基本信息
赵宝锋  男  博导  中国科学院大连化学物理研究所
电子邮件: baofzhao@dicp.ac.cn
通信地址: 辽宁大连中山路457号大连化物所1810组
邮政编码: 116023

研究领域

1.膜蛋白质复合体样品制备方法及复合体组成检测
2.基于组学的神经退行性疾病及肿瘤发病机制
3.纳米医学

教育背景

2004-09--2007-06   中国疾病预防控制中心   博士
2001-09--2004-06   兰州大学   硕士
1997-09--2001-06   兰州大学   学士
学历
1997.9-2001.7 兰州大学 生物学 学士
2001.9-2004.7 兰州大学 生物学 硕士 
2004.9-2007.7 中国疾病预防控制中心 分子肿瘤学 博士

工作经历

2007.7-2007.12 大连医科大学 讲师
2008.2-2014.2 Medical College of Wisconsin 博士后 
2014.3-2015.5 大连化学物理研究所 副研究员

2015.6-今 大连化学物理研究所 研究员

出版信息

(1) Baofeng Zhao#,Wenquan Hu#,S Kumar,P Gonyo,U Rana,Z Liu,B Wang,WQ Duong,Z Yang,CL Williams,QR Miao*,The Nogo-B receptor promotes Ras plasma membrane localization and activation.,Oncogene. 2017, 36(24): 3406-3416.

(2) Chengyong Dong#,Baofeng Zhao#, Fei Long,Ying Liu,Zhenzhen Liu,Song Li,Xuejun Yang,Deguang Sun,Haibo Wang,Qinlong Liu,Rui Liang,Yan Li,Zhenming Gao,Shujuan Shao,Qing Robert Miao*,Liming Wang*,Nogo-B receptor promotes the chemoresistance of human hepatocellular carcinoma via the ubiquitination of p53 protein.,Oncotarget,2016,7(8):8850~8865.

(3) Baofeng Zhao#,Bo Xu#,Wenquan Hu#,Chunxia Song#,Fangjun Wang,Zhong Liu,Mingliang Ye,Hanfa Zou*,Qing R. Miao*,Comprehensive proteome quantification reveals NgBR as a new regulator forepithelial-mesenchymal transition of breast tumor cells.,Journal of Proteomics,2015,112:38~52.

(4) Bei Wang#,Baofeng Zhao#,Paula North,Amanda Kong,Jian Huang*,Qing Robert Miao*,Expression of NgBR is highly associated with estrogen receptor alpha and survivin in breast cancer.,PLoS One, 2013,8(11):e78083. 

(5) Baofeng Zhao#,Changzoon Chun,Zhong Liu,Mark A Horswill,Kallal Pramanik, George A Wilkinson,Ramani Ramchandran,Robert Q Miao*,Nogo-B receptor is essential for angiogenesis in zebrafish via Akt pathway., Blood, 2010, 116(24): 5423-33.

(6) Huiming Yuan#, Shen Zhang#, Baofeng Zhao, Yejing Weng, Xudong Zhu, Senwu Li, Lihua Zhang*, Yukui Zhang, Enzymatic Reactor with Trypsin Immobilized on Graphene Oxide Modified Polymer Microspheres To Achieve Automated Proteome Quantification. Analytical Chemistry, 2017, 89(12):6324-6329. 

(7) Qun Zhao#, Fei Fang#, Yichu Shan, Zhigang Sui, Baofeng Zhao, Zhen Liang, Lihua Zhang*, Yukui Zhang, In-Depth Proteome Coverage by Improving Efficiency for Membrane Proteome Analysis., Analytical Chemistry, 2017, 89(10):5179-5185.

(8) Wenquan Hu#,Wenwen Zhang,Yuanli Chen,Ujala Rana, Ru-Jeng Teng, Yajun Duan,Zhong Liu,Baofeng Zhao, Jamie Foeckler, Hartmut Weiler, Rachel E Kallinger, Michael J Thomas, Kezhong Zhang, Jihong Han*, Qing Robert Miao*, Nogo-B receptor deficiency increases liver X receptor alpha nuclear translocation and hepatic lipogenesis through an adenosine monophosphate-activated protein kinase alpha-dependent pathway.,Hepatology,2016,64(5):1559~1576.

(9) Ujala Rana#,ZhongLiu#,Suresh N. Kumar,Baofeng Zhao,Wenquan Hu,Michelle Bordas,Stephanie Cossette,Sara Szabo,Jamie Foeckler,Hartmut Weiler,Magdalena Chrzanowska-Wodnicka,Mary L. Holtz, Ravindra P. Misra,Valerie Salato,Paula E. North,Ramani Ramchandran*,Qing Robert Miao*,Nogo-B receptor deficiency causes cerebral vasculature defects during embryonic development in mice.,Developmental Biology,2016,410(2):190~201.

(10) Shen Zhang#, Qi Wu#,Yichu Shan#, Qun Zhao, Baofeng Zhao, Yejing Weng, Zhigang Sui, Lihua Zhang*, Yukui Zhang,Fast MS/MS acquisition without dynamic exclusion enables precise and accurate quantification of proteome by MS/MS fragment intensity,Scientific Reports,2016,6:23692.

(11) Senwu Li#, Kaiguang Yang#, Baofeng Zhao, Xiao Li, Lukuan Liu,Yuanbo Chen, Lihua Zhang*, Yukui Zhang,Epitope imprinting enhanced IMAC(EI-IMAC) for highly selective purification of His-tagged protein,Journal of Materials Chemistry B,2016, 4(11):1960~1967.

(12) Shen Zhang#,Huiming Yuan#,Baofeng Zhao,Yuan Zhou,Hao Jiang,Lihua Zhang*,Zhen Liang,Yukui Zhang,Integrated platform with a combination of online digestion and (18)O labeling for proteome quantification via an immobilized trypsin microreactor.,Analyst,2015.8.7,140(15):5227~5234.

(13) Ru-Jeng Teng*,Ujala Rana,Adeleye J. Afolayan,Baofeng Zhao,Qing R. Miao,Girija G. Konduri,Nogo-B receptor modulates angiogenesis response of pulmonary artery endothelial cells through eNOS coupling.,American Journal of Respiratory Cell and Molecular Biology,2014,51(2):169~177.

(14) Sreenivasulu KilariIndulekha RemadeviBaofeng ZhaoJing PanRobert MiaoRamani RamchandranPaula E. NorthMing YouNader RahimiGeorge A. Wilkinson*Endothelial cell-specific chemotaxis receptor(ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR.Journal of Biological Chemistry201328815):10265~10274




科研活动

   
科研项目
( 1 ) 蛋白质复合物的规模化分析鉴定方法, 主持, 国家级, 2016-07--2021-06
( 2 ) 基于原位化学交联-质谱鉴定新技术解析NgBR蛋白质复合体, 主持, 国家级, 2018-01--2021-12
( 3 ) 细胞膜蛋白样品制备新方法及其在发掘NgBR相互作用蛋白中的应用, 主持, 国家级, 2014-01--2017-12
( 4 ) Folr1在肝癌索拉非尼耐药中的功能及作用机制研究, 主持, 国家级, 2021-01--2024-12
( 5 ) 基于氧空位调控的纳米酶定向设计及其选择性杀伤肿瘤细胞的作用机制研究, 主持, 市地级, 2019-07--2021-12

指导学生

现指导学生

王子璇  硕士研究生  070302-分析化学  

马宝福  博士研究生  070302-分析化学  

郑诗颖  硕士研究生  070302-分析化学  

潘慧  博士研究生  070302-分析化学