癌症相关蛋白的功能和作用机理以及潜在药物发现的研究

   

070302-分析化学

细胞分子生物学，肿瘤生物学，生物化学

2013-08--2017-06   中山大学   理学博士
2010-09--2013-06   东南大学   医学硕士
2006-09--2010-07   江西中医药大学   理学学士

博士研究生

理学博士

   

2021-01~现在, 中国科学院大连化学物理研究所, 研究组长/副研究员
2018-09~2019-09,美国辛辛那提大学医学院, 博士后
2017-04~2020-11,美国国立卫生研究院（NIH）, 博士后

   

（1） 赣江新区“赣江海智”人才, 市地级, 2021
（2） 大连市引进高层次人才, 市地级, 2021
（3） 大连市青年科技之星, 市地级, 2021
（4） 江西省“双千计划”创新领军人才, 省级, 2020
（5） 美国国立卫生研究院访问学者奖, 院级, 2019
（6） 美国国立卫生研究院访问学者奖, 院级, 2017
（7） 第五届国际暨第十四届全国膜生物学研讨会最佳墙报奖, 其他, 2016

   

[1] Yanqing Liu, Shicheng Guo, Tao Yuan, Yang Chen. Editorial: Novel advances in gastrointestinal cancer treatment. FRONTIERS IN MOLECULAR BIOSCIENCES. 2023, 10: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348898/.
[2] Wei, Lai, Xiang, Kaijing, Kang, Hongjian, Yu, Yancheng, Fan, Hongjie, Zhou, Han, Hou, Tao, Ge, Yonglin, Wang, Jixia, Guo, Zhimou, Chen, Yang, Zhao, Yaopeng, Liang, Xinmiao. Development and Characterization of Fluorescent Probes for the G Protein-Coupled Receptor 35. ACS MEDICINAL CHEMISTRY LETTERS. 2023, http://dx.doi.org/10.1021/acsmedchemlett.2c00461.
[3] Chen, Gang, Khan, Imran Mahmood, He, Wensen, Li, Yongxin, Jin, Peng, Campanella, Osvaldo H, Zhang, Haihua, Huo, Yanrong, Chen, Yang, Yang, Huqing, Miao, Ming. Rebuilding the lid region from conformational and dynamic features to engineering applications of lipase in foods: Current status and future prospects. Comprehensive Reviews in Food Science and Food Safety[J]. 2022, 21(3): 2688-2714, https://pubmed.ncbi.nlm.nih.gov/35470946/.
[4] Zhang, Hong, Zhang, ShiHui, Hu, JiaLi, Wu, YuTong, Ma, XiaoYan, Chen, Yang, Yu, Bing, Liao, Shuang, Huang, Huilin, Gao, Song. Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C. CANCER COMMUNICATIONS[J]. 2021, 41(7): 615-630, http://lib.cqvip.com/Qikan/Article/Detail?id=7105205598.
[5] Chen, Qixin, Hao, Mingang, Wang, Lei, Li, Linsen, Chen, Yang, Shao, Xintian, Tian, Zhiqi, Pfuetzner, Richard A, Zhong, Qing, Brunger, Axel T, Guan, JunLin, Diao, Jiajie. Prefused lysosomes cluster on autophagosomes regulated by VAMP8. CELL DEATH & DISEASE[J]. 2021, 12(10): http://dx.doi.org/10.1038/s41419-021-04243-0.
[6] Jun Yin, Emma Spillman, Ethan S Cheng, Jacob Short, Yang Chen, Jingce Lei, Mary Gibbs, Justin S Rosenthal, Chengyu Sheng, Yuki X Chen, Kelly Veerasammy, Tenzin Choetso, Rinat Abzalimov, Bei Wang, Chun Han, Ye He, Quan Yuan. Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling. NATURE COMMUNICATIONS[J]. 2021, 12(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065144/.
[7] Hu, JiaLi, Liang, He, Zhang, Hong, Yang, MingZhu, Sun, Wei, Zhang, Peng, Luo, Li, Feng, JianXiong, Bai, Huajun, Liu, Fang, Zhang, Tianpeng, Yang, JinYu, Gao, Qingsong, Long, Yongkang, Ma, XiaoYan, Chen, Yang, Zhong, Qian, Yu, Bing, Liao, Shuang, Wang, Yongbo, Zhao, Yong, Zeng, MuSheng, Cao, Nan, Wang, Jichang, Chen, Wei, Yang, HuangTian, Gao, Song. FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells. NUCLEIC ACIDS RESEARCH[J]. 2020, 48(5): 2733-2748, https://www.webofscience.com/wos/woscc/full-record/WOS:000525957100044.
[8] TaeSung Kim, Liang Zhang, Jong Il Ahn, Lingjun Meng, Yang Chen, Eunhye Lee, Jeong Kyu Bang, Jung Mi Lim, Rodolfo Ghirlando, Lixin Fan, YunXing Wang, Bo Yeon Kim, JungEun Park, Kyung S Lee. Molecular architecture of a cylindrical self-assembly at human centrosomes. NATURE COMMUNICATIONS[J]. 2019, 10(1): 1-15, https://doaj.org/article/5400f07be0494a47a4919ee1084eef02.
[9] YingNan Wang, YunXin Lu, Jie Liu, Ying Jin, HuiChang Bi, Qi Zhao, ZeXian Liu, YingQin Li, JiaJia Hu, Hui Sheng, YiMing Jiang, Chao Zhang, Feng Tian, Yang Chen, ZhiZhong Pan, Gong Chen, ZhaoLei Zeng, KaiYan Liu, Marcia Ogasawara, JinPing Yun, HuaiQiang Ju, JianXiong Feng, Dan Xie, Song Gao, WeiHua Jia, Scott Kopetz, RuiHua Xu, Feng Wang. AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation. ONCOGENE[J]. 2019, 39(3): 637-650, https://www.nature.com/articles/s41388-019-1004-2.
[10] Chen Qixin, Shao Xintian, Tian Zhiqi, Chen Yang, Mondal Payel, Liu Fei, Wang Fengshan, Ling Peixue, He Weijiang, Zhang Kai, Guo Zijian, Diao Jiajie. Nanoscale monitoring of mitochondria and lysosome interactions for drug screening and discovery. NANO RESEARCH[J]. 2019, 12(5): 1009-1015, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6619154&detailType=1.
[11] JinYu Yang, XiangYu Deng, YiSheng Li, XianCai Ma, JianXiong Feng, Bing Yu, Yang Chen, YiLing Luo, Xi Wang, MeiLing Chen, ZhiXin Fang, FuXiang Zheng, YiPing Li, Qian Zhong, TieBang Kang, LiBing Song, RuiHua Xu, MuSheng Zeng, Wei Chen, Hui Zhang, Wei Xie, Song Gao. Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control. NATURE COMMUNICATIONS[J]. 2018, 9(1): https://doaj.org/article/970dc6c72ffc4e9cbce88e5095a77123.
[12] Cao, YuLu, Meng, Shuxia, Chen, Yang, Feng, JianXiong, Gu, DongDong, Yu, Bing, Li, YuJie, Yang, JinYu, Liao, Shuang, Chan, David C, Gao, Song. MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion. NATURE[J]. 2017, 542(7641): 372-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000394451600042.
[13] Yang Chen, Lei Zhang, Laura Graf, Bing Yu, Yue Liu, Georg Kochs, Yongfang Zhao, Song Gao. Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET. NATURE COMMUNICATIONS[J]. 2017, 8(1): https://doaj.org/article/238a897e890a4cd0ae63f68efa6cfb0a.
[14] Hu, JiaLi, Hua, YiJun, Chen, Yang, Yu, Bing, Gao, Song. Structural analysis of tumor-related single amino acid mutations in human MxA protein. CHINESE JOURNAL OF CANCER[J]. 2015, 34(12): http://lib.cqvip.com/Qikan/Article/Detail?id=667815215.
[15] He, Ze, Tian, Tian, Guo, Dan, Wu, Huijuan, Chen, Yang, Zhang, Yongchen, Wan, Qing, Zhao, Huzi, Wang, Congyang, Shen, Hongjing, Zhao, Lei, Bu, Xiaodong, Wan, Meiling, Shen, Chuanlu. Cytoplasmic Retention of a Nucleocytoplasmic Protein TBC1D3 by Microtubule Network Is Required for Enhanced EGFR Signaling. PLOS ONE[J]. 2014, 9(4): https://doaj.org/article/61812b304b994c6f8c89e616a3f06350.

   

（ 1 ） 癌蛋白TBC1D3的结构及其在胰腺癌发生中的功能研究, 负责人, 国家任务, 2022-01--2024-12
（ 2 ） CHD1L对乳腺癌化疗耐药的作用和结构机制研究, 负责人, 国家任务, 2021-01--2024-12
（ 3 ） TBC1D3 蛋白的结构测定及其与胰腺癌发生的关系研究, 负责人, 地方任务, 2022-01--2023-12
（ 4 ） 肿瘤疾病关键蛋白的结构和功能研究, 负责人, 地方任务, 2021-01--2022-12