofeng. One-Pot Synthesis of 2-C-Branched Glycosyl Triazoles by Integrating 1,2-Cyclopropanated Sugar Ring-Opening Azidation and CuAAC Reaction. JOURNAL OF ORGANIC CHEMISTRY[J]. 2022, [12] Zhang, Xiaoke, Liu, YaZhou, Shao, Huawu, Ma, Xiaofeng. Advances in Atroposelectively De Novo Synthesis of Axially Chiral Heterobiaryl Scaffolds. MOLECULESnull. 2022, 27(23): http://dx.doi.org/10.3390/molecules27238517.
[13] 胡晓芳, 马小锋, 赵晋忠, 张建刚. 薯蓣皂苷元-葡萄糖C-苷类似物的合成. 合成化学[J]. 2021, 29(4): 293-297, http://lib.cqvip.com/Qikan/Article/Detail?id=7104479539.
[14] Damseaux, Caroline, Scholl, Georges, Damblon, Christian, Dejeaifve, Alain, Dobson, Rowan, Ma, Xiaofeng, Marko, Istvan, Monbaliu, JeanChristophe M, De Pauw, Edwin, Eppe, Gauthier. Identification of the Degradation Products from alpha-Ionone Used as Stabiliser in "Green" Propellants through its Lifetime. PROPELLANTS EXPLOSIVES PYROTECHNICS[J]. 2021, 46(11): 1653-1661, http://dx.doi.org/10.1002/prep.202100191.
[15] Zhang, Xiaoke, Pan, Yang, Wang, Haibo, Liang, Chong, Ma, Xiaofeng, Jiao, Wei, Shao, Huawu. Strategy to Construct 1,2,3-Triazoles by K2CO3-Mediated 4+1 Annulation Reactions of N-Acetyl Hydrazones with Bifunctional Amino Reagents. ADVANCED SYNTHESIS & CATALYSIS[J]. 2021, 363(2): 459-463, https://www.webofscience.com/wos/woscc/full-record/WOS:000596586300001.
[16] Liang, Peng, Zhao, Hang, Zhou, Tingting, Zeng, Kaiyun, Jiao, Wei, Pan, Yang, Liu, Yazhou, Fang, Dongmei, Ma, Xiaofeng, Shao, Huawu. Rapid Oxidation Indoles into 2-Oxindoles Mediated by PIFA in Combination with n-Bu4NCl center dot H2O. ADVANCED SYNTHESIS & CATALYSIS[J]. 2021, 363(14): 3532-3538, http://dx.doi.org/10.1002/adsc.202100234.
[17] Xiaofeng Ma, Yazhou Liu, Le Du, Jingwei Zhou, Istvn E Mark. Post-functionalization of dibenzothiophene to functionalized biphenyls via a photoinduced thia-Baeyer-Villiger oxidation. NATURE COMMUNICATIONS[J]. 2020, 11(1): http://dx.doi.org/10.1038/s41467-020-14522-7.
[18] Pan, Yang, Li, Jiangtao, Li, Zhefeng, Huang, Feng, Ma, Xiaofeng, Jiao, Wei, Shao, Huawu. An efficient and facile strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes. CHEMICAL COMMUNICATIONS[J]. 2020, 56(56): 7813-7816, https://www.webofscience.com/wos/woscc/full-record/WOS:000548421300028.
[19] Ma, Xiaofeng, Hazelden, Ian R, Langer, Thomas, Munday, Rachel H, Bower, John F. Enantioselective Aza-Heck Cyclizations of N-(Tosyloxy)carbamates: Synthesis of Pyrrolidines and Piperidines. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 141(8): 3356-3360, http://dx.doi.org/10.1021/jacs.8b12689.
[20] Zhang, Xiaoke, Pan, Yang, Liang, Peng, Ma, Xiaofeng, Jiao, Wei, Shao, Huawu. An Effective Method for the Synthesis of 1,3-Dihydro-2H-indazoles via N-N Bond Formation. ADVANCED SYNTHESIS & CATALYSIS[J]. 2019, 361(24): 5552-5557, [21] Ma, Xiaofeng, Dewez, Damien F, Du, Le, Luo, Xiya, Marko, Istvan E, Lam, Kevin. Synthesis of Diketones, Ketoesters, and Tetraketones by Electrochemical Oxidative Decarboxylation of Malonic Acid Derivatives: Application to the Synthesis of cis-Jasmone. JOURNAL OF ORGANIC CHEMISTRY[J]. 2018, 83(19): 12044-12055, https://www.webofscience.com/wos/woscc/full-record/WOS:000447118100054.
[22] Liang, Peng, Pan, Yang, Ma, Xiaofeng, Jiao, Wei, Shao, Huawu. A facile method for the synthesis of fused perhydropyrano2,3-bpyrans promoted by Yb(OTf)(3). JOURNAL OF MATERIALS CHEMISTRY B[J]. 2018, 6(14): 3763-3766, [23] Zhang, Xiaoke, Pan, Yang, Liang, Peng, Pang, Lu, Ma, Xiaofeng, Jiao, Wei, Shao, Huawu. Oxadiazepine Synthesis by Formal 4+3 Cycloaddition of o-Chloromethyl Arylsulfonamides with Nitrones Promoted by NaHCO3. ADVANCED SYNTHESIS & CATALYSIS[J]. 2018, 360(16): 3015-3019, https://www.webofscience.com/wos/woscc/full-record/WOS:000441874400004.
[24] Luo, Xiya, Ma, Xiaofeng, Lebreux, Frederic, Marko, Istvan E, Lam, Kevin. Electrochemical methoxymethylation of alcohols - a new, green and safe approach for the preparation of MOM ethers and other acetals. CHEMICAL COMMUNICATIONS[J]. 2018, 54(71): 9969-9972, https://www.webofscience.com/wos/woscc/full-record/WOS:000443170200022.
[25] Farndon, Joshua J, Ma, Xiaofeng, Bower, John F. Transition Metal Free C-N Bond Forming Dearomatizations and Aryl C-H Aminations by in Situ Release of a Hydroxylamine-Based Aminating Agent. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2017, 139(40): 14005-14008, http://dx.doi.org/10.1021/jacs.7b07830.
[26] Ma, Xiaofeng, Farndon, Joshua J, Young, Tom A, Fey, Natalie, Bower, John F. A Simple and Broadly Applicable C-N Bond Forming Dearomatization Protocol Enabled by Bifunctional Amino Reagents. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 56(46): 14531-14535, http://dx.doi.org/10.1002/anie.201708176.
[27] Ian R. Hazelden, Ma Xiaofeng, Thomas Langer, Bower John F.. Diverse N-Heterocyclic Ring Systems via Aza-Heck Cyclizations of N-(Pentafluorobenzoyloxy)sulfonamides.. ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH)[J]. 2016, 55(37): 11198-11202, https://doi.org/10.1002/anie.201605152.
[28] Xiaofeng Ma, Hodney Lubin, Enikő Ioja, Orsolya Kékesi, Ágnes Simon, Ágota Apáti, Tamás I. Orbán, László Héja, Julianna Kardos, István E. Markó. Straightforward and effective synthesis of γ-aminobutyric acid transporter subtype 2-selective acyl-substituted azaspiro4.5decanes. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2016, 26(2): 417-423, http://dx.doi.org/10.1016/j.bmcl.2015.11.100.
[29] Shen, Xudong, Xia, Jianhui, Liang, Peng, Ma, Xiaofeng, Jiao, Wei, Shao, Huawu. Zn(OTf)(2) promoted rearrangement of 1,2-cyclopropanated sugars with amines: a convenient method for the synthesis of 3-polyhydroxyalkyl-substituted pyrrole derivatives. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2015, 13(44): 10865-10873, http://210.75.237.14/handle/351003/27600.
[30] Ma, Xiaofeng, Luo, Xiya, Dochain, Simon, Mathot, Charlotte, Marko, Istvan E. Electrochemical Oxidative Decarboxylation of Malonic Acid Derivatives: A Method for the Synthesis of Ketals and Ketones. ORGANIC LETTERS[J]. 2015, 17(19): 4690-4693, https://www.webofscience.com/wos/woscc/full-record/WOS:000362384700011.
[31] Wang, Cong, Ma, Xiaofeng, Zhang, Jichao, Tang, Qin, Jiao, Wei, Shao, Huawu. Methanesulfonic-Acid-Catalysed Ring Opening and Glycosylation of 1,2-(Acetylcyclopropane)-Annulated D-Lyxofuranose. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2014, 2014(21): 4592-4599, http://210.75.237.14/handle/351003/26675.
[32] Ma, Xiaofeng, Tang, Qin, Ke, Jun, Zhang, Jichao, Yang, Xinglong, Shen, Xudong, Shao, Huawu. A neighboring group participation strategy: direct and highly diastereoselective synthesis of 2-substituted and 2,2-bisubstituted perhydrofuro2,3-b pyran derivatives. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2014, 12(37): 7381-7388, http://210.75.237.14/handle/351003/26699.
[33] Ma, Xiaofeng, Zhang, Jichao, Tang, Qin, Ke, Jun, Zou, Wei, Shao, Huawu. Stereospecific 3+2 cycloaddition of 1,2-cyclopropanated sugars and ketones catalyzed by SnCl4: an efficient synthesis of multi-substituted perhydrofuro2,3-bfurans and perhydrofuro2,3-bpyrans. CHEMICAL COMMUNICATIONS[J]. 2014, 50(26): 3505-3508, http://210.75.237.14/handle/351003/26709.
[34] Zhang, Jichao, Yuan, Wen, Ma, Xiaofeng, Wang, Haibo, Shao, Huawu. An Efficient and Simple Method for Stereoselective Synthesis of N-Substituted Iminosugars from D-Xylose Derivative. CHINESE JOURNAL OF CHEMISTRY[J]. 2014, 32(4): 361-364, http://210.75.237.14/handle/351003/26690.
[35] Ma, Xiaofeng, Tang, Qin, Ke, Jun, Zhang, Jichao, Wang, Cong, Wang, Haibo, Li, Yuxue, Shao, Huawu. Straightforward and highly diastereoselective synthesis of 2,2-di-substituted perhydrofuro2,3-bpyran (and furan) derivatives promoted by BiCl3. CHEMICAL COMMUNICATIONS[J]. 2013, 49(63): 7085-7087, http://www.irgrid.ac.cn/handle/1471x/900508.
[36] Ma, Xiaofeng, Tang, Qin, Ke, Jun, Wang, Haibo, Zou, Wei, Shao, Huawu. A convenient and highly stereoselective method for synthesis of octahydropyrano3,2-bpyrrole derivatives. CARBOHYDRATE RESEARCH[J]. 2013, 366: 55-62, http://dx.doi.org/10.1016/j.carres.2012.11.016.
[37] Ma, Xiaofeng, Tang, Qin, Ke, Jun, Yang, Xinglong, Zhang, Jichao, Shao, Huawu. InCl3 Catalyzed Highly Diastereoselective 3+2 Cycloaddition of 1,2-Cyclopropanated Sugars with Aldehydes: A Straightforward Synthesis of Persubstituted Bis-Tetrahydrofurans and Perhydrofuro2,3-bpyrans. ORGANIC LETTERS[J]. 2013, 15(20): 5170-5173, http://www.irgrid.ac.cn/handle/1471x/900532.
[38] Zhang, ShuaiBing, Ma, XiaoFeng, Pei, XiaoQiong, Liu, JingYuan, Shao, HuaWu, Wu, ZhongLiu. A practical high-throughput screening system for feruloyl esterases: Substrate design and evaluation. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC[J]. 2012, 74(1-2): 36-40, http://dx.doi.org/10.1016/j.molcatb.2011.08.011.
[39] Wang, Haibo, Luo, Hairong, Ma, Xiaofeng, Zou, Wei, Shao, Huawu. Stereoselective Synthesis of a Series of New N-Alkyl-3-hydroxypiperidine Derivatives Containing a Hemiketal. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2011, 2011(25): 4834-4840, http://www.irgrid.ac.cn/handle/1471x/517870.
[40] Ma, Xiaofeng, Tian, Qiang, Tang, Qin, Zhao, Jinzhong, Shao, Huawu. A Novel and Highly Stereoselective Synthesis of 2-Substituted Perhydrofuro2,3-bpyran Derivatives. ORGANIC LETTERS[J]. 2011, 13(16): 4276-4279, http://www.irgrid.ac.cn/handle/1471x/517871.
[41] Tian, Qiang, Dong, Liang, Ma, Xiaofeng, Xu, Liyan, Hu, Changwei, Zou, Wei, Shao, Huawu. Stereoselective Synthesis of 2-C-Branched (Acetylmethyl) Oligosaccharides and Glycoconjugates: Lewis Acid-Catalyzed Glycosylation from 1,2-Cyclopropaneacetylated Sugars. JOURNAL OF ORGANIC CHEMISTRY[J]. 2011, 76(4): 1045-1053, http://www.irgrid.ac.cn/handle/1471x/517898.
[42] Zhao, Jinzhong, Wei, Shanqiao, Ma, Xiaofeng, Shao, Huawu. A simple and convenient method for the synthesis of pyranoid glycals. CARBOHYDRATE RESEARCH[J]. 2010, 345(1): 168-171, http://dx.doi.org/10.1016/j.carres.2009.10.003.
[43] Tian, Qiang, Xu, Liyan, Ma, Xiaofeng, Zou, Wei, Shao, Huawu. Stereoselective Synthesis of 2-C-Acetonyl-2-Deoxy-D-Galactosides using 1,2-Cyclopropaneacetylated Sugar as Novel Glycosyl Donor. ORGANIC LETTERS[J]. 2010, 12(3): 540-543, http://www.chinair.org.cn/handle/1471x/1748698.
[44] Zhao, Jinzhong, Wei, Shanqiao, Ma, Xiaofeng, Shao, Huawu. A mild and environmentally benign method for the synthesis of glycals in PEG-600/H2O. GREEN CHEMISTRY[J]. 2009, 11(8): 1124-1127, http://www.irgrid.ac.cn/handle/1471x/256535.

   

（1）糖的1,2-/1,3-双官能团化修饰   中国化学会第五届全国糖化学会议   2023-05-13

已指导学生

申忠珂  硕士研究生  078001-药物化学  

现指导学生

张力  博士研究生  100701-药物化学  

李江涛  博士研究生  100701-药物化学  

王阿木  硕士研究生  078001-药物化学  

李小燕  硕士研究生  086002-制药工程  

杨建  博士研究生  100701-药物化学  

简银香  硕士研究生  078001-药物化学  

曾薇  硕士研究生  078001-药物化学  

乔泽恩  博士研究生  100701-药物化学