基本信息

畅君雷  博导,研究员

中国科学院深圳先进技术研究院
电子邮件: jl.chang@siat.ac.cn
通信地址: 深圳市南山区西丽大学城学苑大道1068号
邮政编码: 518055

部门/实验室:医药所

研究领域

脑血管发育与血脑屏障功能的分子调节机制;

脑血管病发生发展的机制与治疗药物研发;

Wnt信号通路的调节与生物学功能。

教育背景

2008-09--2012-02   美国哈佛医学院麻省总医院   联合培养博士生
2007-09--2012-11   香港大学李嘉诚医学院   博士
2005-09--2007-07   清华大学医学院   硕士
2001-09--2005-07   清华大学生物科学与技术系   本科

工作经历

2017-01~至今, 中国科学院深圳先进技术研究院,生物医药与技术研究所,研究员.

2012-02~2016-12, 美国斯坦福大学医学院, 博士后. 导师:Calvin J. Kuo.


教授课程

神经生物学基础

专利与奖励

奖励信息
(1) 美国心脏学会博士后奖学金, 一等奖, 专项, 2015
(2) 香港大学研究生特别奖学金, 特等奖, 研究所(学校), 2007
(3) 光华奖学金, 二等奖, 研究所(学校), 2006

发表文章

15. Ma YZ, Li L, Kong LL, Zhu ZM, Zhang W, Song JK, Chang JL* and Du GH*.  Pinocembrin protects blood–brain barrier function and expands the therapeutic time window for tissue-type plasminogen activator treatment in a rat thromboembolic stroke model. BioMed Research International, In press (2018). (*corresponding author). (IF 2.476) 

14. Yan KS, Janda CY, Chang JL, Zheng GX, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J, Davies PS, Ueno H, von Furstenberg RJ, Belgrader P, Ziraldo SB, Ordonez H, Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC and Kuo CJ.  Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal. Nature, May; 545(7653): 238-242 (2017). 

13. Janda CY#, Dang LT#, You CJ, Chang JL, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li XN, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, Kuo CJ and Garcia KC. Surrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signaling.  Nature, May; 545(7653): 234-237 (2017). (#co-first author) 

12. Chang JL#, Mancuso MR#, Maier C, Liang XB, Kanako Y, Yang L, Kwong JK, Wang J, Rao V, Vallon M, Kosinski C, Zhang HJ, Mah A, Xu LJ, Li L, Gholamin S, Reyes T, Li R, Kuhnert F, Han XY, Yuan JJ, Chiou SH, Brettman AD, Daly L, Corney DC, Cheshier S, Shortliffe LD, Wu XW, Snyder M, Chang HY, Giffard R, Chan P, Andreasson KI and Kuo CJ.  Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. Nature Medicine, Apr; 23(4): 450-460 (2017). Article. (#co-first author) ***Recommended by the Faculty of 1000. 

11. Furman D, Chang JL, Lartigue L, Bolen CR, Haddad F, Gaudilliere B, Ganio EA, Fragiadakis GK, Spitzer MH, Douchet I, Daburon S, Moreau JF, Nolan GP, Blanco P, Dechanet-Merville J, Dekker CL, Jojic V, Kuo CJ, Davis MM, Faustin B. Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.  Nature Medicine, Jan; 23(2): 174-184 (2017). Article. 

10. Lange C, Garcia MT, Decimo I, Bifari F, Quaegebeur A, Boon R, Zhao H, Boeckx B, Chang JL, Wu C, Le Noble F, Lambrechts D, Dewerchin M, Kuo CJ, Huttner WB and Carmeliet P.  Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis.   EMBO Journal, Feb; 35(9): 924-941 (2016).  ***Cover article. 

9. Tsai HH, Niu JQ, Munji R, Davalos D, Chang JL, Zhang HJ, Tien AC, Kuo CJ, Chan JR, Daneman R and Fancy SP.  Oligodendrocyte precursors migrate along vasculature in the developing nervous system.  Science, Jan; 351(6271): 379-84 (2016). 

8. Diao S, Blackburn JL, Hong GS, Antaris AL, Chang JL, Wu JZ, Zhang B, Cheng K, Kuo CJ and Dai HJ.  Fluorescence imaging in vivo at wavelengths beyond 1500 nm.  Angew Chem Int Ed Engl. Oct 13; 54(49): 14758-14762 (2015). 

7. Hong GS#, Diao S#, Chang JL#, Antaris AL, Chen CX, Zhang B, Zhao S, Atochin DN, Huang PL, Andreasson KI, Kuo CJ and Dai HJ.   Through skull fluorescence imaging of the brain in a new near-infrared window.  Nature Photonics. Sep; 8(9): 723-730 (2014). (#co-first author). 

6. Vallon M#, Chang JL#, Zhang HJ and Kuo CJ. Developmental and pathological angiogenesis in the central nervous system. Cellular and Molecular Life Sciences. Apr; 71:3489-3506 (2014). (#co-first author). ***Cover article. 

5. Chang JL, Atochin DN, Li Q, Lam KSL, Xu AM and Huang PL.  Bone marrow-derived circulating endothelial progenitor cells contribute to eNOS-regulated endothelial repair and vasodilation after arterial injury in vivo. Journal of Cardiology and Vascular Medicine, Aug; 1: 1-8 (2013). 

4. Chang JL, Li YM, Huang Y, Lam KSL, Hoo RLC, Wong WT, Cheng KKY, Wang YQ, Vanhoutte PM and Xu AM. Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway. Diabetes, Nov; 59(11): 2949-59 (2010). 

3. Atochin DN, Yuzawa I, Li Q, Rauwerdink KM, Malhotra R, Chang JL, Broukaert P, Ayata C, Moskowitz MA, Bloch KD, Huang PL and Buys ES.  Soluble guanylate cyclase alpha1beta1 limits stroke size and attenuates neurological injury.  Stroke. Aug; 41(8): 1815-9 (2010). 

2. Du J, Chang JL, Guo SX, Zhang Q, and Wang Z.  ApoE 4 reduces the expression of A-beta degrading enzyme IDE by activating the NMDA receptor in hippocampal neurons. Neuroscience Letters. Oct; 23; 464(2):140-145 (2009). 

1. Hu QL, Chang JL, Tao LT, Yan GL, Xie MC and Wang Z. Endoplasmic Reticulum mediated necrosis-like apoptosis of HeLa cells induced by Ca2+ oscillation. Journal of Biochemistry and Molecular Biology, Nov; 38(6): 709-716 (2005).