基本信息
万晓春  男  博导  中国科学院深圳先进技术研究院
电子邮件: xc.wan@siat.ac.cn
通信地址: 深圳市南山区西丽深圳大学城学苑大道1068号
邮政编码: 518055
部门/实验室:医药所

招生信息

博士研究生:生物化学与分子生物学、细胞生物学、微生物学

硕士研究生:生物化学与分子生物学、细胞生物学、微生物学

招生专业
071010-生物化学与分子生物学
071009-细胞生物学
071005-微生物学
招生方向
单克隆抗体药物研发
细胞免疫治疗新技术研发
癌症和自身免疫性疾病发病机制

科研活动

   
承担代表性科研项目
( 1 ) c-Rel 调控Th17细胞分化的分子机制研究, 主持, 国家级, 2014-01--2017-12
( 2 ) “个体化细胞治疗”子项目“新一代CAR-T细胞技术研发”, 主持, 省级, 2015-01--2017-12
( 3 ) 重20160266 单个B细胞法制备人源化单克隆抗体关键技术研发, 主持, 省级, 2016-06--2018-06
( 4 ) 以CD22为靶点治疗B细胞肿瘤的CAR-T技术研究与开发, 主持, 省级, 2019-10--2022-09
( 5 ) 设计构建靶向实体瘤的新一代免疫细胞, 主持, 国家级, 2020-01--2024-12
参与会议
(1)TIPE2 Protein Specifies the Functional Polarization of Myeloid-derived Suppressor Cells during Tumorigenesis   2018-09-02
(2)IMMUNOLOGY 2018TM ABSTRACTS   2018-05-05
(3)DcR3/TR6 调节免疫细胞间的相互作用   2013医学科学前沿暨第六届分子靶向药物与肿瘤免疫研究及应用研讨会   2013-11-09
(4)无   广东省免疫学年会   无   2013-11-06
(5)无   广东省免疫学年会   无   2012-09-15
(6)2. P53 is essential in type I diabetes by regulates macrophage function   Xiaochun Wan    2012-05-16
(7)2. P53 is essential in type I diabetes by regulates macrophage function   Xiaochun Wan   2005-05-16
(8)TRAIL regulates the development of autoimmune diseases   Xiaochun Wan   2004-06-04
已授权专利

1)万晓春,林婷婷,向军俭。免疫用抗原乳化装置。实用新型专利,ZL 2012 2 0715989.0,中华人民共和国知识产权局,2013.06.19
(2)万晓春,姚红,吴洪飞。一种混合细胞培养生产纯人源单克隆抗体的方法。发明专利,ZL 2011 1 0214513.9,中华人民共和国知识产权局,2014.09.03
(3)万晓春,王彩霞,向军俭。HAT半固体筛选培养基以及杂交瘤细胞的筛选方法。发明专利,ZL 2012105727598,中华人民共和国知识产权局,2015.12.23
(4)万晓春,刘婕,金言,蔡林涛。半固体筛选培养基以及杂交瘤细胞的筛选方法。发明专利,ZL 2012 1 0576356.0,中华人民共和国知识产权局,2016.01.27;
(5)赵琦,刘婕,万晓春。一种通用型重组表达载体及其构建方法和应用。发明专利,ZL 2013 1 0750733.2,中华人民共和国知识产权局,2016.02.17;
(6)万晓春,刘婕,金言,蔡林涛。半固体培养基及其制备方法和杂交瘤细胞筛选方法。发明专利,ZL 2012 1 0575548.X,中华人民共和国知识产权局,2016.04.13;
(7)万晓春,刘婕,金言。乳胶半固体培养基及其制备方法和杂交瘤细胞筛选方法。发明专利,ZL 2012 1 0575609.2,中华人民共和国知识产权局,2016.04.13;
(8)万晓春,吕卫东。人源化抗体表达载体及其构建方法。发明专利,ZL 2013 1 0737306.0,中华人民共和国知识产权局,2016.06.15;
9万晓春,李俊鑫,任晓虎,王蒲。突变型TNF-α基因和提高抗原TNF-α基因表达量的方法。发明专利,ZL 2012 1 0572674.X,中华人民共和国知识产权局,2016.08.17;
10万晓春、胡玉婷、金言。一种小鼠固定装置。发明专利,ZL 2012 1 0546281.1,中华人民共和国知识产权局,2016.09.07;
(11万晓春,党利君,金言。重金属离子完全抗原的制备方法。发明专利,ZL 2012 1 0568463.9,中华人民共和国知识产权局,2017.02.15;
(12万晓春,党利君,金言。杂交瘤细胞的培养方法。发明专利,ZL 2012 1 0572731.4,中华人民共和国知识产权局,2017.09.29
(13)王蒲,唐超,万晓春,邹军辉。重组蛋白疫苗、含编码该重组蛋白疫苗的基因的重组表达载体及其应用。发明专利,ZL 2013 1 0676489.X,中华人民共和国知识产权局,2017.11.07
(14万晓春,田永帅,陈凤莲。一种负载寡聚脱氧核苷酸的壳聚糖纳米粒及其制备方法和应用。发明专利,ZL 2013 1 0659685.6,中华人民共和国知识产权局,2018.01.23
(16)阮庆国,陈有海,范婷婷,马轶凡,蔡林涛,王绍文,万晓春C-Rel-specific siRNA and its use for preventing and treating autoimmune psoriasis。发明专利,US10081810,美国,2018.09.25
(15万晓春,李俊鑫,赵琦,王蒲。动物细胞用表达载体、其制备方法及应用。发明专利,ZL 2013 1 0674959.9,中华人民共和国知识产权局,2018.03.09
(17)万晓春刘绿艳李俊鑫。抗人 PD-1 的单克隆抗体及其制备方法和应用。 发明专利,ZL 2016 1 1250053.4,中华人民共和国知识产权局,2019.03.15。
18)万晓春,李俊鑫,刘绿艳。抗H7N9全人源单克隆抗体5J13及其制法与应用。发明专利,ZL 2016 1 1038444.X,中华人民共和国知识产权局,2019.09.17。

已发表代表性论文

(1)Xin Li#, Guizhong Zhang#, Qian Chen, Yingxue Lin, Junxin Li, Qinggguo Ruan, Youhai Chen, Guang Yu, and Xiaochun Wan*. CD317 Promotes the survival of cancer cells through apoptosis-inducing factor. Journal of Experimental& Clinical Cancer Research, 2016, 35:117; IF=4.357

(2)Lulu Cui#, Jiacheng Bi#, Dehong Yan, Xiufeng Ye, Mingxing Zheng, Guang Yu, Xiaochun Wan*. JSI-124 inhibits IgE production in an IgE B cell line. BBRC(Biochemical and Biophysical Research Communications). 2017.01.29, 483(1):669-673, IF=2.466;

(3)Jiacheng Bi#, Lulu Cui#, Gang Yu, Xiaolu Yang, Youhai Chen, Xiaochun Wan*. NK cells alleviate lung inflammation by negatively regulating group 2 innate lymphoid cells. The Journal of Immunology. 2017.04.15, 198(8):3336- 3344.  IF= 4.856;

(4)Hongling Zhang#, Jiacheng Bi#, Huqiang Yi, Tingting Fan, Qingguo Ruan, Lintao Cai, Youhai H Chen, Xiaochun Wan*. Silencing c-Rel in macrophages dampens Th1 and Th17 immune responses and alleviates experimental autoimmune encephalomyelitis in mice. Immunology and cell biology. 2017.03.21, 95(7):593-600, IF =4.557;

(5)Abrar Ahmed#, Xiaochun Wan, Izaskun Mitxitorena, Andrew J. Lindsay, Pier Paolo Pandolfi, Mary W. McCaffrey, Karen Keeshan, Youhai H. Chen, Ruaidhrí J. Carmody*. Regulation of NF-κB by PML and PML-RARα. Scientific Reports,.2017.03.20, 7:44539. IF =4.259; 

(6)Hongling Zhang#, Xuhong Chen#, Dongming Li, Lulu Cui, Xin Li, Xiufeng Ye*, Xiaochun Wan*. DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression. Oncology reports. Published online on: May 30, 2017,https://doi.org/10.3892/or.2017.5685, IF= 2.486; 

(7)Junxin Li#, Ni Xie#, Jianhui Yuan#, Lvyan Liu, Qiming Zhou, Xiaohu Ren, Qian Chen, Guizhong Zhang, Qingguo Ruan, Youhai H. Chen, Xiaochun Wan*. DcR3 combined with hematological traits serves as a valuable biomarker for the diagnosis of cancer metastasis. Scientific Reports, 2017.11.20, 8(64):107612- 107620. IF= 5.168;

(8)Haisi Wu#, Jiacheng Bi#, Gaohui Wu, Chaoyue Zheng,Zhen Lu, Lulu Cui, Xiaochun Wan*。Impaired cytolytic activity of asthma-associated natural killer cells is linked to dysregulated transcriptional program in energy metabolism. Molecular Immunology, 2018.08.15, 101(2018):514-520. IF= 3.188;

(9)Guizhong Zhang, Xin Li, Lvyan Liu, Junxin Li, Qian Chen,Shiran Huang, Yutao Li, Xiaochun Wan*. Vaccination with a DNA vaccine encoding CD317-targeting HBs antigen elicits enhanced immunity in mice. Biochemical and Biophysical Research Communications, 2018.09.06, 504(4):865-870. IF= 2.559;

(10)Guizhong Zhang, Xin Li, Qian Chen, Junxin Li, Qingguo Ruan, Youhai H. Chen, Xiaolu Yang* and Xiaochun Wan*.CD317 activates EGFR by regulating its association with lipid rafts.Cancer Research, 2019.03.19,79(9):2220-2231. IF= 9.13;

(11)Dehong Yan, Adeleye O. Adeshakin, Meichen Xu, Lukman O. Afolabi, Guizhong Zhang, Youhai H Chen and Xiaochun Wan*. Lipid metabolic pathways confer immunosuppressive function of myeloid-derived suppressor cells in tumor. Frontiers in Immunology,2019.06.19, 10(1):1399. IF= 5.511;

(12)Qian Chen, Pu Wang, Qingmei Zhang, Meng Xia, Guizhong Zhang1, Junxin Li, Enyun Shen, Youhai H. Chen and Xiaochun Wan*. Preclinical studies of a death receptor-5 fusion protein that ameliorates acute liver failure and inflammation. Journal of Molecular Medicine,2019.6.22, 97(9):1247-1261. IF= 5.114;

(13)Li, JunxinYang, YangWang, MinRen, XiaohuYang, ZhengLiu, LvyanZhang, GuizhongChen, QianYang, WeiChen, Youhai HWan, Xiaochun*. Rapid isolation of a potent human antibody against H7N9 influenza virus from an infected patient. Antiviral Research, 2019.7.20, 170:104564. IF= 4.130;

(14)Afolabi, Lukman; Adeshakin, Adeleye; Sani, Musbahu; Bi, Jiacheng; Wan, Xiaochun*. Genetic Reprogramming For NK cell Cancer Immunotherapy with CRISPR/Cas9. Immunology. 2019 .7.17. 158(2):63-69. IF= 4.147;

(15)Dehong Yan, Jinghui Wang, Honghong Sun, Ali Zamani, Honglin Zhang, Weihong Chen, Aifa Tang, Qingguo Ruan, Xiaolu Yang, Youhai Chen*, and Xiaochun Wan*.TIPE2 Specifies the Functional Polarization of Myeloid-derived Suppressor Cells during Tumorigenesis.2019.10.29,DOI:10.1084/jem.20182005. IF=10.892;

(16)Qian Chen, Dehong Yan, Qingmei Zhang, Guizhong Zhang, Meng Xia, Junxin Li, Wugen Zhan, Enyun Shen, Youhai H. Chen*, and Xiaochun Wan*.Treatment of acetaminophen-induced liver failure by blocking the death checkpoint protein TRAIL.2019.10.16, DOI:10.1016/j.bbadis.2019.165583. IF=4.328;