基本信息
李斌 男 博导 上海巴斯德研究所
电子邮件:binli@sibs.ac.cn
通信地址:上海市岳阳路32号生命科学实验楼巴斯德所B307
邮政编码:200031

研究领域

   

招生信息

   
招生专业
071005-微生物学
招生方向
分子免疫学

教育背景

1996-09--2001-07 北京大学生命科学学院 植物生理学博士学位
1992-09--1996-07 安徽师范大学生物系 学士学位

工作经历

   
工作简历
2009-02--今 中国科学院上海巴斯德研究所 分子免疫学研究组组长,研究员,博士生导师,科研处长
2006-08--2009-02 美国宾夕法尼亚大学医学院病理及实验医学系 高级研究助理
2002-10--2003-07 英国牛津大学Sir William Dunn病理学院 研究访问学者
2001-08--2006-07 美国宾夕法尼亚大学医学院病理及实验医学系 博士后
社会兼职
2013-01--今 中国细胞生物学学会免疫细胞生物学分会,秘书长
2012-01--今 上海市细胞生物学学会,秘书长
2011-01--今 《Frontiers in Immunological Tolerance》期刊,编委

教授课程

   
外出授课

1、 上海大学研究生课程- FOXP3转录蛋白复合体的生化及分子生物学
2、 中科院 实验生物学- FACS的基本原理及其应用
3、 北京大学‘免疫模块课’-获得性免疫及免疫调节&代谢与免疫
4、 国科大科学前沿讲座系列-高级免疫学与病毒学系列讲座
5、 上海交大免疫所研究生暑期课程-炎症微环境下Treg/Th17功能调节基础及其临床应用
6、 上海大学生化与分子生物学进展 上海大学生化与分子生物学进展

专利与奖励

   
奖励信息
   
专利成果
(1) COMPOSITIONS AND METHODS FOR MODULATION OF SUPPRESSOR T CELL ACTIVATION,发明,2007,第2作者,专利号: PCT/US2007/001677 (WO/2007/084775)
(2) METHODS FOR IMMUNO-DETECTION OF EPITOPES ON MOLECULES AND FOR DETECTION OF INTERACTIONS OF MOLECULES VIA FLUORESCENT DYES,发明,2002,第3作者,专利号:PCT/US2002/003640(WO2002/066980)
(3) FOXP3 OLIGOMERIZATION AND INTERMOLECULAR INTERACTIONS,发明,2008,第2作者,专利号:PCT/US2008/066147
(4) FOXP3及调节性T细胞的负调节因子及其应用,发明,2010,第1作者,专利号:201010222995.8
(5) 磷酸化途径相关因子在调控调节性T细胞功能中的应用,发明,2012,第1作者,专利号:201210017885.7

出版信息

   
部分代表论文
(1) Ubiquitin-specific Protease 4 promotes Th17 cell function under inflammation through deubiquitinating and stabilizing RORγt. ,J. Immunol. Cutting Edge.,2015,通讯作者
(2) PIM1 kinase negatively regulates FOXP3-mediated Transcriptional Regulation.,J. Biol. Chem. ,2014,通讯作者
(3) USP22 is a positive regulator of NFATc2 on promoting IL2 expression.,FEBS LETTERS,2014,通讯作者
(4) STUB1 negatively modulates regulatory T cell suppressive activity by promoting FOXP3 degradation,Immunity,2013,通讯作者
(5) Negative Regulation of Interferon-Induced Transmembrane Protein 3 by SET7-mediated Lysine ,J. Biol. Chem,2013,通讯作者
(6) TIP60 positively Regulates ThPOK-Mediated Repression of Eomesodermin in Human CD4+ T Cells,J Biol Chem,2013,通讯作者
(7) Identification of the E3 deubiquitinase USP21 as a positive regulator of GATA3,J Biol Chem ,2013,通讯作者
(8) Ubiquitination Signals Critical to Regulatory T cell Development and Function,Int Immunopharmacol,2013,通讯作者
(9) Structural and Biological Features of FOXP3 Dimerization Relevant to Regulatory T Cell Function,Cell reports,2012,通讯作者
(10) You, me and Foxp3: immune regulation for two,Immunotherapy,2011,通讯作者
(11) Molecular Mechanisms underlying the Regulation and Functional Plasticity of FOXP3+ Treg Cells,Genes and Immunity,2011,通讯作者
(12) Romance of the three kingdoms: RORgammat allies with HIF1alpha against FoxP3 in regulating T cell metabolism and differentiation,Protein Cell ,2011,通讯作者
(13) FOXP3 and RORγt: transcriptional regulation of Treg and Th17,Int Immunopharmacol,2011,通讯作者
(14) FOXP3+调节性T细胞,FOXP3+ regulatory T cells,生命科学,2010,通讯作者
(15) Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function,Current Opinion In Immunology,2010,第2作者
(16) Structural aspects of the FOXP3 regulatory complex as an immunopharmacological target,Int Immunopharmacol,2009,通讯作者
(17) Special regulatory T-cell review: FOXP3 biochemistry in regulatory,Immunology,2008,第1作者
(18) Immunology at the University of Pennsylvania,Immunol Res.,2008,第3作者
(19) FOXP3 and its partners: structural and biochemical insights into the regulation of FOXP3 activity,Immunol Res.,2008,通讯作者
(20) TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3.,Proc Natl Acad Sci U S A,2008,第1作者
(21) FOXP3 actively represses transcription by recruiting the HAT/HDAC complex,Cell Cycle,2007,第1作者
(22) FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression,Proc Natl Acad Sci U S A,2007,第1作者
(23) Biochemistry and therapeutic implications of mechanisms involved in FOXP3 activity in immune suppression.,Curr Opin Immunol,2007,第1作者
(24) FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease,Int Immunol.,2007,第1作者
(25) FOXP3 ensembles in T-cell regulation,Immunol Rev. ,2006,第1作者
发表著作
(1) T Cell Metabolism in Autoimmune Diseases,T Cell Metabolism in Autoimmune Diseases,InTech,2012-07,第1作者
(2) Mechanisms and Control of Regulatory T Cells in Cancer,Mechanisms and Control of Regulatory T Cells in Cancer,Springer Science+Business Media,2012-01,第1作者
(3) The Epigenetics of Autoimmune Disease,The Epigenetics of Autoimmune Disease,John Wiley,2009-07,第1作者
(4) The Immune Synapse as a Novel Target for Therapy,The Immune Synapse as a Novel Target for Therapy,Birkhauser Publishing,2008-07,第1作者

科研活动

   
科研项目
(1) 炎症因子对FOXP3+调节性T细胞分化与功能的动态影响及其机理研究,主持,部委级,2014-01--2018-12
(2) 遗传变异调控AS自身免疫紊乱的分子机制研究,主持,国家级,2014-01--2015-12
(3) FOXP3蛋白泛素化与去泛素化修饰调控Treg细胞功能的机理研究,主持,部委级,2014-01--2017-12
(4) 转录因子IRF4蛋白甲基化修饰及其转录调节功能的分子机理研究,主持,部委级,2012-01--2015-12
参与会议
(1) Stub1 Negatively Modulates Regulatory T Cell Suppressive Activity by Promoting Foxp3 Degradation,海峡两岸细胞生物学研讨会,2014-04,Zuojia Chen
(2) Posttranslational regulation of FOXP3 and Treg stability under inflammation,2014-01,Bin Li
(3) TIP60 Positively Regulates ThPOK-Mediated Repression of Eomesodermin in Human CD4+ T Cells,2013-08,Yangyang Li
(4) PIM1 kinase negatively regulates FOXP3-mediated Transcriptional Regulation,2012-01,Zhiyuan Li, Andy Tsun, Guoping Deng, Chen Chen
(5) Identification of the E3 deubiquitinase USP21 as a positive regulator of GATA3 ,2011-05,李斌
(6) Signaling to FOXP3 activation in regulatory T cells: from cell surface to chromatin,2009-04,李斌
(7) Foxp3 biochemistry in regulatory T cells - how diverse signals regulate suppression,2008-10,李斌
(8) FOXP3 complex in regulatory T cells and its regulation in immune suppression,2008-10,李斌
(9) FOXP3 is a homo-oligomer, and it interactions with histone acetyltransferase and class II histone deacetylases are required for repression,2007-05,李斌
(10) FOXP3-Mediated Transcriptional Repression is Regulated by Histone Acetylase-Deacetylase Complex ,2007-02,李斌

指导学生

已指导学生

高雅懿  博士研究生  071005-微生物学  

陈晨  博士研究生  071005-微生物学  

陈祚珈  博士研究生  071005-微生物学  

殷淑英  硕士研究生  085238-生物工程  

李志远  博士研究生  071005-微生物学  

单昭  博士研究生  071005-微生物学  

杨静  博士研究生  071005-微生物学  

现指导学生

聂佳  博士研究生  071005-微生物学  

李扬扬  博士研究生  071005-微生物学  

罗雪瑞  博士研究生  071005-微生物学  

王爱婷  硕士研究生  071005-微生物学  

朱福香  博士研究生  071009-细胞生物学  

合作情况

   
项目协作单位
   

相关链接

巴斯德所个人介绍:http://sourcedb.cas.cn/sourcedb_shanghaipasteur_cas/zw/zjrc/200906/t20090627_1855523.html
巴斯德所课题组介绍:
http://www.shanghaipasteur.cas.cn/kxyj/yjdy/fzmy/200907/t20090702_1909354.html