基本信息
朱本占  男  博导  中国科学院生态环境研究中心
电子邮件: bzhu@rcees.ac.cn
通信地址: 北京市海淀区双清路18号环境科学楼613室
邮政编码: 100085

研究领域

自由基和过渡金属离子的化学与毒理学协同毒性作用机理


招生信息

   
招生专业
083001-环境科学
招生方向
环境科学,毒理学

教育背景

1994-01--1999-06   以色列希伯来大学哈达萨医学院   哲学博士研究生
1986-09--1989-07   中科院兰州化物所   理学硕士研究生
1981-09--1983-07   山东济宁师专   大学专科

教授课程

自由基化学生物学
化学系列讲座
环境与健康研究进展
自由基生物学导论

专利与奖励

   
奖励信息
(1) 中国科学院杰出科技成就奖, 部委级, 2013
专利成果
( 1 ) 检测卤代芳烃类有机物的方法, 发明, 2012, 第 1 作者, 专利号: 201210299502.X
( 2 ) 一种促进Ru(II)金属络合物细胞核摄取的方法, 发明, 2015, 第 1 作者, 专利号: 201510531733.2

出版信息

   
发表论文
(1) Delivering the cell-impermeable DNA ‘light-switch’ Ru(II) complexes preferentially into live-cell nucleus via an unprecedented ion-pairing method, Chem. Sci., 2016, 第 1 作者
(2) A combined experimental and computational investigation on the unusual molecular mechanism of Lossen rearrangement reaction activated by the carcinogenic halogenated quinones., J. Org. Chem., 2015, 通讯作者
(3) Different modes of synergistic toxicities between metam/copper (II) and metam/zinc (II) in HepG2 cells: apoptosis vs. necrosis., Environ. Toxicol., 2015, 通讯作者
(4) 一类非同寻常的二次Lossen 重排反应: 异羟肟酸的新型解毒分子作用机制, 化学学报, 2015, 第 1 作者
(5) 依赖于羟基自由基的两次化学发光产生体系: 致癌性多卤代醌与过氧化氢, 科学通报, 2015, 第 1 作者
(6) 致癌性卤代醌与有机氢过氧化物不依赖金属分解的分子机制及其潜在生物学意义, 中国科学•化学, 2015, 第 1 作者
(7) Intrinsic chemiluminescence generation during advanced oxidation of persistent halogenated aromatic carcinogens, Environ. Sci. Technol., 2015, 通讯作者
(8) Molecular mechanism of metal-independent decomposition of organic hydroperoxides by the halogenated quinoid carcinogens and the potential biological implications., Chem. Res. Toxicol., 2015, 通讯作者
(9) Chemical toxicology in China: A special issue., Chem. Res. Toxicol., 2015, 第 1 作者
(10) Detoxifying polyhalogenated catechols through a copper-chelating agent by forming stable and redox-inactive hydrogen-bonded complexes with an unusual perpendicular structure, Chemistry-A European Journa, 2014, 通讯作者
(11) Potent methyl oxidation of 5-methyl-2’-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism, Free Radic. Biol. Med., 2013, 通讯作者
(12) Molecular Mechanism of Metal-independent Decomposition of Lipid Hydroperoxide 13-HPODE by Halogenated Quinoid Carcinogens, Free Radic. Biol. Med., 2013, 通讯作者
(13) Bisphenol A at a low concentration boosts mouse spermatogonial cell proliferation by inducing the G protein-coupled receptor 30 expression, Toxicol. Appl. Pharmacol., 2013, 通讯作者
(14) Ofloxacin induces NADPH oxidase-driven ROS accumulation via β1 integrin-EGFR-Rac1 pathway in microencapsulated chondrocytes, Toxicol. Appl. Pharmacol., 2013, 通讯作者
(15) Lethal synergism between organic and inorganic wood preservatives via formation of an unusual Lipophilic ternary complex, Toxicol. Appl. Pharmacol., 2013, 通讯作者
(16) Potent DNA damage by polyhalogenated quinoid carcinogens and H2O2 via a metal-independent and intercalation-enhanced oxidation mechanism, Sci. Rep., 2013, 通讯作者
(17) Low concentrations of bisphenol A suppress thyroid hormone receptor transcription through a nongenomic mechanism, Toxicol. Appl. Pharmacol. , 2012, 通讯作者
(18) Unprecedented hydroxyl radical-dependent two-step chemiluminescence production by polyhalogenated quinoid carcinogens and H2O2,  Proc. Natl. Acad. Sci. USA, 2012, 第 1 作者
(19) Ergothioneine prevents copper-induced oxidative damage to DNA and protein by formation of a redox-inactive ergothioneine-copper complex , Chem. Res. Toxicol. , 2011, 第 1 作者
(20) An electrochemical biosensor for the detection of tyrosine oxidation induced by Fenton reaction, Biosens. Bioelectron. , 2011, 通讯作者
(21) A novel mechanism for metal-independent hydroxyl radical production by hydrogen peroxide and halogenated quinones , Mini-Rev. Org. Chem., 2011, 第 1 作者
(22) Low Concentrations of Bisphenol A Induce Mouse Spermatogonial Cell Proliferation by G-Protein-Coupled Receptor 30 and Estrogen Receptor-α, Environmental Health Perspectives, 2011, 通讯作者
(23) Detoxifying polyhalogenated quinones by hydroxamic acids via an unusual double Lossen rearrangement, Proc. Natl. Acad. Sci. USA, 2010, 第 1 作者
(24) Detection and mechanistic investigation of halogenated benzoquinone induced DNA damage by photoelectrochemical DNA sensor , Anal. Bioanal. Chem., 2010, 第 2 作者
(25) Metal-independent decomposition of hydroperoxides by halogenated quinones: Detection and identification of a quinone ketoxy radical., Proc. Natl. Acad. Sci. USA, 2009, 第 1 作者
(26) Potential mechanism for pentachlorophenol-induced carcinogenicity: A novel mechanism for metal-independent production of hydroxyl radicals, Chem. Res. Toxicol., 2009, 第 1 作者
(27) 新型羟基自由基产生分子机理的研究: 五氯酚的可能致癌机制, 《科学通报》 , 2009, 第 1 作者
(28) Mechanism of metal-independent decomposition of organic hydroperoxides and formation of alkoxyl radicals by halogenated quinones., Proc. Natl. Acad. Sci. USA , 2007, 第 1 作者
(29) Molecular Mechanism for metal-independent production of hydroxyl radicals by hydrogen peroxide and halogenated quinones. , Proc. Natl. Acad. Sci. USA, 2007, 第 1 作者
发表著作
   

科研活动

   
科研项目
( 1 ) 大中型浅水湖泊蓝藻水华暴发机理研究, 主持, 国家级, 2008-01--2012-12
( 2 ) 环境化学, 主持, 国家级, 2010-01--2013-12
( 3 ) 不依赖金属离子存在型羟基自由基的生成及DNA损伤机理的研究, 主持, 国家级, 2008-01--2010-12
( 4 ) 有机与无机木材保护剂协同毒性作用机理的研究, 主持, 国家级, 2009-01--2011-12
( 5 ) 持久性有毒污染物的形态、环境过程与毒理效应, 参与, 国家级, 2008-01--2012-12
( 6 ) 持久性有机污染物的累积代谢及其与生物分子的相互作用, 主持, 国家级, 2009-01--2012-12
( 7 ) 有机农药与含铜、锌无机农药的协同毒性作用机理研究, 主持, 国家级, 2013-01--2017-12
( 8 ) 自由基化学, 主持, 部委级, 2006-06--2010-05
( 9 ) 污染物引发的自由基产生与生物损伤, 主持, 部委级, 2014-07--2019-07
( 10 ) 高级氧化过程中卤代芳烃产生化学发光的分子机制及应用研究, 主持, 国家级, 2015-01--2018-12
( 11 ) 持久性有毒污染物的环境过程与毒理效应, 主持, 国家级, 2014-01--2016-12
参与会议
(1)Redirecting Ru(II)-DPPZ Complex into Nucleus for Enantioselective Live-Cell DNA-Imaging and Photosensitizing via Simple 'Yin-Yang' Ion-Pairing   2016-07-26
(2)"Mechanism of Halogenated Quinone-mediated Free Radical Production and DNA Damage"   自由基专业委员会会议   朱本占   2015-08-13
(3)Delivering the DNA ‘Light-switching’ Ru(II) Complexes into Live-cell Nucleus via Ion-Pairing   15’分子探针与荧光成像国际研讨会   朱本占   2015-07-16
(4)"Mechanism of Free Radical-induced Oxidative DNA Damage/Adduct Formation and a Novel Fluorescent DNA Probe in Live Cells"   第二届活性氧生物学效应学术会议   朱本占   2015-03-10
(5)Molecular Mechanisms for Novel Free Radical Reactions, DNA Damage and Antioxidant Protection   朱本占   2014-11-14
(6)新型氧自由基诱导DNA氧化损伤的机理研究   中国环境诱变剂学会第16次学术大会   朱本占   2014-11-06
(7)新型自由基反应及DNA损伤的分子机理(口头报告)   2014年全国电子顺磁共振波谱学学术研讨会   朱本占   2014-09-11
(8)Hydroxyl radical-dependent chemiluminescence emmision during advanced oxidation of halogenated aromatic compounds   朱本占   2013-10-23
(9)The first purification and unequivocal characterization of an unusual carbon-centered quinone ketoxy radical adduct   朱本占   2012-11-13
(10)Unprecedented hydroxyl radical-dependent two-step chemiluminescence production by polyhalogenated quinoid carcinogens and H2O2   朱本占   2012-10-25
(11)From Free Radicals to Lossen Rearrangement, then Back to Free Radicals   朱本占   2012-10-11
(12)Generation and accumulation of cellular 5-hydroxymethylcytosine by redox-active quinines   朱本占   2012-09-18
(13)Mechanism of synergistic toxicity between organic and inorganic environmental pollutants   朱本占   2011-11-01
(14)Detection and Identification of a Novel Quinone Ketoxy Radical Produced by Metal-independent Decomposition of Hydroperoxides by Halogenated Quinones   Ben-zhan Zhu   2010-05-04
(15)Detection and Identification of a Novel Quinone Ketoxy Radical Produced by Metal-independent Decomposition of Hydroperoxides by Halogenated Quinones   Ben-zhan Zhu   2008-10-23
(16)Molecular Mechanism for metal-independent production of hydroxyl radicals by hydrogen peroxide and halogenated quinones   Ben-zhan Zhu   2007-07-01

合作情况

   
项目协作单位
   

指导学生

已指导学生

单国强  01  19367  

范瑞梅  01  19367  

朱俊歌  01  19367  

毛莉  01  19367  

覃浩  01  19367  

夏海英  01  19367  

刘玉祥  01  19367  

李岩  01  19367  

任福荣  01  19367  

黄春华  01  19367  

邵波  01  19367  

高慧颖  01  19367  

巢细娟  01  19367  

现指导学生

沈忱  01  19367  

李锋  01  19367  

谢琳娜  01  19132  

严诸颖  01  19132  

黄蓉  01  19367  

徐丹  01  19132  

肖璇  02  67011  

秦丽  01  19367  

唐苗  01  19132  

唐天舒  02  63224  

李培林   02  67011