Xiaochun Wan Ph.D.
Deputy Director of Institute of Biomedicine and Biotechnology
Director of Center for Protein and Cell-based Drugs
Director of Guangdong immune cell therapy engineering and technology research center
Shenzhen Institutes of Advanced Technology (SIAT),
Chinese Academy of Sciences (CAS)
1068 Xueyuan Avenue, Shenzhen University Town,
Xili, Nanshan, Shenzhen 518055, China.
Tel: 0755-86585218
E-mail: xc.wan@siat.ac.cn
Research Areas
Education
1998-10--2003-12，University of Montreal, Montreal, Canada，Ph.D. Immunology
1993-07--1998-06，McGill University,Montreal, Canada， Master of Biochemistry
1983-09--1987-07 ，Shihezi University, Xinjiang, China， Bachelor of Biology
Experience
071010- biochemistry and molecular biology
071009- cell biology
071005- microbiology
Work Experience
2011-now , Professor, ShenZhen Institute of Advanced Technology, Chinese Academy of Science, ShenZhen, China
2009-2011, Senior Scientist, Frontage Laboratories (CRO)
2008-2009, Biologist II, Delivery Biology, Merck Research Laboratories
2007-2008, Senior Scientist, Morphotek (Eisai),
2003-2007, Research fellow, University of Pennsylvania School of Medicine, Philadelphia
Teaching Experience
1、Humanities lecture series
2、Comprehensive test of antibody technology
3、immunology
4、Antibody engineering
5、Cell biology
Honors & Distinctions
2019，Dean innovation award，Shenzhen institute of advanced technology, Chinese academy of sciences
2015，Distinguished researcher, Distinguished backbone talents，Chinese Academy of Sciences
2014，Class B shenzhen overseas high-level talents，Shenzhen administration of foreign experts affairs
2005，Abstract and travel award，Federation of clinical immunologist Societies (FOCIS) Conference
2004-2007，Canadian Institute of Health Research (CIHR) Scholar Award，Canadian Institute of Health Research
Publications
Papers
（1）Xin Li#, Guizhong Zhang#, Qian Chen, Yingxue Lin, Junxin Li, Qinggguo Ruan, Youhai Chen, Guang Yu, and Xiaochun Wan*. CD317 Promotes the survival of cancer cells through apoptosis-inducing factor. Journal of Experimental& Clinical Cancer Research, 2016, 35:117; IF=4.357；
（2）Lulu Cui#, Jiacheng Bi#, Dehong Yan, Xiufeng Ye, Mingxing Zheng, Guang Yu, Xiaochun Wan*. JSI-124 inhibits IgE production in an IgE B cell line. BBRC(Biochemical and Biophysical Research Communications). 2017.01.29, 483(1):669-673, IF=2.466；
（3）Jiacheng Bi#, Lulu Cui#, Gang Yu, Xiaolu Yang, Youhai Chen, Xiaochun Wan*. NK cells alleviate lung inflammation by negatively regulating group 2 innate lymphoid cells. The Journal of Immunology. 2017.04.15, 198(8):3336- 3344. IF= 4.856；
（4）Hongling Zhang#, Jiacheng Bi#, Huqiang Yi, Tingting Fan, Qingguo Ruan, Lintao Cai, Youhai H Chen, Xiaochun Wan*. Silencing c-Rel in macrophages dampens Th1 and Th17 immune responses and alleviates experimental autoimmune encephalomyelitis in mice.Immunology and cell biology. 2017.03.21, 95(7):593-600, IF =4.557；
（5）Abrar Ahmed#, Xiaochun Wan, Izaskun Mitxitorena, Andrew J. Lindsay, Pier Paolo Pandolfi, Mary W. McCaffrey, Karen Keeshan, Youhai H. Chen, Ruaidhrí J. Carmody*. Regulation of NF-κB by PML and PML-RARα. Scientific Reports,.2017.03.20, 7:44539. IF =4.259;
（6）Hongling Zhang#, Xuhong Chen#, Dongming Li, Lulu Cui, Xin Li, Xiufeng Ye*, Xiaochun Wan*. DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression. Oncology reports. Published online on: May 30, 2017,https://doi.org/10.3892/or.2017.5685, IF= 2.486；
（7）Junxin Li#, Ni Xie#, Jianhui Yuan#, Lvyan Liu, Qiming Zhou, Xiaohu Ren, Qian Chen, Guizhong Zhang, Qingguo Ruan, Youhai H. Chen, Xiaochun Wan*. DcR3 combined with hematological traits serves as a valuable biomarker for the diagnosis of cancer metastasis.Scientific Reports, 2017.11.20, 8(64):107612- 107620. IF= 5.168；
（8）Haisi Wu#, Jiacheng Bi#, Gaohui Wu, Chaoyue Zheng，Zhen Lu, Lulu Cui, Xiaochun Wan*。Impaired cytolytic activity of asthma-associated natural killer cells is linked to dysregulated transcriptional program in energy metabolism. Molecular Immunology, 2018.08.15, 101（2018）:514-520. IF= 3.188；
（9）Guizhong Zhang, Xin Li, Lvyan Liu, Junxin Li, Qian Chen，Shiran Huang, Yutao Li, Xiaochun Wan*. Vaccination with a DNA vaccine encoding CD317-targeting HBs antigen elicits enhanced immunity in mice. Biochemical and Biophysical Research Communications, 2018.09.06, 504（4）:865-870. IF= 2.559；
（10）Guizhong Zhang, Xin Li, Qian Chen, Junxin Li, Qingguo Ruan, Youhai H. Chen, Xiaolu Yang* and Xiaochun Wan*.CD317 activates EGFR by regulating its association with lipid rafts.Cancer Research, 2019.03.19,79（9）:2220-2231. IF= 9.13；
（11）Dehong Yan, Adeleye O. Adeshakin, Meichen Xu, Lukman O. Afolabi, Guizhong Zhang, Youhai H Chen and Xiaochun Wan*.Lipid metabolic pathways confer immunosuppressive function of myeloid-derived suppressor cells in tumor. Frontiers in Immunology,2019.06.19, 10(1)：1399. IF= 5.511；
（12）Qian Chen, Pu Wang, Qingmei Zhang, Meng Xia, Guizhong Zhang1, Junxin Li, Enyun Shen, Youhai H. Chen and Xiaochun Wan*. Preclinical studies of a death receptor-5 fusion protein that ameliorates acute liver failure and inflammation. Journal of Molecular Medicine,2019.6.22, 97(9):1247-1261. IF= 5.114；
（13）Li, Junxin; Yang, Yang; Wang, Min; Ren, Xiaohu; Yang, Zheng; Liu, Lvyan; Zhang, Guizhong; Chen, Qian; Yang, Wei; Chen, Youhai H; Wan, Xiaochun*. Rapid isolation of a potent human antibody against H7N9 influenza virus from an infected patient. Antiviral Research, 2019.7.20, 170:104564. IF= 4.130；
（14）Afolabi, Lukman; Adeshakin, Adeleye; Sani, Musbahu; Bi, Jiacheng; Wan, Xiaochun*. Genetic Reprogramming For NK cell Cancer Immunotherapy with CRISPR/Cas9. Immunology. 2019 .7.17. 158（2）:63-69. IF= 4.147；
（15）Dehong Yan, Jinghui Wang, Honghong Sun, Ali Zamani, Honglin Zhang, Weihong Chen, Aifa Tang, Qingguo Ruan, Xiaolu Yang, Youhai Chen*, and Xiaochun Wan*.TIPE2 Specifies the Functional Polarization of Myeloid-derived Suppressor Cells during Tumorigenesis.2019.10.29,DOI:10.1084/jem.20182005. IF=10.892；
（16）Qian Chen, Dehong Yan, Qingmei Zhang, Guizhong Zhang, Meng Xia, Junxin Li, Wugen Zhan, Enyun Shen, Youhai H. Chen*, and Xiaochun Wan*.Treatment of acetaminophen-induced liver failure by blocking the death checkpoint protein TRAIL.2019.10.16, DOI:10.1016/j.bbadis.2019.165583. IF=4.328；
Patents
（1）万晓春，林婷婷，向军俭。免疫用抗原乳化装置。实用新型专利，ZL 2012 2 0715989.0，中华人民共和国知识产权局，2013.06.19；
（2）万晓春，姚红，吴洪飞。一种混合细胞培养生产纯人源单克隆抗体的方法。发明专利，ZL 2011 1 0214513.9，中华人民共和国知识产权局，2014.09.03；
（3）万晓春，王彩霞，向军俭。HAT半固体筛选培养基以及杂交瘤细胞的筛选方法。发明专利，ZL 2012105727598，中华人民共和国知识产权局，2015.12.23；
（4）万晓春，刘婕，金言，蔡林涛。半固体筛选培养基以及杂交瘤细胞的筛选方法。发明专利，ZL 2012 1 0576356.0，中华人民共和国知识产权局，2016.01.27；
（5）赵琦，刘婕，万晓春。一种通用型重组表达载体及其构建方法和应用。发明专利，ZL 2013 1 0750733.2，中华人民共和国知识产权局，2016.02.17；
（6）万晓春，刘婕，金言，蔡林涛。半固体培养基及其制备方法和杂交瘤细胞筛选方法。发明专利，ZL 2012 1 0575548.X，中华人民共和国知识产权局，2016.04.13；
（7）万晓春，刘婕，金言。乳胶半固体培养基及其制备方法和杂交瘤细胞筛选方法。发明专利，ZL 2012 1 0575609.2，中华人民共和国知识产权局，2016.04.13；
（8）万晓春，吕卫东。人源化抗体表达载体及其构建方法。发明专利，ZL 2013 1 0737306.0，中华人民共和国知识产权局，2016.06.15；
（9）万晓春，李俊鑫，任晓虎，王蒲。突变型TNF-α基因和提高抗原TNF-α基因表达量的方法。发明专利，ZL 2012 1 0572674.X，中华人民共和国知识产权局，2016.08.17；
（10）万晓春、胡玉婷、金言。一种小鼠固定装置。发明专利，ZL 2012 1 0546281.1，中华人民共和国知识产权局，2016.09.07；
（11）万晓春，党利君，金言。重金属离子完全抗原的制备方法。发明专利，ZL 2012 1 0568463.9，中华人民共和国知识产权局，2017.02.15；
（12）万晓春，党利君，金言。杂交瘤细胞的培养方法。发明专利，ZL 2012 1 0572731.4，中华人民共和国知识产权局，2017.09.29；
（13）王蒲，唐超，万晓春，邹军辉。重组蛋白疫苗、含编码该重组蛋白疫苗的基因的重组表达载体及其应用。发明专利，ZL 2013 1 0676489.X，中华人民共和国知识产权局，2017.11.07；
（14）万晓春，田永帅，陈凤莲。一种负载寡聚脱氧核苷酸的壳聚糖纳米粒及其制备方法和应用。发明专利，ZL 2013 1 0659685.6，中华人民共和国知识产权局，2018.01.23；
（16）阮庆国，陈有海，范婷婷，马轶凡，蔡林涛，王绍文，万晓春。C-Rel-specific siRNA and its use for preventing and treating autoimmune psoriasis。发明专利，US10081810，美国，2018.09.25；
（15）万晓春，李俊鑫，赵琦，王蒲。动物细胞用表达载体、其制备方法及应用。发明专利，ZL 2013 1 0674959.9，中华人民共和国知识产权局，2018.03.09；
（17）万晓春，刘绿艳，李俊鑫。抗人 PD-1 的单克隆抗体及其制备方法和应用。 发明专利，ZL 2016 1 1250053.4，中华人民共和国知识产权局，2019.03.15。
（18）万晓春，李俊鑫，刘绿艳。抗H7N9全人源单克隆抗体5J13及其制法与应用。发明专利，ZL 2016 1 1038444.X，中华人民共和国知识产权局，2019.09.17。
- 已发表代表性论文
（1）Xin Li#, Guizhong Zhang#, Qian Chen, Yingxue Lin, Junxin Li, Qinggguo Ruan, Youhai Chen, Guang Yu, and Xiaochun Wan*. CD317 Promotes the survival of cancer cells through apoptosis-inducing factor.Journal of Experimental& Clinical Cancer Research, 2016, 35:117; IF=4.357；
（2）Lulu Cui#, Jiacheng Bi#, Dehong Yan, Xiufeng Ye, Mingxing Zheng, Guang Yu, Xiaochun Wan*. JSI-124 inhibits IgE production in an IgE B cell line. BBRC(Biochemical and Biophysical Research Communications). 2017.01.29, 483(1):669-673, IF=2.466；
（3）Jiacheng Bi#, Lulu Cui#, Gang Yu, Xiaolu Yang, Youhai Chen, Xiaochun Wan*. NK cells alleviate lung inflammation by negatively regulating group 2 innate lymphoid cells. The Journal of Immunology. 2017.04.15, 198(8):3336- 3344. IF= 4.856；
（4）Hongling Zhang#, Jiacheng Bi#, Huqiang Yi, Tingting Fan, Qingguo Ruan, Lintao Cai, Youhai H Chen, Xiaochun Wan*. Silencing c-Rel in macrophages dampens Th1 and Th17 immune responses and alleviates experimental autoimmune encephalomyelitis in mice. Immunology and cell biology. 2017.03.21, 95(7):593-600, IF =4.557；
（5）Abrar Ahmed#, Xiaochun Wan, Izaskun Mitxitorena, Andrew J. Lindsay, Pier Paolo Pandolfi, Mary W. McCaffrey, Karen Keeshan, Youhai H. Chen, Ruaidhrí J. Carmody*. Regulation of NF-κB by PML and PML-RARα. Scientific Reports,.2017.03.20, 7:44539. IF =4.259;
（6）Hongling Zhang#, Xuhong Chen#, Dongming Li, Lulu Cui, Xin Li, Xiufeng Ye*, Xiaochun Wan*. DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression. Oncology reports. Published online on: May 30, 2017,https://doi.org/10.3892/or.2017.5685, IF= 2.486；
（7）Junxin Li#, Ni Xie#, Jianhui Yuan#, Lvyan Liu, Qiming Zhou, Xiaohu Ren, Qian Chen, Guizhong Zhang, Qingguo Ruan, Youhai H. Chen, Xiaochun Wan*. DcR3 combined with hematological traits serves as a valuable biomarker for the diagnosis of cancer metastasis. Scientific Reports, 2017.11.20, 8(64):107612- 107620. IF= 5.168；
（8）Haisi Wu#, Jiacheng Bi#, Gaohui Wu, Chaoyue Zheng，Zhen Lu, Lulu Cui, Xiaochun Wan*。Impaired cytolytic activity of asthma-associated natural killer cells is linked to dysregulated transcriptional program in energy metabolism. Molecular Immunology, 2018.08.15, 101（2018）:514-520. IF= 3.188；
（9）Guizhong Zhang, Xin Li, Lvyan Liu, Junxin Li, Qian Chen，Shiran Huang, Yutao Li, Xiaochun Wan*. Vaccination with a DNA vaccine encoding CD317-targeting HBs antigen elicits enhanced immunity in mice. Biochemical and Biophysical Research Communications, 2018.09.06, 504（4）:865-870. IF= 2.559；
（10）Guizhong Zhang, Xin Li, Qian Chen, Junxin Li, Qingguo Ruan, Youhai H. Chen, Xiaolu Yang* and Xiaochun Wan*.CD317 activates EGFR by regulating its association with lipid rafts.Cancer Research, 2019.03.19,79（9）:2220-2231. IF= 9.13；
（11）Dehong Yan, Adeleye O. Adeshakin, Meichen Xu, Lukman O. Afolabi, Guizhong Zhang, Youhai H Chen and Xiaochun Wan*. Lipid metabolic pathways confer immunosuppressive function of myeloid-derived suppressor cells in tumor. Frontiers in Immunology,2019.06.19, 10(1)：1399. IF= 5.511；
（12）Qian Chen, Pu Wang, Qingmei Zhang, Meng Xia, Guizhong Zhang1, Junxin Li, Enyun Shen, Youhai H. Chen and Xiaochun Wan*. Preclinical studies of a death receptor-5 fusion protein that ameliorates acute liver failure and inflammation. Journal of Molecular Medicine,2019.6.22, 97(9):1247-1261. IF= 5.114；
（13）Li, Junxin; Yang, Yang; Wang, Min; Ren, Xiaohu; Yang, Zheng; Liu, Lvyan; Zhang, Guizhong; Chen, Qian; Yang, Wei; Chen, Youhai H; Wan, Xiaochun*. Rapid isolation of a potent human antibody against H7N9 influenza virus from an infected patient. Antiviral Research, 2019.7.20, 170:104564. IF= 4.130；
（14）Afolabi, Lukman; Adeshakin, Adeleye; Sani, Musbahu; Bi, Jiacheng; Wan, Xiaochun*. Genetic Reprogramming For NK cell Cancer Immunotherapy with CRISPR/Cas9. Immunology. 2019 .7.17. 158（2）:63-69.IF= 4.147；
（15）Dehong Yan, Jinghui Wang, Honghong Sun, Ali Zamani, Honglin Zhang, Weihong Chen, Aifa Tang, Qingguo Ruan, Xiaolu Yang, Youhai Chen*, and Xiaochun Wan*.TIPE2 Specifies the Functional Polarization of Myeloid-derived Suppressor Cells during Tumorigenesis.2019.10.29,DOI:10.1084/jem.20182005. IF=10.892；
（16）Qian Chen, Dehong Yan, Qingmei Zhang, Guizhong Zhang, Meng Xia, Junxin Li, Wugen Zhan, Enyun Shen, Youhai H. Chen*, and Xiaochun Wan*.Treatment of acetaminophen-induced liver failure by blocking the death checkpoint protein TRAIL.2019.10.16, DOI:10.1016/j.bbadis.2019.165583. IF=4.328；
- 指导学生
已指导学生
李俊鑫 博士研究生 071010-生物化学与分子生物学
现指导学生
刘曌 硕士研究生 071010-生物化学与分子生物学
聂蓓娜 硕士研究生 071009-细胞生物学
逯晓旭 硕士研究生 071010-生物化学与分子生物学
吴海斯 硕士研究生 085238-生物工程
卢珍 博士研究生 071010-生物化学与分子生物学
刘骏晨 博士研究生 071010-生物化学与分子生物学
王琪 硕士研究生 071010-生物化学与分子生物学
Research Interests
1、Research on new technique of immunotherapy of tumor cells（Car-T）；
2、Development of monoclonal antibody drug
Conferences
（2）IMMUNOLOGY 2018TM ABSTRACTS 2018-05-05
（3）DcR3/TR6 调节免疫细胞间的相互作用 2013医学科学前沿暨第六届分子靶向药物与肿瘤免疫研究及应用研讨会 2013-11-09
（4）2. P53 is essential in type I diabetes by regulates macrophage function Xiaochun Wan 2012-05-16
（5）2. P53 is essential in type I diabetes by regulates macrophage function Xiaochun Wan 2005-05-16
（6）TRAIL regulates the development of autoimmune diseases Xiaochun Wan 2004-06-04
Students
已指导学生
李俊鑫 博士研究生 071010-生物化学与分子生物学
刘曌 硕士研究生 071010-生物化学与分子生物学
聂蓓娜 硕士研究生 071009-细胞生物学
逯晓旭 硕士研究生 071010-生物化学与分子生物学
吴海斯 硕士研究生 085238-生物工程
卢珍 博士研究生 071010-生物化学与分子生物学
王琪 硕士研究生 071010-生物化学与分子生物学
现指导学生
刘骏晨 博士研究生 071010-生物化学与分子生物学
张鹏超 博士研究生 071010-生物化学与分子生物学
牛祥云 博士研究生 071010-生物化学与分子生物学